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Protein

Cellular nucleic acid-binding protein

Gene

Cnbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri52 – 69CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri72 – 89CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri96 – 113CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri117 – 134CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri156 – 173CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular nucleic acid-binding protein
Short name:
CNBP
Alternative name(s):
Zinc finger protein 9
Gene namesi
Name:Cnbp
Synonyms:Znf9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621807. Cnbp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000899682 – 177Cellular nucleic acid-binding proteinAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei25Omega-N-methylarginine; by PRMT1By similarity1
Modified residuei27Omega-N-methylarginine; by PRMT1By similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei79Omega-N-methylarginineBy similarity1

Post-translational modificationi

Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP62634.
PRIDEiP62634.

PTM databases

iPTMnetiP62634.
PhosphoSitePlusiP62634.

Expressioni

Tissue specificityi

Present in all tissues examined.

Gene expression databases

BgeeiENSRNOG00000010239.
GenevisibleiP62634. RN.

Interactioni

Protein-protein interaction databases

BioGridi249114. 1 interactor.
STRINGi10116.ENSRNOP00000013884.

Structurei

3D structure databases

ProteinModelPortaliP62634.
SMRiP62634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 42Arg/Gly-richAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri52 – 69CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri72 – 89CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri96 – 113CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri117 – 134CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri156 – 173CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4400. Eukaryota.
COG5082. LUCA.
GeneTreeiENSGT00510000047065.
HOGENOMiHOG000186262.
HOVERGENiHBG000397.
InParanoidiP62634.
KOiK09250.
OMAiRRECDEK.
OrthoDBiEOG091G0LZK.
PhylomeDBiP62634.

Family and domain databases

Gene3Di4.10.60.10. 7 hits.
InterProiView protein in InterPro
IPR001878. Znf_CCHC.
PfamiView protein in Pfam
PF00098. zf-CCHC. 7 hits.
SMARTiView protein in SMART
SM00343. ZnF_C2HC. 7 hits.
SUPFAMiSSF57756. SSF57756. 4 hits.
PROSITEiView protein in PROSITE
PS50158. ZF_CCHC. 7 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL
60 70 80 90 100
PDICYRCGES GHLAKDCDLQ EDACYNCGRG GHIAKDCKEP KREREQCCYN
110 120 130 140 150
CGKPGHLARD CDHADEQKCY SCGEFGHIQK DCTKVKCYRC GETGHVAINC
160 170
SKTSEVNCYR CGESGHLARE CTIEATA
Length:177
Mass (Da):19,463
Last modified:July 19, 2004 - v1
Checksum:i996F398285F52618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45254 mRNA. Translation: BAA08212.1.
AF242550 mRNA. Translation: AAF78224.1.
AY329624 Genomic DNA. Translation: AAR89464.1.
AB158421 mRNA. Translation: BAE16993.1.
AB158422 mRNA. Translation: BAE16994.1.
BC062225 mRNA. Translation: AAH62225.1.
PIRiJC2512.
RefSeqiNP_072120.1. NM_022598.1.
UniGeneiRn.6187.

Genome annotation databases

EnsembliENSRNOT00000013884; ENSRNOP00000013884; ENSRNOG00000010239.
GeneIDi64530.
KEGGirno:64530.

Similar proteinsi

Entry informationi

Entry nameiCNBP_RAT
AccessioniPrimary (citable) accession number: P62634
Secondary accession number(s): P20694, Q5QJQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome