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Protein

60S ribosomal protein L23a

Gene

Rpl23a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23a
Gene namesi
Name:Rpl23a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1304897 Rpl23a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001294692 – 15660S ribosomal protein L23aAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanineBy similarity1
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei41CitrullineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei45PhosphothreonineBy similarity1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP62752
PRIDEiP62752

PTM databases

iPTMnetiP62752
PhosphoSitePlusiP62752

Expressioni

Gene expression databases

BgeeiENSRNOG00000023344
ExpressionAtlasiP62752 differential
GenevisibleiP62752 RN

Interactioni

Subunit structurei

Interacts with LYAR and GNL2. Interacts with MDM2; this interaction may promote MDM2-mediated p53/TP53 polyubiquitination.By similarity

Protein-protein interaction databases

BioGridi262033, 2 interactors
IntActiP62752, 3 interactors
MINTiP62752
STRINGi10116.ENSRNOP00000036391

Structurei

3D structure databases

ProteinModelPortaliP62752
SMRiP62752
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1751 Eukaryota
COG0089 LUCA
GeneTreeiENSGT00390000003263
HOGENOMiHOG000231365
HOVERGENiHBG056619
InParanoidiP62752
KOiK02893
OMAiHKVIIHP
OrthoDBiEOG091G0UYL
PhylomeDBiP62752
TreeFamiTF314116

Family and domain databases

Gene3Di3.30.70.330, 1 hit
HAMAPiMF_01369_A Ribosomal_L23_A, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR019985 Ribosomal_L23
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR001014 Ribosomal_L23/L25_CS
IPR005633 Ribosomal_L23/L25_N
IPR013025 Ribosomal_L25/23
PfamiView protein in Pfam
PF00276 Ribosomal_L23, 1 hit
PF03939 Ribosomal_L23eN, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
TIGRFAMsiTIGR03636 uL23_arch, 1 hit
PROSITEiView protein in PROSITE
PS00050 RIBOSOMAL_L23, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK
60 70 80 90 100
TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV
110 120 130 140 150
DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA

NKIGII
Length:156
Mass (Da):17,695
Last modified:August 16, 2004 - v1
Checksum:i3980E77B47FAB70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65228 mRNA Translation: CAA46336.1
PIRiA45214 R3RT3A
RefSeqiNP_001101753.1, NM_001108283.1
UniGeneiRn.6018

Genome annotation databases

EnsembliENSRNOT00000035657; ENSRNOP00000036391; ENSRNOG00000023344
GeneIDi360572
KEGGirno:360572

Similar proteinsi

Entry informationi

Entry nameiRL23A_RAT
AccessioniPrimary (citable) accession number: P62752
Secondary accession number(s): P29316, P39024, Q92774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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