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Protein

Coiled-coil domain-containing protein 8

Gene

Ccdc8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome (By similarity).By similarity

GO - Biological processi

  1. microtubule cytoskeleton organization Source: UniProtKB
  2. negative regulation of phosphatase activity Source: UniProtKB
  3. regulation of mitotic nuclear division Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 8
Gene namesi
Name:Ccdc8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359717. Ccdc8.

Subcellular locationi

GO - Cellular componenti

  1. 3M complex Source: UniProtKB
  2. centrosome Source: UniProtKB
  3. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Coiled-coil domain-containing protein 8PRO_0000089402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411PhosphoserineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP62521.

Expressioni

Gene expression databases

GenevestigatoriP62521.

Interactioni

Subunit structurei

Component of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. Interacts with OBSL1 (By similarity).By similarity

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 508215Ala-richAdd
BLAST

Phylogenomic databases

HOVERGENiHBG050825.
InParanoidiP62521.
KOiK17561.
PhylomeDBiP62521.

Family and domain databases

InterProiIPR026526. Coiled-coil_p8.
IPR026523. PNMA.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF2. PTHR23095:SF2. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQIGEDVDY LLIPREVRLA GGVWRVISKP ATKEAVFRER LIQFLQEEGR
60 70 80 90 100
TLEDVARIIE KSTPHPPQPP KKAKVPRVRR VPQMVTPPLR LVVGTYDSSN
110 120 130 140 150
GSDSELSDFD TSKVKGNRGS GKTRKVRKMP VSYLGSKFLG SDESEDDQEL
160 170 180 190 200
VEAFLRRGEK KPSAPPPRRR VNLPVPMFEN NLGPQPSKGD RWREYVSQVS
210 220 230 240 250
WGKLKQRVRG WAPRSGSEVG QAQQSSIAER AGEMRHSHTS PDLDDSSRNT
260 270 280 290 300
GDLSDQTLIT RRWKPKIKWV SLRRCRKEQV PPLAHGTAEE PPEAAENQGA
310 320 330 340 350
GAAAEHGVEA AASQRPEAAA SPRAEAAANP RAEATANPRA EAAANPRAEA
360 370 380 390 400
AASPRAEAAA NPRAEAAANP RAEATANPRA EAAANPRAEA TANPRAEAAV
410 420 430 440 450
NPRTEAAVNP RTEAAANPRA EAAVNPRAEA TASPRAEAEV NQKTEATASP
460 470 480 490 500
RAETAASPRV EAAASLRVEA AASPRAEATV SPRAEAVATP RAETAASARV
510 520 530 540 550
EAAANLRAGV LPDQRAEAID SQRAEGPVNQ STGATENQRV EVLADQRAGV
560 570 580 590 600
LHDQREEAGP QAILEASADS GSRARKQVKT VRFQTPGRFS WFHMRRKAFW
610 620 630 640
HTPRLPTLPK RGPRAGAGEA RSLRVLRADT RADMEHREQE EQL
Length:643
Mass (Da):69,589
Last modified:July 18, 2004 - v1
Checksum:i0028464DAE8E9632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060520 mRNA. Translation: AAH60520.1.
RefSeqiNP_001009533.2. NM_001009533.2.
UniGeneiRn.145404.

Genome annotation databases

GeneIDi494320.
KEGGirno:494320.
UCSCiRGD:1359717. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060520 mRNA. Translation: AAH60520.1.
RefSeqiNP_001009533.2. NM_001009533.2.
UniGeneiRn.145404.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP62521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi494320.
KEGGirno:494320.
UCSCiRGD:1359717. rat.

Organism-specific databases

CTDi83987.
RGDi1359717. Ccdc8.

Phylogenomic databases

HOVERGENiHBG050825.
InParanoidiP62521.
KOiK17561.
PhylomeDBiP62521.

Miscellaneous databases

NextBioi697591.

Gene expression databases

GenevestigatoriP62521.

Family and domain databases

InterProiIPR026526. Coiled-coil_p8.
IPR026523. PNMA.
[Graphical view]
PANTHERiPTHR23095. PTHR23095. 1 hit.
PTHR23095:SF2. PTHR23095:SF2. 1 hit.
PfamiPF14893. PNMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiCCDC8_RAT
AccessioniPrimary (citable) accession number: P62521
Secondary accession number(s): Q6P9Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 18, 2004
Last sequence update: July 18, 2004
Last modified: March 31, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Despite its name, does not contain a coiled coil domain.

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.