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Protein

60S ribosomal protein L18a

Gene

Rpl18a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L18a
Gene namesi
Name:Rpl18a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1924058. Rpl18a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139261 – 17660S ribosomal protein L18aAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei63PhosphotyrosineBy similarity1
Modified residuei71PhosphoserineCombined sources1
Modified residuei76N6-succinyllysineCombined sources1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62717.
MaxQBiP62717.
PaxDbiP62717.
PeptideAtlasiP62717.
PRIDEiP62717.

PTM databases

iPTMnetiP62717.
PhosphoSitePlusiP62717.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045128.
CleanExiMM_RPL18A.
ExpressionAtlasiP62717. baseline and differential.
GenevisibleiP62717. MM.

Interactioni

Subunit structurei

Binds IPO9 with high affinity.By similarity

Protein-protein interaction databases

BioGridi218328. 4 interactors.
CORUMiP62717.
IntActiP62717. 4 interactors.
MINTiMINT-1841289.
STRINGi10090.ENSMUSP00000058368.

Structurei

3D structure databases

ProteinModelPortaliP62717.
SMRiP62717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0829. Eukaryota.
COG2157. LUCA.
GeneTreeiENSGT00390000015797.
HOGENOMiHOG000211377.
HOVERGENiHBG066281.
InParanoidiP62717.
KOiK02882.
OrthoDBiEOG091G0LX4.
PhylomeDBiP62717.
TreeFamiTF300086.

Family and domain databases

HAMAPiMF_00273. Ribosomal_L18Ae. 1 hit.
InterProiView protein in InterPro
IPR028877. 50S_L18Ae/Ribosomal_L18a/L20.
IPR023573. Ribosomal_L18a//L18Ae/LX.
IPR021138. Ribosomal_L18a/L20_eukaryotes.
PfamiView protein in Pfam
PF01775. Ribosomal_L18A. 1 hit.
PIRSFiPIRSF002190. Ribosomal_L18a. 1 hit.

Sequencei

Sequence statusi: Complete.

P62717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ
60 70 80 90 100
LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL
110 120 130 140 150
TTAGAVTQCY RDMGARHRAR AHSIQIMKVE EIAAGKCRRP AVKQFHDSKI
160 170
KFPLPHRVLR RQHKPRFTTK RPNTFF
Length:176
Mass (Da):20,732
Last modified:July 19, 2004 - v1
Checksum:i5E404D28875BE580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010983 mRNA. Translation: BAB27304.1.
AK146543 mRNA. Translation: BAE27248.1.
AK161942 mRNA. Translation: BAE36645.1.
AK162047 mRNA. Translation: BAE36696.1.
BC037146 mRNA. Translation: AAH37146.1.
CCDSiCCDS22386.1.
RefSeqiNP_084027.1. NM_029751.4.
UniGeneiMm.379251.
Mm.431334.

Genome annotation databases

EnsembliENSMUST00000054220; ENSMUSP00000058368; ENSMUSG00000045128.
GeneIDi76808.
KEGGimmu:76808.
UCSCiuc009mca.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRL18A_MOUSE
AccessioniPrimary (citable) accession number: P62717
Secondary accession number(s): P11249, Q3TSN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families