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P62701 (RS4X_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein S4, X isoform
Alternative name(s):
SCR10
Single copy abundant mRNA protein
Gene names
Name:RPS4X
Synonyms:CCG2, RPS4, SCAR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Ref.9

Subcellular location

Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ref.9

Sequence similarities

Belongs to the ribosomal protein S4e family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

SRP-dependent cotranslational protein targeting to membrane

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

multicellular organismal development

Inferred from mutant phenotype PubMed 8358435. Source: UniProtKB

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Traceable author statement. Source: Reactome

positive regulation of cell proliferation

Inferred from mutant phenotype Ref.2. Source: UniProtKB

positive regulation of translation

Inferred from mutant phenotype Ref.2. Source: UniProtKB

translation

Inferred from mutant phenotype PubMed 8358435. Source: UniProtKB

translational elongation

Traceable author statement. Source: Reactome

translational initiation

Traceable author statement. Source: Reactome

translational termination

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

viral transcription

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

cytosolic small ribosomal subunit

Inferred from direct assay Ref.7. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

polysome

Inferred from direct assay PubMed 8139551. Source: UniProtKB

ribonucleoprotein complex

Inferred from direct assay Ref.9. Source: UniProtKB

ribosome

Inferred from direct assay PubMed 15883184. Source: UniProtKB

small ribosomal subunit

Inferred from direct assay PubMed 8139551. Source: MGI

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

rRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

structural constituent of ribosome

Inferred from mutant phenotype PubMed 8358435. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 26326240S ribosomal protein S4, X isoform HAMAP-Rule MF_00485
PRO_0000130805

Regions

Domain42 – 10463S4 RNA-binding

Experimental info

Sequence conflict331Missing in AAA36597. Ref.8
Sequence conflict57 – 593TGD → DRR in CAA94808. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P62701 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 87200E545A8958B0

FASTA26329,598
        10         20         30         40         50         60 
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE 

        70         80         90        100        110        120 
VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR LIYDTKGRFA VHRITPEEAK 

       130        140        150        160        170        180 
YKLCKVRKIF VGTKGIPHLV THDARTIRYP DPLIKVNDTI QIDLETGKIT DFIKFDTGNL 

       190        200        210        220        230        240 
CMVTGGANLG RIGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR 

       250        260 
GKGIRLTIAE ERDKRLAAKQ SSG 

« Hide

References

« Hide 'large scale' references
[1]"Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome."
Fisher E.M.C., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C.
Cell 63:1205-1218(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene."
Watanabe M., Furuno N., Goebl M., Go M., Miyauchi K., Sekiguchi T., Basilico C., Nishimoto T.
J. Cell Sci. 100:35-43(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Zuo L., Baybayan P., Kuang W.-J., Brown L., Page D., Chen E.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[6]"Characterization of different mRNA types expressed in human brain."
Dmitrenko V.V., Garifulin O.M., Kavsan V.M.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.
Tissue: Brain.
[7]"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-11.
Tissue: Placenta.
[8]"Isolation of an abundantly expressed sequence from the human X chromosome by differential screening."
Wiles M.V., Alexander C.M., Goodfellow P.N.
Somat. Cell Mol. Genet. 14:31-39(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-263.
[9]"Molecular composition of IMP1 ribonucleoprotein granules."
Joeson L., Vikesaa J., Krogh A., Nielsen L.K., Hansen T., Borup R., Johnsen A.H., Christiansen J., Nielsen F.C.
Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M58458 mRNA. Translation: AAA63255.1.
AF041428 Genomic DNA. Translation: AAB96968.1.
CR456735 mRNA. Translation: CAG33016.1.
BC000472 mRNA. Translation: AAH00472.1.
BC071662 mRNA. Translation: AAH71662.1.
BC100903 mRNA. Translation: AAI00904.1.
BC100904 mRNA. Translation: AAI00905.1.
Z70767 mRNA. Translation: CAA94808.1.
M22146 mRNA. Translation: AAA36597.1.
PIRR3HU4X. B36338.
RefSeqNP_000998.1. NM_001007.4.
UniGeneHs.118076.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00E1-263[»]
ProteinModelPortalP62701.
SMRP62701. Positions 1-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112105. 181 interactions.
IntActP62701. 27 interactions.
MINTMINT-1159032.
STRING9606.ENSP00000362744.

PTM databases

PhosphoSiteP62701.

Polymorphism databases

DMDM50403628.

2D gel databases

SWISS-2DPAGEP62701.

Proteomic databases

PaxDbP62701.
PeptideAtlasP62701.
PRIDEP62701.

Protocols and materials databases

DNASU6191.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316084; ENSP00000362744; ENSG00000198034.
GeneID6191.
KEGGhsa:6191.
UCSCuc004ear.3. human.

Organism-specific databases

CTD6191.
GeneCardsGC0XM071475.
HGNCHGNC:10424. RPS4X.
HPAHPA000857.
MIM312760. gene.
neXtProtNX_P62701.
PharmGKBPA34839.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1471.
HOVERGENHBG000935.
InParanoidP62701.
KOK02987.
OMAGHIQLNL.
OrthoDBEOG77WWD1.
PhylomeDBP62701.
TreeFamTF300612.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressP62701.
BgeeP62701.
CleanExHS_RPS4X.
GenevestigatorP62701.

Family and domain databases

HAMAPMF_00485. Ribosomal_S4e.
InterProIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERPTHR11581. PTHR11581. 1 hit.
PfamPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
PIRSFPIRSF002116. Ribosomal_S4. 1 hit.
ProDomPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00363. S4. 1 hit.
[Graphical view]
PROSITEPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRPS4X. human.
GeneWikiRPS4X.
GenomeRNAi6191.
NextBio24041.
PMAP-CutDBP62701.
PROP62701.
SOURCESearch...

Entry information

Entry nameRS4X_HUMAN
AccessionPrimary (citable) accession number: P62701
Secondary accession number(s): P12631 expand/collapse secondary AC list , P12750, P27576, P55831, Q14727, Q6IPY4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM