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P62750

- RL23A_HUMAN

UniProt

P62750 - RL23A_HUMAN

Protein

60S ribosomal protein L23a

Gene

RPL23A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein binds to a specific region on the 26S rRNA.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. rRNA binding Source: UniProtKB-KW
    5. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. cellular protein metabolic process Source: Reactome
    3. gene expression Source: Reactome
    4. mRNA metabolic process Source: Reactome
    5. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    6. RNA metabolic process Source: Reactome
    7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    8. translation Source: UniProtKB
    9. translational elongation Source: Reactome
    10. translational initiation Source: Reactome
    11. translational termination Source: Reactome
    12. viral life cycle Source: Reactome
    13. viral process Source: Reactome
    14. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L23a
    Gene namesi
    Name:RPL23A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10317. RPL23A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic large ribosomal subunit Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34691.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 15615560S ribosomal protein L23aPRO_0000129467Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N,N,N-trimethylalanineBy similarity
    Modified residuei41 – 411CitrullineBy similarity
    Modified residuei45 – 451Phosphothreonine1 Publication

    Post-translational modificationi

    N-terminus is methylated by METTL11A/NTM1.By similarity
    Citrullinated by PADI4.By similarity

    Keywords - PTMi

    Citrullination, Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiP62750.
    PaxDbiP62750.
    PRIDEiP62750.

    2D gel databases

    SWISS-2DPAGEP62750.

    PTM databases

    PhosphoSiteiP62750.

    Expressioni

    Gene expression databases

    BgeeiP62750.
    CleanExiHS_RPL23A.
    GenevestigatoriP62750.

    Organism-specific databases

    HPAiHPA051754.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LRRK2Q5S0072EBI-353254,EBI-5323863

    Protein-protein interaction databases

    BioGridi112067. 143 interactions.
    IntActiP62750. 24 interactions.
    MINTiMINT-4999907.
    STRINGi9606.ENSP00000389103.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00X1-156[»]
    ProteinModelPortaliP62750.
    SMRiP62750. Positions 36-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L23P family.Curated

    Phylogenomic databases

    eggNOGiCOG0089.
    HOGENOMiHOG000231365.
    HOVERGENiHBG056619.
    KOiK02893.
    PhylomeDBiP62750.
    TreeFamiTF314116.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    HAMAPiMF_01369_A. Ribosomal_L23_A.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR019985. Ribosomal_L23.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    IPR001014. Ribosomal_L23/L25_CS.
    IPR005633. Ribosomal_L23/L25_N.
    IPR013025. Ribosomal_L25/23.
    [Graphical view]
    PfamiPF00276. Ribosomal_L23. 1 hit.
    PF03939. Ribosomal_L23eN. 1 hit.
    [Graphical view]
    SUPFAMiSSF54189. SSF54189. 1 hit.
    TIGRFAMsiTIGR03636. L23_arch. 1 hit.
    PROSITEiPS00050. RIBOSOMAL_L23. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62750-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKAKKEAP APPKAEAKAK ALKAKKAVLK GVHSHKKKKI RTSPTFRRPK    50
    TLRLRRQPKY PRKSAPRRNK LDHYAIIKFP LTTESAMKKI EDNNTLVFIV 100
    DVKANKHQIK QAVKKLYDID VAKVNTLIRP DGEKKAYVRL APDYDALDVA 150
    NKIGII 156
    Length:156
    Mass (Da):17,695
    Last modified:August 16, 2004 - v1
    Checksum:i3980E77B47FAB70E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21A → IP in AAA03341. 1 PublicationCurated
    Sequence conflicti78 – 781K → N in AAB17510. (PubMed:8662070)Curated
    Sequence conflicti110 – 1101K → S in AAB17510. (PubMed:8662070)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti99 – 991I → T Rare variant found in Diamond-Blackfan anemia patients; unknown pathological significance. 1 Publication
    VAR_069221

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43701 mRNA. Translation: AAB03210.1.
    U02032 mRNA. Translation: AAA03341.1.
    U37230 mRNA. Translation: AAB17510.1.
    AF001689 Genomic DNA. Translation: AAC51934.1.
    AK312123 mRNA. Translation: BAG35059.1.
    CH471159 Genomic DNA. Translation: EAW51132.1.
    BC014459 mRNA. Translation: AAH14459.1.
    BC058041 mRNA. Translation: AAH58041.1.
    L13799 mRNA. Translation: AAA35681.1.
    CCDSiCCDS11241.1.
    RefSeqiNP_000975.2. NM_000984.5.
    UniGeneiHs.419463.

