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P62748 (HPCL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hippocalcin-like protein 1
Alternative name(s):
Neural visinin-like protein 3
Short name=NVL-3
Short name=NVP-3
Visinin-like protein 3
Short name=VILIP-3
Gene names
Name:Hpcal1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Miscellaneous

Probably binds two or three calcium ions By similarity.

Sequence similarities

Belongs to the recoverin family.

Contains 4 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 193192Hippocalcin-like protein 1
PRO_0000073772

Regions

Domain23 – 5836EF-hand 1
Domain60 – 9536EF-hand 2
Domain96 – 13136EF-hand 3
Domain144 – 17936EF-hand 4
Calcium binding73 – 84121 Potential
Calcium binding109 – 120122 Potential
Calcium binding157 – 168123 Potential

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62748 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: B7251445F834F91D

FASTA19322,338
        10         20         30         40         50         60 
MGKQNSKLRP EVLQDLREHT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD 

        70         80         90        100        110        120 
ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE 

       130        140        150        160        170        180 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV 

       190 
RLLQCDPSSA SQF 

« Hide

References

« Hide 'large scale' references
[1]"Interactions of the murine neural visinin-like protein 3 (mNVP-3)."
Ritter B., Modregger J., Plomann M.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF085192 mRNA. Translation: AAC35552.1.
BC001997 mRNA. Translation: AAH01997.1.
CCDSCCDS25830.1.
RefSeqNP_057886.1. NM_016677.4.
XP_006515219.1. XM_006515156.1.
XP_006515220.1. XM_006515157.1.
UniGeneMm.313619.
Mm.489835.

3D structure databases

ProteinModelPortalP62748.
SMRP62748. Positions 5-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207322. 2 interactions.
IntActP62748. 4 interactions.

PTM databases

PhosphoSiteP62748.

Proteomic databases

MaxQBP62748.
PaxDbP62748.
PRIDEP62748.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000071858; ENSMUSP00000071756; ENSMUSG00000071379.
GeneID53602.
KEGGmmu:53602.
UCSCuc007ncw.1. mouse.

Organism-specific databases

CTD3241.
MGIMGI:1855689. Hpcal1.

Phylogenomic databases

eggNOGCOG5126.
GeneTreeENSGT00560000076803.
HOGENOMHOG000233019.
HOVERGENHBG108179.
InParanoidP62748.
OMALEIVQXK.
OrthoDBEOG7GJ6F3.
PhylomeDBP62748.
TreeFamTF300009.

Gene expression databases

BgeeP62748.
CleanExMM_HPCAL1.
GenevestigatorP62748.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERPTHR23055. PTHR23055. 1 hit.
PfamPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHPCAL1. mouse.
NextBio310285.
PROP62748.
SOURCESearch...

Entry information

Entry nameHPCL1_MOUSE
AccessionPrimary (citable) accession number: P62748
Secondary accession number(s): P35333
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot