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P62633

- CNBP_HUMAN

UniProt

P62633 - CNBP_HUMAN

Protein

Cellular nucleic acid-binding protein

Gene

CNBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2118CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri52 – 6918CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri72 – 8918CCHC-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri96 – 11318CCHC-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri117 – 13418CCHC-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri135 – 15218CCHC-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17318CCHC-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc
    4. single-stranded DNA binding Source: Ensembl
    5. single-stranded RNA binding Source: Ensembl
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cholesterol biosynthetic process Source: ProtInc
    2. positive regulation of cell proliferation Source: UniProtKB
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. regulation of transcription, DNA-templated Source: ProtInc
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cellular nucleic acid-binding protein
    Short name:
    CNBP
    Alternative name(s):
    Zinc finger protein 9
    Gene namesi
    Name:CNBP
    Synonyms:RNF163, ZNF9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:13164. CNBP.

    Subcellular locationi

    Cytoplasm By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endoplasmic reticulum Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum

    Pathology & Biotechi

    Involvement in diseasei

    Dystrophia myotonica 2 (DM2) [MIM:602668]: A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases.
    Note: The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi25 – 251R → K: Significantly reduces methylation; when associated with K-27. 1 Publication
    Mutagenesisi27 – 271R → K: Significantly reduces methylation; when associated with K-25. 1 Publication

    Organism-specific databases

    MIMi602668. phenotype.
    Orphaneti606. Proximal myotonic myopathy.
    PharmGKBiPA37737.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 177176Cellular nucleic acid-binding proteinPRO_0000089965Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei8 – 81N6-acetyllysineBy similarity
    Modified residuei25 – 251Omega-N-methylarginine; by PRMT11 Publication
    Modified residuei27 – 271Omega-N-methylarginine; by PRMT11 Publication

    Post-translational modificationi

    Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.1 Publication

    Keywords - PTMi

    Acetylation, Methylation

    Proteomic databases

    MaxQBiP62633.
    PaxDbiP62633.
    PRIDEiP62633.

    PTM databases

    PhosphoSiteiP62633.

    Expressioni

    Tissue specificityi

    Present in all tissues examined.

    Gene expression databases

    ArrayExpressiP62633.
    BgeeiP62633.
    CleanExiHS_CNBP.
    GenevestigatoriP62633.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Prmt1Q630092EBI-1047529,EBI-78708From a different organism.

    Protein-protein interaction databases

    BioGridi113387. 49 interactions.
    IntActiP62633. 7 interactions.
    MINTiMINT-4589059.
    STRINGi9606.ENSP00000303844.

    Structurei

    3D structure databases

    ProteinModelPortaliP62633.
    SMRiP62633. Positions 4-70, 74-112, 135-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 4221Arg/Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 7 CCHC-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2118CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri52 – 6918CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri72 – 8918CCHC-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri96 – 11318CCHC-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri117 – 13418CCHC-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri135 – 15218CCHC-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17318CCHC-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5082.
    HOGENOMiHOG000186262.
    HOVERGENiHBG000397.
    InParanoidiP62633.
    KOiK09250.
    OMAiCPNGQGG.
    OrthoDBiEOG790G22.
    PhylomeDBiP62633.
    TreeFamiTF316974.

    Family and domain databases

    Gene3Di4.10.60.10. 4 hits.
    InterProiIPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00098. zf-CCHC. 7 hits.
    [Graphical view]
    SMARTiSM00343. ZnF_C2HC. 7 hits.
    [Graphical view]
    SUPFAMiSSF57756. SSF57756. 4 hits.
    PROSITEiPS50158. ZF_CCHC. 7 hits.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P62633-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGGFTSD RGFQFVSSSL    50
    PDICYRCGES GHLAKDCDLQ EDACYNCGRG GHIAKDCKEP KREREQCCYN 100
    CGKPGHLARD CDHADEQKCY SCGEFGHIQK DCTKVKCYRC GETGHVAINC 150
    SKTSEVNCYR CGESGHLARE CTIEATA 177
    Length:177
    Mass (Da):19,463
    Last modified:July 19, 2004 - v1
    Checksum:i996F398285F52618
    GO
    Isoform 2 (identifier: P62633-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-42: Missing.

