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Protein

60S ribosomal protein L23a

Gene

Rpl23a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds to a specific region on the 26S rRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23a
Gene namesi
Name:Rpl23a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3040672. Rpl23a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 15615560S ribosomal protein L23aPRO_0000129468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N,N,N-trimethylalanine; by NTM11 Publication
Modified residuei41 – 411Citrulline1 Publication
Modified residuei45 – 451PhosphothreonineBy similarity
Modified residuei70 – 701N6-acetyllysineCombined sources

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.1 Publication
Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Proteomic databases

EPDiP62751.
PaxDbiP62751.
PRIDEiP62751.

PTM databases

iPTMnetiP62751.
PhosphoSiteiP62751.

Expressioni

Gene expression databases

BgeeiP62751.
CleanExiMM_RPL23A.
ExpressionAtlasiP62751. baseline and differential.
GenevisibleiP62751. MM.

Interactioni

Protein-protein interaction databases

BioGridi234500. 3 interactions.
DIPiDIP-59973N.
IntActiP62751. 10 interactions.
MINTiMINT-1865331.
STRINGi10090.ENSMUSP00000099541.

Structurei

3D structure databases

ProteinModelPortaliP62751.
SMRiP62751. Positions 73-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L23P family.Curated

Phylogenomic databases

eggNOGiKOG1751. Eukaryota.
COG0089. LUCA.
HOGENOMiHOG000231365.
HOVERGENiHBG056619.
InParanoidiP62751.
KOiK02893.
OMAiPCEAPMA.
OrthoDBiEOG7W155T.
PhylomeDBiP62751.
TreeFamiTF314116.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_01369_A. Ribosomal_L23_A.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
TIGRFAMsiTIGR03636. uL23_arch. 1 hit.
PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK
60 70 80 90 100
TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV
110 120 130 140 150
DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA

NKIGII
Length:156
Mass (Da):17,695
Last modified:August 16, 2004 - v1
Checksum:i3980E77B47FAB70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452721 mRNA. Translation: AAQ04686.1.
BC026656 mRNA. Translation: AAH26656.1.
BC029892 mRNA. Translation: AAH29892.1.
CCDSiCCDS25093.1.
RefSeqiNP_997406.1. NM_207523.2.
UniGeneiMm.22723.
Mm.304790.
Mm.352675.

Genome annotation databases

EnsembliENSMUST00000102483; ENSMUSP00000099541; ENSMUSG00000058546.
GeneIDi268449.
KEGGimmu:268449.
UCSCiuc007kil.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452721 mRNA. Translation: AAQ04686.1.
BC026656 mRNA. Translation: AAH26656.1.
BC029892 mRNA. Translation: AAH29892.1.
CCDSiCCDS25093.1.
RefSeqiNP_997406.1. NM_207523.2.
UniGeneiMm.22723.
Mm.304790.
Mm.352675.

3D structure databases

ProteinModelPortaliP62751.
SMRiP62751. Positions 73-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234500. 3 interactions.
DIPiDIP-59973N.
IntActiP62751. 10 interactions.
MINTiMINT-1865331.
STRINGi10090.ENSMUSP00000099541.

PTM databases

iPTMnetiP62751.
PhosphoSiteiP62751.

Proteomic databases

EPDiP62751.
PaxDbiP62751.
PRIDEiP62751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102483; ENSMUSP00000099541; ENSMUSG00000058546.
GeneIDi268449.
KEGGimmu:268449.
UCSCiuc007kil.3. mouse.

Organism-specific databases

CTDi6147.
MGIiMGI:3040672. Rpl23a.

Phylogenomic databases

eggNOGiKOG1751. Eukaryota.
COG0089. LUCA.
HOGENOMiHOG000231365.
HOVERGENiHBG056619.
InParanoidiP62751.
KOiK02893.
OMAiPCEAPMA.
OrthoDBiEOG7W155T.
PhylomeDBiP62751.
TreeFamiTF314116.

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

NextBioi23883.
PROiP62751.
SOURCEiSearch...

Gene expression databases

BgeeiP62751.
CleanExiMM_RPL23A.
ExpressionAtlasiP62751. baseline and differential.
GenevisibleiP62751. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_01369_A. Ribosomal_L23_A.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
TIGRFAMsiTIGR03636. uL23_arch. 1 hit.
PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, genomic structure, and chromosomal localization of a novel murine ribosomal protein L23a gene."
    Fan Y., Friedman C., Trask B.J.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Liver.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  4. "NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein."
    Tooley C.E., Petkowski J.J., Muratore-Schroeder T.L., Balsbaugh J.L., Shabanowitz J., Sabat M., Minor W., Hunt D.F., Macara I.G.
    Nature 466:1125-1128(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE, METHYLATION AT ALA-2.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  6. Cited for: CITRULLINATION AT ARG-41.

Entry informationi

Entry nameiRL23A_MOUSE
AccessioniPrimary (citable) accession number: P62751
Secondary accession number(s): P29316, P39024, Q92774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.