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Protein

Dynein light chain roadblock-type 1

Gene

Dynlrb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • retrograde axonal transport Source: UniProtKB
  • visual behavior Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain roadblock-type 1
Alternative name(s):
Bithoraxoid-like protein
Short name:
BLP
Short name:
robl/LC7-like protein
Dynein light chain 2A, cytoplasmic
Dynein-associated protein Km23
Gene namesi
Name:Dynlrb1
Synonyms:Dncl2a, Dnlc2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619910. Dynlrb1.

Subcellular locationi

GO - Cellular componenti

  • axon cytoplasm Source: GOC
  • centrosome Source: Ensembl
  • cytoplasm Source: UniProtKB
  • cytoplasmic dynein complex Source: UniProtKB
  • membrane Source: Ensembl
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 9695Dynein light chain roadblock-type 1PRO_0000220957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP62628.
PRIDEiP62628.

PTM databases

iPTMnetiP62628.

Expressioni

Gene expression databases

GenevisibleiP62628. RN.

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB2. Interacts with RAB6A; the interaction is direct. Interacts with RAB6B (GDP-bound) (By similarity).By similarity

Protein-protein interaction databases

BioGridi250982. 1 interaction.
IntActiP62628. 1 interaction.
MINTiMINT-261129.
STRINGi10116.ENSRNOP00000060800.

Structurei

3D structure databases

ProteinModelPortaliP62628.
SMRiP62628. Positions 2-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4115. Eukaryota.
ENOG4111NDV. LUCA.
GeneTreeiENSGT00390000011067.
HOGENOMiHOG000232033.
HOVERGENiHBG058598.
InParanoidiP62628.
KOiK10419.
OMAiQYAGLMH.
OrthoDBiEOG7X0VKJ.
PhylomeDBiP62628.

Family and domain databases

InterProiIPR016561. DYNLRB1/2.
IPR004942. Roadblock/LAMTOR2_dom.
[Graphical view]
PfamiPF03259. Robl_LC7. 1 hit.
[Graphical view]
PIRSFiPIRSF009998. DLC7. 1 hit.
SMARTiSM00960. Robl_LC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVEETLKR LQSQKGVQGI IVVNTEGIPI KSTMDNPTTT QYANLMHNFI
60 70 80 90
LKARSTVREI DPQNDLTFLR IRSKKNEIMV APDKDYFLIV IQNPTE
Length:96
Mass (Da):10,990
Last modified:January 23, 2007 - v3
Checksum:i666734B413AFE7D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073839 mRNA. Translation: AAC25580.2.
AY026512 mRNA. Translation: AAK18711.1.
BC058437 mRNA. Translation: AAH58437.1.
RefSeqiNP_571985.1. NM_131910.3.
UniGeneiRn.3560.

Genome annotation databases

EnsembliENSRNOT00000067854; ENSRNOP00000060800; ENSRNOG00000025715.
GeneIDi170714.
KEGGirno:170714.
UCSCiRGD:619910. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073839 mRNA. Translation: AAC25580.2.
AY026512 mRNA. Translation: AAK18711.1.
BC058437 mRNA. Translation: AAH58437.1.
RefSeqiNP_571985.1. NM_131910.3.
UniGeneiRn.3560.

3D structure databases

ProteinModelPortaliP62628.
SMRiP62628. Positions 2-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250982. 1 interaction.
IntActiP62628. 1 interaction.
MINTiMINT-261129.
STRINGi10116.ENSRNOP00000060800.

PTM databases

iPTMnetiP62628.

Proteomic databases

PaxDbiP62628.
PRIDEiP62628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067854; ENSRNOP00000060800; ENSRNOG00000025715.
GeneIDi170714.
KEGGirno:170714.
UCSCiRGD:619910. rat.

Organism-specific databases

CTDi83658.
RGDi619910. Dynlrb1.

Phylogenomic databases

eggNOGiKOG4115. Eukaryota.
ENOG4111NDV. LUCA.
GeneTreeiENSGT00390000011067.
HOGENOMiHOG000232033.
HOVERGENiHBG058598.
InParanoidiP62628.
KOiK10419.
OMAiQYAGLMH.
OrthoDBiEOG7X0VKJ.
PhylomeDBiP62628.

Enzyme and pathway databases

ReactomeiR-RNO-5620924. Intraflagellar transport.

Miscellaneous databases

PROiP62628.

Gene expression databases

GenevisibleiP62628. RN.

Family and domain databases

InterProiIPR016561. DYNLRB1/2.
IPR004942. Roadblock/LAMTOR2_dom.
[Graphical view]
PfamiPF03259. Robl_LC7. 1 hit.
[Graphical view]
PIRSFiPIRSF009998. DLC7. 1 hit.
SMARTiSM00960. Robl_LC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Light-induced down-regulation of the rat class 1 dynein-associated protein robl/LC7-like gene in visual cortex."
    Ye F.C., Zangenenhpour S., Chaudhuri A.
    J. Biol. Chem. 275:27172-27176(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Visual cortex.
  2. "Km23: role in growth factor signaling."
    Tang Q., Staub C.M., Mulder K.M.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  4. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 59-70, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  5. Lubec G., Chen W.-Q.
    Submitted (FEB-2007) to UniProtKB
    Cited for: ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiDLRB1_RAT
AccessioniPrimary (citable) accession number: P62628
Secondary accession number(s): O88567, Q9D812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.