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P62748

- HPCL1_MOUSE

UniProt

P62748 - HPCL1_MOUSE

Protein

Hippocalcin-like protein 1

Gene

Hpcal1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: MGI

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hippocalcin-like protein 1
    Alternative name(s):
    Neural visinin-like protein 3
    Short name:
    NVL-3
    Short name:
    NVP-3
    Visinin-like protein 3
    Short name:
    VILIP-3
    Gene namesi
    Name:Hpcal1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1855689. Hpcal1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 193192Hippocalcin-like protein 1PRO_0000073772Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiP62748.
    PaxDbiP62748.
    PRIDEiP62748.

    PTM databases

    PhosphoSiteiP62748.

    Expressioni

    Gene expression databases

    BgeeiP62748.
    CleanExiMM_HPCAL1.
    GenevestigatoriP62748.

    Interactioni

    Protein-protein interaction databases

    BioGridi207322. 2 interactions.
    IntActiP62748. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP62748.
    SMRiP62748. Positions 5-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the recoverin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    GeneTreeiENSGT00560000076803.
    HOGENOMiHOG000233019.
    HOVERGENiHBG108179.
    InParanoidiP62748.
    OMAiLEIVQXK.
    OrthoDBiEOG7GJ6F3.
    PhylomeDBiP62748.
    TreeFamiTF300009.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    IPR029535. VILIP-3.
    [Graphical view]
    PANTHERiPTHR23055. PTHR23055. 1 hit.
    PTHR23055:SF79. PTHR23055:SF79. 1 hit.
    PfamiPF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62748-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQNSKLRP EVLQDLREHT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK    50
    IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGKLEQK 100
    LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD 150
    KIFRQMDTNN DGKLSLEEFI KGAKSDPSIV RLLQCDPSSA SQF 193
    Length:193
    Mass (Da):22,338
    Last modified:January 23, 2007 - v2
    Checksum:iB7251445F834F91D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085192 mRNA. Translation: AAC35552.1.
    BC001997 mRNA. Translation: AAH01997.1.
    CCDSiCCDS25830.1.
    RefSeqiNP_057886.1. NM_016677.4.
    XP_006515219.1. XM_006515156.1.
    XP_006515220.1. XM_006515157.1.
    UniGeneiMm.313619.
    Mm.489835.

    Genome annotation databases

    EnsembliENSMUST00000071858; ENSMUSP00000071756; ENSMUSG00000071379.
    GeneIDi53602.
    KEGGimmu:53602.
    UCSCiuc007ncw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085192 mRNA. Translation: AAC35552.1 .
    BC001997 mRNA. Translation: AAH01997.1 .
    CCDSi CCDS25830.1.
    RefSeqi NP_057886.1. NM_016677.4.
    XP_006515219.1. XM_006515156.1.
    XP_006515220.1. XM_006515157.1.
    UniGenei Mm.313619.
    Mm.489835.

    3D structure databases

    ProteinModelPortali P62748.
    SMRi P62748. Positions 5-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207322. 2 interactions.
    IntActi P62748. 4 interactions.

    PTM databases

    PhosphoSitei P62748.

    Proteomic databases

    MaxQBi P62748.
    PaxDbi P62748.
    PRIDEi P62748.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071858 ; ENSMUSP00000071756 ; ENSMUSG00000071379 .
    GeneIDi 53602.
    KEGGi mmu:53602.
    UCSCi uc007ncw.1. mouse.

    Organism-specific databases

    CTDi 3241.
    MGIi MGI:1855689. Hpcal1.

    Phylogenomic databases

    eggNOGi COG5126.
    GeneTreei ENSGT00560000076803.
    HOGENOMi HOG000233019.
    HOVERGENi HBG108179.
    InParanoidi P62748.
    OMAi LEIVQXK.
    OrthoDBi EOG7GJ6F3.
    PhylomeDBi P62748.
    TreeFami TF300009.

    Miscellaneous databases

    ChiTaRSi HPCAL1. mouse.
    NextBioi 310285.
    PROi P62748.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62748.
    CleanExi MM_HPCAL1.
    Genevestigatori P62748.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028846. Recoverin.
    IPR029535. VILIP-3.
    [Graphical view ]
    PANTHERi PTHR23055. PTHR23055. 1 hit.
    PTHR23055:SF79. PTHR23055:SF79. 1 hit.
    Pfami PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interactions of the murine neural visinin-like protein 3 (mNVP-3)."
      Ritter B., Modregger J., Plomann M.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiHPCL1_MOUSE
    AccessioniPrimary (citable) accession number: P62748
    Secondary accession number(s): P35333
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Probably binds two or three calcium ions.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3