Reviewed,
UniProtKB/Swiss-Prot P62753 (RS6_HUMAN)
Last modified
November 25, 2008.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 40S ribosomal protein S6 Alternative name(s): Phosphoprotein NP33 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 249 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. |
| Post-translational modification | Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. |
| Sequence similarities | Belongs to the ribosomal protein S6e family. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Molecular function | Ribonucleoprotein Ribosomal protein |
| PTM | Phosphoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | TOR signaling pathway Inferred from direct assay. Source: UniProtKB glucose homeostasisInferred from sequence or structural similarity. Source: UniProtKB positive regulation of apoptosisInferred from direct assay. Source: UniProtKB rRNA processingInferred from mutant phenotype. Source: UniProtKB ribosomal small subunit biogenesisInferred from mutant phenotype. Source: UniProtKB translational elongationInferred from Experiment. Source: Reactome |
| Cellular component | cytosolic small ribosomal subunit Ref.3 Inferred from direct assay. Source: UniProtKB nucleolusInferred from direct assay. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction. Source: UniProtKB structural constituent of ribosomeInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| NCBP1 | Q09161 | 2 | EBI-356625,EBI-464743 | |
| NDRG1 | Q92597 | 1 | EBI-356625,EBI-716486 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 249 | 249 | 40S ribosomal protein S6 | PRO_0000137312 | |||||
Amino acid modifications | |||||||||
| Modified residue | 78 | 1 | Phosphoserine | ||||||
| Modified residue | 148 | 1 | Phosphoserine | ||||||
| Modified residue | 235 | 1 | Phosphoserine | ||||||
| Modified residue | 236 | 1 | Phosphoserine | ||||||
| Modified residue | 240 | 1 | Phosphoserine | ||||||
| Modified residue | 244 | 1 | Phosphoserine | ||||||
| Modified residue | 246 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 247 | 1 | Phosphoserine | ||||||
Natural variations | |||||||||
| Natural variant | 221 | 1 | K → R: dbSNP rs17852447. | VAR_025314 | |||||
Experimental info | |||||||||
| Sequence conflict | 23 | 1 | K → T in AAA60288. Ref.1 | ||||||
| Sequence conflict | 144 | 1 | L → R in AAA60288. Ref.1 | ||||||
| Sequence conflict | 155 – 156 | 2 | QY → EC in AAA60287. Ref.2 | ||||||
| Sequence conflict | 168 | 1 | K → R in AAA60287. Ref.2 | ||||||
| Sequence conflict | 196 | 1 | K → Q in AAA60288. Ref.1 | ||||||
| Sequence conflict | 219 | 1 | E → Q in AAA60287. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterization of cloned cDNAs that code for human ribosomal protein S6." Lott J.B., Mackie G.A. Gene 65:31-39(1988) [PubMed: 2840355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The primary structure of the human ribosomal protein S6 derived from a cloned cDNA." Heinze H., Arnold H.H., Fischer D., Kruppa J. J. Biol. Chem. 263:4139-4144(1988) [PubMed: 3279029] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21." Antoine M., Fried M. Hum. Mol. Genet. 1:565-570(1992) [PubMed: 1301164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9." Pata I., Hoth S., Kruppa J., Metspalu A. Gene 121:387-392(1992) [PubMed: 1446836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients." Shichijo S., Itoh K. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon adenocarcinoma. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-221. Tissue: Colon, Muscle, Pancreas, Skin and Testis. |
| [7] | "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed: 8706699] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-15. Tissue: Placenta. |
| [8] | "Global phosphoproteome of HT-29 human colon adenocarcinoma cells." Kim J.-E., Tannenbaum S.R., White F.M. J. Proteome Res. 4:1339-1346(2005) [PubMed: 16083285] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235 AND SER-236, MASS SPECTROMETRY. |
| [9] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235; SER-236 AND SER-240, MASS SPECTROMETRY. Tissue: Epithelium. |
| [10] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78; SER-235; SER-236; SER-240 AND SER-244, MASS SPECTROMETRY. |
| [11] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, MASS SPECTROMETRY. |
| [12] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148; SER-235; SER-236; SER-240; SER-244 AND SER-247, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M20020 mRNA. Translation: AAA60288.1. J03537 mRNA. Translation: AAA60287.1. X67309 Genomic DNA. Translation: CAA47719.1. M77232 Genomic DNA. Translation: AAA60289.1. AB062123 mRNA. Translation: BAB93455.1. BC000524 mRNA. Translation: AAH00524.1. BC009427 mRNA. Translation: AAH09427.2. BC027620 mRNA. Translation: AAH27620.1. BC071907 mRNA. Translation: AAH71907.1. BC071908 mRNA. Translation: AAH71908.1. BC094826 mRNA. Translation: AAH94826.1. | |
| PIR | R3HU6. JC1394. |
| RefSeq | NP_001001.2. |
| UniGene | Hs.408073 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P62753. |
PTM databases | |
| PhosphoSite | P62753. |
Genome annotation databases | |
| Ensembl | ENSG00000137154. Homo sapiens. [Contig view] |
| GeneID | 6194. |
| KEGG | hsa:6194. |
Organism-specific databases | |
| H-InvDB | HIX0007947. |
| HGNC | HGNC:10429. RPS6. |
| HPA | CAB004027. |
| MIM | 180460. gene. |
| PharmGKB | PA31025. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P62753. |
| HOVERGEN | P62753. |
Enzyme and pathway databases | |
| Reactome | REACT_1762. 3' -UTR-mediated translational regulation. REACT_498. Signaling by insulin receptor. REACT_6167. Influenza Infection. REACT_71. Gene Expression. |
Gene expression databases | |
| ArrayExpress | P62753. |
| CleanEx | HS_RPS6. |
| GermOnline | ENSG00000137154. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR014401. Ribosomal_S6_euk. IPR001377. Ribosomal_S6e. [Graphical view] |
| PANTHER | PTHR11502. Ribosomal_S6E. 1 hit. |
| Pfam | PF01092. Ribosomal_S6e. 1 hit. [Graphical view] |
| PIRSF | PIRSF002129. Ribosom_S6_euk. 1 hit. |
| ProDom | PD003460. Ribosomal_S6E. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00578. RIBOSOMAL_S6E. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P62753. |
| NextBio | 24053. |
| SOURCE | Search... |
Entry information
| Entry name | RS6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P62753 Secondary accession number(s): P08227 Q8N6Z7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Ribosomal proteins Ribosomal proteins families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


