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P62594

- BLAT_SALTI

UniProt

P62594 - BLAT_SALTI

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Protein
Beta-lactamase TEM
Gene
bla, HCM1.216
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins By similarity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Acyl-ester intermediate By similarity
Active sitei166 – 1661Proton acceptor By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase TEM (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
Ordered Locus Names:HCM1.216
Encoded oniPlasmid pHCM10 Publication
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Plasmid pHCM1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 286263Beta-lactamase TEM
PRO_0000016979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 121 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP62594.

Interactioni

Protein-protein interaction databases

STRINGi220341.HCM1.216.

Structurei

3D structure databases

ProteinModelPortaliP62594.
SMRiP62594. Positions 24-286.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni232 – 2343Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2367.
HOGENOMiHOG000201073.
KOiK17836.
OMAiMKLIGGP.
OrthoDBiEOG6K9QFS.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62594-1 [UniParc]FASTAAdd to Basket

« Hide

MSIQHFRVAL IPFFAAFCLP VFAHPETLVK VKDAEDQLGA RVGYIELDLN    50
SGKILESFRP EERFPMMSTF KVLLCGAVLS RVDAGQEQLG RRIHYSQNDL 100
VEYSPVTEKH LTDGMTVREL CSAAITMSDN TAANLLLTTI GGPKELTAFL 150
HNMGDHVTRL DRWEPELNEA IPNDERDTTM PAAMATTLRK LLTGELLTLA 200
SRQQLIDWME ADKVAGPLLR SALPAGWFIA DKSGAGERGS RGIIAALGPD 250
GKPSRIVVIY TTGSQATMDE RNRQIAEIGA SLIKHW 286
Length:286
Mass (Da):31,515
Last modified:July 21, 1986 - v1
Checksum:iBB678943BB18934B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513383 Genomic DNA. Translation: CAD09800.1.
RefSeqiNP_569411.1. NC_003384.1.

Genome annotation databases

EnsemblBacteriaiCAD09800; CAD09800; CAD09800.
GeneIDi1251335.
KEGGisty:HCM1.216.
PATRICi18548533. VBISalEnt120419_5236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513383 Genomic DNA. Translation: CAD09800.1 .
RefSeqi NP_569411.1. NC_003384.1.

3D structure databases

ProteinModelPortali P62594.
SMRi P62594. Positions 24-286.
ModBasei Search...

Protein-protein interaction databases

STRINGi 220341.HCM1.216.

Chemistry

BindingDBi P62594.

Proteomic databases

PRIDEi P62594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD09800 ; CAD09800 ; CAD09800 .
GeneIDi 1251335.
KEGGi sty:HCM1.216.
PATRICi 18548533. VBISalEnt120419_5236.

Phylogenomic databases

eggNOGi COG2367.
HOGENOMi HOG000201073.
KOi K17836.
OMAi MKLIGGP.
OrthoDBi EOG6K9QFS.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.

Entry informationi

Entry nameiBLAT_SALTI
AccessioniPrimary (citable) accession number: P62594
Secondary accession number(s): P00810, Q47313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi