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Protein

60S ribosomal protein L23a

Gene

Rpl23a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds to a specific region on the 26S rRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23a
Gene namesi
Name:Rpl23a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3040672. Rpl23a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001294682 – 15660S ribosomal protein L23aAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanine; by NTM11 Publication1
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei41Citrulline1 Publication1
Modified residuei43PhosphoserineBy similarity1
Modified residuei45PhosphothreonineBy similarity1

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.1 Publication
Citrullinated by PADI4.1 Publication

Keywords - PTMi

Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62751.
PaxDbiP62751.
PeptideAtlasiP62751.
PRIDEiP62751.

PTM databases

iPTMnetiP62751.
PhosphoSitePlusiP62751.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058546.
CleanExiMM_RPL23A.
ExpressionAtlasiP62751. baseline and differential.
GenevisibleiP62751. MM.

Interactioni

Protein-protein interaction databases

BioGridi234500. 3 interactors.
DIPiDIP-59973N.
IntActiP62751. 11 interactors.
MINTiMINT-1865331.
STRINGi10090.ENSMUSP00000099541.

Structurei

3D structure databases

ProteinModelPortaliP62751.
SMRiP62751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1751. Eukaryota.
COG0089. LUCA.
GeneTreeiENSGT00390000003263.
HOGENOMiHOG000231365.
HOVERGENiHBG056619.
InParanoidiP62751.
KOiK02893.
OMAiHKVIIHP.
OrthoDBiEOG091G0UYL.
PhylomeDBiP62751.
TreeFamiTF314116.

Family and domain databases

HAMAPiMF_01369_A. Ribosomal_L23_A. 1 hit.
InterProiView protein in InterPro
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom_sf.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
PfamiView protein in Pfam
PF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
SUPFAMiSSF54189. SSF54189. 1 hit.
TIGRFAMsiTIGR03636. uL23_arch. 1 hit.
PROSITEiView protein in PROSITE
PS00050. RIBOSOMAL_L23. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK
60 70 80 90 100
TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV
110 120 130 140 150
DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA

NKIGII
Length:156
Mass (Da):17,695
Last modified:August 16, 2004 - v1
Checksum:i3980E77B47FAB70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452721 mRNA. Translation: AAQ04686.1.
BC026656 mRNA. Translation: AAH26656.1.
BC029892 mRNA. Translation: AAH29892.1.
CCDSiCCDS25093.1.
RefSeqiNP_997406.1. NM_207523.2.
UniGeneiMm.22723.
Mm.304790.
Mm.352675.

Genome annotation databases

EnsembliENSMUST00000102483; ENSMUSP00000099541; ENSMUSG00000058546.
GeneIDi268449.
KEGGimmu:268449.
UCSCiuc007kil.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiRL23A_MOUSE
AccessioniPrimary (citable) accession number: P62751
Secondary accession number(s): P29316, P39024, Q92774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families