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P62750

- RL23A_HUMAN

UniProt

P62750 - RL23A_HUMAN

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Protein

60S ribosomal protein L23a

Gene

RPL23A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein binds to a specific region on the 26S rRNA.By similarity

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
  3. rRNA binding Source: UniProtKB-KW
  4. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. cellular protein metabolic process Source: Reactome
  3. gene expression Source: Reactome
  4. mRNA metabolic process Source: Reactome
  5. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  6. RNA metabolic process Source: Reactome
  7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  8. translation Source: UniProtKB
  9. translational elongation Source: Reactome
  10. translational initiation Source: Reactome
  11. translational termination Source: Reactome
  12. viral life cycle Source: Reactome
  13. viral process Source: Reactome
  14. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23a
Gene namesi
Name:RPL23A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10317. RPL23A.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic large ribosomal subunit Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 15615560S ribosomal protein L23aPRO_0000129467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N,N,N-trimethylalanineBy similarity
Modified residuei41 – 411CitrullineBy similarity
Modified residuei45 – 451Phosphothreonine1 Publication

Post-translational modificationi

N-terminus is methylated by METTL11A/NTM1.By similarity
Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP62750.
PaxDbiP62750.
PRIDEiP62750.

2D gel databases

SWISS-2DPAGEP62750.

PTM databases

PhosphoSiteiP62750.

Expressioni

Gene expression databases

BgeeiP62750.
CleanExiHS_RPL23A.
ExpressionAtlasiP62750. baseline.
GenevestigatoriP62750.

Organism-specific databases

HPAiHPA051754.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-353254,EBI-5323863

Protein-protein interaction databases

BioGridi112067. 149 interactions.
IntActiP62750. 24 interactions.
MINTiMINT-4999907.
STRINGi9606.ENSP00000389103.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00X1-156[»]
ProteinModelPortaliP62750.
SMRiP62750. Positions 38-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L23P family.Curated

Phylogenomic databases

eggNOGiCOG0089.
GeneTreeiENSGT00390000003263.
HOGENOMiHOG000231365.
HOVERGENiHBG056619.
InParanoidiP62750.
KOiK02893.
PhylomeDBiP62750.
TreeFamiTF314116.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_01369_A. Ribosomal_L23_A.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamiPF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
TIGRFAMsiTIGR03636. L23_arch. 1 hit.
PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62750-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK
60 70 80 90 100
TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV
110 120 130 140 150
DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA

NKIGII
Length:156
Mass (Da):17,695
Last modified:August 16, 2004 - v1
Checksum:i3980E77B47FAB70E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → IP in AAA03341. 1 PublicationCurated
Sequence conflicti78 – 781K → N in AAB17510. (PubMed:8662070)Curated
Sequence conflicti110 – 1101K → S in AAB17510. (PubMed:8662070)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991I → T Rare variant found in Diamond-Blackfan anemia patients; unknown pathological significance. 1 Publication
VAR_069221

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43701 mRNA. Translation: AAB03210.1.
U02032 mRNA. Translation: AAA03341.1.
U37230 mRNA. Translation: AAB17510.1.
AF001689 Genomic DNA. Translation: AAC51934.1.
AK312123 mRNA. Translation: BAG35059.1.
CH471159 Genomic DNA. Translation: EAW51132.1.
BC014459 mRNA. Translation: AAH14459.1.
BC058041 mRNA. Translation: AAH58041.1.
L13799 mRNA. Translation: AAA35681.1.
CCDSiCCDS11241.1.
RefSeqiNP_000975.2. NM_000984.5.
UniGeneiHs.419463.

Genome annotation databases

EnsembliENST00000422514; ENSP00000389103; ENSG00000198242.
GeneIDi6147.
KEGGihsa:6147.
UCSCiuc002hci.3. human.

Polymorphism databases

DMDMi51338637.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43701 mRNA. Translation: AAB03210.1 .
U02032 mRNA. Translation: AAA03341.1 .
U37230 mRNA. Translation: AAB17510.1 .
AF001689 Genomic DNA. Translation: AAC51934.1 .
AK312123 mRNA. Translation: BAG35059.1 .
CH471159 Genomic DNA. Translation: EAW51132.1 .
BC014459 mRNA. Translation: AAH14459.1 .
BC058041 mRNA. Translation: AAH58041.1 .
L13799 mRNA. Translation: AAA35681.1 .
CCDSi CCDS11241.1.
RefSeqi NP_000975.2. NM_000984.5.
UniGenei Hs.419463.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3B electron microscopy 5.00 X 1-156 [» ]
ProteinModelPortali P62750.
SMRi P62750. Positions 38-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112067. 149 interactions.
IntActi P62750. 24 interactions.
MINTi MINT-4999907.
STRINGi 9606.ENSP00000389103.

PTM databases

PhosphoSitei P62750.

Polymorphism databases

DMDMi 51338637.

2D gel databases

SWISS-2DPAGE P62750.

Proteomic databases

MaxQBi P62750.
PaxDbi P62750.
PRIDEi P62750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000422514 ; ENSP00000389103 ; ENSG00000198242 .
GeneIDi 6147.
KEGGi hsa:6147.
UCSCi uc002hci.3. human.

Organism-specific databases

CTDi 6147.
GeneCardsi GC17P027046.
H-InvDB HIX0016623.
HGNCi HGNC:10317. RPL23A.
HPAi HPA051754.
MIMi 602326. gene.
neXtProti NX_P62750.
PharmGKBi PA34691.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0089.
GeneTreei ENSGT00390000003263.
HOGENOMi HOG000231365.
HOVERGENi HBG056619.
InParanoidi P62750.
KOi K02893.
PhylomeDBi P62750.
TreeFami TF314116.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPL23A. human.
GeneWikii RPL23A.
GenomeRNAii 6147.
NextBioi 23883.
PROi P62750.
SOURCEi Search...

Gene expression databases

Bgeei P62750.
CleanExi HS_RPL23A.
ExpressionAtlasi P62750. baseline.
Genevestigatori P62750.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
HAMAPi MF_01369_A. Ribosomal_L23_A.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR019985. Ribosomal_L23.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR005633. Ribosomal_L23/L25_N.
IPR013025. Ribosomal_L25/23.
[Graphical view ]
Pfami PF00276. Ribosomal_L23. 1 hit.
PF03939. Ribosomal_L23eN. 1 hit.
[Graphical view ]
SUPFAMi SSF54189. SSF54189. 1 hit.
TIGRFAMsi TIGR03636. L23_arch. 1 hit.
PROSITEi PS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Jiang H., Lin J., Tao J., Fisher P.B.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Melanoma.
  2. Reddy K.B., Lin C.W., Howe P.H.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Identification of seven new human MHC class I region genes around the HLA-F locus."
    Fan W., Cai W., Parimoo S., Lennon G.G., Weissman S.M.
    Immunogenetics 44:97-103(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene."
    Fan W., Christensen M., Eichler E., Zhang X., Lennon G.
    Genomics 46:234-239(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  8. "Identification and localization of six liver expressed genes on human chromosome 13."
    Bonaldo M., Soares M.B.
    Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-156.
    Tissue: Liver.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.
  15. "Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia."
    Gazda H.T., Preti M., Sheen M.R., O'Donohue M.F., Vlachos A., Davies S.M., Kattamis A., Doherty L., Landowski M., Buros C., Ghazvinian R., Sieff C.A., Newburger P.E., Niewiadomska E., Matysiak M., Glader B., Atsidaftos E., Lipton J.M., Gleizes P.E., Beggs A.H.
    Hum. Mutat. 33:1037-1044(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THR-99.

Entry informationi

Entry nameiRL23A_HUMAN
AccessioniPrimary (citable) accession number: P62750
Secondary accession number(s): B2R5B2
, P29316, P39024, Q92774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3