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P62693 (LYS_BPPHV) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene names
Name:L3
OrganismLactococcus phage phivML3 (Lactococcus bacteriophage phi-vML3)
Taxonomic identifier10746 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
Virus hostLactococcus lactis [TaxID: 1358]

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The bacteriophage lysin is a powerful lytic agent with a narrow target specifically for dairy lactic streptococci, and it may be involved in phage maturation (like protein 15).

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Lysozyme
PRO_0000218095

Sites

Active site151Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P62693 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 30EDC142BE07B0DE

FASTA22625,370
        10         20         30         40         50         60 
MKVSQNGLNL IKEFEGCRLT AYKPVPWEQM YTIGWGHYGV TAGTTWTQAQ ADSQLEIDIN 

        70         80         90        100        110        120 
NKYAPMVDAY VKGKANQNEF DALVSLAYNC GNVFVADGWA PFSHAYCASM IPKYRNAGGQ 

       130        140        150        160        170        180 
VLQGLVRRRQ AELNLFNKPV SSNSNQNNQT GGMIKMYLII GLDNSGKAKH WYVSDGVSVR 

       190        200        210        220 
HVRTIRMLEN YQNKWAKLNL PVDTMFIAEI EAEFGRKIDM ASGEVK 

« Hide

References

[1]"Cloning and DNA sequence analysis of a Lactococcus bacteriophage lysin gene."
Shearman C.A., Underwood H., Jury K., Gasson M.
Mol. Gen. Genet. 218:214-221(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Shearman C.A.
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16178 Genomic DNA. Translation: CAA34300.1.
PIRS05335.

3D structure databases

ProteinModelPortalP62693.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.530.40. 1 hit.
InterProIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYS_BPPHV
AccessionPrimary (citable) accession number: P62693
Secondary accession number(s): P13003 expand/collapse secondary AC list , Q38298, Q38562, Q38651
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 16, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries