Reviewed,
UniProtKB/Swiss-Prot P62594 (BLAT_SALTI)
Last modified
November 3, 2009.
Version 30.
History...
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90%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Beta-lactamase TEM EC=3.5.2.6 Alternative name(s): Penicillinase | ||||
| Gene names |
| ||||
| Encoded on | Plasmid pHCM1 | ||||
| Organism | Salmonella typhi [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 90370 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 286 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins By similarity. |
| Catalytic activity | A beta-lactam + H2O = a substituted beta-amino acid. |
| Sequence similarities | Belongs to the class-A beta-lactamase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Antibiotic resistance |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | Disulfide bond |
| Technical term | Complete proteome Plasmid |
| Gene Ontology (GO) | |
| Biological process | beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibioticInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | beta-lactamase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | By similarity | ||||||||
| Chain | 24 – 286 | 263 | Beta-lactamase TEM | PRO_0000016979 | |||||||
Regions | |||||||||||
| Region | 232 – 234 | 3 | Substrate binding By similarity | ||||||||
Sites | |||||||||||
| Active site | 68 | 1 | Acyl-ester intermediate By similarity | ||||||||
| Active site | 166 | 1 | Proton acceptor By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 75 ↔ 121 | By similarity | |||||||||
Sequences
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References
| [1] | "Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18." Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P. Barrell B.G.Nature 413:848-852(2001) [PubMed: 11677608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT18. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AL513383 Genomic DNA. Translation: CAD09800.1. | |
| RefSeq | NP_569411.1. |
3D structure databases | |
| SMR | P62594. Positions 24-286. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P62594. |
Genome annotation databases | |
| GeneID | 1251335. |
| GenomeReviews | Gene locus HCM1.216 in contig AL513383_GR. |
| KEGG | sty:HCM1.216. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P62594. |
| OMA | RVGDKTG. |
Enzyme and pathway databases | |
| BRENDA | 3.5.2.6. 3716. |
Family and domain databases | |
| InterPro | IPR001466. Beta_lactamase-related. IPR000871. Beta_lactamase_A/D. [Graphical view] |
| Pfam | PF00144. Beta-lactamase. 1 hit. [Graphical view] |
| PRINTS | PR00118. BLACTAMASEA. |
| PROSITE | PS00146. BETA_LACTAMASE_A. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BLAT_SALTI | ||||||||
| Accession | Primary (citable) accession number: P62594 Secondary accession number(s): P00810, Q47313 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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