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P62521

- CCDC8_RAT

UniProt

P62521 - CCDC8_RAT

Protein

Coiled-coil domain-containing protein 8

Gene

Ccdc8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome By similarity.By similarity

    GO - Biological processi

    1. microtubule cytoskeleton organization Source: UniProtKB
    2. negative regulation of phosphatase activity Source: UniProtKB
    3. regulation of mitosis Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 8
    Gene namesi
    Name:Ccdc8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1359717. Ccdc8.

    Subcellular locationi

    GO - Cellular componenti

    1. 3M complex Source: UniProtKB
    2. centrosome Source: UniProtKB
    3. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 643643Coiled-coil domain-containing protein 8PRO_0000089402Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei141 – 1411PhosphoserineBy similarity
    Modified residuei144 – 1441PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP62521.

    Expressioni

    Gene expression databases

    GenevestigatoriP62521.

    Interactioni

    Subunit structurei

    Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Interacts with OBSL1 By similarity.By similarity

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi294 – 508215Ala-richAdd
    BLAST

    Phylogenomic databases

    HOVERGENiHBG050825.
    InParanoidiP62521.
    KOiK17561.
    PhylomeDBiP62521.

    Family and domain databases

    InterProiIPR026526. Coiled-coil_p8.
    IPR026523. PNMA.
    [Graphical view]
    PANTHERiPTHR23095. PTHR23095. 1 hit.
    PTHR23095:SF2. PTHR23095:SF2. 1 hit.
    PfamiPF14893. PNMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62521-1 [UniParc]FASTAAdd to Basket

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    MLQIGEDVDY LLIPREVRLA GGVWRVISKP ATKEAVFRER LIQFLQEEGR    50
    TLEDVARIIE KSTPHPPQPP KKAKVPRVRR VPQMVTPPLR LVVGTYDSSN 100
    GSDSELSDFD TSKVKGNRGS GKTRKVRKMP VSYLGSKFLG SDESEDDQEL 150
    VEAFLRRGEK KPSAPPPRRR VNLPVPMFEN NLGPQPSKGD RWREYVSQVS 200
    WGKLKQRVRG WAPRSGSEVG QAQQSSIAER AGEMRHSHTS PDLDDSSRNT 250
    GDLSDQTLIT RRWKPKIKWV SLRRCRKEQV PPLAHGTAEE PPEAAENQGA 300
    GAAAEHGVEA AASQRPEAAA SPRAEAAANP RAEATANPRA EAAANPRAEA 350
    AASPRAEAAA NPRAEAAANP RAEATANPRA EAAANPRAEA TANPRAEAAV 400
    NPRTEAAVNP RTEAAANPRA EAAVNPRAEA TASPRAEAEV NQKTEATASP 450
    RAETAASPRV EAAASLRVEA AASPRAEATV SPRAEAVATP RAETAASARV 500
    EAAANLRAGV LPDQRAEAID SQRAEGPVNQ STGATENQRV EVLADQRAGV 550
    LHDQREEAGP QAILEASADS GSRARKQVKT VRFQTPGRFS WFHMRRKAFW 600
    HTPRLPTLPK RGPRAGAGEA RSLRVLRADT RADMEHREQE EQL 643
    Length:643
    Mass (Da):69,589
    Last modified:July 19, 2004 - v1
    Checksum:i0028464DAE8E9632
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060520 mRNA. Translation: AAH60520.1.
    RefSeqiNP_001009533.2. NM_001009533.2.
    UniGeneiRn.145404.

    Genome annotation databases

    GeneIDi494320.
    KEGGirno:494320.
    UCSCiRGD:1359717. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060520 mRNA. Translation: AAH60520.1 .
    RefSeqi NP_001009533.2. NM_001009533.2.
    UniGenei Rn.145404.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P62521.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 494320.
    KEGGi rno:494320.
    UCSCi RGD:1359717. rat.

    Organism-specific databases

    CTDi 83987.
    RGDi 1359717. Ccdc8.

    Phylogenomic databases

    HOVERGENi HBG050825.
    InParanoidi P62521.
    KOi K17561.
    PhylomeDBi P62521.

    Miscellaneous databases

    NextBioi 697591.

    Gene expression databases

    Genevestigatori P62521.

    Family and domain databases

    InterProi IPR026526. Coiled-coil_p8.
    IPR026523. PNMA.
    [Graphical view ]
    PANTHERi PTHR23095. PTHR23095. 1 hit.
    PTHR23095:SF2. PTHR23095:SF2. 1 hit.
    Pfami PF14893. PNMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiCCDC8_RAT
    AccessioniPrimary (citable) accession number: P62521
    Secondary accession number(s): Q6P9Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Despite its name, does not contain a coiled coil domain.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3