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P62702

- RS4X_MOUSE

UniProt

P62702 - RS4X_MOUSE

Protein

40S ribosomal protein S4, X isoform

Gene

Rps4x

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: Ensembl

    GO - Biological processi

    1. multicellular organismal development Source: Ensembl
    2. positive regulation of cell proliferation Source: Ensembl
    3. positive regulation of translation Source: Ensembl
    4. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S4, X isoform
    Gene namesi
    Name:Rps4x
    Synonyms:Rps4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:98158. Rps4x.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

    GO - Cellular componenti

    1. polysome Source: Ensembl
    2. ribonucleoprotein complex Source: UniProtKB
    3. ribosome Source: UniProtKB
    4. small ribosomal subunit Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 26326240S ribosomal protein S4, X isoformPRO_0000130809Add
    BLAST

    Proteomic databases

    MaxQBiP62702.
    PaxDbiP62702.
    PRIDEiP62702.

    PTM databases

    PhosphoSiteiP62702.

    Expressioni

    Gene expression databases

    BgeeiP62702.
    CleanExiMM_RPS4X.
    GenevestigatoriP62702.

    Interactioni

    Subunit structurei

    Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.By similarity

    Protein-protein interaction databases

    BioGridi203011. 3 interactions.
    IntActiP62702. 8 interactions.
    MINTiMINT-1845743.

    Structurei

    3D structure databases

    ProteinModelPortaliP62702.
    SMRiP62702. Positions 1-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10463S4 RNA-bindingAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein S4e family.Curated
    Contains 1 S4 RNA-binding domain.Curated

    Phylogenomic databases

    eggNOGiCOG1471.
    HOVERGENiHBG000935.
    InParanoidiP62702.
    KOiK02987.
    OMAiKAWMLDK.
    OrthoDBiEOG77WWD1.
    PhylomeDBiP62702.
    TreeFamiTF300612.

    Family and domain databases

    HAMAPiMF_00485. Ribosomal_S4e.
    InterProiIPR005824. KOW.
    IPR000876. Ribosomal_S4e.
    IPR013845. Ribosomal_S4e_central_region.
    IPR013843. Ribosomal_S4e_N.
    IPR018199. Ribosomal_S4e_N_CS.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PANTHERiPTHR11581. PTHR11581. 1 hit.
    PfamiPF00467. KOW. 1 hit.
    PF00900. Ribosomal_S4e. 1 hit.
    PF08071. RS4NT. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
    ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62702-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN    50
    RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR 100
    LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP 150
    DPLIKVNDTI QIDLETGKIT DFIKFDTGNL CMVTGGANLG RIGVITNRER 200
    HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR GKGIRLTIAE 250
    ERDKRLAAKQ SSG 263
    Length:263
    Mass (Da):29,598
    Last modified:January 23, 2007 - v2
    Checksum:i87200E545A8958B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91L → M in BAB29207. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73436 mRNA. Translation: AAA40075.1.
    AK014210 mRNA. Translation: BAB29207.1.
    BC009100 mRNA. Translation: AAH09100.1.
    M77296 Genomic DNA. Translation: AAA40072.1.
    CCDSiCCDS41083.1.
    RefSeqiNP_033120.1. NM_009094.1.
    UniGeneiMm.66.

    Genome annotation databases

    EnsembliENSMUST00000033683; ENSMUSP00000033683; ENSMUSG00000031320.
    GeneIDi20102.
    KEGGimmu:20102.
    UCSCiuc009tyl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73436 mRNA. Translation: AAA40075.1 .
    AK014210 mRNA. Translation: BAB29207.1 .
    BC009100 mRNA. Translation: AAH09100.1 .
    M77296 Genomic DNA. Translation: AAA40072.1 .
    CCDSi CCDS41083.1.
    RefSeqi NP_033120.1. NM_009094.1.
    UniGenei Mm.66.

    3D structure databases

    ProteinModelPortali P62702.
    SMRi P62702. Positions 1-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203011. 3 interactions.
    IntActi P62702. 8 interactions.
    MINTi MINT-1845743.

    PTM databases

    PhosphoSitei P62702.

    Proteomic databases

    MaxQBi P62702.
    PaxDbi P62702.
    PRIDEi P62702.

    Protocols and materials databases

    DNASUi 20102.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033683 ; ENSMUSP00000033683 ; ENSMUSG00000031320 .
    GeneIDi 20102.
    KEGGi mmu:20102.
    UCSCi uc009tyl.1. mouse.

    Organism-specific databases

    CTDi 6191.
    MGIi MGI:98158. Rps4x.

    Phylogenomic databases

    eggNOGi COG1471.
    HOVERGENi HBG000935.
    InParanoidi P62702.
    KOi K02987.
    OMAi KAWMLDK.
    OrthoDBi EOG77WWD1.
    PhylomeDBi P62702.
    TreeFami TF300612.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    ChiTaRSi RPS4X. mouse.
    NextBioi 297599.
    PROi P62702.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62702.
    CleanExi MM_RPS4X.
    Genevestigatori P62702.

    Family and domain databases

    HAMAPi MF_00485. Ribosomal_S4e.
    InterProi IPR005824. KOW.
    IPR000876. Ribosomal_S4e.
    IPR013845. Ribosomal_S4e_central_region.
    IPR013843. Ribosomal_S4e_N.
    IPR018199. Ribosomal_S4e_N_CS.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    PANTHERi PTHR11581. PTHR11581. 1 hit.
    Pfami PF00467. KOW. 1 hit.
    PF00900. Ribosomal_S4e. 1 hit.
    PF08071. RS4NT. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002116. Ribosomal_S4. 1 hit.
    ProDomi PD002667. Ribosomal_S4e_central. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    PROSITEi PS00528. RIBOSOMAL_S4E. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. "Rps4 maps near the inactivation center on the mouse X chromosome."
      Hamvas R.M., Zinn A.R., Keer J.T., Fisher E.M., Beer-Romero P., Brown S.D., Page D.C.
      Genomics 12:363-367(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-237.

    Entry informationi

    Entry nameiRS4X_MOUSE
    AccessioniPrimary (citable) accession number: P62702
    Secondary accession number(s): P12631
    , P12750, P27576, P55831, Q14727, Q9CXN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3