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P62701

- RS4X_HUMAN

UniProt

P62701 - RS4X_HUMAN

Protein

40S ribosomal protein S4, X isoform

Gene

RPS4X

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. rRNA binding Source: UniProtKB-KW
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. multicellular organismal development Source: UniProtKB
    5. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    6. positive regulation of cell proliferation Source: UniProtKB
    7. positive regulation of translation Source: UniProtKB
    8. RNA metabolic process Source: Reactome
    9. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    10. translation Source: UniProtKB
    11. translational elongation Source: Reactome
    12. translational initiation Source: Reactome
    13. translational termination Source: Reactome
    14. viral life cycle Source: Reactome
    15. viral process Source: Reactome
    16. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S4, X isoform
    Alternative name(s):
    SCR10
    Single copy abundant mRNA protein
    Gene namesi
    Name:RPS4X
    Synonyms:CCG2, RPS4, SCAR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:10424. RPS4X.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

    GO - Cellular componenti

    1. cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
    2. cytosol Source: Reactome
    3. cytosolic small ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: UniProtKB
    6. polysome Source: UniProtKB
    7. ribonucleoprotein complex Source: UniProtKB
    8. ribosome Source: UniProtKB
    9. small ribosomal subunit Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34839.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 26326240S ribosomal protein S4, X isoformPRO_0000130805Add
    BLAST

    Proteomic databases

    MaxQBiP62701.
    PaxDbiP62701.
    PeptideAtlasiP62701.
    PRIDEiP62701.

    2D gel databases

    SWISS-2DPAGEP62701.

    PTM databases

    PhosphoSiteiP62701.

    Miscellaneous databases

    PMAP-CutDBP62701.

    Expressioni

    Gene expression databases

    ArrayExpressiP62701.
    BgeeiP62701.
    CleanExiHS_RPS4X.
    GenevestigatoriP62701.

    Organism-specific databases

    HPAiHPA000857.

    Interactioni

    Subunit structurei

    Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

    Protein-protein interaction databases

    BioGridi112105. 153 interactions.
    IntActiP62701. 27 interactions.
    MINTiMINT-1159032.
    STRINGi9606.ENSP00000362744.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00E1-263[»]
    ProteinModelPortaliP62701.
    SMRiP62701. Positions 1-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10463S4 RNA-bindingAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein S4e family.Curated
    Contains 1 S4 RNA-binding domain.Curated

    Phylogenomic databases

    eggNOGiCOG1471.
    HOVERGENiHBG000935.
    InParanoidiP62701.
    KOiK02987.
    OMAiKAWMLDK.
    OrthoDBiEOG77WWD1.
    PhylomeDBiP62701.
    TreeFamiTF300612.

    Family and domain databases

    HAMAPiMF_00485. Ribosomal_S4e.
    InterProiIPR005824. KOW.
    IPR000876. Ribosomal_S4e.
    IPR013845. Ribosomal_S4e_central_region.
    IPR013843. Ribosomal_S4e_N.
    IPR018199. Ribosomal_S4e_N_CS.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PANTHERiPTHR11581. PTHR11581. 1 hit.
    PfamiPF00467. KOW. 1 hit.
    PF00900. Ribosomal_S4e. 1 hit.
    PF08071. RS4NT. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
    ProDomiPD002667. Ribosomal_S4e_central. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    PROSITEiPS00528. RIBOSOMAL_S4E. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62701-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN    50
    RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR 100
    LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP 150
    DPLIKVNDTI QIDLETGKIT DFIKFDTGNL CMVTGGANLG RIGVITNRER 200
    HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR GKGIRLTIAE 250
    ERDKRLAAKQ SSG 263
    Length:263
    Mass (Da):29,598
    Last modified:January 23, 2007 - v2
    Checksum:i87200E545A8958B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331Missing in AAA36597. (PubMed:2829364)Curated
    Sequence conflicti57 – 593TGD → DRR in CAA94808. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58458 mRNA. Translation: AAA63255.1.
    AF041428 Genomic DNA. Translation: AAB96968.1.
    CR456735 mRNA. Translation: CAG33016.1.
    BC000472 mRNA. Translation: AAH00472.1.
    BC071662 mRNA. Translation: AAH71662.1.
    BC100903 mRNA. Translation: AAI00904.1.
    BC100904 mRNA. Translation: AAI00905.1.
    Z70767 mRNA. Translation: CAA94808.1.
    M22146 mRNA. Translation: AAA36597.1.
    CCDSiCCDS14418.1.
    PIRiB36338. R3HU4X.
    RefSeqiNP_000998.1. NM_001007.4.
    UniGeneiHs.118076.

