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P62631 (EF1A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor 1-alpha 2

Short name=EF-1-alpha-2
Alternative name(s):
Eukaryotic elongation factor 1 A-2
Short name=eEF1A-2
Statin-S1
Gene names
Name:Eef1a2
Synonyms:Eef1al, Stn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. HAMAP-Rule MF_00118_A

Subunit structure

Monomer.

Subcellular location

Nucleus HAMAP-Rule MF_00118_A.

Tissue specificity

Found in a wide range of tissues.

Developmental stage

The statin expression is specific for nonproliferating cells. Its message is most abundant in G0 phase of 3T3 mouse fibroblasts, but becomes significantly reduced in G1 and S1 phases cells. HAMAP-Rule MF_00118_A

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463Elongation factor 1-alpha 2 HAMAP-Rule MF_00118_A
PRO_0000090892

Regions

Nucleotide binding14 – 218GTP By similarity
Nucleotide binding91 – 955GTP By similarity
Nucleotide binding153 – 1564GTP By similarity

Amino acid modifications

Modified residue551N6,N6,N6-trimethyllysine By similarity
Modified residue1651N6,N6,N6-trimethyllysine By similarity
Modified residue1791N6-acetyllysine By similarity
Modified residue30115-glutamyl glycerylphosphorylethanolamine By similarity
Modified residue37415-glutamyl glycerylphosphorylethanolamine By similarity
Modified residue4391N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62631 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 31E4F59BC05D8F8C

FASTA46350,454
        10         20         30         40         50         60 
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 

        70         80         90        100        110        120 
DKLKAERERG ITIDISLWKF ETTKYYITII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 

       130        140        150        160        170        180 
GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP AYSEKRYDEI VKEVSAYIKK 

       190        200        210        220        230        240 
IGYNPATVPF VPISGWHGDN MLEPSPNMPW FKGWKVERKE GNASGVSLLE ALDTILPPTR 

       250        260        270        280        290        300 
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG ILRPGMVVTF APVNITTEVK SVEMHHEALS 

       310        320        330        340        350        360 
EALPGDNVGF NVKNVSVKDI RRGNVCGDSK ADPPQEAAQF TSQVIILNHP GQISAGYSPV 

       370        380        390        400        410        420 
IDCHTAHIAC KFAELKEKID RRSGKKLEDN PKSLKSGDAA IVEMVPGKPM CVESFSQYPP 

       430        440        450        460 
LGRFAVRDMR QTVAVGVIKN VEKKSGGAGK VTKSAQKAQK AGK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway."
Lee S., Ann D.K., Wang E.
Biochem. Biophys. Res. Commun. 203:1371-1377(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[3]Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 6-30; 85-96; 135-146; 155-165; 248-266 AND 431-439, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6 and OF1.
Tissue: Brain and Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L26479 mRNA. Translation: AAA91870.1.
BC018235 mRNA. Translation: AAH18235.1.
CCDSCCDS17201.1.
PIRJC2445.
RefSeqNP_031932.1. NM_007906.2.
UniGeneMm.2645.

3D structure databases

ProteinModelPortalP62631.
SMRP62631. Positions 2-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199386. 11 interactions.
IntActP62631. 8 interactions.
MINTMINT-1676226.

Proteomic databases

MaxQBP62631.
PaxDbP62631.
PRIDEP62631.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055990; ENSMUSP00000054556; ENSMUSG00000016349.
GeneID13628.
KEGGmmu:13628.
UCSCuc008olh.1. mouse.

Organism-specific databases

CTD1917.
MGIMGI:1096317. Eef1a2.

Phylogenomic databases

eggNOGCOG5256.
GeneTreeENSGT00670000097815.
HOGENOMHOG000229291.
HOVERGENHBG000179.
InParanoidP62631.
KOK03231.
OMAVACTFES.
OrthoDBEOG7NKKK3.
TreeFamTF300304.

Gene expression databases

BgeeP62631.
GenevestigatorP62631.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00118_A. EF_Tu_A.
InterProIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00483. EF-1_alpha. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284308.
PROP62631.
SOURCESearch...

Entry information

Entry nameEF1A2_MOUSE
AccessionPrimary (citable) accession number: P62631
Secondary accession number(s): P27706
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot