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P62594 (BLAT_SALTI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase TEM

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
Ordered Locus Names:HCM1.216
Encoded onPlasmid pHCM1
OrganismSalmonella typhi [Complete proteome] [HAMAP]
Taxonomic identifier90370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins By similarity.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 286263Beta-lactamase TEM
PRO_0000016979

Regions

Region232 – 2343Substrate binding By similarity

Sites

Active site681Acyl-ester intermediate By similarity
Active site1661Proton acceptor By similarity

Amino acid modifications

Disulfide bond75 ↔ 121 By similarity

Sequences

Sequence LengthMass (Da)Tools
P62594 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: BB678943BB18934B

FASTA28631,515
        10         20         30         40         50         60 
MSIQHFRVAL IPFFAAFCLP VFAHPETLVK VKDAEDQLGA RVGYIELDLN SGKILESFRP 

        70         80         90        100        110        120 
EERFPMMSTF KVLLCGAVLS RVDAGQEQLG RRIHYSQNDL VEYSPVTEKH LTDGMTVREL 

       130        140        150        160        170        180 
CSAAITMSDN TAANLLLTTI GGPKELTAFL HNMGDHVTRL DRWEPELNEA IPNDERDTTM 

       190        200        210        220        230        240 
PAAMATTLRK LLTGELLTLA SRQQLIDWME ADKVAGPLLR SALPAGWFIA DKSGAGERGS 

       250        260        270        280 
RGIIAALGPD GKPSRIVVIY TTGSQATMDE RNRQIAEIGA SLIKHW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL513383 Genomic DNA. Translation: CAD09800.1.
RefSeqNP_569411.1. NC_003384.1.

3D structure databases

ProteinModelPortalP62594.
SMRP62594. Positions 24-286.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220341.HCM1.216.

Chemistry

BindingDBP62594.

Proteomic databases

PRIDEP62594.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD09800; CAD09800; CAD09800.
GeneID1251335.
PATRIC18548533. VBISalEnt120419_5236.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2367.
HOGENOMHOG000201073.
KOK17836.
OMAAVIWPPD.
OrthoDBEOG6K9QFS.
ProtClustDBPRK15442.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAT_SALTI
AccessionPrimary (citable) accession number: P62594
Secondary accession number(s): P00810, Q47313
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families