P62760 (VISL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Visinin-like protein 1
Short name=VILIP
Short name=VLP-1

Alternative name(s):
Hippocalcin-like protein 3
Short name=HLP3

Gene names

Name:	VSNL1
Synonyms:	VISL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner By similarity.
Tissue specificity	Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level). Ref.6
Miscellaneous	Probably binds three calcium ions.
Sequence similarities	Belongs to the recoverin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Visinin-like protein 1		PRO_0000073763
Regions
	Domain	23 – 58	36	EF-hand 1
	Domain	60 – 95	36	EF-hand 2
	Domain	96 – 131	36	EF-hand 3
	Domain	146 – 181	36	EF-hand 4
	Calcium binding	73 – 84	12	1 Potential
	Calcium binding	109 – 120	12	2 Potential
	Calcium binding	159 – 170	12	3 Potential
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity
Natural variations
	Natural variant	65	1	A → G. Ref.1 Corresponds to variant rs1042674 [ dbSNP | Ensembl ].		VAR_047313
	Natural variant	172	1	K → R. Ref.1 Corresponds to variant rs1042685 [ dbSNP | Ensembl ].		VAR_047314
Experimental info
	Sequence conflict	75	1	N → I in AAA91295. Ref.1
	Sequence conflict	140	1	M → K in BAA86891. Ref.3
	Sequence conflict	158	1	M → K in BAA86891. Ref.3
	Sequence conflict	169	1	D → G in AAA91295. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P62760 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: ACDC3B4FE8C79265	FASTA	191	22,142
	10 20 30 40 50 60 MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD 70 80 90 100 110 120 ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE 130 140 150 160 170 180 MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS 190 IVLLLQCDIQ K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1." Polymeropoulos M.H., Ide S., Soares M.B., Lennon G.G. Genomics 29:273-275(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-65 AND ARG-172.
[2]	"Peptide conservation between avian and mammalian visinin-like proteins." Bellingham J. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes." Kobayashi M., Sakai E., Furuta Y., Takamatsu K. DNA Seq. 9:171-176(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[6]	"The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients." Lee J.M., Blennow K., Andreasen N., Laterza O., Modur V., Olander J., Gao F., Ohlendorf M., Ladenson J.H. Clin. Chem. 54:1617-1623(2008) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14747 mRNA. Translation: AAA91295.1. AF039555 mRNA. Translation: AAD02174.1. AB001104 mRNA. Translation: BAA86891.1. CH471053 Genomic DNA. Translation: EAX00870.1. CH471053 Genomic DNA. Translation: EAX00871.1. CH471053 Genomic DNA. Translation: EAX00872.1. CH471053 Genomic DNA. Translation: EAX00875.1. BC022012 mRNA. Translation: AAH22012.1.
IPI	IPI00216313.
RefSeq	NP_003376.2. NM_003385.4.
UniGene	Hs.444212.
3D structure databases
ProteinModelPortal	P62760.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62760. 4 interactions.
MINT	MINT-1436309.
STRING	9606.ENSP00000295156.
PTM databases
PhosphoSite	P62760.
Polymorphism databases
DMDM	51338696.
Proteomic databases
PaxDb	P62760.
PRIDE	P62760.
Protocols and materials databases
DNASU	7447.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295156; ENSP00000295156; ENSG00000163032. ENST00000404666; ENSP00000384014; ENSG00000163032. ENST00000406397; ENSP00000384719; ENSG00000163032.
GeneID	7447.
KEGG	hsa:7447.
UCSC	uc002rcm.3. human.
Organism-specific databases
CTD	7447.
GeneCards	GC02P017643.
HGNC	HGNC:12722. VSNL1.
MIM	600817. gene.
neXtProt	NX_P62760.
PharmGKB	PA37333.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5126.
HOGENOM	HOG000233019.
HOVERGEN	HBG108179.
InParanoid	P62760.
OMA	CCHIDLK.
OrthoDB	EOG40VVQK.
PhylomeDB	P62760.
Gene expression databases
ArrayExpress	P62760.
Bgee	P62760.
CleanEx	HS_VSNL1.
Genevestigator	P62760.
GermOnline	ENSG00000163032. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 3 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001125. Recoverin. [Graphical view]
Pfam	PF00036. efhand. 3 hits. [Graphical view]
PRINTS	PR00450. RECOVERIN.
SMART	SM00054. EFh. 3 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VSNL1. human.
GenomeRNAi	7447.
NextBio	29162.
SOURCE	Search...

Entry information

Entry name

VISL1_HUMAN

Accession

Primary (citable) accession number: P62760
Secondary accession number(s): D6W515 , P28677, P29103, P42323, Q9UM20

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.