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Protein

60S ribosomal protein L23a

Gene

Rpl23a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds to a specific region on the 26S rRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23a
Gene namesi
Name:Rpl23a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1304897. Rpl23a.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD
  • nucleus Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 15615560S ribosomal protein L23aPRO_0000129469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N,N,N-trimethylalanineBy similarity
Modified residuei41 – 411CitrullineBy similarity
Modified residuei43 – 431PhosphoserineBy similarity
Modified residuei45 – 451PhosphothreonineBy similarity

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP62752.
PRIDEiP62752.

PTM databases

iPTMnetiP62752.
PhosphoSiteiP62752.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023344.
ExpressionAtlasiP62752. baseline.
GenevisibleiP62752. RN.

Interactioni

Protein-protein interaction databases

BioGridi262033. 2 interactions.
IntActiP62752. 2 interactions.
MINTiMINT-154728.
STRINGi10116.ENSRNOP00000036391.

Structurei

3D structure databases

ProteinModelPortaliP62752.
SMRiP62752. Positions 73-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L23P family.Curated

Phylogenomic databases

eggNOGiKOG1751. Eukaryota.
COG0089. LUCA.
GeneTreeiENSGT00390000003263.
HOGENOMiHOG000231365.
HOVERGENiHBG056619.
InParanoidiP62752.
KOiK02893.
OMAiFPRKSAP.
OrthoDBiEOG091G0UYL.
PhylomeDBiP62752.
TreeFamiTF314116.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_01369_A. Ribosomal_L23_A. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
TIGRFAMsiTIGR03636. uL23_arch. 1 hit.
PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK
60 70 80 90 100
TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV
110 120 130 140 150
DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA

NKIGII
Length:156
Mass (Da):17,695
Last modified:August 16, 2004 - v1
Checksum:i3980E77B47FAB70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65228 mRNA. Translation: CAA46336.1.
PIRiA45214. R3RT3A.
RefSeqiNP_001101753.1. NM_001108283.1.
UniGeneiRn.6018.

Genome annotation databases

EnsembliENSRNOT00000035657; ENSRNOP00000036391; ENSRNOG00000023344.
GeneIDi360572.
KEGGirno:360572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65228 mRNA. Translation: CAA46336.1.
PIRiA45214. R3RT3A.
RefSeqiNP_001101753.1. NM_001108283.1.
UniGeneiRn.6018.

3D structure databases

ProteinModelPortaliP62752.
SMRiP62752. Positions 73-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262033. 2 interactions.
IntActiP62752. 2 interactions.
MINTiMINT-154728.
STRINGi10116.ENSRNOP00000036391.

PTM databases

iPTMnetiP62752.
PhosphoSiteiP62752.

Proteomic databases

PaxDbiP62752.
PRIDEiP62752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035657; ENSRNOP00000036391; ENSRNOG00000023344.
GeneIDi360572.
KEGGirno:360572.

Organism-specific databases

CTDi6147.
RGDi1304897. Rpl23a.

Phylogenomic databases

eggNOGiKOG1751. Eukaryota.
COG0089. LUCA.
GeneTreeiENSGT00390000003263.
HOGENOMiHOG000231365.
HOVERGENiHBG056619.
InParanoidiP62752.
KOiK02893.
OMAiFPRKSAP.
OrthoDBiEOG091G0UYL.
PhylomeDBiP62752.
TreeFamiTF314116.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP62752.

Gene expression databases

BgeeiENSRNOG00000023344.
ExpressionAtlasiP62752. baseline.
GenevisibleiP62752. RN.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_01369_A. Ribosomal_L23_A. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
TIGRFAMsiTIGR03636. uL23_arch. 1 hit.
PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL23A_RAT
AccessioniPrimary (citable) accession number: P62752
Secondary accession number(s): P29316, P39024, Q92774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.