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P62693

- LYS_BPPHV

UniProt

P62693 - LYS_BPPHV

Protein

Lysozyme

Gene

L3

Organism
Lactococcus phage phivML3 (Lactococcus bacteriophage phi-vML3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    The bacteriophage lysin is a powerful lytic agent with a narrow target specifically for dairy lactic streptococci, and it may be involved in phage maturation (like protein 15).

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei15 – 151Proton donorBy similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH24. Glycoside Hydrolase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    Lysis protein
    Muramidase
    Gene namesi
    Name:L3
    OrganismiLactococcus phage phivML3 (Lactococcus bacteriophage phi-vML3)
    Taxonomic identifieri10746 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
    Virus hostiLactococcus lactis [TaxID: 1358]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226LysozymePRO_0000218095Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP62693.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    InterProiIPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62693-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSQNGLNL IKEFEGCRLT AYKPVPWEQM YTIGWGHYGV TAGTTWTQAQ    50
    ADSQLEIDIN NKYAPMVDAY VKGKANQNEF DALVSLAYNC GNVFVADGWA 100
    PFSHAYCASM IPKYRNAGGQ VLQGLVRRRQ AELNLFNKPV SSNSNQNNQT 150
    GGMIKMYLII GLDNSGKAKH WYVSDGVSVR HVRTIRMLEN YQNKWAKLNL 200
    PVDTMFIAEI EAEFGRKIDM ASGEVK 226
    Length:226
    Mass (Da):25,370
    Last modified:July 19, 2004 - v1
    Checksum:i30EDC142BE07B0DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16178 Genomic DNA. Translation: CAA34300.1.
    PIRiS05335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16178 Genomic DNA. Translation: CAA34300.1 .
    PIRi S05335.

    3D structure databases

    ProteinModelPortali P62693.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH24. Glycoside Hydrolase Family 24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    InterProi IPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and DNA sequence analysis of a Lactococcus bacteriophage lysin gene."
      Shearman C.A., Underwood H., Jury K., Gasson M.
      Mol. Gen. Genet. 218:214-221(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Shearman C.A.
      Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiLYS_BPPHV
    AccessioniPrimary (citable) accession number: P62693
    Secondary accession number(s): P13003
    , Q38298, Q38562, Q38651
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3