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P62756 (IATR_CAPHI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inter-alpha-trypsin inhibitor

Short name=ITI
Alternative name(s):
GIK-14
Inhibitory fragment of ITI
OrganismCapra hircus (Goat)
Taxonomic identifier9925 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Protein attributes

Sequence length123 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.

Subcellular location

Secreted.

Miscellaneous

The amino acid at position p2' (17) appears to determine the specificity of the inhibition of domain I. Inhibitors with methionine in this position interact weakly with chymotrypsin and elastase; those with leucine interact strongly.

Sequence similarities

Contains 2 BPTI/Kunitz inhibitor domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
Glycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›123›123Inter-alpha-trypsin inhibitor
PRO_0000155404

Regions

Domain5 – 5551BPTI/Kunitz inhibitor 1
Domain61 – 11151BPTI/Kunitz inhibitor 2

Sites

Site15 – 162Reactive bond for chymotrypsin and elastase
Site71 – 722Reactive bond for trypsin

Amino acid modifications

Glycosylation241N-linked (GlcNAc...)
Disulfide bond5 ↔ 55 By similarity
Disulfide bond14 ↔ 38 By similarity
Disulfide bond30 ↔ 51 By similarity
Disulfide bond61 ↔ 111 By similarity
Disulfide bond70 ↔ 94 By similarity
Disulfide bond86 ↔ 107 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1231

Sequences

Sequence LengthMass (Da)Tools
P62756 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 295038173F22D2D1

FASTA12313,687
        10         20         30         40         50         60 
KEDSCQLGYS QGPCLGMFKR YFYNGTSMAC ETFYYGGCMG NGNNFPSEKE CLQTCRTVQA 

        70         80         90        100        110        120 
CNLPIVRGPC RAGIELWAFD AVKGKCVRFI YGGCNGNGNQ FYSQKECKEY CGIPGEADEE 


LLR 

« Hide

References

[1]"Primary structure of a proteinase inhibitor released from goat serum inter-alpha-trypsin inhibitor."
Rasp G., Hochstrasser K., Gerl C., Wachter E.
Biochim. Biophys. Acta 999:335-337(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases

ProteinModelPortalP62756.
SMRP62756. Positions 4-113.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG056804.

Family and domain databases

Gene3D4.10.410.10. 2 hits.
InterProIPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamPF00014. Kunitz_BPTI. 2 hits.
[Graphical view]
PRINTSPR00759. BASICPTASE.
SMARTSM00131. KU. 2 hits.
[Graphical view]
SUPFAMSSF57362. SSF57362. 2 hits.
PROSITEPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIATR_CAPHI
AccessionPrimary (citable) accession number: P62756
Secondary accession number(s): P13371
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families