    Genome annotation databases

    EnsembliENST00000422514; ENSP00000389103; ENSG00000198242.
    GeneIDi6147.
    KEGGihsa:6147.
    UCSCiuc002hci.3. human.

    Polymorphism databases

    DMDMi51338637.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43701 mRNA. Translation: AAB03210.1 .
    U02032 mRNA. Translation: AAA03341.1 .
    U37230 mRNA. Translation: AAB17510.1 .
    AF001689 Genomic DNA. Translation: AAC51934.1 .
    AK312123 mRNA. Translation: BAG35059.1 .
    CH471159 Genomic DNA. Translation: EAW51132.1 .
    BC014459 mRNA. Translation: AAH14459.1 .
    BC058041 mRNA. Translation: AAH58041.1 .
    L13799 mRNA. Translation: AAA35681.1 .
    CCDSi CCDS11241.1.
    RefSeqi NP_000975.2. NM_000984.5.
    UniGenei Hs.419463.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 X 1-156 [» ]
    ProteinModelPortali P62750.
    SMRi P62750. Positions 36-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112067. 143 interactions.
    IntActi P62750. 24 interactions.
    MINTi MINT-4999907.
    STRINGi 9606.ENSP00000389103.

    PTM databases

    PhosphoSitei P62750.

    Polymorphism databases

    DMDMi 51338637.

    2D gel databases

    SWISS-2DPAGE P62750.

    Proteomic databases

    MaxQBi P62750.
    PaxDbi P62750.
    PRIDEi P62750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000422514 ; ENSP00000389103 ; ENSG00000198242 .
    GeneIDi 6147.
    KEGGi hsa:6147.
    UCSCi uc002hci.3. human.

    Organism-specific databases

    CTDi 6147.
    GeneCardsi GC17P027046.
    H-InvDB HIX0016623.
    HGNCi HGNC:10317. RPL23A.
    HPAi HPA051754.
    MIMi 602326. gene.
    neXtProti NX_P62750.
    PharmGKBi PA34691.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0089.
    HOGENOMi HOG000231365.
    HOVERGENi HBG056619.
    KOi K02893.
    PhylomeDBi P62750.
    TreeFami TF314116.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL23A. human.
    GeneWikii RPL23A.
    GenomeRNAii 6147.
    NextBioi 23883.
    PROi P62750.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62750.
    CleanExi HS_RPL23A.
    Genevestigatori P62750.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    HAMAPi MF_01369_A. Ribosomal_L23_A.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR019985. Ribosomal_L23.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    IPR001014. Ribosomal_L23/L25_CS.
    IPR005633. Ribosomal_L23/L25_N.
    IPR013025. Ribosomal_L25/23.
    [Graphical view ]
    Pfami PF00276. Ribosomal_L23. 1 hit.
    PF03939. Ribosomal_L23eN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54189. SSF54189. 1 hit.
    TIGRFAMsi TIGR03636. L23_arch. 1 hit.
    PROSITEi PS00050. RIBOSOMAL_L23. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jiang H., Lin J., Tao J., Fisher P.B.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Melanoma.
    2. Reddy K.B., Lin C.W., Howe P.H.
      Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Identification of seven new human MHC class I region genes around the HLA-F locus."
      Fan W., Cai W., Parimoo S., Lennon G.G., Weissman S.M.
      Immunogenetics 44:97-103(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene."
      Fan W., Christensen M., Eichler E., Zhang X., Lennon G.
      Genomics 46:234-239(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    8. "Identification and localization of six liver expressed genes on human chromosome 13."
      Bonaldo M., Soares M.B.
      Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-156.
      Tissue: Liver.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.
    15. "Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia."
      Gazda H.T., Preti M., Sheen M.R., O'Donohue M.F., Vlachos A., Davies S.M., Kattamis A., Doherty L., Landowski M., Buros C., Ghazvinian R., Sieff C.A., Newburger P.E., Niewiadomska E., Matysiak M., Glader B., Atsidaftos E., Lipton J.M., Gleizes P.E., Beggs A.H.
      Hum. Mutat. 33:1037-1044(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT THR-99.

    Entry informationi

    Entry nameiRL23A_HUMAN
    AccessioniPrimary (citable) accession number: P62750
    Secondary accession number(s): B2R5B2
    , P29316, P39024, Q92774
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Ribosomal proteins
      Ribosomal proteins families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3