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Protein

40S ribosomal protein S6

Gene

Rps6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

GO - Molecular functioni

  • mRNA binding Source: RGD
  • structural constituent of ribosome Source: RGD

GO - Biological processi

  • cellular response to ethanol Source: RGD
  • glucose homeostasis Source: UniProtKB
  • negative regulation of bicellular tight junction assembly Source: RGD
  • response to insulin Source: RGD
  • ribosomal small subunit assembly Source: RGD
  • translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S6
Gene namesi
Name:Rps6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3602. Rps6.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24924940S ribosomal protein S6PRO_0000137314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111N6-acetyllysineBy similarity
Modified residuei235 – 2351Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASKBy similarity
Modified residuei236 – 2361PhosphoserineCombined sources
Modified residuei240 – 2401PhosphoserineCombined sources
Modified residuei242 – 2421PhosphoserineBy similarity
Modified residuei244 – 2441PhosphoserineCombined sources
Modified residuei247 – 2471PhosphoserineBy similarity

Post-translational modificationi

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62755.
PRIDEiP62755.

PTM databases

iPTMnetiP62755.
PhosphoSiteiP62755.

Expressioni

Gene expression databases

GenevisibleiP62755. RN.

Interactioni

Protein-protein interaction databases

BioGridi247970. 2 interactions.
IntActiP62755. 2 interactions.
MINTiMINT-203887.
STRINGi10116.ENSRNOP00000010383.

Structurei

3D structure databases

ProteinModelPortaliP62755.
SMRiP62755. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S6e family.Curated

Phylogenomic databases

eggNOGiKOG1646. Eukaryota.
COG2125. LUCA.
HOGENOMiHOG000190952.
HOVERGENiHBG011441.
InParanoidiP62755.
KOiK02991.
OMAiEGKKERF.
OrthoDBiEOG7Z0JXB.
PhylomeDBiP62755.
TreeFamiTF300035.

Family and domain databases

InterProiIPR014401. Ribosomal_S6_euk.
IPR001377. Ribosomal_S6e.
IPR018282. Ribosomal_S6e_CS.
[Graphical view]
PANTHERiPTHR11502. PTHR11502. 1 hit.
PfamiPF01092. Ribosomal_S6e. 1 hit.
[Graphical view]
PIRSFiPIRSF002129. Ribosom_S6_euk. 1 hit.
SMARTiSM01405. Ribosomal_S6e. 1 hit.
[Graphical view]
PROSITEiPS00578. RIBOSOMAL_S6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV
60 70 80 90 100
RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC
110 120 130 140 150
IVDANLSVLN LVIVKKGEKD IPGLTDTTVP RRLGPKRASR IRKLFNLSKE
160 170 180 190 200
DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV TPRVLQHKRR RIALKKQRTK
210 220 230 240
KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS TSKSESSQK
Length:249
Mass (Da):28,681
Last modified:August 1, 1988 - v1
Checksum:iA61E435884E636AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29358 mRNA. Translation: AAA42079.1.
BC058149 mRNA. Translation: AAH58149.1.
PIRiA29929. R3RTS6.
RefSeqiNP_058856.1. NM_017160.1.
XP_003750019.1. XM_003749971.3.
UniGeneiRn.147848.
Rn.34341.

Genome annotation databases

GeneIDi100911372.
29304.
KEGGirno:100911372.
rno:29304.
UCSCiRGD:3602. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29358 mRNA. Translation: AAA42079.1.
BC058149 mRNA. Translation: AAH58149.1.
PIRiA29929. R3RTS6.
RefSeqiNP_058856.1. NM_017160.1.
XP_003750019.1. XM_003749971.3.
UniGeneiRn.147848.
Rn.34341.

3D structure databases

ProteinModelPortaliP62755.
SMRiP62755. Positions 1-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247970. 2 interactions.
IntActiP62755. 2 interactions.
MINTiMINT-203887.
STRINGi10116.ENSRNOP00000010383.

PTM databases

iPTMnetiP62755.
PhosphoSiteiP62755.

Proteomic databases

PaxDbiP62755.
PRIDEiP62755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100911372.
29304.
KEGGirno:100911372.
rno:29304.
UCSCiRGD:3602. rat.

Organism-specific databases

CTDi6194.
RGDi3602. Rps6.

Phylogenomic databases

eggNOGiKOG1646. Eukaryota.
COG2125. LUCA.
HOGENOMiHOG000190952.
HOVERGENiHBG011441.
InParanoidiP62755.
KOiK02991.
OMAiEGKKERF.
OrthoDBiEOG7Z0JXB.
PhylomeDBiP62755.
TreeFamiTF300035.

Miscellaneous databases

PROiP62755.

Gene expression databases

GenevisibleiP62755. RN.

Family and domain databases

InterProiIPR014401. Ribosomal_S6_euk.
IPR001377. Ribosomal_S6e.
IPR018282. Ribosomal_S6e_CS.
[Graphical view]
PANTHERiPTHR11502. PTHR11502. 1 hit.
PfamiPF01092. Ribosomal_S6e. 1 hit.
[Graphical view]
PIRSFiPIRSF002129. Ribosom_S6_euk. 1 hit.
SMARTiSM01405. Ribosomal_S6e. 1 hit.
[Graphical view]
PROSITEiPS00578. RIBOSOMAL_S6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of rat ribosomal protein S6."
    Chan Y.-L., Wool I.G.
    J. Biol. Chem. 263:2891-2896(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "Sequence of the amino-terminal region of rat liver ribosomal proteins S4, S6, S8, L6, L7a, L18, L27, L30, L37, L37a, and L39."
    Wittmann-Liebold B., Geissler A.W., Lin A., Wool I.G.
    J. Supramol. Struct. 12:425-433(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS.
  4. "Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6."
    Franco R., Rosenfeld M.G.
    J. Biol. Chem. 265:4321-4325(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, PROTEIN SEQUENCE OF 1-23.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236; SER-240 AND SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRS6_RAT
AccessioniPrimary (citable) accession number: P62755
Secondary accession number(s): P08227, P10660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.