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P62760

- VISL1_HUMAN

UniProt

P62760 - VISL1_HUMAN

Protein

Visinin-like protein 1

Gene

VSNL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi159 – 170123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Visinin-like protein 1
    Short name:
    VILIP
    Short name:
    VLP-1
    Alternative name(s):
    Hippocalcin-like protein 3
    Short name:
    HLP3
    Gene namesi
    Name:VSNL1
    Synonyms:VISL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:12722. VSNL1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37333.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 191190Visinin-like protein 1PRO_0000073763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiP62760.
    PaxDbiP62760.
    PRIDEiP62760.

    PTM databases

    PhosphoSiteiP62760.

    Expressioni

    Tissue specificityi

    Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP62760.
    BgeeiP62760.
    CleanExiHS_VSNL1.
    GenevestigatoriP62760.

    Interactioni

    Protein-protein interaction databases

    BioGridi113286. 5 interactions.
    IntActiP62760. 4 interactions.
    MINTiMINT-1436309.
    STRINGi9606.ENSP00000295156.

    Structurei

    3D structure databases

    ProteinModelPortaliP62760.
    SMRiP62760. Positions 5-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini146 – 18136EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233019.
    HOVERGENiHBG108179.
    InParanoidiP62760.
    OMAiFDVDNSK.
    OrthoDBiEOG7GJ6F3.
    PhylomeDBiP62760.
    TreeFamiTF300009.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    IPR029533. VILIP-1.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PTHR23055:SF72. PTHR23055:SF72. 1 hit.
    PfamiPF00036. EF-hand_1. 3 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62760-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ    50
    LYVKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK 100
    LNWAFNMYDL DGDGKITRVE MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR 150
    VDKIFSKMDK NKDDQITLDE FKEAAKSDPS IVLLLQCDIQ K 191
    Length:191
    Mass (Da):22,142
    Last modified:January 23, 2007 - v2
    Checksum:iACDC3B4FE8C79265
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751N → I in AAA91295. (PubMed:8530085)Curated
    Sequence conflicti140 – 1401M → K in BAA86891. (PubMed:10520747)Curated
    Sequence conflicti158 – 1581M → K in BAA86891. (PubMed:10520747)Curated
    Sequence conflicti169 – 1691D → G in AAA91295. (PubMed:8530085)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651A → G.1 Publication
    Corresponds to variant rs1042674 [ dbSNP | Ensembl ].
    VAR_047313
    Natural varianti172 – 1721K → R.1 Publication
    Corresponds to variant rs1042685 [ dbSNP | Ensembl ].
    VAR_047314

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14747 mRNA. Translation: AAA91295.1.
    AF039555 mRNA. Translation: AAD02174.1.
    AB001104 mRNA. Translation: BAA86891.1.
    CH471053 Genomic DNA. Translation: EAX00870.1.
    CH471053 Genomic DNA. Translation: EAX00871.1.
    CH471053 Genomic DNA. Translation: EAX00872.1.
    CH471053 Genomic DNA. Translation: EAX00875.1.
    BC022012 mRNA. Translation: AAH22012.1.
    CCDSiCCDS1689.1.
    RefSeqiNP_003376.2. NM_003385.4.
    UniGeneiHs.444212.

    Genome annotation databases

    EnsembliENST00000295156; ENSP00000295156; ENSG00000163032.
    ENST00000404666; ENSP00000384014; ENSG00000163032.
    ENST00000406397; ENSP00000384719; ENSG00000163032.
    GeneIDi7447.
    KEGGihsa:7447.
    UCSCiuc002rcm.3. human.

    Polymorphism databases

    DMDMi51338696.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14747 mRNA. Translation: AAA91295.1 .
    AF039555 mRNA. Translation: AAD02174.1 .
    AB001104 mRNA. Translation: BAA86891.1 .
    CH471053 Genomic DNA. Translation: EAX00870.1 .
    CH471053 Genomic DNA. Translation: EAX00871.1 .
    CH471053 Genomic DNA. Translation: EAX00872.1 .
    CH471053 Genomic DNA. Translation: EAX00875.1 .
    BC022012 mRNA. Translation: AAH22012.1 .
    CCDSi CCDS1689.1.
    RefSeqi NP_003376.2. NM_003385.4.
    UniGenei Hs.444212.

    3D structure databases

    ProteinModelPortali P62760.
    SMRi P62760. Positions 5-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113286. 5 interactions.
    IntActi P62760. 4 interactions.
    MINTi MINT-1436309.
    STRINGi 9606.ENSP00000295156.

    PTM databases

    PhosphoSitei P62760.

    Polymorphism databases

    DMDMi 51338696.

    Proteomic databases

    MaxQBi P62760.
    PaxDbi P62760.
    PRIDEi P62760.

    Protocols and materials databases

    DNASUi 7447.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295156 ; ENSP00000295156 ; ENSG00000163032 .
    ENST00000404666 ; ENSP00000384014 ; ENSG00000163032 .
    ENST00000406397 ; ENSP00000384719 ; ENSG00000163032 .
    GeneIDi 7447.
    KEGGi hsa:7447.
    UCSCi uc002rcm.3. human.

    Organism-specific databases

    CTDi 7447.
    GeneCardsi GC02P017643.
    HGNCi HGNC:12722. VSNL1.
    MIMi 600817. gene.
    neXtProti NX_P62760.
    PharmGKBi PA37333.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233019.
    HOVERGENi HBG108179.
    InParanoidi P62760.
    OMAi FDVDNSK.
    OrthoDBi EOG7GJ6F3.
    PhylomeDBi P62760.
    TreeFami TF300009.

    Miscellaneous databases

    ChiTaRSi VSNL1. human.
    GeneWikii VSNL1.
    GenomeRNAii 7447.
    NextBioi 29162.
    PROi P62760.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62760.
    Bgeei P62760.
    CleanExi HS_VSNL1.
    Genevestigatori P62760.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    IPR029533. VILIP-1.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    PTHR23055:SF72. PTHR23055:SF72. 1 hit.
    Pfami PF00036. EF-hand_1. 3 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1."
      Polymeropoulos M.H., Ide S., Soares M.B., Lennon G.G.
      Genomics 29:273-275(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-65 AND ARG-172.
    2. "Peptide conservation between avian and mammalian visinin-like proteins."
      Bellingham J.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes."
      Kobayashi M., Sakai E., Furuta Y., Takamatsu K.
      DNA Seq. 9:171-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. "The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients."
      Lee J.M., Blennow K., Andreasen N., Laterza O., Modur V., Olander J., Gao F., Ohlendorf M., Ladenson J.H.
      Clin. Chem. 54:1617-1623(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVISL1_HUMAN
    AccessioniPrimary (citable) accession number: P62760
    Secondary accession number(s): D6W515
    , P28677, P29103, P42323, Q9UM20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Probably binds three calcium ions.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3