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Protein

40S ribosomal protein S4, X isoform

Gene

RPS4X

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S4, X isoform
Alternative name(s):
SCR10
Single copy abundant mRNA protein
Small ribosomal subunit protein eS41 Publication
Gene namesi
Name:RPS4X
Synonyms:CCG2, RPS4, SCAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198034.10
HGNCiHGNC:10424 RPS4X
MIMi312760 gene
neXtProtiNX_P62701

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6191
OpenTargetsiENSG00000198034
PharmGKBiPA34839

Polymorphism and mutation databases

BioMutaiRPS4X
DMDMi50403628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001308052 – 26340S ribosomal protein S4, X isoformAdd BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki230Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei233N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62701
MaxQBiP62701
PaxDbiP62701
PeptideAtlasiP62701
PRIDEiP62701
TopDownProteomicsiP62701

2D gel databases

SWISS-2DPAGEiP62701

PTM databases

iPTMnetiP62701
PhosphoSitePlusiP62701
SwissPalmiP62701

Miscellaneous databases

PMAP-CutDBiP62701

Expressioni

Gene expression databases

BgeeiENSG00000198034
CleanExiHS_RPS4X
ExpressionAtlasiP62701 baseline and differential
GenevisibleiP62701 HS

Organism-specific databases

HPAiHPA000857

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Protein-protein interaction databases

BioGridi112105, 214 interactors
CORUMiP62701
IntActiP62701, 50 interactors
MINTiP62701
STRINGi9606.ENSP00000362744

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SE1-263[»]
4V6Xelectron microscopy5.00AE1-263[»]
5A2Qelectron microscopy3.90E1-263[»]
5LKSelectron microscopy3.60SE1-263[»]
5OA3electron microscopy4.30E1-263[»]
5T2Celectron microscopy3.60Ar1-263[»]
5VYCX-ray6.00E1/E2/E3/E4/E5/E61-263[»]
6EK0electron microscopy2.90SE1-263[»]
6FECelectron microscopy6.30I1-263[»]
ProteinModelPortaliP62701
SMRiP62701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 104S4 RNA-bindingAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0378 Eukaryota
COG1471 LUCA
GeneTreeiENSGT00390000005569
HOVERGENiHBG000935
InParanoidiP62701
KOiK02987
OMAiRKDYKFP
OrthoDBiEOG091G0MYF
PhylomeDBiP62701
TreeFamiTF300612

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di2.30.30.30, 1 hit
2.40.50.740, 1 hit
HAMAPiMF_00485 Ribosomal_S4e, 1 hit
InterProiView protein in InterPro
IPR032277 40S_S4_C
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR000876 Ribosomal_S4e
IPR013845 Ribosomal_S4e_central_region
IPR038237 Ribosomal_S4e_central_sf
IPR013843 Ribosomal_S4e_N
IPR018199 Ribosomal_S4e_N_CS
IPR002942 S4_RNA-bd
PANTHERiPTHR11581 PTHR11581, 1 hit
PfamiView protein in Pfam
PF16121 40S_S4_C, 1 hit
PF00467 KOW, 1 hit
PF00900 Ribosomal_S4e, 1 hit
PF08071 RS4NT, 1 hit
PF01479 S4, 1 hit
PIRSFiPIRSF002116 Ribosomal_S4, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002667 Ribosomal_S4e_central, 1 hit
SMARTiView protein in SMART
SM00363 S4, 1 hit
PROSITEiView protein in PROSITE
PS00528 RIBOSOMAL_S4E, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN
60 70 80 90 100
RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR
110 120 130 140 150
LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP
160 170 180 190 200
DPLIKVNDTI QIDLETGKIT DFIKFDTGNL CMVTGGANLG RIGVITNRER
210 220 230 240 250
HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR GKGIRLTIAE
260
ERDKRLAAKQ SSG
Length:263
Mass (Da):29,598
Last modified:January 23, 2007 - v2
Checksum:i87200E545A8958B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33Missing in AAA36597 (PubMed:2829364).Curated1
Sequence conflicti57 – 59TGD → DRR in CAA94808 (Ref. 6) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58458 mRNA Translation: AAA63255.1
AF041428 Genomic DNA Translation: AAB96968.1
CR456735 mRNA Translation: CAG33016.1
BC000472 mRNA Translation: AAH00472.1
BC071662 mRNA Translation: AAH71662.1
BC100903 mRNA Translation: AAI00904.1
BC100904 mRNA Translation: AAI00905.1
Z70767 mRNA Translation: CAA94808.1
M22146 mRNA Translation: AAA36597.1
CCDSiCCDS14418.1
PIRiB36338 R3HU4X
RefSeqiNP_000998.1, NM_001007.4
UniGeneiHs.118076

Genome annotation databases

EnsembliENST00000316084; ENSP00000362744; ENSG00000198034
GeneIDi6191
KEGGihsa:6191
UCSCiuc004ear.4 human

Similar proteinsi

Entry informationi

Entry nameiRS4X_HUMAN
AccessioniPrimary (citable) accession number: P62701
Secondary accession number(s): P12631
, P12750, P27576, P55831, Q14727, Q6IPY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health