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Protein

Visinin-like protein 1

Gene

Vsnl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi159 – 170123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. calcium-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Visinin-like protein 1
Short name:
VILIP
Alternative name(s):
Neural visinin-like protein 1
Short name:
NVL-1
Short name:
NVP-1
Gene namesi
Name:Vsnl1
Synonyms:Visl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1349453. Vsnl1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 191190Visinin-like protein 1PRO_0000073764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP62761.
PaxDbiP62761.
PRIDEiP62761.

PTM databases

PhosphoSiteiP62761.

Expressioni

Gene expression databases

BgeeiP62761.
CleanExiMM_VSNL1.
ExpressionAtlasiP62761. baseline and differential.
GenevestigatoriP62761.

Interactioni

Protein-protein interaction databases

IntActiP62761. 1 interaction.
MINTiMINT-4429110.

Structurei

3D structure databases

ProteinModelPortaliP62761.
SMRiP62761. Positions 5-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini146 – 18136EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62761.
OMAiDRIFSKM.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62761.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029533. VILIP-1.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF72. PTHR23055:SF72. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ
60 70 80 90 100
LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK
110 120 130 140 150
LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR
160 170 180 190
VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K
Length:191
Mass (Da):22,142
Last modified:January 23, 2007 - v2
Checksum:iACDC3B4FE8C79265
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21165 mRNA. Translation: BAA04701.1.
AY101375 mRNA. Translation: AAM48292.1.
BC046226 mRNA. Translation: AAH46226.1.
CCDSiCCDS25816.1.
RefSeqiNP_036168.1. NM_012038.4.
UniGeneiMm.27005.

Genome annotation databases

EnsembliENSMUST00000072299; ENSMUSP00000072145; ENSMUSG00000054459.
GeneIDi26950.
KEGGimmu:26950.
UCSCiuc011ykf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21165 mRNA. Translation: BAA04701.1.
AY101375 mRNA. Translation: AAM48292.1.
BC046226 mRNA. Translation: AAH46226.1.
CCDSiCCDS25816.1.
RefSeqiNP_036168.1. NM_012038.4.
UniGeneiMm.27005.

3D structure databases

ProteinModelPortaliP62761.
SMRiP62761. Positions 5-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62761. 1 interaction.
MINTiMINT-4429110.

PTM databases

PhosphoSiteiP62761.

Proteomic databases

MaxQBiP62761.
PaxDbiP62761.
PRIDEiP62761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072299; ENSMUSP00000072145; ENSMUSG00000054459.
GeneIDi26950.
KEGGimmu:26950.
UCSCiuc011ykf.1. mouse.

Organism-specific databases

CTDi7447.
MGIiMGI:1349453. Vsnl1.

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62761.
OMAiDRIFSKM.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62761.
TreeFamiTF300009.

Miscellaneous databases

NextBioi304891.
PROiP62761.
SOURCEiSearch...

Gene expression databases

BgeeiP62761.
CleanExiMM_VSNL1.
ExpressionAtlasiP62761. baseline and differential.
GenevestigatoriP62761.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029533. VILIP-1.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF72. PTHR23055:SF72. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and primary structure of mouse neural visinin-like CA2+-binding protein type 1 (NVP-1)."
    Shirai Y., Asami M., Mukai H., Chang C., Shuntoh H., Kuno T., Tanaka C.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Searching for the endomorphin-1-2 pro-peptide precursor(s) protein(s): cloning of a protein encoding an endomorphin-2-like peptide sequence."
    Anton B., Matus M., Leff P., Calva J.C., Acevedo R., Hernandez A., Medecigo M., Valdez A., Sanchez Lopez R., Vergara P., Torner C., Segovia J., Alagon A.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Kang S.U.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 8-18; 43-63 AND 119-150, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiVISL1_MOUSE
AccessioniPrimary (citable) accession number: P62761
Secondary accession number(s): P28677
, P29103, P42323, Q9UM20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds three calcium ions.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.