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P62515

- PO3F4_MOUSE

UniProt

P62515 - PO3F4_MOUSE

Protein

POU domain, class 3, transcription factor 4

Gene

Pou3f4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi278 – 33760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. AT DNA binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. cochlea morphogenesis Source: UniProtKB
    2. forebrain neuron differentiation Source: MGI
    3. inner ear development Source: MGI
    4. negative regulation of mesenchymal cell apoptotic process Source: UniProtKB
    5. sensory perception of sound Source: MGI
    6. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 4
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 4
    Short name:
    Brain-4
    Short name:
    Brn-4
    Octamer-binding protein 9
    Short name:
    Oct-9
    Octamer-binding transcription factor 9
    Short name:
    OTF-9
    Gene namesi
    Name:Pou3f4
    Synonyms:Brn-4, Brn4, Otf9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:101894. Pou3f4.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: MGI
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361POU domain, class 3, transcription factor 4PRO_0000100734Add
    BLAST

    Proteomic databases

    PRIDEiP62515.

    PTM databases

    PhosphoSiteiP62515.

    Expressioni

    Tissue specificityi

    Brain specific.

    Gene expression databases

    BgeeiP62515.
    CleanExiMM_POU3F4.
    GenevestigatoriP62515.

    Interactioni

    Protein-protein interaction databases

    BioGridi202308. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP62515.
    SMRiP62515. Positions 189-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini186 – 26075POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    GeneTreeiENSGT00730000110809.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiP62515.
    KOiK09365.
    OMAiMQPASPY.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiP62515.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62515-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAASNPYS ILSSSSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG    50
    HPLGHHWVTS LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH 100
    VAHHSPHTNH PNAWGASPAP NSSITSSGQP LNVYSQPGFT VSGMLEHGGL 150
    TPPPAAASTQ SLHPVLREPP DHGELGSHHC QDHSDEETPT SDELEQFAKQ 200
    FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL SFKNMCKLKP 250
    LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 300
    PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH 350
    TVKTDASCHD L 361
    Length:361
    Mass (Da):39,417
    Last modified:July 19, 2004 - v1
    Checksum:iEA1D32DAA168D0BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88301 Genomic DNA. Translation: AAA39962.1.
    CCDSiCCDS30355.1.
    PIRiS31225.
    RefSeqiNP_032927.1. NM_008901.1.
    UniGeneiMm.405149.
    Mm.56946.

    Genome annotation databases

    EnsembliENSMUST00000078229; ENSMUSP00000077354; ENSMUSG00000056854.
    GeneIDi18994.
    KEGGimmu:18994.
    UCSCiuc009ucv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88301 Genomic DNA. Translation: AAA39962.1 .
    CCDSi CCDS30355.1.
    PIRi S31225.
    RefSeqi NP_032927.1. NM_008901.1.
    UniGenei Mm.405149.
    Mm.56946.

    3D structure databases

    ProteinModelPortali P62515.
    SMRi P62515. Positions 189-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202308. 1 interaction.

    PTM databases

    PhosphoSitei P62515.

    Proteomic databases

    PRIDEi P62515.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078229 ; ENSMUSP00000077354 ; ENSMUSG00000056854 .
    GeneIDi 18994.
    KEGGi mmu:18994.
    UCSCi uc009ucv.1. mouse.

    Organism-specific databases

    CTDi 5456.
    MGIi MGI:101894. Pou3f4.

    Phylogenomic databases

    eggNOGi NOG261729.
    GeneTreei ENSGT00730000110809.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi P62515.
    KOi K09365.
    OMAi MQPASPY.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi P62515.
    TreeFami TF316413.

    Miscellaneous databases

    NextBioi 295394.
    PROi P62515.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62515.
    CleanExi MM_POU3F4.
    Genevestigatori P62515.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and evolution of four POU domain genes expressed in mouse brain."
      Hara Y., Rovescalli C., Kim Y., Nirenberg M.
      Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPO3F4_MOUSE
    AccessioniPrimary (citable) accession number: P62515
    Secondary accession number(s): P25216
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3