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P62761

- VISL1_MOUSE

UniProt

P62761 - VISL1_MOUSE

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Protein
Visinin-like protein 1
Gene
Vsnl1, Visl1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121 Reviewed prediction
Add
BLAST
Calcium bindingi109 – 120122 Reviewed prediction
Add
BLAST
Calcium bindingi159 – 170123 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Visinin-like protein 1
Short name:
VILIP
Alternative name(s):
Neural visinin-like protein 1
Short name:
NVL-1
Short name:
NVP-1
Gene namesi
Name:Vsnl1
Synonyms:Visl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1349453. Vsnl1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 191190Visinin-like protein 1
PRO_0000073764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP62761.
PaxDbiP62761.
PRIDEiP62761.

PTM databases

PhosphoSiteiP62761.

Expressioni

Gene expression databases

ArrayExpressiP62761.
BgeeiP62761.
CleanExiMM_VSNL1.
GenevestigatoriP62761.

Interactioni

Protein-protein interaction databases

IntActiP62761. 1 interaction.
MINTiMINT-4429110.

Structurei

3D structure databases

ProteinModelPortaliP62761.
SMRiP62761. Positions 5-187.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1
Add
BLAST
Domaini60 – 9536EF-hand 2
Add
BLAST
Domaini96 – 13136EF-hand 3
Add
BLAST
Domaini146 – 18136EF-hand 4
Add
BLAST

Sequence similaritiesi

Belongs to the recoverin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62761.
OMAiFDVDNSK.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62761.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029533. VILIP-1.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF72. PTHR23055:SF72. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62761-1 [UniParc]FASTAAdd to Basket

« Hide

MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ    50
LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK 100
LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR 150
VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K 191
Length:191
Mass (Da):22,142
Last modified:January 23, 2007 - v2
Checksum:iACDC3B4FE8C79265
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D21165 mRNA. Translation: BAA04701.1.
AY101375 mRNA. Translation: AAM48292.1.
BC046226 mRNA. Translation: AAH46226.1.
CCDSiCCDS25816.1.
RefSeqiNP_036168.1. NM_012038.4.
UniGeneiMm.27005.

Genome annotation databases

EnsembliENSMUST00000072299; ENSMUSP00000072145; ENSMUSG00000054459.
GeneIDi26950.
KEGGimmu:26950.
UCSCiuc011ykf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D21165 mRNA. Translation: BAA04701.1 .
AY101375 mRNA. Translation: AAM48292.1 .
BC046226 mRNA. Translation: AAH46226.1 .
CCDSi CCDS25816.1.
RefSeqi NP_036168.1. NM_012038.4.
UniGenei Mm.27005.

3D structure databases

ProteinModelPortali P62761.
SMRi P62761. Positions 5-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P62761. 1 interaction.
MINTi MINT-4429110.

PTM databases

PhosphoSitei P62761.

Proteomic databases

MaxQBi P62761.
PaxDbi P62761.
PRIDEi P62761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072299 ; ENSMUSP00000072145 ; ENSMUSG00000054459 .
GeneIDi 26950.
KEGGi mmu:26950.
UCSCi uc011ykf.1. mouse.

Organism-specific databases

CTDi 7447.
MGIi MGI:1349453. Vsnl1.

Phylogenomic databases

eggNOGi COG5126.
HOGENOMi HOG000233019.
HOVERGENi HBG108179.
InParanoidi P62761.
OMAi FDVDNSK.
OrthoDBi EOG7GJ6F3.
PhylomeDBi P62761.
TreeFami TF300009.

Miscellaneous databases

NextBioi 304891.
PROi P62761.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62761.
Bgeei P62761.
CleanExi MM_VSNL1.
Genevestigatori P62761.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029533. VILIP-1.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
PTHR23055:SF72. PTHR23055:SF72. 1 hit.
Pfami PF00036. EF-hand_1. 3 hits.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and primary structure of mouse neural visinin-like CA2+-binding protein type 1 (NVP-1)."
    Shirai Y., Asami M., Mukai H., Chang C., Shuntoh H., Kuno T., Tanaka C.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Searching for the endomorphin-1-2 pro-peptide precursor(s) protein(s): cloning of a protein encoding an endomorphin-2-like peptide sequence."
    Anton B., Matus M., Leff P., Calva J.C., Acevedo R., Hernandez A., Medecigo M., Valdez A., Sanchez Lopez R., Vergara P., Torner C., Segovia J., Alagon A.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 8-18; 43-63 AND 119-150, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiVISL1_MOUSE
AccessioniPrimary (citable) accession number: P62761
Secondary accession number(s): P28677
, P29103, P42323, Q9UM20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds three calcium ions.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi