Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P62736 (ACTA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin, aortic smooth muscle
Alternative name(s):
Alpha-actin-2
Cell growth-inhibiting gene 46 protein
Gene names
Name:ACTA2
Synonyms:ACTSA, ACTVS
ORF Names:GIG46
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Subunit structure

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Subcellular location

Cytoplasmcytoskeleton.

Induction

Up-regulated in response to enterovirus 71 (EV71) infection. Ref.11

Post-translational modification

Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization By similarity.

Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration By similarity.

Involvement in disease

ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, premature onset coronary artery disease (CAD), premature ischemic strokes and Moyamoya disease. Ref.15

Aortic aneurysm, familial thoracic 6 (AAT6) [MIM:611788]: A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Ref.14 Ref.15

Moyamoya disease 5 (MYMY5) [MIM:614042]: A progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15 Ref.17

Multisystemic smooth muscle dysfunction syndrome (MSMDYS) [MIM:613834]: A syndrome characterized by dysfunction of smooth muscle cells throughout the body, leading to aortic and cerebrovascular disease, fixed dilated pupils, hypotonic bladder, malrotation, and hypoperistalsis of the gut and pulmonary hypertension.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.15 Ref.16

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

Sequence similarities

Belongs to the actin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 22Removed in mature form By similarity
PRO_0000000738
Chain3 – 377375Actin, aortic smooth muscle
PRO_0000000739

Amino acid modifications

Modified residue31N-acetylglutamate By similarity
Modified residue461Methionine (R)-sulfoxide By similarity
Modified residue491Methionine (R)-sulfoxide By similarity
Modified residue751Tele-methylhistidine By similarity

Natural variations

Natural variant391R → H in AAT6. Ref.14
VAR_062577
Natural variant1171N → T in AAT6. Ref.13 Ref.14
VAR_045915
Natural variant1181R → Q in AAT6. Ref.13 Ref.14
VAR_045916
Natural variant1351Y → H in AAT6. Ref.13
VAR_045917
Natural variant1451Y → C in AAT6. Ref.15
VAR_062578
Natural variant1491R → C in AAT6. Ref.13 Ref.14 Ref.15
VAR_045918
Natural variant1541V → A in AAT6. Ref.13 Ref.14
VAR_045919
Natural variant1791R → H in MYMY5 and MSMDYS; disease phenotype include smooth muscle cells dysfunction in organs throughout the body with decreased contractile function in the iris, bladder and gastrointestinal tract. Ref.16 Ref.17
VAR_064516
Natural variant1851R → Q in AAT6. Ref.14
VAR_062579
Natural variant1961T → S.
Corresponds to variant rs1803028 [ dbSNP | Ensembl ].
VAR_011944
Natural variant2121R → Q in AAT6. Ref.14 Ref.15
VAR_062580
Natural variant2581R → C in AAT6. Ref.13 Ref.14
VAR_045920
Natural variant2581R → H in AAT6. Ref.13 Ref.14
VAR_045921
Natural variant2921R → G in AAT6. Ref.13
VAR_045922
Natural variant3201T → A.
Corresponds to variant rs1803027 [ dbSNP | Ensembl ].
VAR_011945
Natural variant3261T → N in AAT6. Ref.14
VAR_062581
Natural variant3531T → N in AAT6. Ref.13 Ref.14
VAR_045923
Natural variant3731H → P.
Corresponds to variant rs1062398 [ dbSNP | Ensembl ].
VAR_011946

Experimental info

Sequence conflict2341S → W in AAA51577. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P62736 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 2D0543262DB35CA5

FASTA37742,009
        10         20         30         40         50         60 
MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA 

        70         80         90        100        110        120 
QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK 

       130        140        150        160        170        180 
MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL 

       190        200        210        220        230        240 
DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK 

       250        260        270        280        290        300 
SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV 

       310        320        330        340        350        360 
LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS 

       370 
KQEYDEAGPS IVHRKCF 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of a human smooth muscle alpha-actin (aortic type) cDNA."
Kamada S., Kakunaga T.
Nucleic Acids Res. 17:1767-1767(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region."
Reddy S., Ozgur K., Lu M., Chang W., Mohan S.R., Kumar C.C., Ruley H.E.
J. Biol. Chem. 265:1683-1687(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of a human cell growth inhibiting gene."
Kim J.W.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
[6]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[9]"Structure of a human smooth muscle actin gene (aortic type) with a unique intron site."
Ueyama H., Hamada H., Battula N., Kakunaga T.
Mol. Cell. Biol. 4:1073-1078(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-330.
[10]"Structure of 3'-downstream segment of the human smooth muscle (aortic-type) alpha-actin-encoding gene and isolation of the specific DNA probe."
Kamada S., Nakano Y., Kakunaga T.
Gene 84:455-462(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 331-377.
[11]"Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
Leong W.F., Chow V.T.
Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
[12]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections."
Guo D.-C., Pannu H., Tran-Fadulu V., Papke C.L., Yu R.K., Avidan N., Bourgeois S., Estrera A.L., Safi H.J., Sparks E., Amor D., Ades L., McConnell V., Willoughby C.E., Abuelo D., Willing M., Lewis R.A., Kim D.H. expand/collapse author list , Scherer S., Tung P.P., Ahn C., Buja L.M., Raman C.S., Shete S.S., Milewicz D.M.
Nat. Genet. 39:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS AAT6 THR-117; GLN-118; HIS-135; CYS-149; ALA-154; CYS-258; HIS-258; GLY-292 AND ASN-353.
[14]"Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease."
Guo D.-C., Papke C.L., Tran-Fadulu V., Regalado E.S., Avidan N., Johnson R.J., Kim D.H., Pannu H., Willing M.C., Sparks E., Pyeritz R.E., Singh M.N., Dalman R.L., Grotta J.C., Marian A.J., Boerwinkle E.A., Frazier L.Q., LeMaire S.A. expand/collapse author list , Coselli J.S., Estrera A.L., Safi H.J., Veeraraghavan S., Muzny D.M., Wheeler D.A., Willerson J.T., Yu R.K., Shete S.S., Scherer S.E., Raman C.S., Buja L.M., Milewicz D.M.
Am. J. Hum. Genet. 84:617-627(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS AAT6 HIS-39; THR-117; GLN-118; CYS-149; ALA-154; GLN-185; GLN-212; HIS-258; CYS-258; ASN-326 AND ASN-353.
[15]"Mutation of ACTA2 gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD)."
Morisaki H., Akutsu K., Ogino H., Kondo N., Yamanaka I., Tsutsumi Y., Yoshimuta T., Okajima T., Matsuda H., Minatoya K., Sasaki H., Tanaka H., Ishibashi-Ueda H., Morisaki T.
Hum. Mutat. 30:1406-1411(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS AAT6 CYS-145; CYS-149 AND GLN-212, PREDISPOSITION TO A VARIETY OF VASCULAR DISEASES.
[16]"De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction."
Milewicz D.M., Ostergaard J.R., Ala-Kokko L.M., Khan N., Grange D.K., Mendoza-Londono R., Bradley T.J., Olney A.H., Ades L., Maher J.F., Guo D., Buja L.M., Kim D., Hyland J.C., Regalado E.S.
Am. J. Med. Genet. A 152:2437-2443(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MSMDYS HIS-179.
[17]"Analysis of ACTA2 in European Moyamoya disease patients."
Roder C., Peters V., Kasuya H., Nishizawa T., Wakita S., Berg D., Schulte C., Khan N., Tatagiba M., Krischek B.
Eur. J. Paediatr. Neurol. 15:117-122(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MYMY5 HIS-179.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13839 mRNA. Translation: CAA32064.1.
J05192 mRNA. Translation: AAA51577.1.
AY692464 mRNA. Translation: AAW29811.1.
CR536518 mRNA. Translation: CAG38756.1.
AK313294 mRNA. Translation: BAG36101.1.
AL157394 Genomic DNA. Translation: CAI13864.1.
CH471066 Genomic DNA. Translation: EAW50153.1.
BC017554 mRNA. Translation: AAH17554.1.
BC093052 mRNA. Translation: AAH93052.1.
K01741 Genomic DNA. No translation available.
K01742 Genomic DNA. No translation available.
K01743 Genomic DNA. No translation available.
M33216 Genomic DNA. Translation: AAA60560.1.
CCDSCCDS7392.1.
PIRATHUSM. A35020.
RefSeqNP_001135417.1. NM_001141945.1.
NP_001604.1. NM_001613.2.
UniGeneHs.500483.

3D structure databases

ProteinModelPortalP62736.
SMRP62736. Positions 4-377.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106574. 57 interactions.
IntActP62736. 19 interactions.
STRING9606.ENSP00000224784.

PTM databases

PhosphoSiteP62736.

Polymorphism databases

DMDM51316972.

2D gel databases

REPRODUCTION-2DPAGEIPI00008603.
UCD-2DPAGEP62736.

Proteomic databases

MaxQBP62736.
PaxDbP62736.
PRIDEP62736.

Protocols and materials databases

DNASU59.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000224784; ENSP00000224784; ENSG00000107796.
ENST00000458208; ENSP00000402373; ENSG00000107796.
GeneID59.
KEGGhsa:59.
UCSCuc001kfp.3. human.

Organism-specific databases

CTD59.
GeneCardsGC10M090684.
GeneReviewsACTA2.
HGNCHGNC:130. ACTA2.
HPACAB000002.
HPA041271.
MIM102620. gene.
611788. phenotype.
613834. phenotype.
614042. phenotype.
neXtProtNX_P62736.
Orphanet91387. Familial thoracic aortic aneurysm and aortic dissection.
2573. Moyamoya disease.
PharmGKBPA24456.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5277.
HOGENOMHOG000233340.
HOVERGENHBG003771.
InParanoidP62736.
KOK12313.
OMANSICVIL.
OrthoDBEOG72RMZ1.
PhylomeDBP62736.
TreeFamTF354237.

Enzyme and pathway databases

ReactomeREACT_17044. Muscle contraction.
SignaLinkP62736.

Gene expression databases

ArrayExpressP62736.
BgeeP62736.
CleanExHS_ACTA2.
GenevestigatorP62736.

Family and domain databases

InterProIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERPTHR11937. PTHR11937. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
PRINTSPR00190. ACTIN.
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiACTA2.
GenomeRNAi59.
NextBio249.
PMAP-CutDBP62736.
PROP62736.
SOURCESearch...

Entry information

Entry nameACTA_HUMAN
AccessionPrimary (citable) accession number: P62736
Secondary accession number(s): B2R8A4 expand/collapse secondary AC list , P03996, P04108, Q6FI19
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM