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Protein

Hippocalcin-like protein 1

Gene

Hpcal1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Neural visinin-like protein 3
Short name:
NVL-3
Short name:
NVP-3
Visinin-like protein 3
Short name:
VILIP-3
Gene namesi
Name:Hpcal1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi708375. Hpcal1.

Subcellular locationi

  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 193192Hippocalcin-like protein 1PRO_0000073774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP62749.
PRIDEiP62749.

PTM databases

iPTMnetiP62749.
PhosphoSiteiP62749.

Expressioni

Tissue specificityi

In neuronal cells, but not as specifically as VILIP-1 or VILIP-2.1 Publication

Gene expression databases

GenevisibleiP62749. RN.

Interactioni

Protein-protein interaction databases

BioGridi248435. 1 interaction.
STRINGi10116.ENSRNOP00000007374.

Structurei

3D structure databases

ProteinModelPortaliP62749.
SMRiP62749. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62749.
OMAiLEIVQXK.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62749.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLREHT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,338
Last modified:January 23, 2007 - v2
Checksum:iB7251445F834F91D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13126 mRNA. Translation: BAA02428.1.
BC088759 mRNA. Translation: AAH88759.1.
PIRiJH0816.
RefSeqiNP_059052.1. NM_017356.2.
XP_006239976.1. XM_006239914.2.
XP_006239978.1. XM_006239916.2.
XP_008762827.1. XM_008764605.1.
XP_008762828.1. XM_008764606.1.
UniGeneiRn.102820.

Genome annotation databases

EnsembliENSRNOT00000007374; ENSRNOP00000007374; ENSRNOG00000005492.
GeneIDi50871.
KEGGirno:50871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13126 mRNA. Translation: BAA02428.1.
BC088759 mRNA. Translation: AAH88759.1.
PIRiJH0816.
RefSeqiNP_059052.1. NM_017356.2.
XP_006239976.1. XM_006239914.2.
XP_006239978.1. XM_006239916.2.
XP_008762827.1. XM_008764605.1.
XP_008762828.1. XM_008764606.1.
UniGeneiRn.102820.

3D structure databases

ProteinModelPortaliP62749.
SMRiP62749. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248435. 1 interaction.
STRINGi10116.ENSRNOP00000007374.

PTM databases

iPTMnetiP62749.
PhosphoSiteiP62749.

Proteomic databases

PaxDbiP62749.
PRIDEiP62749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007374; ENSRNOP00000007374; ENSRNOG00000005492.
GeneIDi50871.
KEGGirno:50871.

Organism-specific databases

CTDi3241.
RGDi708375. Hpcal1.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62749.
OMAiLEIVQXK.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62749.
TreeFamiTF300009.

Miscellaneous databases

PROiP62749.

Gene expression databases

GenevisibleiP62749. RN.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of two additional members of the neural visinin-like Ca(2+)-binding protein gene family."
    Kajimoto Y., Shirai Y., Mukai H., Kuno T., Tanaka C.
    J. Neurochem. 61:1091-1096(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 8-17; 51-94; 119-130; 138-148; 164-171 AND 175-181, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiHPCL1_RAT
AccessioniPrimary (citable) accession number: P62749
Secondary accession number(s): P35333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.