    Show »
    Length:170
    Mass (Da):18,742
    Checksum:i152BEC42881358E8
    GO
    Isoform 3 (identifier: P62633-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-51: Missing.

    Show »
    Length:167
    Mass (Da):18,413
    Checksum:iD59B4E42A6477FF2
    GO
    Isoform 4 (identifier: P62633-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         72-72: D → DE

    Show »
    Length:178
    Mass (Da):19,592
    Checksum:iDF0CDAB9BF3D96BB
    GO
    Isoform 5 (identifier: P62633-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-42: Missing.
         72-72: D → DVE

    Note: No experimental confirmation available.

    Show »
    Length:172
    Mass (Da):18,970
    Checksum:iE2C0B3EF2820CD94
    GO
    Isoform 6 (identifier: P62633-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         72-72: D → DVE

    Note: No experimental confirmation available.

    Show »
    Length:179
    Mass (Da):19,691
    Checksum:iAB793FABFDE0C072
    GO
    Isoform 7 (identifier: P62633-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         35-51: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:160
    Mass (Da):17,692
    Checksum:i1C2D9D62F90EFCFB
    GO
    Isoform 8 (identifier: P62633-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-42: Missing.
         72-72: D → DE

    Show »
    Length:171
    Mass (Da):18,871
    Checksum:i46809E6C7F3070C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61C → R in BAF84808. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei35 – 5117Missing in isoform 7. 1 PublicationVSP_055084Add
    BLAST
    Alternative sequencei36 – 427Missing in isoform 2, isoform 5 and isoform 8. 2 PublicationsVSP_010981
    Alternative sequencei42 – 5110Missing in isoform 3. 1 PublicationVSP_010982
    Alternative sequencei72 – 721D → DE in isoform 4 and isoform 8. 2 PublicationsVSP_043304
    Alternative sequencei72 – 721D → DVE in isoform 5 and isoform 6. 2 PublicationsVSP_043424

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28372 mRNA. Translation: AAA61975.1.
    U19765 Genomic DNA. Translation: AAA91782.1.
    AY329622 Genomic DNA. Translation: AAR89462.1.
    DQ092366 mRNA. Translation: AAY96754.1.
    DQ092367 mRNA. Translation: AAY96755.1.
    DQ091187 mRNA. Translation: AAY89856.1.
    AK054592 mRNA. Translation: BAB70769.1.
    AK298154 mRNA. Translation: BAG60429.1.
    AK292119 mRNA. Translation: BAF84808.1.
    AK314380 mRNA. Translation: BAG37006.1.
    BT019613 mRNA. Translation: AAV38419.1.
    AC108673 Genomic DNA. No translation available.
    AC135587 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79271.1.
    CH471052 Genomic DNA. Translation: EAW79272.1.
    CH471052 Genomic DNA. Translation: EAW79273.1.
    CH471052 Genomic DNA. Translation: EAW79274.1.
    CH471052 Genomic DNA. Translation: EAW79275.1.
    CH471052 Genomic DNA. Translation: EAW79277.1.
    BC000288 mRNA. Translation: AAH00288.1.
    BC014911 mRNA. Translation: AAH14911.1.
    BC093058 mRNA. Translation: AAH93058.1.
    CCDSiCCDS3056.1. [P62633-1]
    CCDS46906.1. [P62633-6]
    CCDS46907.1. [P62633-4]
    CCDS46908.1. [P62633-5]
    CCDS54637.1. [P62633-2]
    PIRiA32760.
    RefSeqiNP_001120664.1. NM_001127192.1. [P62633-6]
    NP_001120665.1. NM_001127193.1. [P62633-4]
    NP_001120666.1. NM_001127194.1. [P62633-5]
    NP_001120667.1. NM_001127195.1.
    NP_001120668.1. NM_001127196.1. [P62633-2]
    NP_003409.1. NM_003418.4. [P62633-1]
    UniGeneiHs.518249.

