Reviewed, UniProtKB/Swiss-Prot P62760 (VISL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Visinin-like protein 1
      Short name=VILIP
      Short name=VLP-1
Alternative name(s):
    Hippocalcin-like protein 3
      Short name=HLP3

Gene names

Name:	VSNL1
Synonyms:	VISL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner By similarity.
Tissue specificity	Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level).
Miscellaneous	Probably binds three calcium ions.
Sequence similarities	Belongs to the recoverin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium
PTM	Lipoprotein Myristate
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 191	190	Visinin-like protein 1		PRO_0000073763
Regions
	Domain	23 – 58	36	EF-hand 1
	Domain	60 – 95	36	EF-hand 2
	Domain	96 – 131	36	EF-hand 3
	Domain	146 – 181	36	EF-hand 4
	Calcium binding	73 – 84	12	1 Potential
	Calcium binding	109 – 120	12	2 Potential
	Calcium binding	159 – 170	12	3 Potential
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity
Natural variations
	Natural variant	65	1	A → G: dbSNP rs1042674.		VAR_047313
	Natural variant	172	1	K → R: dbSNP rs1042685.		VAR_047314
Experimental info
	Sequence conflict	75	1	N → I in AAA91295. Ref.1
	Sequence conflict	140	1	M → K in BAA86891. Ref.3
	Sequence conflict	158	1	M → K in BAA86891. Ref.3
	Sequence conflict	169	1	D → G in AAA91295. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P62760-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: ACDC3B4FE8C79265	FASTA	191	22,142
	10 20 30 40 50 60 MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD 70 80 90 100 110 120 ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE 130 140 150 160 170 180 MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS 190 IVLLLQCDIQ K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1." Polymeropoulos M.H., Ide S., Soares M.B., Lennon G.G. Genomics 29:273-275(1995) [PubMed: 8530085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-65 AND ARG-172.
[2]	"Peptide conservation between avian and mammalian visinin-like proteins." Bellingham J. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes." Kobayashi M., Sakai E., Furuta Y., Takamatsu K. DNA Seq. 9:171-176(1998) [PubMed: 10520747] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients." Lee J.M., Blennow K., Andreasen N., Laterza O., Modur V., Olander J., Gao F., Ohlendorf M., Ladenson J.H. Clin. Chem. 54:1617-1623(2008) [PubMed: 18703769] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U14747 mRNA. Translation: AAA91295.1. AF039555 mRNA. Translation: AAD02174.1. AB001104 mRNA. Translation: BAA86891.1. BC022012 mRNA. Translation: AAH22012.1.
RefSeq	NP_003376.2.
UniGene	Hs.444212
3D structure databases
HSSP	HSSP built from PDB template 1BJF based on UniProtKB P29554.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62760.
Genome annotation databases
Ensembl	ENSG00000163032. Homo sapiens. [Contig view]
GeneID	7447.
KEGG	hsa:7447.
Organism-specific databases
HGNC	HGNC:12722. VSNL1.
MIM	600817. gene.
PharmGKB	PA37333.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P62760.
HOVERGEN	P62760.
Gene expression databases
ArrayExpress	P62760.
CleanEx	HS_VSNL1.
GermOnline	ENSG00000163032. Homo sapiens.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR002048. EF_hand_Ca_bd. IPR001125. Recoverin. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF00036. efhand. 3 hits. [Graphical view]
PRINTS	PR00450. RECOVERIN.
ProDom	PD000012. EF-hand. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00054. EFh. 3 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	29162.
SOURCE	Search...

Entry information

Entry name

VISL1_HUMAN

Accession

Primary (citable) accession number: P62760
Secondary accession number(s): P28677 , P29103, P42323, Q9UM20

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)