    Genome annotation databases

    EnsembliENST00000316084; ENSP00000362744; ENSG00000198034.
    GeneIDi6191.
    KEGGihsa:6191.
    UCSCiuc004ear.3. human.

    Polymorphism databases

    DMDMi50403628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58458 mRNA. Translation: AAA63255.1 .
    AF041428 Genomic DNA. Translation: AAB96968.1 .
    CR456735 mRNA. Translation: CAG33016.1 .
    BC000472 mRNA. Translation: AAH00472.1 .
    BC071662 mRNA. Translation: AAH71662.1 .
    BC100903 mRNA. Translation: AAI00904.1 .
    BC100904 mRNA. Translation: AAI00905.1 .
    Z70767 mRNA. Translation: CAA94808.1 .
    M22146 mRNA. Translation: AAA36597.1 .
    CCDSi CCDS14418.1.
    PIRi B36338. R3HU4X.
    RefSeqi NP_000998.1. NM_001007.4.
    UniGenei Hs.118076.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 E 1-263 [» ]
    ProteinModelPortali P62701.
    SMRi P62701. Positions 1-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112105. 153 interactions.
    IntActi P62701. 27 interactions.
    MINTi MINT-1159032.
    STRINGi 9606.ENSP00000362744.

    PTM databases

    PhosphoSitei P62701.

    Polymorphism databases

    DMDMi 50403628.

    2D gel databases

    SWISS-2DPAGE P62701.

    Proteomic databases

    MaxQBi P62701.
    PaxDbi P62701.
    PeptideAtlasi P62701.
    PRIDEi P62701.

    Protocols and materials databases

    DNASUi 6191.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316084 ; ENSP00000362744 ; ENSG00000198034 .
    GeneIDi 6191.
    KEGGi hsa:6191.
    UCSCi uc004ear.3. human.

    Organism-specific databases

    CTDi 6191.
    GeneCardsi GC0XM071475.
    HGNCi HGNC:10424. RPS4X.
    HPAi HPA000857.
    MIMi 312760. gene.
    neXtProti NX_P62701.
    PharmGKBi PA34839.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1471.
    HOVERGENi HBG000935.
    InParanoidi P62701.
    KOi K02987.
    OMAi KAWMLDK.
    OrthoDBi EOG77WWD1.
    PhylomeDBi P62701.
    TreeFami TF300612.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPS4X. human.
    GeneWikii RPS4X.
    GenomeRNAii 6191.
    NextBioi 24041.
    PMAP-CutDB P62701.
    PROi P62701.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62701.
    Bgeei P62701.
    CleanExi HS_RPS4X.
    Genevestigatori P62701.

    Family and domain databases

    HAMAPi MF_00485. Ribosomal_S4e.
    InterProi IPR005824. KOW.
    IPR000876. Ribosomal_S4e.
    IPR013845. Ribosomal_S4e_central_region.
    IPR013843. Ribosomal_S4e_N.
    IPR018199. Ribosomal_S4e_N_CS.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    PANTHERi PTHR11581. PTHR11581. 1 hit.
    Pfami PF00467. KOW. 1 hit.
    PF00900. Ribosomal_S4e. 1 hit.
    PF08071. RS4NT. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002116. Ribosomal_S4. 1 hit.
    ProDomi PD002667. Ribosomal_S4e_central. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    PROSITEi PS00528. RIBOSOMAL_S4E. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome."
      Fisher E.M.C., Beer-Romero P., Brown L.G., Ridley A., McNeil J.A., Lawrence J.B., Willard H.F., Bieber F.R., Page D.C.
      Cell 63:1205-1218(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene."
      Watanabe M., Furuno N., Goebl M., Go M., Miyauchi K., Sekiguchi T., Basilico C., Nishimoto T.
      J. Cell Sci. 100:35-43(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Zuo L., Baybayan P., Kuang W.-J., Brown L., Page D., Chen E.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    6. "Characterization of different mRNA types expressed in human brain."
      Dmitrenko V.V., Garifulin O.M., Kavsan V.M.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.
      Tissue: Brain.
    7. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-11.
      Tissue: Placenta.
    8. "Isolation of an abundantly expressed sequence from the human X chromosome by differential screening."
      Wiles M.V., Alexander C.M., Goodfellow P.N.
      Somat. Cell Mol. Genet. 14:31-39(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-263.
    9. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRS4X_HUMAN
    AccessioniPrimary (citable) accession number: P62701
    Secondary accession number(s): P12631
    , P12750, P27576, P55831, Q14727, Q6IPY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3