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P62748

- HPCL1_MOUSE

UniProt

P62748 - HPCL1_MOUSE

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Protein
Hippocalcin-like protein 1
Gene
Hpcal1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121 Reviewed prediction
Add
BLAST
Calcium bindingi109 – 120122 Reviewed prediction
Add
BLAST
Calcium bindingi157 – 168123 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 1
Alternative name(s):
Neural visinin-like protein 3
Short name:
NVL-3
Short name:
NVP-3
Visinin-like protein 3
Short name:
VILIP-3
Gene namesi
Name:Hpcal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1855689. Hpcal1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 193192Hippocalcin-like protein 1
PRO_0000073772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP62748.
PaxDbiP62748.
PRIDEiP62748.

PTM databases

PhosphoSiteiP62748.

Expressioni

Gene expression databases

BgeeiP62748.
CleanExiMM_HPCAL1.
GenevestigatoriP62748.

Interactioni

Protein-protein interaction databases

BioGridi207322. 2 interactions.
IntActiP62748. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP62748.
SMRiP62748. Positions 5-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1
Add
BLAST
Domaini60 – 9536EF-hand 2
Add
BLAST
Domaini96 – 13136EF-hand 3
Add
BLAST
Domaini144 – 17936EF-hand 4
Add
BLAST

Sequence similaritiesi

Belongs to the recoverin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00560000076803.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP62748.
OMAiLEIVQXK.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP62748.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029535. VILIP-3.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF79. PTHR23055:SF79. 1 hit.
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62748-1 [UniParc]FASTAAdd to Basket

« Hide

MGKQNSKLRP EVLQDLREHT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK    50
IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGKLEQK 100
LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD 150
KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV RLLQCDPSSA SQF 193
Length:193
Mass (Da):22,338
Last modified:January 23, 2007 - v2
Checksum:iB7251445F834F91D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085192 mRNA. Translation: AAC35552.1.
BC001997 mRNA. Translation: AAH01997.1.
CCDSiCCDS25830.1.
RefSeqiNP_057886.1. NM_016677.4.
XP_006515219.1. XM_006515156.1.
XP_006515220.1. XM_006515157.1.
UniGeneiMm.313619.
Mm.489835.

Genome annotation databases

EnsembliENSMUST00000071858; ENSMUSP00000071756; ENSMUSG00000071379.
GeneIDi53602.
KEGGimmu:53602.
UCSCiuc007ncw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085192 mRNA. Translation: AAC35552.1 .
BC001997 mRNA. Translation: AAH01997.1 .
CCDSi CCDS25830.1.
RefSeqi NP_057886.1. NM_016677.4.
XP_006515219.1. XM_006515156.1.
XP_006515220.1. XM_006515157.1.
UniGenei Mm.313619.
Mm.489835.

3D structure databases

ProteinModelPortali P62748.
SMRi P62748. Positions 5-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207322. 2 interactions.
IntActi P62748. 4 interactions.

PTM databases

PhosphoSitei P62748.

Proteomic databases

MaxQBi P62748.
PaxDbi P62748.
PRIDEi P62748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071858 ; ENSMUSP00000071756 ; ENSMUSG00000071379 .
GeneIDi 53602.
KEGGi mmu:53602.
UCSCi uc007ncw.1. mouse.

Organism-specific databases

CTDi 3241.
MGIi MGI:1855689. Hpcal1.

Phylogenomic databases

eggNOGi COG5126.
GeneTreei ENSGT00560000076803.
HOGENOMi HOG000233019.
HOVERGENi HBG108179.
InParanoidi P62748.
OMAi LEIVQXK.
OrthoDBi EOG7GJ6F3.
PhylomeDBi P62748.
TreeFami TF300009.

Miscellaneous databases

ChiTaRSi HPCAL1. mouse.
NextBioi 310285.
PROi P62748.
SOURCEi Search...

Gene expression databases

Bgeei P62748.
CleanExi MM_HPCAL1.
Genevestigatori P62748.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029535. VILIP-3.
[Graphical view ]
PANTHERi PTHR23055. PTHR23055. 1 hit.
PTHR23055:SF79. PTHR23055:SF79. 1 hit.
Pfami PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interactions of the murine neural visinin-like protein 3 (mNVP-3)."
    Ritter B., Modregger J., Plomann M.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiHPCL1_MOUSE
AccessioniPrimary (citable) accession number: P62748
Secondary accession number(s): P35333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi