P62748 (HPCL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hippocalcin-like protein 1

Alternative name(s):
Neural visinin-like protein 3
Short name=NVL-3
Short name=NVP-3
Visinin-like protein 3
Short name=VILIP-3

Gene names

Name:

Hpcal1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
Miscellaneous	Probably binds two or three calcium ions By similarity.
Sequence similarities	Belongs to the recoverin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Hippocalcin-like protein 1		PRO_0000073772
Regions
	Domain	23 – 58	36	EF-hand 1
	Domain	60 – 95	36	EF-hand 2
	Domain	96 – 131	36	EF-hand 3
	Domain	144 – 179	36	EF-hand 4
	Calcium binding	73 – 84	12	1 Potential
	Calcium binding	109 – 120	12	2 Potential
	Calcium binding	157 – 168	12	3 Potential
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62748 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: B7251445F834F91D	FASTA	193	22,338
	10 20 30 40 50 60 MGKQNSKLRP EVLQDLREHT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 70 80 90 100 110 120 ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 130 140 150 160 170 180 MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV 190 RLLQCDPSSA SQF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interactions of the murine neural visinin-like protein 3 (mNVP-3)." Ritter B., Modregger J., Plomann M. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF085192 mRNA. Translation: AAC35552.1. BC001997 mRNA. Translation: AAH01997.1.
IPI	IPI00230449.
RefSeq	NP_057886.1. NM_016677.4.
UniGene	Mm.313619. Mm.489835.
3D structure databases
ProteinModelPortal	P62748.
SMR	P62748. Positions 5-185.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62748. 3 interactions.
PTM databases
PhosphoSite	P62748.
Proteomic databases
PaxDb	P62748.
PRIDE	P62748.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000071858; ENSMUSP00000071756; ENSMUSG00000071379.
GeneID	53602.
KEGG	mmu:53602.
UCSC	uc008uwb.2. mouse.
Organism-specific databases
CTD	3241.
MGI	MGI:1855689. Hpcal1.
Phylogenomic databases
eggNOG	COG5126.
GeneTree	ENSGT00560000076803.
HOGENOM	HOG000233019.
HOVERGEN	HBG108179.
InParanoid	P62748.
OMA	LEIVQXK.
OrthoDB	EOG4G1MHC.
Gene expression databases
Bgee	P62748.
CleanEx	MM_HPCAL1.
Genevestigator	P62748.
GermOnline	ENSMUSG00000071379. Mus musculus.
Family and domain databases
Gene3D	1.10.238.10. 3 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001125. Recoverin. [Graphical view]
Pfam	PF13499. EF_hand_5. 1 hit. PF00036. efhand. 1 hit. [Graphical view]
PRINTS	PR00450. RECOVERIN.
SMART	SM00054. EFh. 3 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HPCAL1. mouse.
NextBio	310285.
SOURCE	Search...

Entry information

Entry name

HPCL1_MOUSE

Accession

Primary (citable) accession number: P62748
Secondary accession number(s): P35333

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program