P62750 (RL23A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L23a

Gene names

Name:

RPL23A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein binds to a specific region on the 26S rRNA By similarity.
Post-translational modification	N-terminus is methylated by METTL11A/NTM1 By similarity.
Sequence similarities	Belongs to the ribosomal protein L23P family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Methylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome cell proliferation Inferred from mutant phenotype PubMed 9053844. Source: UniProtKB nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay PubMed 12962325. Source: UniProtKB nucleus Inferred from direct assay PubMed 9687515. Source: UniProtKB
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Non-traceable author statement PubMed 12962325Ref.4. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CNBP	P62633	1	EBI-353254,EBI-1047529
DDX56	Q9NY93	1	EBI-353254,EBI-372376
LYAR	Q9NX58	1	EBI-353254,EBI-713507
MAGEB2	O15479	1	EBI-353254,EBI-1057615
PACSIN3	Q9UKS6	1	EBI-353254,EBI-77926
PINX1	Q96BK5	1	EBI-353254,EBI-721782
PSTPIP1	O43586	1	EBI-353254,EBI-1050964
RTCD1	O00442	1	EBI-353254,EBI-1045306

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 156	155	60S ribosomal protein L23a		PRO_0000129467
Amino acid modifications
	Modified residue	2	1	N,N,N-trimethylalanine By similarity
	Modified residue	45	1	Phosphothreonine Ref.11
Natural variations
	Natural variant	99	1	I → T Rare variant found in Diamond-Blackfan anemia patients; unknown pathological significance. Ref.14		VAR_069221
Experimental info
	Sequence conflict	1 – 2	2	MA → IP in AAA03341. Ref.2
	Sequence conflict	78	1	K → N in AAB17510. Ref.3
	Sequence conflict	110	1	K → S in AAB17510. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P62750 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 3980E77B47FAB70E	FASTA	156	17,695
	10 20 30 40 50 60 MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK TLRLRRQPKY 70 80 90 100 110 120 PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV DVKANKHQIK QAVKKLYDID 130 140 150 VAKVNTLIRP DGEKKAYVRL APDYDALDVA NKIGII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Jiang H., Lin J., Tao J., Fisher P.B. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Melanoma.
[2]	Reddy K.B., Lin C.W., Howe P.H. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"Identification of seven new human MHC class I region genes around the HLA-F locus." Fan W., Cai W., Parimoo S., Lennon G.G., Weissman S.M. Immunogenetics 44:97-103(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene." Fan W., Christensen M., Eichler E., Zhang X., Lennon G. Genomics 46:234-239(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[8]	"Identification and localization of six liver expressed genes on human chromosome 13." Bonaldo M., Soares M.B. Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-156. Tissue: Liver.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia." Gazda H.T., Preti M., Sheen M.R., O'Donohue M.F., Vlachos A., Davies S.M., Kattamis A., Doherty L., Landowski M., Buros C., Ghazvinian R., Sieff C.A., Newburger P.E., Niewiadomska E., Matysiak M., Glader B., Atsidaftos E., Lipton J.M., Gleizes P.E., Beggs A.H. Hum. Mutat. 33:1037-1044(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT THR-99.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43701 mRNA. Translation: AAB03210.1. U02032 mRNA. Translation: AAA03341.1. U37230 mRNA. Translation: AAB17510.1. AF001689 Genomic DNA. Translation: AAC51934.1. AK312123 mRNA. Translation: BAG35059.1. CH471159 Genomic DNA. Translation: EAW51132.1. BC014459 mRNA. Translation: AAH14459.1. BC058041 mRNA. Translation: AAH58041.1. L13799 mRNA. Translation: AAA35681.1.
IPI	IPI00021266.
RefSeq	NP_000975.2. NM_000984.5.
UniGene	Hs.419463.
3D structure databases
ProteinModelPortal	P62750.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62750. 15 interactions.
STRING	9606.ENSP00000389103.
PTM databases
PhosphoSite	P62750.
Polymorphism databases
DMDM	51338637.
2D gel databases
SWISS-2DPAGE	P62750.
Proteomic databases
PaxDb	P62750.
PRIDE	P62750.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000422514; ENSP00000389103; ENSG00000198242.
GeneID	6147.
KEGG	hsa:6147.
UCSC	uc002hci.3. human.
Organism-specific databases
CTD	6147.
GeneCards	GC17P027046.
H-InvDB	HIX0016623.
HGNC	HGNC:10317. RPL23A.
HPA	HPA051754.
MIM	602326. gene.
neXtProt	NX_P62750.
PharmGKB	PA34691.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0089.
HOGENOM	HOG000231365.
HOVERGEN	HBG056619.
KO	K02893.
OrthoDB	EOG43JC62.
PhylomeDB	P62750.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P62750.
Bgee	P62750.
CleanEx	HS_RPL23A.
Genevestigator	P62750.
GermOnline	ENSG00000198242. Homo sapiens.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR019985. Ribosomal_L23. IPR012678. Ribosomal_L23/L15e_core_dom. IPR001014. Ribosomal_L23/L25_CS. IPR005633. Ribosomal_L23/L25_N. IPR013025. Ribosomal_L25/23. [Graphical view]
Pfam	PF00276. Ribosomal_L23. 1 hit. PF03939. Ribosomal_L23eN. 1 hit. [Graphical view]
SUPFAM	SSF54189. L23_L15e_core. 1 hit.
TIGRFAMs	TIGR03636. L23_arch. 1 hit.
PROSITE	PS00050. RIBOSOMAL_L23. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPL23A. human.
GenomeRNAi	6147.
NextBio	23883.
SOURCE	Search...

Entry information

Entry name

RL23A_HUMAN

Accession

Primary (citable) accession number: P62750
Secondary accession number(s): B2R5B2 , P29316, P39024, Q92774

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.