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P62631

- EF1A2_MOUSE

UniProt

P62631 - EF1A2_MOUSE

Protein

Elongation factor 1-alpha 2

Gene

Eef1a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 218GTPBy similarity
    Nucleotide bindingi91 – 955GTPBy similarity
    Nucleotide bindingi153 – 1564GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. translation elongation factor activity Source: MGI

    GO - Biological processi

    1. positive regulation of apoptotic process Source: MGI
    2. response to inorganic substance Source: Ensembl
    3. translational elongation Source: MGI

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor 1-alpha 2
    Short name:
    EF-1-alpha-2
    Alternative name(s):
    Eukaryotic elongation factor 1 A-2
    Short name:
    eEF1A-2
    Statin-S1
    Gene namesi
    Name:Eef1a2
    Synonyms:Eef1al, Stn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1096317. Eef1a2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. eukaryotic translation elongation factor 1 complex Source: MGI
    3. neuronal cell body Source: Ensembl
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463Elongation factor 1-alpha 2PRO_0000090892Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei55 – 551N6,N6,N6-trimethyllysineBy similarity
    Modified residuei165 – 1651N6,N6,N6-trimethyllysineBy similarity
    Modified residuei179 – 1791N6-acetyllysineBy similarity
    Modified residuei301 – 30115-glutamyl glycerylphosphorylethanolamineBy similarity
    Modified residuei374 – 37415-glutamyl glycerylphosphorylethanolamineBy similarity
    Modified residuei439 – 4391N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiP62631.
    PaxDbiP62631.
    PRIDEiP62631.

    Expressioni

    Tissue specificityi

    Found in a wide range of tissues.

    Developmental stagei

    The statin expression is specific for nonproliferating cells. Its message is most abundant in G0 phase of 3T3 mouse fibroblasts, but becomes significantly reduced in G1 and S1 phases cells.

    Gene expression databases

    BgeeiP62631.
    GenevestigatoriP62631.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi199386. 11 interactions.
    IntActiP62631. 8 interactions.
    MINTiMINT-1676226.

    Structurei

    3D structure databases

    ProteinModelPortaliP62631.
    SMRiP62631. Positions 2-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 242238tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 218G1By similarity
    Regioni70 – 745G2By similarity
    Regioni91 – 944G3By similarity
    Regioni153 – 1564G4By similarity
    Regioni194 – 1963G5By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5256.
    GeneTreeiENSGT00670000097815.
    HOGENOMiHOG000229291.
    HOVERGENiHBG000179.
    InParanoidiP62631.
    KOiK03231.
    OMAiVACTFES.
    OrthoDBiEOG7NKKK3.
    TreeFamiTF300304.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_A. EF_Tu_A.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004539. Transl_elong_EF1A_euk/arc.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62631-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG    50
    KGSFKYAWVL DKLKAERERG ITIDISLWKF ETTKYYITII DAPGHRDFIK 100
    NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV 150
    GVNKMDSTEP AYSEKRYDEI VKEVSAYIKK IGYNPATVPF VPISGWHGDN 200
    MLEPSPNMPW FKGWKVERKE GNASGVSLLE ALDTILPPTR PTDKPLRLPL 250
    QDVYKIGGIG TVPVGRVETG ILRPGMVVTF APVNITTEVK SVEMHHEALS 300
    EALPGDNVGF NVKNVSVKDI RRGNVCGDSK ADPPQEAAQF TSQVIILNHP 350
    GQISAGYSPV IDCHTAHIAC KFAELKEKID RRSGKKLEDN PKSLKSGDAA 400
    IVEMVPGKPM CVESFSQYPP LGRFAVRDMR QTVAVGVIKN VEKKSGGAGK 450
    VTKSAQKAQK AGK 463
    Length:463
    Mass (Da):50,454
    Last modified:July 19, 2004 - v1
    Checksum:i31E4F59BC05D8F8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26479 mRNA. Translation: AAA91870.1.
    BC018235 mRNA. Translation: AAH18235.1.
    CCDSiCCDS17201.1.
    PIRiJC2445.
    RefSeqiNP_031932.1. NM_007906.2.
    UniGeneiMm.2645.

    Genome annotation databases

    EnsembliENSMUST00000055990; ENSMUSP00000054556; ENSMUSG00000016349.
    GeneIDi13628.
    KEGGimmu:13628.
    UCSCiuc008olh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26479 mRNA. Translation: AAA91870.1 .
    BC018235 mRNA. Translation: AAH18235.1 .
    CCDSi CCDS17201.1.
    PIRi JC2445.
    RefSeqi NP_031932.1. NM_007906.2.
    UniGenei Mm.2645.

    3D structure databases

    ProteinModelPortali P62631.
    SMRi P62631. Positions 2-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199386. 11 interactions.
    IntActi P62631. 8 interactions.
    MINTi MINT-1676226.

    Proteomic databases

    MaxQBi P62631.
    PaxDbi P62631.
    PRIDEi P62631.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055990 ; ENSMUSP00000054556 ; ENSMUSG00000016349 .
    GeneIDi 13628.
    KEGGi mmu:13628.
    UCSCi uc008olh.1. mouse.

    Organism-specific databases

    CTDi 1917.
    MGIi MGI:1096317. Eef1a2.

    Phylogenomic databases

    eggNOGi COG5256.
    GeneTreei ENSGT00670000097815.
    HOGENOMi HOG000229291.
    HOVERGENi HBG000179.
    InParanoidi P62631.
    KOi K03231.
    OMAi VACTFES.
    OrthoDBi EOG7NKKK3.
    TreeFami TF300304.

    Miscellaneous databases

    NextBioi 284308.
    PROi P62631.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62631.
    Genevestigatori P62631.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_A. EF_Tu_A.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004539. Transl_elong_EF1A_euk/arc.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00483. EF-1_alpha. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway."
      Lee S., Ann D.K., Wang E.
      Biochem. Biophys. Res. Commun. 203:1371-1377(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 6-30; 85-96; 135-146; 155-165; 248-266 AND 431-439, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.

    Entry informationi

    Entry nameiEF1A2_MOUSE
    AccessioniPrimary (citable) accession number: P62631
    Secondary accession number(s): P27706
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3