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P62692

- LYS_BPLC2

UniProt

P62692 - LYS_BPLC2

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Protein

Lysozyme

Gene

L3

Organism
Lactococcus phage c2
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The bacteriophage lysin is a powerful lytic agent with a narrow target specifically for dairy lactic streptococci, and it may be involved in phage maturation (like protein 15).

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei15 – 151Proton donorBy similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene namesi
Name:L3
OrganismiLactococcus phage c2
Taxonomic identifieri31537 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeC2likevirus
Virus hostiLactococcus (lactic streptococci) [TaxID: 1357]
ProteomesiUP000001835: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226LysozymePRO_0000218094Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP62692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P62692-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSQNGLNL IKEFEGCRLT AYKPVPWEQM YTIGWGHYGV TAGTTWTQAQ
60 70 80 90 100
ADSQLEIDIN NKYAPMVDAY VKGKANQNEF DALVSLAYNC GNVFVADGWA
110 120 130 140 150
PFSHAYCASM IPKYRNAGGQ VLQGLVRRRQ AELNLFNKPV SSNSNQNNQT
160 170 180 190 200
GGMIKMYLII GLDNSGKAKH WYVSDGVSVR HVRTIRMLEN YQNKWAKLNL
210 220
PVDTMFIAEI EAEFGRKIDM ASGEVK
Length:226
Mass (Da):25,370
Last modified:July 19, 2004 - v1
Checksum:i30EDC142BE07B0DE
GO

Sequence cautioni

The sequence CAA84289.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z34528 Genomic DNA. Translation: CAA84289.1. Different initiation.
L48605 Genomic DNA. Translation: AAA92182.1.
PIRiS49014.
RefSeqiNP_043551.1. NC_001706.1.

Genome annotation databases

GeneIDi1261153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z34528 Genomic DNA. Translation: CAA84289.1 . Different initiation.
L48605 Genomic DNA. Translation: AAA92182.1 .
PIRi S49014.
RefSeqi NP_043551.1. NC_001706.1.

3D structure databases

ProteinModelPortali P62692.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1261153.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the lysin gene region of the prolate lactococcal bacteriophage c2."
    Ward L.J., Beresford T.P., Lubbers M.W., Jarvis B.D., Jarvis A.W.
    Can. J. Microbiol. 39:767-774(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequencing and analysis of the prolate-headed lactococcal bacteriophage c2 genome and identification of the structural genes."
    Lubbers M.W., Waterfield N.R., Beresford T.P., Le Page R.W., Jarvis A.W.
    Appl. Environ. Microbiol. 61:4348-4356(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLYS_BPLC2
AccessioniPrimary (citable) accession number: P62692
Secondary accession number(s): P13003
, Q38298, Q38562, Q38651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3