ID PO3F4_RAT Reviewed; 361 AA. AC P62516; P25216; DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot. DT 19-JUL-2004, sequence version 1. DT 24-JAN-2024, entry version 137. DE RecName: Full=POU domain, class 3, transcription factor 4; DE AltName: Full=Brain-specific homeobox/POU domain protein 4; DE Short=Brain-4; DE Short=Brn-4; DE AltName: Full=Octamer-binding protein 9; DE Short=Oct-9; DE AltName: Full=Octamer-binding transcription factor 9; DE Short=OTF-9; DE AltName: Full=RHS2 class III POU protein; GN Name=Pou3f4; Synonyms=Brn-4, Brn4, Otf9; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; RX PubMed=1628619; DOI=10.1002/j.1460-2075.1992.tb05320.x; RA Mathis J.M., Simmons D.M., He X., Swanson L.W., Rosenfeld M.G.; RT "Brain 4: a novel mammalian POU domain transcription factor exhibiting RT restricted brain-specific expression."; RL EMBO J. 11:2551-2561(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=1348858; DOI=10.1073/pnas.89.8.3285; RA le Moine C., Young W.S.; RT "RHS2, a POU domain-containing gene, and its expression in developing and RT adult rat."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3285-3289(1992). CC -!- FUNCTION: Probable transcription factor which exert its primary action CC widely during early neural development and in a very limited set of CC neurons in the mature brain. CC -!- SUBUNIT: Interacts with HNRNPU. {ECO:0000250|UniProtKB:P49335}. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- TISSUE SPECIFICITY: Brain specific. CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z11834; CAA77855.1; -; mRNA. DR EMBL; M84645; AAA42042.1; -; mRNA. DR PIR; A44144; A44144. DR RefSeq; NP_058948.1; NM_017252.2. DR AlphaFoldDB; P62516; -. DR SMR; P62516; -. DR BioGRID; 248222; 5. DR STRING; 10116.ENSRNOP00000003724; -. DR iPTMnet; P62516; -. DR PhosphoSitePlus; P62516; -. DR PaxDb; 10116-ENSRNOP00000003724; -. DR Ensembl; ENSRNOT00000003724.7; ENSRNOP00000003724.4; ENSRNOG00000002784.7. DR Ensembl; ENSRNOT00055048040; ENSRNOP00055039545; ENSRNOG00055027746. DR Ensembl; ENSRNOT00060044014; ENSRNOP00060036517; ENSRNOG00060025440. DR Ensembl; ENSRNOT00065046047; ENSRNOP00065037781; ENSRNOG00065026685. DR GeneID; 29589; -. DR KEGG; rno:29589; -. DR UCSC; RGD:61947; rat. DR AGR; RGD:61947; -. DR CTD; 5456; -. DR RGD; 61947; Pou3f4. DR eggNOG; KOG3802; Eukaryota. DR GeneTree; ENSGT00940000161429; -. DR HOGENOM; CLU_013065_1_2_1; -. DR InParanoid; P62516; -. DR OMA; QHEVYSH; -. DR OrthoDB; 4250502at2759; -. DR PhylomeDB; P62516; -. DR TreeFam; TF316413; -. DR PRO; PR:P62516; -. DR Proteomes; UP000002494; Chromosome X. DR Bgee; ENSRNOG00000002784; Expressed in frontal cortex and 1 other cell type or tissue. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0003690; F:double-stranded DNA binding; IDA:RGD. DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IDA:RGD. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD. DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD. DR GO; GO:0090103; P:cochlea morphogenesis; ISS:UniProtKB. DR GO; GO:0021879; P:forebrain neuron differentiation; ISO:RGD. DR GO; GO:0048839; P:inner ear development; ISO:RGD. DR GO; GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; ISS:UniProtKB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0007605; P:sensory perception of sound; ISO:RGD. DR GO; GO:0006366; P:transcription by RNA polymerase II; IDA:RGD. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf. DR InterPro; IPR013847; POU. DR InterPro; IPR000327; POU_dom. DR InterPro; IPR016362; TF_POU_3. DR PANTHER; PTHR11636; POU DOMAIN; 1. DR PANTHER; PTHR11636:SF83; POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 4; 1. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00157; Pou; 1. DR PIRSF; PIRSF002629; Transcription_factor_POU; 1. DR PRINTS; PR00028; POUDOMAIN. DR SMART; SM00389; HOX; 1. DR SMART; SM00352; POU; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00035; POU_1; 1. DR PROSITE; PS00465; POU_2; 1. DR PROSITE; PS51179; POU_3; 1. DR Genevisible; P62516; RN. PE 2: Evidence at transcript level; KW DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome; KW Transcription; Transcription regulation. FT CHAIN 1..361 FT /note="POU domain, class 3, transcription factor 4" FT /id="PRO_0000100735" FT DOMAIN 186..260 FT /note="POU-specific" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530" FT DNA_BIND 278..337 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 99..131 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 144..192 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 334..361 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 110..131 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 167..192 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 265 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P20265" SQ SEQUENCE 361 AA; 39417 MW; EA1D32DAA168D0BF CRC64; MATAASNPYS ILSSSSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP NSSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASTQ SLHPVLREPP DHGELGSHHC QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDASCHD L //