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Protein

Hippocalcin-like protein 1

Gene

Hpcal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1683PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Neural visinin-like protein 3
Short name:
NVL-3
Short name:
NVP-3
Visinin-like protein 3
Short name:
VILIP-3
Gene namesi
Name:Hpcal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1855689. Hpcal1.

Subcellular locationi

  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000737722 – 193Hippocalcin-like protein 1Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP62748.
MaxQBiP62748.
PaxDbiP62748.
PeptideAtlasiP62748.
PRIDEiP62748.

PTM databases

iPTMnetiP62748.
PhosphoSitePlusiP62748.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071379.
CleanExiMM_HPCAL1.
GenevisibleiP62748. MM.

Interactioni

Protein-protein interaction databases

BioGridi207322. 3 interactors.
IntActiP62748. 4 interactors.
STRINGi10090.ENSMUSP00000071756.

Structurei

3D structure databases

ProteinModelPortaliP62748.
SMRiP62748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62748.
OMAiLEIVQXK.
OrthoDBiEOG091G11T4.
PhylomeDBiP62748.
TreeFamiTF300009.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLREHT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,338
Last modified:January 23, 2007 - v2
Checksum:iB7251445F834F91D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085192 mRNA. Translation: AAC35552.1.
BC001997 mRNA. Translation: AAH01997.1.
CCDSiCCDS25830.1.
RefSeqiNP_057886.1. NM_016677.4.
XP_006515219.1. XM_006515156.3.
XP_006515220.1. XM_006515157.2.
UniGeneiMm.313619.
Mm.489835.

Genome annotation databases

EnsembliENSMUST00000071858; ENSMUSP00000071756; ENSMUSG00000071379.
GeneIDi53602.
KEGGimmu:53602.
UCSCiuc007ncw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085192 mRNA. Translation: AAC35552.1.
BC001997 mRNA. Translation: AAH01997.1.
CCDSiCCDS25830.1.
RefSeqiNP_057886.1. NM_016677.4.
XP_006515219.1. XM_006515156.3.
XP_006515220.1. XM_006515157.2.
UniGeneiMm.313619.
Mm.489835.

3D structure databases

ProteinModelPortaliP62748.
SMRiP62748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207322. 3 interactors.
IntActiP62748. 4 interactors.
STRINGi10090.ENSMUSP00000071756.

PTM databases

iPTMnetiP62748.
PhosphoSitePlusiP62748.

Proteomic databases

EPDiP62748.
MaxQBiP62748.
PaxDbiP62748.
PeptideAtlasiP62748.
PRIDEiP62748.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071858; ENSMUSP00000071756; ENSMUSG00000071379.
GeneIDi53602.
KEGGimmu:53602.
UCSCiuc007ncw.1. mouse.

Organism-specific databases

CTDi3241.
MGIiMGI:1855689. Hpcal1.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62748.
OMAiLEIVQXK.
OrthoDBiEOG091G11T4.
PhylomeDBiP62748.
TreeFamiTF300009.

Miscellaneous databases

ChiTaRSiHpcal1. mouse.
PROiP62748.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071379.
CleanExiMM_HPCAL1.
GenevisibleiP62748. MM.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHPCL1_MOUSE
AccessioniPrimary (citable) accession number: P62748
Secondary accession number(s): P35333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.