Elongation factor 1-alpha 2 - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (?) or add your own

P62631 (EF1A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 90. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Elongation factor 1-alpha 2
Short name=EF-1-alpha-2

Alternative name(s):
Eukaryotic elongation factor 1 A-2
Short name=eEF1A-2
Statin-S1

Gene names

Name:	Eef1a2
Synonyms:	Eef1al, Stn

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subunit structure	Monomer.
Subcellular location	Nucleus.
Tissue specificity	Found in a wide range of tissues.
Developmental stage	The statin expression is specific for nonproliferating cells. Its message is most abundant in G0 phase of 3T3 mouse fibroblasts, but becomes significantly reduced in G1 and S1 phases cells.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
PTM	Acetylation Methylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC negative regulation of apoptotic process Inferred from direct assay PubMed 11724805. Source: MGI response to inorganic substance Inferred from electronic annotation. Source: Compara
Cellular_component	eukaryotic translation elongation factor 1 complex Inferred from direct assay PubMed 9588196. Source: MGI neuronal cell body Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from direct assay PubMed 9588196. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 463

463

Elongation factor 1-alpha 2

PRO_0000090892

Regions

Nucleotide binding

14 – 21

GTP By similarity

Nucleotide binding

91 – 95

GTP By similarity

Nucleotide binding

153 – 156

GTP By similarity

Amino acid modifications

Modified residue

Phosphotyrosine Ref.5

Modified residue

N6,N6,N6-trimethyllysine By similarity

Modified residue

141

Phosphotyrosine Ref.4 Ref.5

Modified residue

165

N6,N6,N6-trimethyllysine By similarity

Modified residue

179

N6-acetyllysine By similarity

Modified residue

301

5-glutamyl glycerylphosphorylethanolamine By similarity

Modified residue

374

5-glutamyl glycerylphosphorylethanolamine By similarity

Modified residue

439

N6-acetyllysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P62631 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 31E4F59BC05D8F8C
Show »

FASTA

463

50,454

        10         20         30         40         50         60 
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 

        70         80         90        100        110        120 
DKLKAERERG ITIDISLWKF ETTKYYITII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 

       130        140        150        160        170        180 
GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP AYSEKRYDEI VKEVSAYIKK 

       190        200        210        220        230        240 
IGYNPATVPF VPISGWHGDN MLEPSPNMPW FKGWKVERKE GNASGVSLLE ALDTILPPTR 

       250        260        270        280        290        300 
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG ILRPGMVVTF APVNITTEVK SVEMHHEALS 

       310        320        330        340        350        360 
EALPGDNVGF NVKNVSVKDI RRGNVCGDSK ADPPQEAAQF TSQVIILNHP GQISAGYSPV 

       370        380        390        400        410        420 
IDCHTAHIAC KFAELKEKID RRSGKKLEDN PKSLKSGDAA IVEMVPGKPM CVESFSQYPP 

       430        440        450        460 
LGRFAVRDMR QTVAVGVIKN VEKKSGGAGK VTKSAQKAQK AGK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway." Lee S., Ann D.K., Wang E. Biochem. Biophys. Res. Commun. 203:1371-1377(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[3]	Lubec G., Kang S.U., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 6-30; 85-96; 135-146; 155-165; 248-266 AND 431-439, MASS SPECTROMETRY. Strain: C57BL/6 and OF1. Tissue: Brain and Hippocampus.
[4]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-141, MASS SPECTROMETRY. Tissue: Mast cell.
[5]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-29 AND TYR-141, MASS SPECTROMETRY. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L26479 mRNA. Translation: AAA91870.1. BC018235 mRNA. Translation: AAH18235.1.
IPI	IPI00119667.
PIR	JC2445.
RefSeq	NP_031932.1. NM_007906.2.
UniGene	Mm.2645.
3D structure databases
ProteinModelPortal	P62631.
SMR	P62631. Positions 2-443.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62631. 3 interactions.
MINT	MINT-1676226.
Proteomic databases
PaxDb	P62631.
PRIDE	P62631.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000055990; ENSMUSP00000054556; ENSMUSG00000016349.
GeneID	13628.
KEGG	mmu:13628.
UCSC	uc008olh.1. mouse.
Organism-specific databases
CTD	1917.
MGI	MGI:1096317. Eef1a2.
Phylogenomic databases
eggNOG	COG5256.
GeneTree	ENSGT00670000097815.
HOGENOM	HOG000229291.
HOVERGEN	HBG000179.
InParanoid	P62631.
KO	K03231.
OMA	PVFHCHT.
Gene expression databases
Bgee	P62631.
Genevestigator	P62631.
GermOnline	ENSMUSG00000016349. Mus musculus.
Family and domain databases
InterPro	IPR000795. EF_GTP-bd_dom. IPR027417. P-loop_NTPase. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR004539. Transl_elong_EF1A_euk/arc. IPR004161. Transl_elong_EFTu/EF1A_2. IPR004160. Transl_elong_EFTu/EF1A_C. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF03143. GTP_EFTU_D3. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF50465. Elong_init_C. 1 hit. SSF52540. SSF52540. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00483. EF-1_alpha. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	284308.
SOURCE	Search...

Entry information

Entry name

EF1A2_MOUSE

Accession

Primary (citable) accession number: P62631
Secondary accession number(s): P27706

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 29, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents