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P62761

- VISL1_MOUSE

UniProt

P62761 - VISL1_MOUSE

Protein

Visinin-like protein 1

Gene

Vsnl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi159 – 170123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Visinin-like protein 1
    Short name:
    VILIP
    Alternative name(s):
    Neural visinin-like protein 1
    Short name:
    NVL-1
    Short name:
    NVP-1
    Gene namesi
    Name:Vsnl1
    Synonyms:Visl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1349453. Vsnl1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 191190Visinin-like protein 1PRO_0000073764Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiP62761.
    PaxDbiP62761.
    PRIDEiP62761.

    PTM databases

    PhosphoSiteiP62761.

    Expressioni

    Gene expression databases

    ArrayExpressiP62761.
    BgeeiP62761.
    CleanExiMM_VSNL1.
    GenevestigatoriP62761.

    Interactioni

    Protein-protein interaction databases

    IntActiP62761. 1 interaction.
    MINTiMINT-4429110.

    Structurei

    3D structure databases

    ProteinModelPortaliP62761.
    SMRiP62761. Positions 5-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini146 – 18136EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233019.
    HOVERGENiHBG108179.
    InParanoidiP62761.
    OMAiFDVDNSK.
    OrthoDBiEOG7GJ6F3.
    PhylomeDBiP62761.
    TreeFamiTF300009.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    IPR029533. VILIP-1.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PTHR23055:SF72. PTHR23055:SF72. 1 hit.
    PfamiPF00036. EF-hand_1. 3 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62761-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ    50
    LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK 100
    LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR 150
    VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K 191
    Length:191
    Mass (Da):22,142
    Last modified:January 23, 2007 - v2
    Checksum:iACDC3B4FE8C79265
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21165 mRNA. Translation: BAA04701.1.
    AY101375 mRNA. Translation: AAM48292.1.
    BC046226 mRNA. Translation: AAH46226.1.
    CCDSiCCDS25816.1.
    RefSeqiNP_036168.1. NM_012038.4.
    UniGeneiMm.27005.

    Genome annotation databases

    EnsembliENSMUST00000072299; ENSMUSP00000072145; ENSMUSG00000054459.
    GeneIDi26950.
    KEGGimmu:26950.
    UCSCiuc011ykf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21165 mRNA. Translation: BAA04701.1 .
    AY101375 mRNA. Translation: AAM48292.1 .
    BC046226 mRNA. Translation: AAH46226.1 .
    CCDSi CCDS25816.1.
    RefSeqi NP_036168.1. NM_012038.4.
    UniGenei Mm.27005.

    3D structure databases

    ProteinModelPortali P62761.
    SMRi P62761. Positions 5-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P62761. 1 interaction.
    MINTi MINT-4429110.

    PTM databases

    PhosphoSitei P62761.

    Proteomic databases

    MaxQBi P62761.
    PaxDbi P62761.
    PRIDEi P62761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072299 ; ENSMUSP00000072145 ; ENSMUSG00000054459 .
    GeneIDi 26950.
    KEGGi mmu:26950.
    UCSCi uc011ykf.1. mouse.

    Organism-specific databases

    CTDi 7447.
    MGIi MGI:1349453. Vsnl1.

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233019.
    HOVERGENi HBG108179.
    InParanoidi P62761.
    OMAi FDVDNSK.
    OrthoDBi EOG7GJ6F3.
    PhylomeDBi P62761.
    TreeFami TF300009.

    Miscellaneous databases

    NextBioi 304891.
    PROi P62761.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62761.
    Bgeei P62761.
    CleanExi MM_VSNL1.
    Genevestigatori P62761.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    IPR029533. VILIP-1.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    PTHR23055:SF72. PTHR23055:SF72. 1 hit.
    Pfami PF00036. EF-hand_1. 3 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and primary structure of mouse neural visinin-like CA2+-binding protein type 1 (NVP-1)."
      Shirai Y., Asami M., Mukai H., Chang C., Shuntoh H., Kuno T., Tanaka C.
      Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Searching for the endomorphin-1-2 pro-peptide precursor(s) protein(s): cloning of a protein encoding an endomorphin-2-like peptide sequence."
      Anton B., Matus M., Leff P., Calva J.C., Acevedo R., Hernandez A., Medecigo M., Valdez A., Sanchez Lopez R., Vergara P., Torner C., Segovia J., Alagon A.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 8-18; 43-63 AND 119-150, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiVISL1_MOUSE
    AccessioniPrimary (citable) accession number: P62761
    Secondary accession number(s): P28677
    , P29103, P42323, Q9UM20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Probably binds three calcium ions.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3