    Genome annotation databases

    EnsembliENST00000422453; ENSP00000410619; ENSG00000169714. [P62633-1]
    ENST00000441626; ENSP00000410769; ENSG00000169714. [P62633-6]
    ENST00000446936; ENSP00000400444; ENSG00000169714. [P62633-5]
    ENST00000451728; ENSP00000399488; ENSG00000169714. [P62633-4]
    ENST00000500450; ENSP00000426223; ENSG00000169714. [P62633-7]
    ENST00000502976; ENSP00000421323; ENSG00000169714. [P62633-2]
    ENST00000504813; ENSP00000422110; ENSG00000169714. [P62633-3]
    GeneIDi7555.
    KEGGihsa:7555.
    UCSCiuc003elq.4. human. [P62633-1]
    uc003elr.4. human. [P62633-2]
    uc021xdt.1. human. [P62633-5]

    Polymorphism databases

    DMDMi50401852.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28372 mRNA. Translation: AAA61975.1 .
    U19765 Genomic DNA. Translation: AAA91782.1 .
    AY329622 Genomic DNA. Translation: AAR89462.1 .
    DQ092366 mRNA. Translation: AAY96754.1 .
    DQ092367 mRNA. Translation: AAY96755.1 .
    DQ091187 mRNA. Translation: AAY89856.1 .
    AK054592 mRNA. Translation: BAB70769.1 .
    AK298154 mRNA. Translation: BAG60429.1 .
    AK292119 mRNA. Translation: BAF84808.1 .
    AK314380 mRNA. Translation: BAG37006.1 .
    BT019613 mRNA. Translation: AAV38419.1 .
    AC108673 Genomic DNA. No translation available.
    AC135587 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79271.1 .
    CH471052 Genomic DNA. Translation: EAW79272.1 .
    CH471052 Genomic DNA. Translation: EAW79273.1 .
    CH471052 Genomic DNA. Translation: EAW79274.1 .
    CH471052 Genomic DNA. Translation: EAW79275.1 .
    CH471052 Genomic DNA. Translation: EAW79277.1 .
    BC000288 mRNA. Translation: AAH00288.1 .
    BC014911 mRNA. Translation: AAH14911.1 .
    BC093058 mRNA. Translation: AAH93058.1 .
    CCDSi CCDS3056.1. [P62633-1 ]
    CCDS46906.1. [P62633-6 ]
    CCDS46907.1. [P62633-4 ]
    CCDS46908.1. [P62633-5 ]
    CCDS54637.1. [P62633-2 ]
    PIRi A32760.
    RefSeqi NP_001120664.1. NM_001127192.1. [P62633-6 ]
    NP_001120665.1. NM_001127193.1. [P62633-4 ]
    NP_001120666.1. NM_001127194.1. [P62633-5 ]
    NP_001120667.1. NM_001127195.1.
    NP_001120668.1. NM_001127196.1. [P62633-2 ]
    NP_003409.1. NM_003418.4. [P62633-1 ]
    UniGenei Hs.518249.

    3D structure databases

    ProteinModelPortali P62633.
    SMRi P62633. Positions 4-70, 74-112, 135-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113387. 49 interactions.
    IntActi P62633. 7 interactions.
    MINTi MINT-4589059.
    STRINGi 9606.ENSP00000303844.

    PTM databases

    PhosphoSitei P62633.

    Polymorphism databases

    DMDMi 50401852.

    Proteomic databases

    MaxQBi P62633.
    PaxDbi P62633.
    PRIDEi P62633.

    Protocols and materials databases

    DNASUi 7555.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000422453 ; ENSP00000410619 ; ENSG00000169714 . [P62633-1 ]
    ENST00000441626 ; ENSP00000410769 ; ENSG00000169714 . [P62633-6 ]
    ENST00000446936 ; ENSP00000400444 ; ENSG00000169714 . [P62633-5 ]
    ENST00000451728 ; ENSP00000399488 ; ENSG00000169714 . [P62633-4 ]
    ENST00000500450 ; ENSP00000426223 ; ENSG00000169714 . [P62633-7 ]
    ENST00000502976 ; ENSP00000421323 ; ENSG00000169714 . [P62633-2 ]
    ENST00000504813 ; ENSP00000422110 ; ENSG00000169714 . [P62633-3 ]
    GeneIDi 7555.
    KEGGi hsa:7555.
    UCSCi uc003elq.4. human. [P62633-1 ]
    uc003elr.4. human. [P62633-2 ]
    uc021xdt.1. human. [P62633-5 ]

    Organism-specific databases

    CTDi 7555.
    GeneCardsi GC03M128886.
    GeneReviewsi CNBP.
    HGNCi HGNC:13164. CNBP.
    MIMi 116955. gene.
    602668. phenotype.
    neXtProti NX_P62633.
    Orphaneti 606. Proximal myotonic myopathy.
    PharmGKBi PA37737.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5082.
    HOGENOMi HOG000186262.
    HOVERGENi HBG000397.
    InParanoidi P62633.
    KOi K09250.
    OMAi CPNGQGG.
    OrthoDBi EOG790G22.
    PhylomeDBi P62633.
    TreeFami TF316974.

    Miscellaneous databases

    ChiTaRSi CNBP. human.
    GeneWikii CNBP.
    GenomeRNAii 7555.
    NextBioi 29559.
    PROi P62633.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62633.
    Bgeei P62633.
    CleanExi HS_CNBP.
    Genevestigatori P62633.

    Family and domain databases

    Gene3Di 4.10.60.10. 4 hits.
    InterProi IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00098. zf-CCHC. 7 hits.
    [Graphical view ]
    SMARTi SM00343. ZnF_C2HC. 7 hits.
    [Graphical view ]
    SUPFAMi SSF57756. SSF57756. 4 hits.
    PROSITEi PS50158. ZF_CCHC. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a zinc finger protein that binds to the sterol regulatory element."
      Rajavashisth T.B., Taylor A.K., Andalibi A., Svenson K.L., Lusis A.J.
      Science 245:640-643(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Organization of the gene encoding cellular nucleic acid-binding protein."
      Flink I.L., Morkin E.
      Gene 163:279-282(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    3. "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9."
      Liquori C.L., Ricker K., Moseley M.L., Jacobsen J.F., Kress W., Naylor S.L., Day J.W., Ranum L.P.
      Science 293:864-867(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISEASE.
    4. "Cloning of novel transcript variants of human cellular nucleic acid binding protein."
      Yang F., Yan H., Zhang S.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5 AND 8).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 6 AND 7).
      Tissue: Placenta and Synovium.
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    7. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Lung and Uterus.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    12. "Arginine methylation of the cellular nucleic acid binding protein does not affect its subcellular localization but impedes RNA binding."
      Wei H.M., Hu H.H., Chang G.Y., Lee Y.J., Li Y.C., Chang H.H., Li C.
      FEBS Lett. 588:1542-1548(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: METHYLATION AT ARG-25 AND ARG-27, MUTAGENESIS OF ARG-25 AND ARG-27.

    Entry informationi

    Entry nameiCNBP_HUMAN
    AccessioniPrimary (citable) accession number: P62633
    Secondary accession number(s): A8K7V4
    , B2RAV9, B4DP17, D3DNB9, D3DNC0, D3DNC1, E9PDR7, P20694, Q4JGY0, Q4JGY1, Q5QJR0, Q5U0E9, Q6PJI7, Q96NV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3