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Protein

Visinin-like protein 1

Gene

VSNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi159 – 170123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Visinin-like protein 1
Short name:
VILIP
Short name:
VLP-1
Alternative name(s):
Hippocalcin-like protein 3
Short name:
HLP3
Gene namesi
Name:VSNL1
Synonyms:VISL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12722. VSNL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37333.

Polymorphism and mutation databases

BioMutaiVSNL1.
DMDMi51338696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 191190Visinin-like protein 1PRO_0000073763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP62760.
PaxDbiP62760.
PRIDEiP62760.

PTM databases

PhosphoSiteiP62760.

Expressioni

Tissue specificityi

Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level).1 Publication

Gene expression databases

BgeeiP62760.
CleanExiHS_VSNL1.
ExpressionAtlasiP62760. baseline and differential.
GenevisibleiP62760. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DTX2Q4ZH493EBI-740943,EBI-10192429
DTX2Q86UW94EBI-740943,EBI-740376
FAM131CQ96AQ94EBI-740943,EBI-741921

Protein-protein interaction databases

BioGridi113286. 11 interactions.
IntActiP62760. 5 interactions.
MINTiMINT-1436309.
STRINGi9606.ENSP00000295156.

Structurei

3D structure databases

ProteinModelPortaliP62760.
SMRiP62760. Positions 5-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini146 – 18136EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62760.
OMAiDRIFSKM.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62760.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029533. VILIP-1.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF72. PTHR23055:SF72. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ
60 70 80 90 100
LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK
110 120 130 140 150
LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR
160 170 180 190
VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K
Length:191
Mass (Da):22,142
Last modified:January 23, 2007 - v2
Checksum:iACDC3B4FE8C79265
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751N → I in AAA91295 (PubMed:8530085).Curated
Sequence conflicti140 – 1401M → K in BAA86891 (PubMed:10520747).Curated
Sequence conflicti158 – 1581M → K in BAA86891 (PubMed:10520747).Curated
Sequence conflicti169 – 1691D → G in AAA91295 (PubMed:8530085).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651A → G.1 Publication
Corresponds to variant rs1042674 [ dbSNP | Ensembl ].
VAR_047313
Natural varianti172 – 1721K → R.1 Publication
Corresponds to variant rs1042685 [ dbSNP | Ensembl ].
VAR_047314

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14747 mRNA. Translation: AAA91295.1.
AF039555 mRNA. Translation: AAD02174.1.
AB001104 mRNA. Translation: BAA86891.1.
CH471053 Genomic DNA. Translation: EAX00870.1.
CH471053 Genomic DNA. Translation: EAX00871.1.
CH471053 Genomic DNA. Translation: EAX00872.1.
CH471053 Genomic DNA. Translation: EAX00875.1.
BC022012 mRNA. Translation: AAH22012.1.
CCDSiCCDS1689.1.
RefSeqiNP_003376.2. NM_003385.4.
UniGeneiHs.444212.

Genome annotation databases

EnsembliENST00000295156; ENSP00000295156; ENSG00000163032.
ENST00000404666; ENSP00000384014; ENSG00000163032.
ENST00000406397; ENSP00000384719; ENSG00000163032.
GeneIDi7447.
KEGGihsa:7447.
UCSCiuc002rcm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14747 mRNA. Translation: AAA91295.1.
AF039555 mRNA. Translation: AAD02174.1.
AB001104 mRNA. Translation: BAA86891.1.
CH471053 Genomic DNA. Translation: EAX00870.1.
CH471053 Genomic DNA. Translation: EAX00871.1.
CH471053 Genomic DNA. Translation: EAX00872.1.
CH471053 Genomic DNA. Translation: EAX00875.1.
BC022012 mRNA. Translation: AAH22012.1.
CCDSiCCDS1689.1.
RefSeqiNP_003376.2. NM_003385.4.
UniGeneiHs.444212.

3D structure databases

ProteinModelPortaliP62760.
SMRiP62760. Positions 5-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113286. 11 interactions.
IntActiP62760. 5 interactions.
MINTiMINT-1436309.
STRINGi9606.ENSP00000295156.

PTM databases

PhosphoSiteiP62760.

Polymorphism and mutation databases

BioMutaiVSNL1.
DMDMi51338696.

Proteomic databases

MaxQBiP62760.
PaxDbiP62760.
PRIDEiP62760.

Protocols and materials databases

DNASUi7447.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295156; ENSP00000295156; ENSG00000163032.
ENST00000404666; ENSP00000384014; ENSG00000163032.
ENST00000406397; ENSP00000384719; ENSG00000163032.
GeneIDi7447.
KEGGihsa:7447.
UCSCiuc002rcm.3. human.

Organism-specific databases

CTDi7447.
GeneCardsiGC02P017720.
HGNCiHGNC:12722. VSNL1.
MIMi600817. gene.
neXtProtiNX_P62760.
PharmGKBiPA37333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62760.
OMAiDRIFSKM.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62760.
TreeFamiTF300009.

Miscellaneous databases

ChiTaRSiVSNL1. human.
GeneWikiiVSNL1.
GenomeRNAii7447.
NextBioi29162.
PROiP62760.
SOURCEiSearch...

Gene expression databases

BgeeiP62760.
CleanExiHS_VSNL1.
ExpressionAtlasiP62760. baseline and differential.
GenevisibleiP62760. HS.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029533. VILIP-1.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF72. PTHR23055:SF72. 1 hit.
PfamiPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1."
    Polymeropoulos M.H., Ide S., Soares M.B., Lennon G.G.
    Genomics 29:273-275(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-65 AND ARG-172.
  2. "Peptide conservation between avian and mammalian visinin-like proteins."
    Bellingham J.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes."
    Kobayashi M., Sakai E., Furuta Y., Takamatsu K.
    DNA Seq. 9:171-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients."
    Lee J.M., Blennow K., Andreasen N., Laterza O., Modur V., Olander J., Gao F., Ohlendorf M., Ladenson J.H.
    Clin. Chem. 54:1617-1623(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVISL1_HUMAN
AccessioniPrimary (citable) accession number: P62760
Secondary accession number(s): D6W515
, P28677, P29103, P42323, Q9UM20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Probably binds three calcium ions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.