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P62761 (VISL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Visinin-like protein 1

Short name=VILIP
Alternative name(s):
Neural visinin-like protein 1
Short name=NVL-1
Short name=NVP-1
Gene names
Name:Vsnl1
Synonyms:Visl1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner By similarity.

Miscellaneous

Probably binds three calcium ions.

Sequence similarities

Belongs to the recoverin family.

Contains 4 EF-hand domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 191190Visinin-like protein 1
PRO_0000073764

Regions

Domain23 – 5836EF-hand 1
Domain60 – 9536EF-hand 2
Domain96 – 13136EF-hand 3
Domain146 – 18136EF-hand 4
Calcium binding73 – 84121 Potential
Calcium binding109 – 120122 Potential
Calcium binding159 – 170123 Potential

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62761 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: ACDC3B4FE8C79265

FASTA19122,142
        10         20         30         40         50         60 
MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD 

        70         80         90        100        110        120 
ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE 

       130        140        150        160        170        180 
MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS 

       190 
IVLLLQCDIQ K 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning and primary structure of mouse neural visinin-like CA2+-binding protein type 1 (NVP-1)."
Shirai Y., Asami M., Mukai H., Chang C., Shuntoh H., Kuno T., Tanaka C.
Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Searching for the endomorphin-1-2 pro-peptide precursor(s) protein(s): cloning of a protein encoding an endomorphin-2-like peptide sequence."
Anton B., Matus M., Leff P., Calva J.C., Acevedo R., Hernandez A., Medecigo M., Valdez A., Sanchez Lopez R., Vergara P., Torner C., Segovia J., Alagon A.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 8-18; 43-63 AND 119-150, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D21165 mRNA. Translation: BAA04701.1.
AY101375 mRNA. Translation: AAM48292.1.
BC046226 mRNA. Translation: AAH46226.1.
RefSeqNP_036168.1. NM_012038.4.
UniGeneMm.27005.

3D structure databases

ProteinModelPortalP62761.
SMRP62761. Positions 5-187.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP62761. 1 interaction.
MINTMINT-4429110.

PTM databases

PhosphoSiteP62761.

Proteomic databases

PaxDbP62761.
PRIDEP62761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072299; ENSMUSP00000072145; ENSMUSG00000054459.
GeneID26950.
KEGGmmu:26950.
UCSCuc011ykf.1. mouse.

Organism-specific databases

CTD7447.
MGIMGI:1349453. Vsnl1.

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233019.
HOVERGENHBG108179.
InParanoidP62761.
OMALQFFPYG.
OrthoDBEOG7GJ6F3.
PhylomeDBP62761.
TreeFamTF300009.

Gene expression databases

ArrayExpressP62761.
BgeeP62761.
CleanExMM_VSNL1.
GenevestigatorP62761.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001125. Recoverin_like.
[Graphical view]
PfamPF00036. EF-hand_1. 3 hits.
[Graphical view]
PRINTSPR00450. RECOVERIN.
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio304891.
PROP62761.
SOURCESearch...

Entry information

Entry nameVISL1_MOUSE
AccessionPrimary (citable) accession number: P62761
Secondary accession number(s): P28677 expand/collapse secondary AC list , P29103, P42323, Q9UM20
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot