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Protein

Lysozyme

Gene

L3

Organism
Lactococcus phage phivML3 (Lactococcus bacteriophage phi-vML3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The bacteriophage lysin is a powerful lytic agent with a narrow target specifically for dairy lactic streptococci, and it may be involved in phage maturation (like protein 15).

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene namesi
Name:L3
OrganismiLactococcus phage phivML3 (Lactococcus bacteriophage phi-vML3)
Taxonomic identifieri10746 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
Virus hostiLactococcus lactis [TaxID: 1358]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002180951 – 226LysozymeAdd BLAST226

Structurei

3D structure databases

ProteinModelPortaliP62693.
SMRiP62693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Family and domain databases

CDDicd00737. endolysin_autolysin. 1 hit.
Gene3Di1.10.530.40. 1 hit.
InterProiView protein in InterPro
IPR033907. Endolysin_autolysin.
IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
PfamiView protein in Pfam
PF00959. Phage_lysozyme. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P62693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSQNGLNL IKEFEGCRLT AYKPVPWEQM YTIGWGHYGV TAGTTWTQAQ
60 70 80 90 100
ADSQLEIDIN NKYAPMVDAY VKGKANQNEF DALVSLAYNC GNVFVADGWA
110 120 130 140 150
PFSHAYCASM IPKYRNAGGQ VLQGLVRRRQ AELNLFNKPV SSNSNQNNQT
160 170 180 190 200
GGMIKMYLII GLDNSGKAKH WYVSDGVSVR HVRTIRMLEN YQNKWAKLNL
210 220
PVDTMFIAEI EAEFGRKIDM ASGEVK
Length:226
Mass (Da):25,370
Last modified:July 19, 2004 - v1
Checksum:i30EDC142BE07B0DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16178 Genomic DNA. Translation: CAA34300.1.
PIRiS05335.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLYS_BPPHV
AccessioniPrimary (citable) accession number: P62693
Secondary accession number(s): P13003
, Q38298, Q38562, Q38651
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 5, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families