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Protein

40S ribosomal protein S4, X isoform

Gene

RPS4X

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, X isoform
Alternative name(s):
SCR10
Single copy abundant mRNA protein
Small ribosomal subunit protein eS41 Publication
Gene namesi
Name:RPS4X
Synonyms:CCG2, RPS4, SCAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198034.10.
HGNCiHGNC:10424. RPS4X.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6191.
OpenTargetsiENSG00000198034.
PharmGKBiPA34839.

Polymorphism and mutation databases

BioMutaiRPS4X.
DMDMi50403628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001308052 – 26340S ribosomal protein S4, X isoformAdd BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki230Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei233N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62701.
MaxQBiP62701.
PaxDbiP62701.
PeptideAtlasiP62701.
PRIDEiP62701.
TopDownProteomicsiP62701.

2D gel databases

SWISS-2DPAGEiP62701.

PTM databases

iPTMnetiP62701.
PhosphoSitePlusiP62701.
SwissPalmiP62701.

Miscellaneous databases

PMAP-CutDBiP62701.

Expressioni

Gene expression databases

BgeeiENSG00000198034.
CleanExiHS_RPS4X.
ExpressionAtlasiP62701. baseline and differential.
GenevisibleiP62701. HS.

Organism-specific databases

HPAiHPA000857.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Protein-protein interaction databases

BioGridi112105. 210 interactors.
CORUMiP62701.
IntActiP62701. 45 interactors.
MINTiMINT-1159032.
STRINGi9606.ENSP00000362744.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SE1-263[»]
4V6Xelectron microscopy5.00AE1-263[»]
5A2Qelectron microscopy3.90E1-263[»]
5LKSelectron microscopy3.60SE1-263[»]
5OA3electron microscopy4.30E1-263[»]
5T2Celectron microscopy3.60Ar1-263[»]
5VYCX-ray6.00E1/E2/E3/E4/E5/E61-263[»]
ProteinModelPortaliP62701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 104S4 RNA-bindingAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0378. Eukaryota.
COG1471. LUCA.
GeneTreeiENSGT00390000005569.
HOVERGENiHBG000935.
InParanoidiP62701.
KOiK02987.
OMAiRKDYKFP.
OrthoDBiEOG091G0MYF.
PhylomeDBiP62701.
TreeFamiTF300612.

Family and domain databases

CDDicd00165. S4. 1 hit.
Gene3Di3.10.290.10. 2 hits.
HAMAPiMF_00485. Ribosomal_S4e. 1 hit.
InterProiView protein in InterPro
IPR032277. 40S_S4_C.
IPR005824. KOW.
IPR000876. Ribosomal_S4e.
IPR013845. Ribosomal_S4e_central_region.
IPR013843. Ribosomal_S4e_N.
IPR018199. Ribosomal_S4e_N_CS.
IPR002942. S4_RNA-bd.
IPR036986. S4_RNA-bd_sf.
PANTHERiPTHR11581. PTHR11581. 1 hit.
PfamiView protein in Pfam
PF16121. 40S_S4_C. 1 hit.
PF00467. KOW. 1 hit.
PF00900. Ribosomal_S4e. 1 hit.
PF08071. RS4NT. 1 hit.
PF01479. S4. 1 hit.
PIRSFiPIRSF002116. Ribosomal_S4. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002667. Ribosomal_S4e_central. 1 hit.
SMARTiView protein in SMART
SM00363. S4. 1 hit.
PROSITEiView protein in PROSITE
PS00528. RIBOSOMAL_S4E. 1 hit.
PS50889. S4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN
60 70 80 90 100
RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR
110 120 130 140 150
LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP
160 170 180 190 200
DPLIKVNDTI QIDLETGKIT DFIKFDTGNL CMVTGGANLG RIGVITNRER
210 220 230 240 250
HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR GKGIRLTIAE
260
ERDKRLAAKQ SSG
Length:263
Mass (Da):29,598
Last modified:January 23, 2007 - v2
Checksum:i87200E545A8958B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33Missing in AAA36597 (PubMed:2829364).Curated1
Sequence conflicti57 – 59TGD → DRR in CAA94808 (Ref. 6) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58458 mRNA. Translation: AAA63255.1.
AF041428 Genomic DNA. Translation: AAB96968.1.
CR456735 mRNA. Translation: CAG33016.1.
BC000472 mRNA. Translation: AAH00472.1.
BC071662 mRNA. Translation: AAH71662.1.
BC100903 mRNA. Translation: AAI00904.1.
BC100904 mRNA. Translation: AAI00905.1.
Z70767 mRNA. Translation: CAA94808.1.
M22146 mRNA. Translation: AAA36597.1.
CCDSiCCDS14418.1.
PIRiB36338. R3HU4X.
RefSeqiNP_000998.1. NM_001007.4.
UniGeneiHs.118076.

Genome annotation databases

EnsembliENST00000316084; ENSP00000362744; ENSG00000198034.
GeneIDi6191.
KEGGihsa:6191.
UCSCiuc004ear.4. human.

Similar proteinsi

Entry informationi

Entry nameiRS4X_HUMAN
AccessioniPrimary (citable) accession number: P62701
Secondary accession number(s): P12631
, P12750, P27576, P55831, Q14727, Q6IPY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families