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Protein

Protein yippee-like 5

Gene

YPEL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171ZincPROSITE-ProRule annotation
Metal bindingi20 – 201ZincPROSITE-ProRule annotation
Metal bindingi73 – 731ZincPROSITE-ProRule annotation
Metal bindingi76 – 761ZincPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yippee-like 5
Gene namesi
Name:YPEL5
ORF Names:CGI-127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18329. YPEL5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863727.

Polymorphism and mutation databases

BioMutaiYPEL5.
DMDMi50428911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 121121Protein yippee-like 5PRO_0000212396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP62699.
MaxQBiP62699.
PaxDbiP62699.
PRIDEiP62699.

PTM databases

iPTMnetiP62699.
PhosphoSiteiP62699.

Expressioni

Gene expression databases

BgeeiP62699.
CleanExiHS_YPEL5.
GenevisibleiP62699. HS.

Organism-specific databases

HPAiHPA042809.

Interactioni

Protein-protein interaction databases

BioGridi119655. 11 interactions.
STRINGi9606.ENSP00000261353.

Structurei

3D structure databases

ProteinModelPortaliP62699.
SMRiP62699. Positions 10-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 11098YippeePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the yippee family.Curated
Contains 1 Yippee domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiP62699.
OMAiNCDAKLG.
OrthoDBiEOG7TXKJJ.
PhylomeDBiP62699.
TreeFamiTF323378.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
PROSITEiPS51792. YIPPEE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRIFLDHIG GTRLFSCANC DTILTNRSEL ISTRFTGATG RAFLFNKVVN
60 70 80 90 100
LQYSEVQDRV MLTGRHMVRD VSCKNCNSKL GWIYEFATED SQRYKEGRVI
110 120
LERALVRESE GFEEHVPSDN S
Length:121
Mass (Da):13,842
Last modified:July 19, 2004 - v1
Checksum:iADCF8C4C3B154EAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098739 mRNA. Translation: BAD51380.1.
AF151885 mRNA. Translation: AAD34122.1.
AF135161 mRNA. Translation: AAF43785.1.
AC016907 Genomic DNA. Translation: AAY14780.1.
CH471053 Genomic DNA. Translation: EAX00500.1.
CH471053 Genomic DNA. Translation: EAX00501.1.
CH471053 Genomic DNA. Translation: EAX00504.1.
CH471053 Genomic DNA. Translation: EAX00505.1.
BC000836 mRNA. Translation: AAH00836.1.
BC047237 mRNA. Translation: AAH47237.1.
AF172940 mRNA. Translation: AAD47882.1.
CCDSiCCDS1771.1.
PIRiT50836.
RefSeqiNP_001120871.1. NM_001127399.1.
NP_001120872.1. NM_001127400.1.
NP_001120873.1. NM_001127401.1.
NP_057145.1. NM_016061.2.
UniGeneiHs.515890.

Genome annotation databases

EnsembliENST00000261353; ENSP00000261353; ENSG00000119801.
ENST00000379519; ENSP00000368834; ENSG00000119801.
ENST00000379520; ENSP00000368835; ENSG00000119801.
ENST00000402003; ENSP00000383974; ENSG00000119801.
ENST00000402708; ENSP00000385278; ENSG00000119801.
GeneIDi51646.
KEGGihsa:51646.
UCSCiuc002rmz.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098739 mRNA. Translation: BAD51380.1.
AF151885 mRNA. Translation: AAD34122.1.
AF135161 mRNA. Translation: AAF43785.1.
AC016907 Genomic DNA. Translation: AAY14780.1.
CH471053 Genomic DNA. Translation: EAX00500.1.
CH471053 Genomic DNA. Translation: EAX00501.1.
CH471053 Genomic DNA. Translation: EAX00504.1.
CH471053 Genomic DNA. Translation: EAX00505.1.
BC000836 mRNA. Translation: AAH00836.1.
BC047237 mRNA. Translation: AAH47237.1.
AF172940 mRNA. Translation: AAD47882.1.
CCDSiCCDS1771.1.
PIRiT50836.
RefSeqiNP_001120871.1. NM_001127399.1.
NP_001120872.1. NM_001127400.1.
NP_001120873.1. NM_001127401.1.
NP_057145.1. NM_016061.2.
UniGeneiHs.515890.

3D structure databases

ProteinModelPortaliP62699.
SMRiP62699. Positions 10-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119655. 11 interactions.
STRINGi9606.ENSP00000261353.

PTM databases

iPTMnetiP62699.
PhosphoSiteiP62699.

Polymorphism and mutation databases

BioMutaiYPEL5.
DMDMi50428911.

Proteomic databases

EPDiP62699.
MaxQBiP62699.
PaxDbiP62699.
PRIDEiP62699.

Protocols and materials databases

DNASUi51646.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261353; ENSP00000261353; ENSG00000119801.
ENST00000379519; ENSP00000368834; ENSG00000119801.
ENST00000379520; ENSP00000368835; ENSG00000119801.
ENST00000402003; ENSP00000383974; ENSG00000119801.
ENST00000402708; ENSP00000385278; ENSG00000119801.
GeneIDi51646.
KEGGihsa:51646.
UCSCiuc002rmz.5. human.

Organism-specific databases

CTDi51646.
GeneCardsiYPEL5.
HGNCiHGNC:18329. YPEL5.
HPAiHPA042809.
MIMi609726. gene.
neXtProtiNX_P62699.
PharmGKBiPA134863727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiP62699.
OMAiNCDAKLG.
OrthoDBiEOG7TXKJJ.
PhylomeDBiP62699.
TreeFamiTF323378.

Miscellaneous databases

ChiTaRSiYPEL5. human.
GenomeRNAii51646.
PROiP62699.
SOURCEiSearch...

Gene expression databases

BgeeiP62699.
CleanExiHS_YPEL5.
GenevisibleiP62699. HS.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
PROSITEiPS51792. YIPPEE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species."
    Hosono K., Sasaki T., Minoshima S., Shimizu N.
    Gene 340:31-43(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Isolating a new human cDNA."
    Luo W.Q., Chen J.H., Hu S.N., Zhou Y., Huang X.W., Zhou H.J., Yuan J.G., Qiang B.Q.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  7. "The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes."
    Roxstroem-Lindquist K., Faye I.
    Insect Mol. Biol. 10:77-86(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-101.
    Tissue: Intestine.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYPEL5_HUMAN
AccessioniPrimary (citable) accession number: P62699
Secondary accession number(s): D6W568
, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.