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P62701

- RS4X_HUMAN

UniProt

P62701 - RS4X_HUMAN

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Protein
40S ribosomal protein S4, X isoform
Gene
RPS4X, CCG2, RPS4, SCAR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. rRNA binding Source: UniProtKB-KW
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  3. cellular protein metabolic process Source: Reactome
  4. gene expression Source: Reactome
  5. mRNA metabolic process Source: Reactome
  6. multicellular organismal development Source: UniProtKB
  7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  8. positive regulation of cell proliferation Source: UniProtKB
  9. positive regulation of translation Source: UniProtKB
  10. translation Source: UniProtKB
  11. translational elongation Source: Reactome
  12. translational initiation Source: Reactome
  13. translational termination Source: Reactome
  14. viral life cycle Source: Reactome
  15. viral process Source: Reactome
  16. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, X isoform
Alternative name(s):
SCR10
Single copy abundant mRNA protein
Gene namesi
Name:RPS4X
Synonyms:CCG2, RPS4, SCAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:10424. RPS4X.

Subcellular locationi

Cytoplasm
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic small ribosomal subunit Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. polysome Source: UniProtKB
  5. ribonucleoprotein complex Source: UniProtKB
  6. ribosome Source: UniProtKB
  7. small ribosomal subunit Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 26326240S ribosomal protein S4, X isoformUniRule annotation
PRO_0000130805Add
BLAST

Proteomic databases

MaxQBiP62701.
PaxDbiP62701.
PeptideAtlasiP62701.
PRIDEiP62701.

2D gel databases

SWISS-2DPAGEP62701.

PTM databases

PhosphoSiteiP62701.

Miscellaneous databases

PMAP-CutDBP62701.

Expressioni

Gene expression databases

ArrayExpressiP62701.
BgeeiP62701.
CleanExiHS_RPS4X.
GenevestigatoriP62701.

Organism-specific databases

HPAiHPA000857.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Protein-protein interaction databases

BioGridi112105. 153 interactions.
IntActiP62701. 27 interactions.
MINTiMINT-1159032.
STRINGi9606.ENSP00000362744.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00E1-263[»]
ProteinModelPortaliP62701.
SMRiP62701. Positions 1-263.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10463S4 RNA-binding
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1471.
HOVERGENiHBG000935.
InParanoidiP62701.
KOiK02987.
OMAiKAWMLDK.
OrthoDBiEOG77WWD1.
PhylomeDBiP62701.
TreeFamiTF300612.

Family and domain databases

HAMAPiMF_00485. Ribosomal_S4e.
InterProiIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62701-1 [UniParc]FASTAAdd to Basket

« Hide

MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN    50
RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR 100
LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP 150
DPLIKVNDTI QIDLETGKIT DFIKFDTGNL CMVTGGANLG RIGVITNRER 200
HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR GKGIRLTIAE 250
ERDKRLAAKQ SSG 263
Length:263
Mass (Da):29,598
Last modified:January 23, 2007 - v2
Checksum:i87200E545A8958B0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331Missing in AAA36597. 1 Publication
Sequence conflicti57 – 593TGD → DRR in CAA94808. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58458 mRNA. Translation: AAA63255.1.
AF041428 Genomic DNA. Translation: AAB96968.1.
CR456735 mRNA. Translation: CAG33016.1.
BC000472 mRNA. Translation: AAH00472.1.
BC071662 mRNA. Translation: AAH71662.1.
BC100903 mRNA. Translation: AAI00904.1.
BC100904 mRNA. Translation: AAI00905.1.
Z70767 mRNA. Translation: CAA94808.1.
M22146 mRNA. Translation: AAA36597.1.
CCDSiCCDS14418.1.
PIRiB36338. R3HU4X.
RefSeqiNP_000998.1. NM_001007.4.
UniGeneiHs.118076.

Genome annotation databases

EnsembliENST00000316084; ENSP00000362744; ENSG00000198034.
GeneIDi6191.
KEGGihsa:6191.
UCSCiuc004ear.3. human.

Polymorphism databases

DMDMi50403628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58458 mRNA. Translation: AAA63255.1 .
AF041428 Genomic DNA. Translation: AAB96968.1 .
CR456735 mRNA. Translation: CAG33016.1 .
BC000472 mRNA. Translation: AAH00472.1 .
BC071662 mRNA. Translation: AAH71662.1 .
BC100903 mRNA. Translation: AAI00904.1 .
BC100904 mRNA. Translation: AAI00905.1 .
Z70767 mRNA. Translation: CAA94808.1 .
M22146 mRNA. Translation: AAA36597.1 .
CCDSi CCDS14418.1.
PIRi B36338. R3HU4X.
RefSeqi NP_000998.1. NM_001007.4.
UniGenei Hs.118076.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3A electron microscopy 5.00 E 1-263 [» ]
ProteinModelPortali P62701.
SMRi P62701. Positions 1-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112105. 153 interactions.
IntActi P62701. 27 interactions.
MINTi MINT-1159032.
STRINGi 9606.ENSP00000362744.

PTM databases

PhosphoSitei P62701.

Polymorphism databases

DMDMi 50403628.

2D gel databases

SWISS-2DPAGE P62701.

Proteomic databases

MaxQBi P62701.
PaxDbi P62701.
PeptideAtlasi P62701.
PRIDEi P62701.

Protocols and materials databases

DNASUi 6191.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316084 ; ENSP00000362744 ; ENSG00000198034 .
GeneIDi 6191.
KEGGi hsa:6191.
UCSCi uc004ear.3. human.

Organism-specific databases

CTDi 6191.
GeneCardsi GC0XM071475.
HGNCi HGNC:10424. RPS4X.
HPAi HPA000857.
MIMi 312760. gene.
neXtProti NX_P62701.
PharmGKBi PA34839.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1471.
HOVERGENi HBG000935.
InParanoidi P62701.
KOi K02987.
OMAi KAWMLDK.
OrthoDBi EOG77WWD1.
PhylomeDBi P62701.
TreeFami TF300612.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPS4X. human.
GeneWikii RPS4X.
GenomeRNAii 6191.
NextBioi 24041.
PMAP-CutDB P62701.
PROi P62701.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62701.
Bgeei P62701.
CleanExi HS_RPS4X.
Genevestigatori P62701.

Family and domain databases

HAMAPi MF_00485. Ribosomal_S4e.
InterProi IPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view ]
PANTHERi PTHR11581. PTHR11581. 1 hit.
Pfami PF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002116. Ribosomal_S4. 1 hit.
ProDomi PD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
PROSITEi PS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome."
    Fisher E.M.C., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C.
    Cell 63:1205-1218(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene."
    Watanabe M., Furuno N., Goebl M., Go M., Miyauchi K., Sekiguchi T., Basilico C., Nishimoto T.
    J. Cell Sci. 100:35-43(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Zuo L., Baybayan P., Kuang W.-J., Brown L., Page D., Chen E.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  6. "Characterization of different mRNA types expressed in human brain."
    Dmitrenko V.V., Garifulin O.M., Kavsan V.M.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.
    Tissue: Brain.
  7. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11.
    Tissue: Placenta.
  8. "Isolation of an abundantly expressed sequence from the human X chromosome by differential screening."
    Wiles M.V., Alexander C.M., Goodfellow P.N.
    Somat. Cell Mol. Genet. 14:31-39(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-263.
  9. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRS4X_HUMAN
AccessioniPrimary (citable) accession number: P62701
Secondary accession number(s): P12631
, P12750, P27576, P55831, Q14727, Q6IPY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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