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P62760 (VISL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Visinin-like protein 1

Short name=VILIP
Short name=VLP-1
Alternative name(s):
Hippocalcin-like protein 3
Short name=HLP3
Gene names
Name:VSNL1
Synonyms:VISL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner By similarity.

Tissue specificity

Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level). Ref.6

Miscellaneous

Probably binds three calcium ions.

Sequence similarities

Belongs to the recoverin family.

Contains 4 EF-hand domains.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
   LigandCalcium
Metal-binding
   PTMLipoprotein
Myristate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 191190Visinin-like protein 1
PRO_0000073763

Regions

Domain23 – 5836EF-hand 1
Domain60 – 9536EF-hand 2
Domain96 – 13136EF-hand 3
Domain146 – 18136EF-hand 4
Calcium binding73 – 84121 Potential
Calcium binding109 – 120122 Potential
Calcium binding159 – 170123 Potential

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Natural variations

Natural variant651A → G. Ref.1
Corresponds to variant rs1042674 [ dbSNP | Ensembl ].
VAR_047313
Natural variant1721K → R. Ref.1
Corresponds to variant rs1042685 [ dbSNP | Ensembl ].
VAR_047314

Experimental info

Sequence conflict751N → I in AAA91295. Ref.1
Sequence conflict1401M → K in BAA86891. Ref.3
Sequence conflict1581M → K in BAA86891. Ref.3
Sequence conflict1691D → G in AAA91295. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P62760 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: ACDC3B4FE8C79265

FASTA19122,142
        10         20         30         40         50         60 
MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD 

        70         80         90        100        110        120 
ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE 

       130        140        150        160        170        180 
MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS 

       190 
IVLLLQCDIQ K 

« Hide

References

« Hide 'large scale' references
[1]"Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1."
Polymeropoulos M.H., Ide S., Soares M.B., Lennon G.G.
Genomics 29:273-275(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-65 AND ARG-172.
[2]"Peptide conservation between avian and mammalian visinin-like proteins."
Bellingham J.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes."
Kobayashi M., Sakai E., Furuta Y., Takamatsu K.
DNA Seq. 9:171-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[6]"The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients."
Lee J.M., Blennow K., Andreasen N., Laterza O., Modur V., Olander J., Gao F., Ohlendorf M., Ladenson J.H.
Clin. Chem. 54:1617-1623(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14747 mRNA. Translation: AAA91295.1.
AF039555 mRNA. Translation: AAD02174.1.
AB001104 mRNA. Translation: BAA86891.1.
CH471053 Genomic DNA. Translation: EAX00870.1.
CH471053 Genomic DNA. Translation: EAX00871.1.
CH471053 Genomic DNA. Translation: EAX00872.1.
CH471053 Genomic DNA. Translation: EAX00875.1.
BC022012 mRNA. Translation: AAH22012.1.
CCDSCCDS1689.1.
RefSeqNP_003376.2. NM_003385.4.
UniGeneHs.444212.

3D structure databases

ProteinModelPortalP62760.
SMRP62760. Positions 5-187.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113286. 5 interactions.
IntActP62760. 4 interactions.
MINTMINT-1436309.
STRING9606.ENSP00000295156.

PTM databases

PhosphoSiteP62760.

Polymorphism databases

DMDM51338696.

Proteomic databases

MaxQBP62760.
PaxDbP62760.
PRIDEP62760.

Protocols and materials databases

DNASU7447.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295156; ENSP00000295156; ENSG00000163032.
ENST00000404666; ENSP00000384014; ENSG00000163032.
ENST00000406397; ENSP00000384719; ENSG00000163032.
GeneID7447.
KEGGhsa:7447.
UCSCuc002rcm.3. human.

Organism-specific databases

CTD7447.
GeneCardsGC02P017643.
HGNCHGNC:12722. VSNL1.
MIM600817. gene.
neXtProtNX_P62760.
PharmGKBPA37333.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233019.
HOVERGENHBG108179.
InParanoidP62760.
OMAFDVDNSK.
OrthoDBEOG7GJ6F3.
PhylomeDBP62760.
TreeFamTF300009.

Gene expression databases

ArrayExpressP62760.
BgeeP62760.
CleanExHS_VSNL1.
GenevestigatorP62760.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERPTHR23055. PTHR23055. 1 hit.
PfamPF00036. EF-hand_1. 3 hits.
[Graphical view]
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSVSNL1. human.
GeneWikiVSNL1.
GenomeRNAi7447.
NextBio29162.
PROP62760.
SOURCESearch...

Entry information

Entry nameVISL1_HUMAN
AccessionPrimary (citable) accession number: P62760
Secondary accession number(s): D6W515 expand/collapse secondary AC list , P28677, P29103, P42323, Q9UM20
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM