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Protein

Cellular nucleic acid-binding protein

Gene

CNBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri52 – 69CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri72 – 89CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri96 – 113CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri117 – 134CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri156 – 173CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiP62633

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular nucleic acid-binding protein
Short name:
CNBP
Alternative name(s):
Zinc finger protein 9
Gene namesi
Name:CNBP
Synonyms:RNF163, ZNF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000169714.16
HGNCiHGNC:13164 CNBP
MIMi116955 gene
neXtProtiNX_P62633

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Dystrophia myotonica 2 (DM2)
The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.
Disease descriptionA multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases.
See also OMIM:602668

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25R → K: Significantly reduces methylation; when associated with K-27. 1 Publication1
Mutagenesisi27R → K: Significantly reduces methylation; when associated with K-25. 1 Publication1

Organism-specific databases

DisGeNETi7555
GeneReviewsiCNBP
MalaCardsiCNBP
MIMi602668 phenotype
OpenTargetsiENSG00000169714
Orphaneti606 Proximal myotonic myopathy
PharmGKBiPA37737

Polymorphism and mutation databases

BioMutaiCNBP
DMDMi50401852

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000899652 – 177Cellular nucleic acid-binding proteinAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei25Omega-N-methylarginine; by PRMT11 Publication1
Modified residuei27Omega-N-methylarginine; by PRMT11 Publication1
Modified residuei49PhosphoserineBy similarity1
Modified residuei79Omega-N-methylarginineCombined sources1
Isoform 2 (identifier: P62633-2)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Isoform 5 (identifier: P62633-5)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Isoform 8 (identifier: P62633-8)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Modified residuei73Omega-N-methylarginineCombined sources1
Isoform 4 (identifier: P62633-4)
Modified residuei80Omega-N-methylarginineCombined sources1

Post-translational modificationi

Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP62633
MaxQBiP62633
PaxDbiP62633
PeptideAtlasiP62633
PRIDEiP62633

PTM databases

iPTMnetiP62633
PhosphoSitePlusiP62633
SwissPalmiP62633

Expressioni

Tissue specificityi

Present in all tissues examined.

Gene expression databases

BgeeiENSG00000169714
CleanExiHS_CNBP
ExpressionAtlasiP62633 baseline and differential
GenevisibleiP62633 HS

Organism-specific databases

HPAiHPA063097

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Prmt1Q630092EBI-1047529,EBI-78708From Rattus norvegicus.

Protein-protein interaction databases

BioGridi113387, 157 interactors
IntActiP62633, 14 interactors
MINTiP62633
STRINGi9606.ENSP00000410769

Structurei

3D structure databases

ProteinModelPortaliP62633
SMRiP62633
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 42Arg/Gly-richAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri52 – 69CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri72 – 89CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri96 – 113CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri117 – 134CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri156 – 173CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4400 Eukaryota
COG5082 LUCA
GeneTreeiENSGT00510000047065
HOGENOMiHOG000186262
HOVERGENiHBG000397
InParanoidiP62633
KOiK09250
OMAiRRECDEK
OrthoDBiEOG091G0LZK
PhylomeDBiP62633
TreeFamiTF316974

Family and domain databases

InterProiView protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 7 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 7 hits
SUPFAMiSSF57756 SSF57756, 4 hits
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 7 hits

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62633-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL
60 70 80 90 100
PDICYRCGES GHLAKDCDLQ EDACYNCGRG GHIAKDCKEP KREREQCCYN
110 120 130 140 150
CGKPGHLARD CDHADEQKCY SCGEFGHIQK DCTKVKCYRC GETGHVAINC
160 170
SKTSEVNCYR CGESGHLARE CTIEATA
Length:177
Mass (Da):19,463
Last modified:July 19, 2004 - v1
Checksum:i996F398285F52618
GO
Isoform 2 (identifier: P62633-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.

Show »
Length:170
Mass (Da):18,742
Checksum:i152BEC42881358E8
GO
Isoform 3 (identifier: P62633-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-51: Missing.

Show »
Length:167
Mass (Da):18,413
Checksum:iD59B4E42A6477FF2
GO
Isoform 4 (identifier: P62633-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: D → DE

Show »
Length:178
Mass (Da):19,592
Checksum:iDF0CDAB9BF3D96BB
GO
Isoform 5 (identifier: P62633-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.
     72-72: D → DVE

Note: No experimental confirmation available.Combined sources
Show »
Length:172
Mass (Da):18,970
Checksum:iE2C0B3EF2820CD94
GO
Isoform 6 (identifier: P62633-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: D → DVE

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):19,691
Checksum:iAB793FABFDE0C072
GO
Isoform 7 (identifier: P62633-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-51: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):17,692
Checksum:i1C2D9D62F90EFCFB
GO
Isoform 8 (identifier: P62633-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.
     72-72: D → DE

Show »
Length:171
Mass (Da):18,871
Checksum:i46809E6C7F3070C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6C → R in BAF84808 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05508435 – 51Missing in isoform 7. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_01098136 – 42Missing in isoform 2, isoform 5 and isoform 8. 2 Publications7
Alternative sequenceiVSP_01098242 – 51Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_04330472D → DE in isoform 4 and isoform 8. 2 Publications1
Alternative sequenceiVSP_04342472D → DVE in isoform 5 and isoform 6. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28372 mRNA Translation: AAA61975.1
U19765 Genomic DNA Translation: AAA91782.1
AY329622 Genomic DNA Translation: AAR89462.1
DQ092366 mRNA Translation: AAY96754.1
DQ092367 mRNA Translation: AAY96755.1
DQ091187 mRNA Translation: AAY89856.1
AK054592 mRNA Translation: BAB70769.1
AK298154 mRNA Translation: BAG60429.1
AK292119 mRNA Translation: BAF84808.1
AK314380 mRNA Translation: BAG37006.1
BT019613 mRNA Translation: AAV38419.1
AC108673 Genomic DNA No translation available.
AC135587 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79271.1
CH471052 Genomic DNA Translation: EAW79272.1
CH471052 Genomic DNA Translation: EAW79273.1
CH471052 Genomic DNA Translation: EAW79274.1
CH471052 Genomic DNA Translation: EAW79275.1
CH471052 Genomic DNA Translation: EAW79277.1
BC000288 mRNA Translation: AAH00288.1
BC014911 mRNA Translation: AAH14911.1
BC093058 mRNA Translation: AAH93058.1
CCDSiCCDS3056.1 [P62633-1]
CCDS46906.1 [P62633-6]
CCDS46907.1 [P62633-4]
CCDS46908.1 [P62633-5]
CCDS54637.1 [P62633-2]
PIRiA32760
RefSeqiNP_001120664.1, NM_001127192.1 [P62633-6]
NP_001120665.1, NM_001127193.1 [P62633-4]
NP_001120666.1, NM_001127194.1 [P62633-5]
NP_001120667.1, NM_001127195.1 [P62633-8]
NP_001120668.1, NM_001127196.1 [P62633-2]
NP_003409.1, NM_003418.4 [P62633-1]
UniGeneiHs.518249

Genome annotation databases

EnsembliENST00000422453; ENSP00000410619; ENSG00000169714 [P62633-1]
ENST00000441626; ENSP00000410769; ENSG00000169714 [P62633-6]
ENST00000446936; ENSP00000400444; ENSG00000169714 [P62633-5]
ENST00000451728; ENSP00000399488; ENSG00000169714 [P62633-4]
ENST00000500450; ENSP00000426223; ENSG00000169714 [P62633-7]
ENST00000502976; ENSP00000421323; ENSG00000169714 [P62633-2]
ENST00000504813; ENSP00000422110; ENSG00000169714 [P62633-3]
GeneIDi7555
KEGGihsa:7555
UCSCiuc003elq.5 human [P62633-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCNBP_HUMAN
AccessioniPrimary (citable) accession number: P62633
Secondary accession number(s): A8K7V4
, B2RAV9, B4DP17, D3DNB9, D3DNC0, D3DNC1, E9PDR7, P20694, Q4JGY0, Q4JGY1, Q5QJR0, Q5U0E9, Q6PJI7, Q96NV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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