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Protein

40S ribosomal protein S4, X isoform

Gene

RPS4X

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • cellular protein metabolic process Source: Reactome
  • gene expression Source: Reactome
  • multicellular organismal development Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational elongation Source: Reactome
  • translational initiation Source: Reactome
  • translational termination Source: Reactome
  • viral life cycle Source: Reactome
  • viral process Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, X isoform
Alternative name(s):
SCR10
Single copy abundant mRNA protein
Gene namesi
Name:RPS4X
Synonyms:CCG2, RPS4, SCAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10424. RPS4X.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • polysome Source: UniProtKB
  • ribonucleoprotein complex Source: UniProtKB
  • ribosome Source: UniProtKB
  • small ribosomal subunit Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34839.

Polymorphism and mutation databases

BioMutaiRPS4X.
DMDMi50403628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 26326240S ribosomal protein S4, X isoformPRO_0000130805Add
BLAST

Proteomic databases

MaxQBiP62701.
PaxDbiP62701.
PeptideAtlasiP62701.
PRIDEiP62701.

2D gel databases

SWISS-2DPAGEP62701.

PTM databases

PhosphoSiteiP62701.

Miscellaneous databases

PMAP-CutDBP62701.

Expressioni

Gene expression databases

BgeeiP62701.
CleanExiHS_RPS4X.
ExpressionAtlasiP62701. baseline and differential.
GenevestigatoriP62701.

Organism-specific databases

HPAiHPA000857.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Protein-protein interaction databases

BioGridi112105. 175 interactions.
IntActiP62701. 28 interactions.
MINTiMINT-1159032.
STRINGi9606.ENSP00000362744.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00AE1-263[»]
ProteinModelPortaliP62701.
SMRiP62701. Positions 1-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10463S4 RNA-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S4e family.Curated
Contains 1 S4 RNA-binding domain.Curated

Phylogenomic databases

eggNOGiCOG1471.
GeneTreeiENSGT00390000005569.
HOVERGENiHBG000935.
InParanoidiP62701.
KOiK02987.
OMAiHIQLNLH.
OrthoDBiEOG77WWD1.
PhylomeDBiP62701.
TreeFamiTF300612.

Family and domain databases

HAMAPiMF_00485. Ribosomal_S4e.
InterProiIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN
60 70 80 90 100
RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR
110 120 130 140 150
LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP
160 170 180 190 200
DPLIKVNDTI QIDLETGKIT DFIKFDTGNL CMVTGGANLG RIGVITNRER
210 220 230 240 250
HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR GKGIRLTIAE
260
ERDKRLAAKQ SSG
Length:263
Mass (Da):29,598
Last modified:January 23, 2007 - v2
Checksum:i87200E545A8958B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331Missing in AAA36597 (PubMed:2829364).Curated
Sequence conflicti57 – 593TGD → DRR in CAA94808 (Ref. 6) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58458 mRNA. Translation: AAA63255.1.
AF041428 Genomic DNA. Translation: AAB96968.1.
CR456735 mRNA. Translation: CAG33016.1.
BC000472 mRNA. Translation: AAH00472.1.
BC071662 mRNA. Translation: AAH71662.1.
BC100903 mRNA. Translation: AAI00904.1.
BC100904 mRNA. Translation: AAI00905.1.
Z70767 mRNA. Translation: CAA94808.1.
M22146 mRNA. Translation: AAA36597.1.
CCDSiCCDS14418.1.
PIRiB36338. R3HU4X.
RefSeqiNP_000998.1. NM_001007.4.
UniGeneiHs.118076.

Genome annotation databases

EnsembliENST00000316084; ENSP00000362744; ENSG00000198034.
GeneIDi6191.
KEGGihsa:6191.
UCSCiuc004ear.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58458 mRNA. Translation: AAA63255.1.
AF041428 Genomic DNA. Translation: AAB96968.1.
CR456735 mRNA. Translation: CAG33016.1.
BC000472 mRNA. Translation: AAH00472.1.
BC071662 mRNA. Translation: AAH71662.1.
BC100903 mRNA. Translation: AAI00904.1.
BC100904 mRNA. Translation: AAI00905.1.
Z70767 mRNA. Translation: CAA94808.1.
M22146 mRNA. Translation: AAA36597.1.
CCDSiCCDS14418.1.
PIRiB36338. R3HU4X.
RefSeqiNP_000998.1. NM_001007.4.
UniGeneiHs.118076.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00AE1-263[»]
ProteinModelPortaliP62701.
SMRiP62701. Positions 1-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112105. 175 interactions.
IntActiP62701. 28 interactions.
MINTiMINT-1159032.
STRINGi9606.ENSP00000362744.

PTM databases

PhosphoSiteiP62701.

Polymorphism and mutation databases

BioMutaiRPS4X.
DMDMi50403628.

2D gel databases

SWISS-2DPAGEP62701.

Proteomic databases

MaxQBiP62701.
PaxDbiP62701.
PeptideAtlasiP62701.
PRIDEiP62701.

Protocols and materials databases

DNASUi6191.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316084; ENSP00000362744; ENSG00000198034.
GeneIDi6191.
KEGGihsa:6191.
UCSCiuc004ear.3. human.

Organism-specific databases

CTDi6191.
GeneCardsiGC0XM071475.
HGNCiHGNC:10424. RPS4X.
HPAiHPA000857.
MIMi312760. gene.
neXtProtiNX_P62701.
PharmGKBiPA34839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1471.
GeneTreeiENSGT00390000005569.
HOVERGENiHBG000935.
InParanoidiP62701.
KOiK02987.
OMAiHIQLNLH.
OrthoDBiEOG77WWD1.
PhylomeDBiP62701.
TreeFamiTF300612.

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSiRPS4X. human.
GeneWikiiRPS4X.
GenomeRNAii6191.
NextBioi24041.
PMAP-CutDBP62701.
PROiP62701.
SOURCEiSearch...

Gene expression databases

BgeeiP62701.
CleanExiHS_RPS4X.
ExpressionAtlasiP62701. baseline and differential.
GenevestigatoriP62701.

Family and domain databases

HAMAPiMF_00485. Ribosomal_S4e.
InterProiIPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome."
    Fisher E.M.C., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C.
    Cell 63:1205-1218(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene."
    Watanabe M., Furuno N., Goebl M., Go M., Miyauchi K., Sekiguchi T., Basilico C., Nishimoto T.
    J. Cell Sci. 100:35-43(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Zuo L., Baybayan P., Kuang W.-J., Brown L., Page D., Chen E.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  6. "Characterization of different mRNA types expressed in human brain."
    Dmitrenko V.V., Garifulin O.M., Kavsan V.M.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.
    Tissue: Brain.
  7. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11.
    Tissue: Placenta.
  8. "Isolation of an abundantly expressed sequence from the human X chromosome by differential screening."
    Wiles M.V., Alexander C.M., Goodfellow P.N.
    Somat. Cell Mol. Genet. 14:31-39(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-263.
  9. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  12. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRS4X_HUMAN
AccessioniPrimary (citable) accession number: P62701
Secondary accession number(s): P12631
, P12750, P27576, P55831, Q14727, Q6IPY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.