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P62515 (PO3F4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 4
Alternative name(s):
Brain-specific homeobox/POU domain protein 4
Short name=Brain-4
Short name=Brn-4
Octamer-binding protein 9
Short name=Oct-9
Octamer-binding transcription factor 9
Short name=OTF-9
Gene names
Name:Pou3f4
Synonyms:Brn-4, Brn4, Otf9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.

Subcellular location

Nucleus.

Tissue specificity

Brain specific.

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361POU domain, class 3, transcription factor 4
PRO_0000100734

Regions

Domain186 – 26075POU-specific
DNA binding278 – 33760Homeobox

Sequences

Sequence LengthMass (Da)Tools
P62515 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: EA1D32DAA168D0BF

FASTA36139,417
        10         20         30         40         50         60 
MATAASNPYS ILSSSSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS 

        70         80         90        100        110        120 
LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP 

       130        140        150        160        170        180 
NSSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASTQ SLHPVLREPP DHGELGSHHC 

       190        200        210        220        230        240 
QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL 

       250        260        270        280        290        300 
SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 

       310        320        330        340        350        360 
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDASCHD 


L 

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References

[1]"Structure and evolution of four POU domain genes expressed in mouse brain."
Hara Y., Rovescalli C., Kim Y., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M88301 Genomic DNA. Translation: AAA39962.1.
PIRS31225.
RefSeqNP_032927.1. NM_008901.1.
UniGeneMm.405149.
Mm.56946.

3D structure databases

ProteinModelPortalP62515.
SMRP62515. Positions 189-338.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202308. 1 interaction.

PTM databases

PhosphoSiteP62515.

Proteomic databases

PRIDEP62515.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000078229; ENSMUSP00000077354; ENSMUSG00000056854.
GeneID18994.
KEGGmmu:18994.
UCSCuc009ucv.1. mouse.

Organism-specific databases

CTD5456.
MGIMGI:101894. Pou3f4.

Phylogenomic databases

eggNOGNOG261729.
GeneTreeENSGT00730000110809.
HOGENOMHOG000116303.
HOVERGENHBG053120.
InParanoidP62515.
KOK09365.
OMAMQPASPY.
OrthoDBEOG7DJSMG.
PhylomeDBP62515.
TreeFamTF316413.

Gene expression databases

BgeeP62515.
CleanExMM_POU3F4.
GenevestigatorP62515.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295394.
PROP62515.
SOURCESearch...

Entry information

Entry namePO3F4_MOUSE
AccessionPrimary (citable) accession number: P62515
Secondary accession number(s): P25216
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot