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P62756

- IATR_CAPHI

UniProt

P62756 - IATR_CAPHI

Protein

Inter-alpha-trypsin inhibitor

Gene
N/A
Organism
Capra hircus (Goat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This inhibitory fragment, released from native ITI after limited proteolysis with trypsin, contains two homologous domains. Whereas the second domain is a strong inhibitor of trypsin, the first domain interacts weakly with PMN-granulocytic elastase and not at all with pancreatic elastase.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei15 – 162Reactive bond for chymotrypsin and elastase
    Sitei71 – 722Reactive bond for trypsin

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inter-alpha-trypsin inhibitor
    Short name:
    ITI
    Alternative name(s):
    GIK-14
    Inhibitory fragment of ITI
    OrganismiCapra hircus (Goat)
    Taxonomic identifieri9925 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›123›123Inter-alpha-trypsin inhibitorPRO_0000155404Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi5 ↔ 55PROSITE-ProRule annotation
    Disulfide bondi14 ↔ 38PROSITE-ProRule annotation
    Glycosylationi24 – 241N-linked (GlcNAc...)
    Disulfide bondi30 ↔ 51PROSITE-ProRule annotation
    Disulfide bondi61 ↔ 111PROSITE-ProRule annotation
    Disulfide bondi70 ↔ 94PROSITE-ProRule annotation
    Disulfide bondi86 ↔ 107PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP62756.
    SMRiP62756. Positions 4-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 5551BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini61 – 11151BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 BPTI/Kunitz inhibitor domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG056804.

    Family and domain databases

    Gene3Di4.10.410.10. 2 hits.
    InterProiIPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    [Graphical view]
    PfamiPF00014. Kunitz_BPTI. 2 hits.
    [Graphical view]
    PRINTSiPR00759. BASICPTASE.
    SMARTiSM00131. KU. 2 hits.
    [Graphical view]
    SUPFAMiSSF57362. SSF57362. 2 hits.
    PROSITEiPS00280. BPTI_KUNITZ_1. 2 hits.
    PS50279. BPTI_KUNITZ_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P62756-1 [UniParc]FASTAAdd to Basket

    « Hide

    KEDSCQLGYS QGPCLGMFKR YFYNGTSMAC ETFYYGGCMG NGNNFPSEKE    50
    CLQTCRTVQA CNLPIVRGPC RAGIELWAFD AVKGKCVRFI YGGCNGNGNQ 100
    FYSQKECKEY CGIPGEADEE LLR 123
    Length:123
    Mass (Da):13,687
    Last modified:August 16, 2004 - v1
    Checksum:i295038173F22D2D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei123 – 1231

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P62756.
    SMRi P62756. Positions 4-113.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG056804.

    Family and domain databases

    Gene3Di 4.10.410.10. 2 hits.
    InterProi IPR002223. Prot_inh_Kunz-m.
    IPR020901. Prtase_inh_Kunz-CS.
    [Graphical view ]
    Pfami PF00014. Kunitz_BPTI. 2 hits.
    [Graphical view ]
    PRINTSi PR00759. BASICPTASE.
    SMARTi SM00131. KU. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57362. SSF57362. 2 hits.
    PROSITEi PS00280. BPTI_KUNITZ_1. 2 hits.
    PS50279. BPTI_KUNITZ_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of a proteinase inhibitor released from goat serum inter-alpha-trypsin inhibitor."
      Rasp G., Hochstrasser K., Gerl C., Wachter E.
      Biochim. Biophys. Acta 999:335-337(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiIATR_CAPHI
    AccessioniPrimary (citable) accession number: P62756
    Secondary accession number(s): P13371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The amino acid at position p2' (17) appears to determine the specificity of the inhibition of domain I. Inhibitors with methionine in this position interact weakly with chymotrypsin and elastase; those with leucine interact strongly.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3