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Protein

40S ribosomal protein S6

Gene

Rps6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

GO - Molecular functioni

  • mRNA binding Source: RGD
  • structural constituent of ribosome Source: RGD

GO - Biological processi

  • cellular response to ethanol Source: RGD
  • glucose homeostasis Source: UniProtKB
  • negative regulation of bicellular tight junction assembly Source: RGD
  • response to insulin Source: RGD
  • ribosomal small subunit assembly Source: RGD
  • rRNA processing Source: GO_Central
  • translation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S6
Gene namesi
Name:Rps6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3602. Rps6.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: RGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001373141 – 24940S ribosomal protein S6Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei148PhosphoserineBy similarity1
Modified residuei211N6-acetyllysineBy similarity1
Modified residuei235Phosphoserine; by RPS6KA1, RPS6KA3, DAPK1 and PASKBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei242PhosphoserineBy similarity1
Modified residuei244PhosphoserineCombined sources1
Modified residuei247PhosphoserineBy similarity1

Post-translational modificationi

Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP62755.
PRIDEiP62755.

PTM databases

iPTMnetiP62755.
PhosphoSitePlusiP62755.

Expressioni

Gene expression databases

GenevisibleiP62755. RN.

Interactioni

Protein-protein interaction databases

BioGridi247970. 3 interactors.
IntActiP62755. 2 interactors.
MINTiMINT-203887.
STRINGi10116.ENSRNOP00000010383.

Structurei

3D structure databases

ProteinModelPortaliP62755.
SMRiP62755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1646. Eukaryota.
COG2125. LUCA.
HOGENOMiHOG000190952.
HOVERGENiHBG011441.
InParanoidiP62755.
KOiK02991.
OrthoDBiEOG091G089B.
PhylomeDBiP62755.
TreeFamiTF300035.

Family and domain databases

InterProiView protein in InterPro
IPR014401. Ribosomal_S6_euk.
IPR001377. Ribosomal_S6e.
IPR018282. Ribosomal_S6e_CS.
PANTHERiPTHR11502. PTHR11502. 1 hit.
PfamiView protein in Pfam
PF01092. Ribosomal_S6e. 1 hit.
PIRSFiPIRSF002129. Ribosom_S6_euk. 1 hit.
SMARTiView protein in SMART
SM01405. Ribosomal_S6e. 1 hit.
PROSITEiView protein in PROSITE
PS00578. RIBOSOMAL_S6E. 1 hit.

Sequencei

Sequence statusi: Complete.

P62755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV
60 70 80 90 100
RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC
110 120 130 140 150
IVDANLSVLN LVIVKKGEKD IPGLTDTTVP RRLGPKRASR IRKLFNLSKE
160 170 180 190 200
DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV TPRVLQHKRR RIALKKQRTK
210 220 230 240
KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS TSKSESSQK
Length:249
Mass (Da):28,681
Last modified:August 1, 1988 - v1
Checksum:iA61E435884E636AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29358 mRNA. Translation: AAA42079.1.
BC058149 mRNA. Translation: AAH58149.1.
PIRiA29929. R3RTS6.
RefSeqiNP_058856.1. NM_017160.1.
XP_003750019.1. XM_003749971.3.
UniGeneiRn.147848.
Rn.34341.

Genome annotation databases

GeneIDi100911372.
29304.
KEGGirno:100911372.
rno:29304.
UCSCiRGD:3602. rat.

Similar proteinsi

Entry informationi

Entry nameiRS6_RAT
AccessioniPrimary (citable) accession number: P62755
Secondary accession number(s): P08227, P10660
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: August 30, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families