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P62748

- HPCL1_MOUSE

UniProt

P62748 - HPCL1_MOUSE

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Protein

Hippocalcin-like protein 1

Gene

Hpcal1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Neural visinin-like protein 3
Short name:
NVL-3
Short name:
NVP-3
Visinin-like protein 3
Short name:
VILIP-3
Gene namesi
Name:Hpcal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1855689. Hpcal1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 193192Hippocalcin-like protein 1PRO_0000073772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP62748.
PaxDbiP62748.
PRIDEiP62748.

PTM databases

PhosphoSiteiP62748.

Expressioni

Gene expression databases

BgeeiP62748.
CleanExiMM_HPCAL1.
GenevestigatoriP62748.

Interactioni

Protein-protein interaction databases

BioGridi207322. 2 interactions.
IntActiP62748. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP62748.
SMRiP62748. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62748.
OMAiLEIVQXK.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62748.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029535. VILIP-3.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF79. PTHR23055:SF79. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62748-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLREHT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,338
Last modified:January 23, 2007 - v2
Checksum:iB7251445F834F91D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085192 mRNA. Translation: AAC35552.1.
BC001997 mRNA. Translation: AAH01997.1.
CCDSiCCDS25830.1.
RefSeqiNP_057886.1. NM_016677.4.
XP_006515219.1. XM_006515156.1.
XP_006515220.1. XM_006515157.1.
UniGeneiMm.313619.
Mm.489835.

Genome annotation databases

EnsembliENSMUST00000071858; ENSMUSP00000071756; ENSMUSG00000071379.
GeneIDi53602.
KEGGimmu:53602.
UCSCiuc007ncw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085192 mRNA. Translation: AAC35552.1 .
BC001997 mRNA. Translation: AAH01997.1 .
CCDSi CCDS25830.1.
RefSeqi NP_057886.1. NM_016677.4.
XP_006515219.1. XM_006515156.1.
XP_006515220.1. XM_006515157.1.
UniGenei Mm.313619.
Mm.489835.

3D structure databases

ProteinModelPortali P62748.
SMRi P62748. Positions 5-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207322. 2 interactions.
IntActi P62748. 4 interactions.

PTM databases

PhosphoSitei P62748.

Proteomic databases

MaxQBi P62748.
PaxDbi P62748.
PRIDEi P62748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071858 ; ENSMUSP00000071756 ; ENSMUSG00000071379 .
GeneIDi 53602.
KEGGi mmu:53602.
UCSCi uc007ncw.1. mouse.

Organism-specific databases

CTDi 3241.
MGIi MGI:1855689. Hpcal1.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00760000118820.
HOGENOMi HOG000233019.
HOVERGENi HBG108179.
InParanoidi P62748.
OMAi LEIVQXK.
OrthoDBi EOG7GJ6F3.
PhylomeDBi P62748.
TreeFami TF300009.

Miscellaneous databases

ChiTaRSi Hpcal1. mouse.
NextBioi 310285.
PROi P62748.
SOURCEi Search...

Gene expression databases

Bgeei P62748.
CleanExi MM_HPCAL1.
Genevestigatori P62748.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029535. VILIP-3.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
PTHR23055:SF79. PTHR23055:SF79. 1 hit.
Pfami PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interactions of the murine neural visinin-like protein 3 (mNVP-3)."
    Ritter B., Modregger J., Plomann M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiHPCL1_MOUSE
AccessioniPrimary (citable) accession number: P62748
Secondary accession number(s): P35333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3