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P62702

- RS4X_MOUSE

UniProt

P62702 - RS4X_MOUSE

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Protein

40S ribosomal protein S4, X isoform

Gene
Rps4x, Rps4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: Ensembl

GO - Biological processi

  1. multicellular organismal development Source: Ensembl
  2. positive regulation of cell proliferation Source: Ensembl
  3. positive regulation of translation Source: Ensembl
  4. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, X isoform
Gene namesi
Name:Rps4x
Synonyms:Rps4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:98158. Rps4x.

Subcellular locationi

Cytoplasm By similarity
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs By similarity.UniRule annotation

GO - Cellular componenti

  1. polysome Source: Ensembl
  2. ribonucleoprotein complex Source: UniProtKB
  3. ribosome Source: UniProtKB
  4. small ribosomal subunit Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 26326240S ribosomal protein S4, X isoformUniRule annotationPRO_0000130809Add
BLAST

Proteomic databases

MaxQBiP62702.
PaxDbiP62702.
PRIDEiP62702.

PTM databases

PhosphoSiteiP62702.

Expressioni

Gene expression databases

BgeeiP62702.
CleanExiMM_RPS4X.
GenevestigatoriP62702.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs By similarity.

Protein-protein interaction databases

BioGridi203011. 3 interactions.
IntActiP62702. 8 interactions.
MINTiMINT-1845743.

Structurei

3D structure databases

ProteinModelPortaliP62702.
SMRiP62702. Positions 1-263.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10463S4 RNA-bindingAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1471.
HOVERGENiHBG000935.
InParanoidiP62702.
KOiK02987.
OMAiKAWMLDK.
OrthoDBiEOG77WWD1.
PhylomeDBiP62702.
TreeFamiTF300612.

Family and domain databases

HAMAPiMF_00485. Ribosomal_S4e.
InterProiIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62702-1 [UniParc]FASTAAdd to Basket

« Hide

MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN    50
RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR 100
LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP 150
DPLIKVNDTI QIDLETGKIT DFIKFDTGNL CMVTGGANLG RIGVITNRER 200
HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR GKGIRLTIAE 250
ERDKRLAAKQ SSG 263
Length:263
Mass (Da):29,598
Last modified:January 23, 2007 - v2
Checksum:i87200E545A8958B0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91L → M in BAB29207. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73436 mRNA. Translation: AAA40075.1.
AK014210 mRNA. Translation: BAB29207.1.
BC009100 mRNA. Translation: AAH09100.1.
M77296 Genomic DNA. Translation: AAA40072.1.
CCDSiCCDS41083.1.
RefSeqiNP_033120.1. NM_009094.1.
UniGeneiMm.66.

Genome annotation databases

EnsembliENSMUST00000033683; ENSMUSP00000033683; ENSMUSG00000031320.
GeneIDi20102.
KEGGimmu:20102.
UCSCiuc009tyl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73436 mRNA. Translation: AAA40075.1 .
AK014210 mRNA. Translation: BAB29207.1 .
BC009100 mRNA. Translation: AAH09100.1 .
M77296 Genomic DNA. Translation: AAA40072.1 .
CCDSi CCDS41083.1.
RefSeqi NP_033120.1. NM_009094.1.
UniGenei Mm.66.

3D structure databases

ProteinModelPortali P62702.
SMRi P62702. Positions 1-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203011. 3 interactions.
IntActi P62702. 8 interactions.
MINTi MINT-1845743.

PTM databases

PhosphoSitei P62702.

Proteomic databases

MaxQBi P62702.
PaxDbi P62702.
PRIDEi P62702.

Protocols and materials databases

DNASUi 20102.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033683 ; ENSMUSP00000033683 ; ENSMUSG00000031320 .
GeneIDi 20102.
KEGGi mmu:20102.
UCSCi uc009tyl.1. mouse.

Organism-specific databases

CTDi 6191.
MGIi MGI:98158. Rps4x.

Phylogenomic databases

eggNOGi COG1471.
HOVERGENi HBG000935.
InParanoidi P62702.
KOi K02987.
OMAi KAWMLDK.
OrthoDBi EOG77WWD1.
PhylomeDBi P62702.
TreeFami TF300612.

Enzyme and pathway databases

Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSi RPS4X. mouse.
NextBioi 297599.
PROi P62702.
SOURCEi Search...

Gene expression databases

Bgeei P62702.
CleanExi MM_RPS4X.
Genevestigatori P62702.

Family and domain databases

HAMAPi MF_00485. Ribosomal_S4e.
InterProi IPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view ]
PANTHERi PTHR11581. PTHR11581. 1 hit.
Pfami PF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002116. Ribosomal_S4. 1 hit.
ProDomi PD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
PROSITEi PS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "Rps4 maps near the inactivation center on the mouse X chromosome."
    Hamvas R.M., Zinn A.R., Keer J.T., Fisher E.M., Beer-Romero P., Brown S.D., Page D.C.
    Genomics 12:363-367(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-237.

Entry informationi

Entry nameiRS4X_MOUSE
AccessioniPrimary (citable) accession number: P62702
Secondary accession number(s): P12631
, P12750, P27576, P55831, Q14727, Q9CXN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi