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P62576

- NANA_STRR6

UniProt

P62576 - NANA_STRR6

Protein

Sialidase A

Gene

nanA

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei347 – 3471SubstrateBy similarity
    Active sitei372 – 3721Proton acceptorBy similarity
    Active sitei647 – 6471By similarity
    Binding sitei663 – 6631SubstrateBy similarity

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciSPNE171101:GJC8-1550-MONOMER.

    Protein family/group databases

    CAZyiCBM40. Carbohydrate-Binding Module Family 40.
    GH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialidase A (EC:3.2.1.18)
    Alternative name(s):
    Neuraminidase A
    Gene namesi
    Name:nanA
    Ordered Locus Names:spr1536
    OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
    Taxonomic identifieri171101 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000586: Chromosome

    Subcellular locationi

    Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5353Sequence AnalysisAdd
    BLAST
    Chaini54 – 1006953Sialidase APRO_0000012036Add
    BLAST
    Propeptidei1007 – 103529Removed by sortasePROSITE-ProRule annotationPRO_0000012037Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1006 – 10061Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

    Keywords - PTMi

    Peptidoglycan-anchor

    Interactioni

    Protein-protein interaction databases

    STRINGi171101.spr1536.

    Structurei

    Secondary structure

    1
    1035
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi327 – 3304
    Beta strandi345 – 3539
    Beta strandi359 – 36810
    Beta strandi370 – 38516
    Beta strandi394 – 3974
    Helixi408 – 4103
    Beta strandi414 – 4229
    Turni424 – 4263
    Beta strandi429 – 4368
    Beta strandi438 – 4403
    Helixi441 – 4444
    Beta strandi453 – 4564
    Beta strandi459 – 4668
    Beta strandi473 – 4753
    Helixi477 – 4793
    Beta strandi480 – 4823
    Beta strandi488 – 4936
    Helixi500 – 5023
    Turni503 – 5064
    Beta strandi507 – 5104
    Beta strandi513 – 5175
    Beta strandi525 – 5295
    Beta strandi535 – 5439
    Helixi555 – 5584
    Beta strandi566 – 5683
    Beta strandi570 – 5723
    Turni580 – 5834
    Beta strandi585 – 5917
    Turni594 – 5963
    Helixi597 – 6004
    Beta strandi603 – 6119
    Turni622 – 6254
    Beta strandi626 – 6283
    Beta strandi631 – 6333
    Turni635 – 6373
    Helixi641 – 6433
    Beta strandi647 – 6526
    Beta strandi658 – 6625
    Beta strandi665 – 68016
    Beta strandi686 – 6927
    Beta strandi699 – 7057
    Beta strandi708 – 7169
    Beta strandi718 – 73114
    Beta strandi733 – 7353
    Beta strandi737 – 74913
    Beta strandi753 – 7597
    Beta strandi762 – 7698
    Beta strandi778 – 7858
    Helixi786 – 7894

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2W20X-ray1.49A/B321-791[»]
    3H71X-ray1.70A/B317-793[»]
    3H72X-ray1.70A/B317-793[»]
    3H73X-ray1.70A/B317-793[»]
    ProteinModelPortaliP62576.
    SMRiP62576. Positions 322-791.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP62576.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati381 – 39212BNR 1Add
    BLAST
    Repeati539 – 55012BNR 2Add
    BLAST
    Repeati607 – 61812BNR 3Add
    BLAST
    Repeati672 – 68312BNR 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1003 – 10075LPXTG sorting signalPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated
    Contains 4 BNR repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4409.
    HOGENOMiHOG000284737.
    KOiK01186.
    OMAiGGPKREN.
    OrthoDBiEOG61CM2G.

