Reviewed, UniProtKB/Swiss-Prot P62515 (PO3F4_MOUSE)

Names and origin

Protein names

Recommended name:
    POU domain, class 3, transcription factor 4
Alternative name(s):
    Brain-specific homeobox/POU domain protein 4
      Short name=Brain-4
      Short name=Brn-4

Gene names

Name:	Pou3f4
Synonyms:	Brn-4, Brn4, Otf9

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.
Subcellular location	Nucleus.
Tissue specificity	Brain specific.
Sequence similarities	Belongs to the POU transcription factor family. Class-3 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	forebrain neuron differentiation Inferred from mutant phenotype. Source: MGI inner ear development Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of sound Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: MGI transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	POU domain, class 3, transcription factor 4		PRO_0000100734
Regions
	Domain	186 – 260	75	POU-specific
	DNA binding	278 – 337	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	P62515-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: EA1D32DAA168D0BF	FASTA	361	39,417
	10 20 30 40 50 60 MATAASNPYS ILSSSSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS 70 80 90 100 110 120 LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP 130 140 150 160 170 180 NSSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASTQ SLHPVLREPP DHGELGSHHC 190 200 210 220 230 240 QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL 250 260 270 280 290 300 SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC 310 320 330 340 350 360 PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDASCHD L

References

[1]	"Structure and evolution of four POU domain genes expressed in mouse brain." Hara Y., Rovescalli C., Kim Y., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992) [PubMed: 1565620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M88301 Genomic DNA. Translation: AAA39962.1.
IPI	IPI00108391.
PIR	S31225.
RefSeq	NP_032927.1.
UniGene	Mm.405149 Mm.56946
3D structure databases
HSSP	HSSP built from PDB template 1CQT based on UniProtKB P14859.
SMR	P62515. Positions 192-338.
ModBase	Search...
PTM databases
PhosphoSite	P62515.
Proteomic databases
PRIDE	P62515.
Genome annotation databases
Ensembl	ENSMUSG00000056854. Mus musculus. [Contig view]
GeneID	18994.
KEGG	mmu:18994.
Organism-specific databases
MGI	MGI:101894. Pou3f4.
Phylogenomic databases
HOGENOM	P62515.
HOVERGEN	P62515.
OMA	P62515. RMTPPGE.
Gene expression databases
ArrayExpress	P62515.
Bgee	P62515.
CleanEx	MM_POU3F4.
GermOnline	ENSMUSG00000056854. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR013847. POU. IPR000327. POU_specific. IPR016362. Transcription_factor_POU. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. [Graphical view]
PIRSF	PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTS	PR00028. POUDOMAIN.
ProDom	PD000010. Homeobox. 1 hit. PD000583. POU. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. SM00352. POU. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	295394.
SOURCE	Search...

Entry information

Entry name

PO3F4_MOUSE

Accession

Primary (citable) accession number: P62515
Secondary accession number(s): P25216

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)