P62679 (MTB_CHIRA) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 34.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein B Short name=MT-B Short name=MT-II | ||
| Gene names |
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| Organism | Chionodraco rastrospinosus (Ocellated icefish) | ||
| Taxonomic identifier | 34790 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Notothenioidei › Channichthyidae › Chionodraco |
Protein attributes
| Sequence length | 60 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster |
| Gene Ontology (GO) | |
| Molecular_function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 60 | 60 | Metallothionein B | PRO_0000197278 | |||||
Regions | |||||||||
| Region | 1 – 28 | 28 | Beta | ||||||
| Region | 29 – 60 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 4 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 12 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 14 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 18 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 23 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 25 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 28 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 32 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 33 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 35 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 36 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 40 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 43 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 47 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 49 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 54 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 58 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 59 | 1 | Divalent metal cation; cluster A | ||||||
Sequences
References
| [1] | "Difference in hepatic metallothionein content in Antarctic red-blooded and haemoglobinless fish: undetectable metallothionein levels in haemoglobinless fish is accompanied by accumulation of untranslated metallothionein mRNA." Scudiero R., Carginale V., Riggio M., Capasso C., Capasso A., Kille P., di Prisco G., Parisi E. Biochem. J. 322:207-211(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z72484 mRNA. Translation: CAA96565.1. |
3D structure databases | |
| ProteinModelPortal | P62679. |
| SMR | P62679. Positions 2-29, 31-60. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG096121. |
Family and domain databases | |
| Gene3D | 4.10.10.10. 1 hit. |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. IPR018064. Metalthion_vert_metal_BS. [Graphical view] |
| PANTHER | PTHR23299. PTHR23299. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTB_CHIRA | ||||||||
| Accession | Primary (citable) accession number: P62679 Secondary accession number(s): Q92145 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |