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P62516

- PO3F4_RAT

UniProt

P62516 - PO3F4_RAT

Protein

POU domain, class 3, transcription factor 4

Gene

Pou3f4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi278 – 33760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. AT DNA binding Source: RGD
    2. double-stranded DNA binding Source: RGD
    3. sequence-specific DNA binding transcription factor activity Source: RGD

    GO - Biological processi

    1. cochlea morphogenesis Source: UniProtKB
    2. forebrain neuron differentiation Source: Ensembl
    3. negative regulation of mesenchymal cell apoptotic process Source: UniProtKB
    4. sensory perception of sound Source: Ensembl
    5. transcription from RNA polymerase II promoter Source: RGD

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 4
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 4
    Short name:
    Brain-4
    Short name:
    Brn-4
    Octamer-binding protein 9
    Short name:
    Oct-9
    Octamer-binding transcription factor 9
    Short name:
    OTF-9
    RHS2 class III POU protein
    Gene namesi
    Name:Pou3f4
    Synonyms:Brn-4, Brn4, Otf9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi61947. Pou3f4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361POU domain, class 3, transcription factor 4PRO_0000100735Add
    BLAST

    Proteomic databases

    PaxDbiP62516.

    Expressioni

    Tissue specificityi

    Brain specific.

    Gene expression databases

    GenevestigatoriP62516.

    Structurei

    3D structure databases

    ProteinModelPortaliP62516.
    SMRiP62516. Positions 189-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini186 – 26075POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    GeneTreeiENSGT00730000110809.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiP62516.
    KOiK09365.
    OMAiMQPASPY.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiP62516.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62516-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAASNPYS ILSSSSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG    50
    HPLGHHWVTS LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH 100
    VAHHSPHTNH PNAWGASPAP NSSITSSGQP LNVYSQPGFT VSGMLEHGGL 150
    TPPPAAASTQ SLHPVLREPP DHGELGSHHC QDHSDEETPT SDELEQFAKQ 200
    FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL SFKNMCKLKP 250
    LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 300
    PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH 350
    TVKTDASCHD L 361
    Length:361
    Mass (Da):39,417
    Last modified:July 19, 2004 - v1
    Checksum:iEA1D32DAA168D0BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11834 mRNA. Translation: CAA77855.1.
    M84645 mRNA. Translation: AAA42042.1.
    PIRiA44144.
    RefSeqiNP_058948.1. NM_017252.2.
    UniGeneiRn.33030.

    Genome annotation databases

    EnsembliENSRNOT00000003724; ENSRNOP00000003724; ENSRNOG00000002784.
    GeneIDi29589.
    KEGGirno:29589.
    UCSCiRGD:61947. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11834 mRNA. Translation: CAA77855.1 .
    M84645 mRNA. Translation: AAA42042.1 .
    PIRi A44144.
    RefSeqi NP_058948.1. NM_017252.2.
    UniGenei Rn.33030.

    3D structure databases

    ProteinModelPortali P62516.
    SMRi P62516. Positions 189-338.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P62516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003724 ; ENSRNOP00000003724 ; ENSRNOG00000002784 .
    GeneIDi 29589.
    KEGGi rno:29589.
    UCSCi RGD:61947. rat.

    Organism-specific databases

    CTDi 5456.
    RGDi 61947. Pou3f4.

    Phylogenomic databases

    eggNOGi NOG261729.
    GeneTreei ENSGT00730000110809.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi P62516.
    KOi K09365.
    OMAi MQPASPY.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi P62516.
    TreeFami TF316413.

    Miscellaneous databases

    NextBioi 295394.
    PROi P62516.

    Gene expression databases

    Genevestigatori P62516.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression."
      Mathis J.M., Simmons D.M., He X., Swanson L.W., Rosenfeld M.G.
      EMBO J. 11:2551-2561(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "RHS2, a POU domain-containing gene, and its expression in developing and adult rat."
      le Moine C., Young W.S.
      Proc. Natl. Acad. Sci. U.S.A. 89:3285-3289(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPO3F4_RAT
    AccessioniPrimary (citable) accession number: P62516
    Secondary accession number(s): P25216
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3