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Protein

Hippocalcin-like protein 1

Gene

Hpcal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Miscellaneous

Probably binds two or three calcium ions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi157 – 1683PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Neural visinin-like protein 3
Short name:
NVL-3
Short name:
NVP-3
Visinin-like protein 3
Short name:
VILIP-3
Gene namesi
Name:Hpcal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1855689 Hpcal1

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000737722 – 193Hippocalcin-like protein 1Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP62748
MaxQBiP62748
PaxDbiP62748
PeptideAtlasiP62748
PRIDEiP62748

PTM databases

iPTMnetiP62748
PhosphoSitePlusiP62748
SwissPalmiP62748

Expressioni

Gene expression databases

BgeeiENSMUSG00000071379
CleanExiMM_HPCAL1
ExpressionAtlasiP62748 baseline and differential
GenevisibleiP62748 MM

Interactioni

Protein-protein interaction databases

BioGridi207322, 3 interactors
IntActiP62748, 4 interactors
MINTiP62748
STRINGi10090.ENSMUSP00000071756

Structurei

3D structure databases

ProteinModelPortaliP62748
SMRiP62748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 58EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini144 – 179EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiP62748
OMAiLEIVQXK
OrthoDBiEOG091G11T4
PhylomeDBiP62748
TreeFamiTF300009

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVLQDLREHT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK
60 70 80 90 100
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD
160 170 180 190
KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV RLLQCDPSSA SQF
Length:193
Mass (Da):22,338
Last modified:January 23, 2007 - v2
Checksum:iB7251445F834F91D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085192 mRNA Translation: AAC35552.1
BC001997 mRNA Translation: AAH01997.1
CCDSiCCDS25830.1
RefSeqiNP_057886.1, NM_016677.4
XP_006515219.1, XM_006515156.3
XP_006515220.1, XM_006515157.2
UniGeneiMm.313619
Mm.489835

Genome annotation databases

EnsembliENSMUST00000071858; ENSMUSP00000071756; ENSMUSG00000071379
GeneIDi53602
KEGGimmu:53602
UCSCiuc007ncw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHPCL1_MOUSE
AccessioniPrimary (citable) accession number: P62748
Secondary accession number(s): P35333
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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