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Protein

60S ribosomal protein L23a

Gene

RPL23A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds to a specific region on the 26S rRNA.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23a
Gene namesi
Name:RPL23A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10317. RPL23A.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
  • TORC2 complex Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34691.

Polymorphism and mutation databases

BioMutaiRPL23A.
DMDMi51338637.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 15615560S ribosomal protein L23aPRO_0000129467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N,N,N-trimethylalanineBy similarity
Modified residuei41 – 411CitrullineBy similarity
Modified residuei43 – 431PhosphoserineCombined sources
Modified residuei45 – 451PhosphothreonineCombined sources

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Methylation, Phosphoprotein

Proteomic databases

EPDiP62750.
MaxQBiP62750.
PaxDbiP62750.
PeptideAtlasiP62750.
PRIDEiP62750.
TopDownProteomicsiP62750.

2D gel databases

SWISS-2DPAGEP62750.

PTM databases

iPTMnetiP62750.
PhosphoSiteiP62750.
SwissPalmiP62750.

Expressioni

Gene expression databases

BgeeiENSG00000198242.
CleanExiHS_RPL23A.
ExpressionAtlasiP62750. baseline and differential.
GenevisibleiP62750. HS.

Organism-specific databases

HPAiHPA051754.
HPA061923.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-353254,EBI-5323863

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi112067. 183 interactions.
IntActiP62750. 44 interactions.
MINTiMINT-4999907.
STRINGi9606.ENSP00000389103.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LX1-156[»]
4V6Xelectron microscopy5.00CX1-156[»]
5AJ0electron microscopy3.50AX1-156[»]
ProteinModelPortaliP62750.
SMRiP62750. Positions 73-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L23P family.Curated

Phylogenomic databases

eggNOGiKOG1751. Eukaryota.
COG0089. LUCA.
GeneTreeiENSGT00390000003263.
HOGENOMiHOG000231365.
HOVERGENiHBG056619.
InParanoidiP62750.
KOiK02893.
PhylomeDBiP62750.
TreeFamiTF314116.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_01369_A. Ribosomal_L23_A. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
TIGRFAMsiTIGR03636. uL23_arch. 1 hit.
PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK
60 70 80 90 100
TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV
110 120 130 140 150
DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA

NKIGII
Length:156
Mass (Da):17,695
Last modified:August 16, 2004 - v1
Checksum:i3980E77B47FAB70E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → IP in AAA03341 (Ref. 2) Curated
Sequence conflicti78 – 781K → N in AAB17510 (PubMed:8662070).Curated
Sequence conflicti110 – 1101K → S in AAB17510 (PubMed:8662070).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991I → T Rare variant found in Diamond-Blackfan anemia patients; unknown pathological significance. 1 Publication
Corresponds to variant rs151327030 [ dbSNP | Ensembl ].
VAR_069221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43701 mRNA. Translation: AAB03210.1.
U02032 mRNA. Translation: AAA03341.1.
U37230 mRNA. Translation: AAB17510.1.
AF001689 Genomic DNA. Translation: AAC51934.1.
AK312123 mRNA. Translation: BAG35059.1.
CH471159 Genomic DNA. Translation: EAW51132.1.
BC014459 mRNA. Translation: AAH14459.1.
BC058041 mRNA. Translation: AAH58041.1.
L13799 mRNA. Translation: AAA35681.1.
CCDSiCCDS11241.1.
RefSeqiNP_000975.2. NM_000984.5.
UniGeneiHs.419463.

Genome annotation databases

EnsembliENST00000422514; ENSP00000389103; ENSG00000198242.
GeneIDi6147.
KEGGihsa:6147.
UCSCiuc002hci.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43701 mRNA. Translation: AAB03210.1.
U02032 mRNA. Translation: AAA03341.1.
U37230 mRNA. Translation: AAB17510.1.
AF001689 Genomic DNA. Translation: AAC51934.1.
AK312123 mRNA. Translation: BAG35059.1.
CH471159 Genomic DNA. Translation: EAW51132.1.
BC014459 mRNA. Translation: AAH14459.1.
BC058041 mRNA. Translation: AAH58041.1.
L13799 mRNA. Translation: AAA35681.1.
CCDSiCCDS11241.1.
RefSeqiNP_000975.2. NM_000984.5.
UniGeneiHs.419463.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LX1-156[»]
4V6Xelectron microscopy5.00CX1-156[»]
5AJ0electron microscopy3.50AX1-156[»]
ProteinModelPortaliP62750.
SMRiP62750. Positions 73-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112067. 183 interactions.
IntActiP62750. 44 interactions.
MINTiMINT-4999907.
STRINGi9606.ENSP00000389103.

PTM databases

iPTMnetiP62750.
PhosphoSiteiP62750.
SwissPalmiP62750.

Polymorphism and mutation databases

BioMutaiRPL23A.
DMDMi51338637.

2D gel databases

SWISS-2DPAGEP62750.

Proteomic databases

EPDiP62750.
MaxQBiP62750.
PaxDbiP62750.
PeptideAtlasiP62750.
PRIDEiP62750.
TopDownProteomicsiP62750.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422514; ENSP00000389103; ENSG00000198242.
GeneIDi6147.
KEGGihsa:6147.
UCSCiuc002hci.4. human.

Organism-specific databases

CTDi6147.
GeneCardsiRPL23A.
H-InvDBHIX0016623.
HGNCiHGNC:10317. RPL23A.
HPAiHPA051754.
HPA061923.
MIMi602326. gene.
neXtProtiNX_P62750.
PharmGKBiPA34691.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1751. Eukaryota.
COG0089. LUCA.
GeneTreeiENSGT00390000003263.
HOGENOMiHOG000231365.
HOVERGENiHBG056619.
InParanoidiP62750.
KOiK02893.
PhylomeDBiP62750.
TreeFamiTF314116.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL23A. human.
GeneWikiiRPL23A.
GenomeRNAii6147.
PROiP62750.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198242.
CleanExiHS_RPL23A.
ExpressionAtlasiP62750. baseline and differential.
GenevisibleiP62750. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_01369_A. Ribosomal_L23_A. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
TIGRFAMsiTIGR03636. uL23_arch. 1 hit.
PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL23A_HUMAN
AccessioniPrimary (citable) accession number: P62750
Secondary accession number(s): B2R5B2
, P29316, P39024, Q92774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.