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P62756

- IATR_CAPHI

UniProt

P62756 - IATR_CAPHI

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Protein

Inter-alpha-trypsin inhibitor

Gene
N/A
Organism
Capra hircus (Goat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei15 – 162Reactive bond for chymotrypsin and elastase
Sitei71 – 722Reactive bond for trypsin

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor
Short name:
ITI
Alternative name(s):
GIK-14
Inhibitory fragment of ITI
OrganismiCapra hircus (Goat)
Taxonomic identifieri9925 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›123›123Inter-alpha-trypsin inhibitorPRO_0000155404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 55PROSITE-ProRule annotation
Disulfide bondi14 ↔ 38PROSITE-ProRule annotation
Glycosylationi24 – 241N-linked (GlcNAc...)
Disulfide bondi30 ↔ 51PROSITE-ProRule annotation
Disulfide bondi61 ↔ 111PROSITE-ProRule annotation
Disulfide bondi70 ↔ 94PROSITE-ProRule annotation
Disulfide bondi86 ↔ 107PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP62756.
SMRiP62756. Positions 4-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 5551BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd
BLAST
Domaini61 – 11151BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 BPTI/Kunitz inhibitor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG056804.

Family and domain databases

Gene3Di4.10.410.10. 2 hits.
InterProiIPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 2 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 2 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 2 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P62756 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
KEDSCQLGYS QGPCLGMFKR YFYNGTSMAC ETFYYGGCMG NGNNFPSEKE
60 70 80 90 100
CLQTCRTVQA CNLPIVRGPC RAGIELWAFD AVKGKCVRFI YGGCNGNGNQ
110 120
FYSQKECKEY CGIPGEADEE LLR
Length:123
Mass (Da):13,687
Last modified:August 16, 2004 - v1
Checksum:i295038173F22D2D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei123 – 1231

Cross-referencesi

3D structure databases

ProteinModelPortali P62756.
SMRi P62756. Positions 4-113.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I02.005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG056804.

Family and domain databases

Gene3Di 4.10.410.10. 2 hits.
InterProi IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view ]
Pfami PF00014. Kunitz_BPTI. 2 hits.
[Graphical view ]
PRINTSi PR00759. BASICPTASE.
SMARTi SM00131. KU. 2 hits.
[Graphical view ]
SUPFAMi SSF57362. SSF57362. 2 hits.
PROSITEi PS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of a proteinase inhibitor released from goat serum inter-alpha-trypsin inhibitor."
    Rasp G., Hochstrasser K., Gerl C., Wachter E.
    Biochim. Biophys. Acta 999:335-337(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiIATR_CAPHI
AccessioniPrimary (citable) accession number: P62756
Secondary accession number(s): P13371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The amino acid at position p2' (17) appears to determine the specificity of the inhibition of domain I. Inhibitors with methionine in this position interact weakly with chymotrypsin and elastase; those with leucine interact strongly.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3