P62692 (LYS_BPLC2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme
EC=3.2.1.17

Alternative name(s):
Endolysin
Lysis protein
Muramidase

Gene names

Name:

L3

Organism

Lactococcus phage c2 [Reference proteome]

Taxonomic identifier

31537 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Siphoviridae › C2likevirus

Virus host

Lactococcus (lactic streptococci) [TaxID: 1357]

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The bacteriophage lysin is a powerful lytic agent with a narrow target specifically for dairy lactic streptococci, and it may be involved in phage maturation (like protein 15).
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 24 family.
Sequence caution	The sequence CAA84289.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Lysozyme		PRO_0000218094
Sites
	Active site	15	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62692 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 30EDC142BE07B0DE	FASTA	226	25,370
	10 20 30 40 50 60 MKVSQNGLNL IKEFEGCRLT AYKPVPWEQM YTIGWGHYGV TAGTTWTQAQ ADSQLEIDIN 70 80 90 100 110 120 NKYAPMVDAY VKGKANQNEF DALVSLAYNC GNVFVADGWA PFSHAYCASM IPKYRNAGGQ 130 140 150 160 170 180 VLQGLVRRRQ AELNLFNKPV SSNSNQNNQT GGMIKMYLII GLDNSGKAKH WYVSDGVSVR 190 200 210 220 HVRTIRMLEN YQNKWAKLNL PVDTMFIAEI EAEFGRKIDM ASGEVK

References

[1]	"Sequence analysis of the lysin gene region of the prolate lactococcal bacteriophage c2." Ward L.J., Beresford T.P., Lubbers M.W., Jarvis B.D., Jarvis A.W. Can. J. Microbiol. 39:767-774(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequencing and analysis of the prolate-headed lactococcal bacteriophage c2 genome and identification of the structural genes." Lubbers M.W., Waterfield N.R., Beresford T.P., Le Page R.W., Jarvis A.W. Appl. Environ. Microbiol. 61:4348-4356(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z34528 Genomic DNA. Translation: CAA84289.1. Different initiation. L48605 Genomic DNA. Translation: AAA92182.1.
PIR	S49014.
RefSeq	NP_043551.1. NC_001706.1.
3D structure databases
ProteinModelPortal	P62692.
ModBase	Search...
Protein family/group databases
CAZy	GH24. Glycoside Hydrolase Family 24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1261153.
Phylogenomic databases
ProtClustDB	CLSP2491438.
Family and domain databases
Gene3D	1.10.530.40. 1 hit.
InterPro	IPR002196. Glyco_hydro_24. IPR023346. Lysozyme-like_dom. IPR023347. Lysozyme_dom. [Graphical view]
Pfam	PF00959. Phage_lysozyme. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYS_BPLC2

Accession

Primary (citable) accession number: P62692
Secondary accession number(s): P13003 , Q38298, Q38562, Q38651

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program