    Family and domain databases

    Gene3Di2.120.10.10. 2 hits.
    2.60.120.200. 1 hit.
    InterProiIPR002860. BNR_rpt.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR004124. Glyco_hydro_33_N.
    IPR001791. Laminin_G.
    IPR019931. LPXTG_anchor.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    IPR005877. YSIRK_signal_dom.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PfamiPF02012. BNR. 1 hit.
    PF02973. Sialidase. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view]
    SMARTiSM00282. LamG. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 2 hits.
    TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62576-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYFRNRDID IERNSMNRSV QERKCRYSIR KLSVGAVSMI VGAVVFGTSP     50
    VLAQEGASEQ PLANETQLSG ESSTLTDTEK SQPSSETELS GNKQEQERKD 100
    KQEEKIPRDY YARDLENVET VIEKEDVETN ASNGQRVDLS SELDKLKKLE 150
    NATVHMEFKP DAKAPAFYNL FSVSSATKKD EYFTMAVYNN TATLEGRGSD 200
    GKQFYNNYND APLKVKPGQW NSVTFTVEKP TAELPKGRVR LYVNGVLSRT 250
    SLRSGNFIKD MPDVTHVQIG ATKRANNTVW GSNLQIRNLT VYNRALTPEE 300
    VQKRSQLFKR SDLEKKLPEG AALTEKTDIF ESGRNGKPNK DGIKSYRIPA 350
    LLKTDKGTLI AGADERRLHS SDWGDIGMVI RRSEDNGKTW GDRVTITNLR 400
    DNPKASDPSI GSPVNIDMVL VQDPETKRIF SIYDMFPEGK GIFGMSSQKE 450
    EAYKKIDGKT YQILYREGEK GAYTIRENGT VYTPDGKATD YRVVVDPVKP 500
    AYSDKGDLYK GNQLLGNIYF TTNKTSPFRI AKDSYLWMSY SDDDGKTWSA 550
    PQDITPMVKA DWMKFLGVGP GTGIVLRNGP HKGRILIPVY TTNNVSHLNG 600
    SQSSRIIYSD DHGKTWHAGE AVNDNRQVDG QKIHSSTMNN RRAQNTESTV 650
    VQLNNGDVKL FMRGLTGDLQ VATSKDGGVT WEKDIKRYPQ VKDVYVQMSA 700
    IHTMHEGKEY IILSNAGGPK RENGMVHLAR VEENGELTWL KHNPIQKGEF 750
    AYNSLQELGN GEYGILYEHT EKGQNAYTLS FRKFNWDFLS KDLISPTEAK 800
    VKRTREMGKG VIGLEFDSEV LVNKAPTLQL ANGKTARFMT QYDTKTLLFT 850
    VDSEDMGQKV TGLAEGAIES MHNLPVSVAG TKLSNGMNGS EAAVHEVPEY 900
    TGPLGTSGEE PAPTVEKPEY TGPLGTSGEE PAPTVEKPEY TGPLGTAGEE 950
    AAPTVEKPEF TGGVNGTEPA VHEIAEYKGS DSLVTLTTKE DYTYKAPLAQ 1000
    QALPETGNKE SDLLASLGLT AFFLGLFTLG KKREQ 1035
    Length:1,035
    Mass (Da):114,742
    Last modified:July 19, 2004 - v1
    Checksum:iC5B8A2D7A12E12F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAL00340.1.
    PIRiG98063.
    RefSeqiNP_359129.1. NC_003098.1.
    WP_010976603.1. NC_003098.1.

    Genome annotation databases

    EnsemblBacteriaiAAL00340; AAL00340; spr1536.
    GeneIDi933902.
    KEGGispr:spr1536.
    PATRICi19703087. VBIStrPne107296_1657.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAL00340.1 .
    PIRi G98063.
    RefSeqi NP_359129.1. NC_003098.1.
    WP_010976603.1. NC_003098.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2W20 X-ray 1.49 A/B 321-791 [» ]
    3H71 X-ray 1.70 A/B 317-793 [» ]
    3H72 X-ray 1.70 A/B 317-793 [» ]
    3H73 X-ray 1.70 A/B 317-793 [» ]
    ProteinModelPortali P62576.
    SMRi P62576. Positions 322-791.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 171101.spr1536.

    Protein family/group databases

    CAZyi CBM40. Carbohydrate-Binding Module Family 40.
    GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL00340 ; AAL00340 ; spr1536 .
    GeneIDi 933902.
    KEGGi spr:spr1536.
    PATRICi 19703087. VBIStrPne107296_1657.

    Phylogenomic databases

    eggNOGi COG4409.
    HOGENOMi HOG000284737.
    KOi K01186.
    OMAi GGPKREN.
    OrthoDBi EOG61CM2G.

    Enzyme and pathway databases

    BioCyci SPNE171101:GJC8-1550-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P62576.

    Family and domain databases

    Gene3Di 2.120.10.10. 2 hits.
    2.60.120.200. 1 hit.
    InterProi IPR002860. BNR_rpt.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR004124. Glyco_hydro_33_N.
    IPR001791. Laminin_G.
    IPR019931. LPXTG_anchor.
    IPR026856. Sialidase_fam.
    IPR011040. Sialidases.
    IPR005877. YSIRK_signal_dom.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    Pfami PF02012. BNR. 1 hit.
    PF02973. Sialidase. 1 hit.
    PF04650. YSIRK_signal. 1 hit.
    [Graphical view ]
    SMARTi SM00282. LamG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 2 hits.
    TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-255 / R6.

    Entry informationi

    Entry nameiNANA_STRR6
    AccessioniPrimary (citable) accession number: P62576
    Secondary accession number(s): Q54722, Q59959
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3