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Protein

Cellular nucleic acid-binding protein

Gene

CNBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri52 – 69CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri72 – 89CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri96 – 113CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri117 – 134CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri156 – 173CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • single-stranded DNA binding Source: Ensembl
  • single-stranded RNA binding Source: Ensembl
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169714-MONOMER.
SIGNORiP62633.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular nucleic acid-binding protein
Short name:
CNBP
Alternative name(s):
Zinc finger protein 9
Gene namesi
Name:CNBP
Synonyms:RNF163, ZNF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13164. CNBP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Dystrophia myotonica 2 (DM2)
The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.
Disease descriptionA multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases.
See also OMIM:602668

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25R → K: Significantly reduces methylation; when associated with K-27. 1 Publication1
Mutagenesisi27R → K: Significantly reduces methylation; when associated with K-25. 1 Publication1

Organism-specific databases

DisGeNETi7555.
MalaCardsiCNBP.
MIMi602668. phenotype.
OpenTargetsiENSG00000169714.
Orphaneti606. Proximal myotonic myopathy.
PharmGKBiPA37737.

Polymorphism and mutation databases

BioMutaiCNBP.
DMDMi50401852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000899652 – 177Cellular nucleic acid-binding proteinAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei25Omega-N-methylarginine; by PRMT11 Publication1
Modified residuei27Omega-N-methylarginine; by PRMT11 Publication1
Modified residuei49PhosphoserineBy similarity1
Modified residuei79Omega-N-methylarginineCombined sources1
Isoform 2 (identifier: P62633-2)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Isoform 5 (identifier: P62633-5)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Isoform 8 (identifier: P62633-8)
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34Omega-N-methylarginineCombined sources1
Modified residuei73Omega-N-methylarginineCombined sources1
Isoform 4 (identifier: P62633-4)
Modified residuei80Omega-N-methylarginineCombined sources1

Post-translational modificationi

Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP62633.
MaxQBiP62633.
PaxDbiP62633.
PeptideAtlasiP62633.
PRIDEiP62633.

PTM databases

iPTMnetiP62633.
PhosphoSitePlusiP62633.
SwissPalmiP62633.

Expressioni

Tissue specificityi

Present in all tissues examined.

Gene expression databases

BgeeiENSG00000169714.
CleanExiHS_CNBP.
ExpressionAtlasiP62633. baseline and differential.
GenevisibleiP62633. HS.

Organism-specific databases

HPAiHPA063097.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Prmt1Q630092EBI-1047529,EBI-78708From a different organism.

Protein-protein interaction databases

BioGridi113387. 139 interactors.
IntActiP62633. 11 interactors.
MINTiMINT-4589059.
STRINGi9606.ENSP00000410769.

Structurei

3D structure databases

ProteinModelPortaliP62633.
SMRiP62633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 42Arg/Gly-richAdd BLAST21

Sequence similaritiesi

Contains 7 CCHC-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri52 – 69CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri72 – 89CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri96 – 113CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri117 – 134CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri156 – 173CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4400. Eukaryota.
COG5082. LUCA.
GeneTreeiENSGT00510000047065.
HOGENOMiHOG000186262.
HOVERGENiHBG000397.
InParanoidiP62633.
KOiK09250.
OMAiSRECDQD.
OrthoDBiEOG091G0LZK.
PhylomeDBiP62633.
TreeFamiTF316974.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 4 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62633-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL
60 70 80 90 100
PDICYRCGES GHLAKDCDLQ EDACYNCGRG GHIAKDCKEP KREREQCCYN
110 120 130 140 150
CGKPGHLARD CDHADEQKCY SCGEFGHIQK DCTKVKCYRC GETGHVAINC
160 170
SKTSEVNCYR CGESGHLARE CTIEATA
Length:177
Mass (Da):19,463
Last modified:July 19, 2004 - v1
Checksum:i996F398285F52618
GO
Isoform 2 (identifier: P62633-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.

Show »
Length:170
Mass (Da):18,742
Checksum:i152BEC42881358E8
GO
Isoform 3 (identifier: P62633-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-51: Missing.

