Reviewed,
UniProtKB/Swiss-Prot P62760 (VISL1_HUMAN)
Last modified
November 25, 2008.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Visinin-like protein 1 Short name=VILIP Short name=VLP-1 Alternative name(s): Hippocalcin-like protein 3 Short name=HLP3 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 191 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner By similarity. |
| Tissue specificity | Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level). |
| Miscellaneous | Probably binds three calcium ions. |
| Sequence similarities | Belongs to the recoverin family. Contains 4 EF-hand domains. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Domain | Repeat |
| Ligand | Calcium |
| PTM | Lipoprotein Myristate |
Gene Ontology (GO) | |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 191 | 190 | Visinin-like protein 1 | PRO_0000073763 | |||||
Regions | |||||||||
| Domain | 23 – 58 | 36 | EF-hand 1 | ||||||
| Domain | 60 – 95 | 36 | EF-hand 2 | ||||||
| Domain | 96 – 131 | 36 | EF-hand 3 | ||||||
| Domain | 146 – 181 | 36 | EF-hand 4 | ||||||
| Calcium binding | 73 – 84 | 12 | 1 Potential | ||||||
| Calcium binding | 109 – 120 | 12 | 2 Potential | ||||||
| Calcium binding | 159 – 170 | 12 | 3 Potential | ||||||
Amino acid modifications | |||||||||
| Lipidation | 2 | 1 | N-myristoyl glycine By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 65 | 1 | A → G: dbSNP rs1042674. | VAR_047313 | |||||
| Natural variant | 172 | 1 | K → R: dbSNP rs1042685. | VAR_047314 | |||||
Experimental info | |||||||||
| Sequence conflict | 75 | 1 | N → I in AAA91295. Ref.1 | ||||||
| Sequence conflict | 140 | 1 | M → K in BAA86891. Ref.3 | ||||||
| Sequence conflict | 158 | 1 | M → K in BAA86891. Ref.3 | ||||||
| Sequence conflict | 169 | 1 | D → G in AAA91295. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1." Polymeropoulos M.H., Ide S., Soares M.B., Lennon G.G. Genomics 29:273-275(1995) [PubMed: 8530085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-65 AND ARG-172. |
| [2] | "Peptide conservation between avian and mammalian visinin-like proteins." Bellingham J. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes." Kobayashi M., Sakai E., Furuta Y., Takamatsu K. DNA Seq. 9:171-176(1998) [PubMed: 10520747] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [5] | "The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients." Lee J.M., Blennow K., Andreasen N., Laterza O., Modur V., Olander J., Gao F., Ohlendorf M., Ladenson J.H. Clin. Chem. 54:1617-1623(2008) [PubMed: 18703769] [Abstract] Cited for: TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U14747 mRNA. Translation: AAA91295.1. AF039555 mRNA. Translation: AAD02174.1. AB001104 mRNA. Translation: BAA86891.1. BC022012 mRNA. Translation: AAH22012.1. | |
| RefSeq | NP_003376.2. |
| UniGene | Hs.444212 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BJF based on UniProtKB P29554. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P62760. |
Genome annotation databases | |
| Ensembl | ENSG00000163032. Homo sapiens. [Contig view] |
| GeneID | 7447. |
| KEGG | hsa:7447. |
Organism-specific databases | |
| HGNC | HGNC:12722. VSNL1. |
| MIM | 600817. gene. |
| PharmGKB | PA37333. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P62760. |
| HOVERGEN | P62760. |
Gene expression databases | |
| ArrayExpress | P62760. |
| CleanEx | HS_VSNL1. |
| GermOnline | ENSG00000163032. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011992. EF-Hand_type. IPR002048. EF_hand_Ca_bd. IPR001125. Recoverin. [Graphical view] |
| Gene3D | G3DSA:1.10.238.10. EF-Hand_type. 1 hit. |
| Pfam | PF00036. efhand. 3 hits. [Graphical view] |
| PRINTS | PR00450. RECOVERIN. |
| ProDom | PD000012. EF-hand. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00054. EFh. 3 hits. [Graphical view] |
| PROSITE | PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 29162. |
| SOURCE | Search... |
Entry information
| Entry name | VISL1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P62760 Secondary accession number(s): P28677 Q9UM20 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