Show »
Length:167
Mass (Da):18,413
Checksum:iD59B4E42A6477FF2
GO
Isoform 4 (identifier: P62633-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: D → DE

Show »
Length:178
Mass (Da):19,592
Checksum:iDF0CDAB9BF3D96BB
GO
Isoform 5 (identifier: P62633-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.
     72-72: D → DVE

Note: No experimental confirmation available.Combined sources
Show »
Length:172
Mass (Da):18,970
Checksum:iE2C0B3EF2820CD94
GO
Isoform 6 (identifier: P62633-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-72: D → DVE

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):19,691
Checksum:iAB793FABFDE0C072
GO
Isoform 7 (identifier: P62633-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-51: Missing.

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):17,692
Checksum:i1C2D9D62F90EFCFB
GO
Isoform 8 (identifier: P62633-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-42: Missing.
     72-72: D → DE

Show »
Length:171
Mass (Da):18,871
Checksum:i46809E6C7F3070C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6C → R in BAF84808 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05508435 – 51Missing in isoform 7. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_01098136 – 42Missing in isoform 2, isoform 5 and isoform 8. 2 Publications7
Alternative sequenceiVSP_01098242 – 51Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_04330472D → DE in isoform 4 and isoform 8. 2 Publications1
Alternative sequenceiVSP_04342472D → DVE in isoform 5 and isoform 6. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28372 mRNA. Translation: AAA61975.1.
U19765 Genomic DNA. Translation: AAA91782.1.
AY329622 Genomic DNA. Translation: AAR89462.1.
DQ092366 mRNA. Translation: AAY96754.1.
DQ092367 mRNA. Translation: AAY96755.1.
DQ091187 mRNA. Translation: AAY89856.1.
AK054592 mRNA. Translation: BAB70769.1.
AK298154 mRNA. Translation: BAG60429.1.
AK292119 mRNA. Translation: BAF84808.1.
AK314380 mRNA. Translation: BAG37006.1.
BT019613 mRNA. Translation: AAV38419.1.
AC108673 Genomic DNA. No translation available.
AC135587 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79271.1.
CH471052 Genomic DNA. Translation: EAW79272.1.
CH471052 Genomic DNA. Translation: EAW79273.1.
CH471052 Genomic DNA. Translation: EAW79274.1.
CH471052 Genomic DNA. Translation: EAW79275.1.
CH471052 Genomic DNA. Translation: EAW79277.1.
BC000288 mRNA. Translation: AAH00288.1.
BC014911 mRNA. Translation: AAH14911.1.
BC093058 mRNA. Translation: AAH93058.1.
CCDSiCCDS3056.1. [P62633-1]
CCDS46906.1. [P62633-6]
CCDS46907.1. [P62633-4]
CCDS46908.1. [P62633-5]
CCDS54637.1. [P62633-2]
PIRiA32760.
RefSeqiNP_001120664.1. NM_001127192.1. [P62633-6]
NP_001120665.1. NM_001127193.1. [P62633-4]
NP_001120666.1. NM_001127194.1. [P62633-5]
NP_001120667.1. NM_001127195.1. [P62633-8]
NP_001120668.1. NM_001127196.1. [P62633-2]
NP_003409.1. NM_003418.4. [P62633-1]
UniGeneiHs.518249.

Genome annotation databases

EnsembliENST00000422453; ENSP00000410619; ENSG00000169714. [P62633-1]
ENST00000441626; ENSP00000410769; ENSG00000169714. [P62633-6]
ENST00000446936; ENSP00000400444; ENSG00000169714. [P62633-5]
ENST00000451728; ENSP00000399488; ENSG00000169714. [P62633-4]
ENST00000500450; ENSP00000426223; ENSG00000169714. [P62633-7]
ENST00000502976; ENSP00000421323; ENSG00000169714. [P62633-2]
ENST00000504813; ENSP00000422110; ENSG00000169714. [P62633-3]
GeneIDi7555.
KEGGihsa:7555.
UCSCiuc003elq.5. human. [P62633-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28372 mRNA. Translation: AAA61975.1.
U19765 Genomic DNA. Translation: AAA91782.1.
AY329622 Genomic DNA. Translation: AAR89462.1.
DQ092366 mRNA. Translation: AAY96754.1.
DQ092367 mRNA. Translation: AAY96755.1.
DQ091187 mRNA. Translation: AAY89856.1.
AK054592 mRNA. Translation: BAB70769.1.
AK298154 mRNA. Translation: BAG60429.1.
AK292119 mRNA. Translation: BAF84808.1.
AK314380 mRNA. Translation: BAG37006.1.
BT019613 mRNA. Translation: AAV38419.1.
AC108673 Genomic DNA. No translation available.
AC135587 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79271.1.
CH471052 Genomic DNA. Translation: EAW79272.1.
CH471052 Genomic DNA. Translation: EAW79273.1.
CH471052 Genomic DNA. Translation: EAW79274.1.
CH471052 Genomic DNA. Translation: EAW79275.1.
CH471052 Genomic DNA. Translation: EAW79277.1.
BC000288 mRNA. Translation: AAH00288.1.
BC014911 mRNA. Translation: AAH14911.1.
BC093058 mRNA. Translation: AAH93058.1.
CCDSiCCDS3056.1. [P62633-1]
CCDS46906.1. [P62633-6]
CCDS46907.1. [P62633-4]
CCDS46908.1. [P62633-5]
CCDS54637.1. [P62633-2]
PIRiA32760.
RefSeqiNP_001120664.1. NM_001127192.1. [P62633-6]
NP_001120665.1. NM_001127193.1. [P62633-4]
NP_001120666.1. NM_001127194.1. [P62633-5]
NP_001120667.1. NM_001127195.1. [P62633-8]
NP_001120668.1. NM_001127196.1. [P62633-2]
NP_003409.1. NM_003418.4. [P62633-1]
UniGeneiHs.518249.

3D structure databases

ProteinModelPortaliP62633.
SMRiP62633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113387. 139 interactors.
IntActiP62633. 11 interactors.
MINTiMINT-4589059.
STRINGi9606.ENSP00000410769.

PTM databases

iPTMnetiP62633.
PhosphoSitePlusiP62633.
SwissPalmiP62633.

Polymorphism and mutation databases

BioMutaiCNBP.
DMDMi50401852.

Proteomic databases

EPDiP62633.
MaxQBiP62633.
PaxDbiP62633.
PeptideAtlasiP62633.
PRIDEiP62633.

Protocols and materials databases

DNASUi7555.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422453; ENSP00000410619; ENSG00000169714. [P62633-1]
ENST00000441626; ENSP00000410769; ENSG00000169714. [P62633-6]
ENST00000446936; ENSP00000400444; ENSG00000169714. [P62633-5]
ENST00000451728; ENSP00000399488; ENSG00000169714. [P62633-4]
ENST00000500450; ENSP00000426223; ENSG00000169714. [P62633-7]
ENST00000502976; ENSP00000421323; ENSG00000169714. [P62633-2]
ENST00000504813; ENSP00000422110; ENSG00000169714. [P62633-3]
GeneIDi7555.
KEGGihsa:7555.
UCSCiuc003elq.5. human. [P62633-1]

Organism-specific databases

CTDi7555.
DisGeNETi7555.
GeneCardsiCNBP.
GeneReviewsiCNBP.
HGNCiHGNC:13164. CNBP.
HPAiHPA063097.
MalaCardsiCNBP.
MIMi116955. gene.
602668. phenotype.
neXtProtiNX_P62633.
OpenTargetsiENSG00000169714.
Orphaneti606. Proximal myotonic myopathy.
PharmGKBiPA37737.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4400. Eukaryota.
COG5082. LUCA.
GeneTreeiENSGT00510000047065.
HOGENOMiHOG000186262.
HOVERGENiHBG000397.
InParanoidiP62633.
KOiK09250.
OMAiSRECDQD.
OrthoDBiEOG091G0LZK.
PhylomeDBiP62633.
TreeFamiTF316974.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169714-MONOMER.
SIGNORiP62633.

Miscellaneous databases

ChiTaRSiCNBP. human.
GeneWikiiCNBP.
GenomeRNAii7555.
PROiP62633.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169714.
CleanExiHS_CNBP.
ExpressionAtlasiP62633. baseline and differential.
GenevisibleiP62633. HS.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 4 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNBP_HUMAN
AccessioniPrimary (citable) accession number: P62633
Secondary accession number(s): A8K7V4
, B2RAV9, B4DP17, D3DNB9, D3DNC0, D3DNC1, E9PDR7, P20694, Q4JGY0, Q4JGY1, Q5QJR0, Q5U0E9, Q6PJI7, Q96NV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.