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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Iron (heme A axial ligand)By similarity1
Metal bindingi242Copper BBy similarity1
Metal bindingi246Copper BBy similarity1
Metal bindingi291Copper BBy similarity1
Metal bindingi292Copper BBy similarity1
Metal bindingi377Iron (heme A3 axial ligand)By similarity1
Metal bindingi379Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Ordered Locus Names:AMI002W
ORF Names:AgCOX1
Encoded oniMitochondrion
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000000591 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Transmembranei58 – 80HelicalSequence analysisAdd BLAST23
Transmembranei147 – 169HelicalSequence analysisAdd BLAST23
Transmembranei190 – 212HelicalSequence analysisAdd BLAST23
Transmembranei238 – 260HelicalSequence analysisAdd BLAST23
Transmembranei267 – 289HelicalSequence analysisAdd BLAST23
Transmembranei304 – 326HelicalSequence analysisAdd BLAST23
Transmembranei339 – 361HelicalSequence analysisAdd BLAST23
Transmembranei376 – 398HelicalSequence analysisAdd BLAST23
Transmembranei415 – 437HelicalSequence analysisAdd BLAST23
Transmembranei452 – 474HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832891 – 535Cytochrome c oxidase subunit 1Add BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki242 ↔ 2461'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP62514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000085274.
InParanoidiP62514.
KOiK02256.
OMAiPYHTFEE.
OrthoDBiEOG092C2KU4.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLQRWLFST NAKDIAILYF IFSTFCGLAG TAMSFIIRME LSAPGQQYLQ
60 70 80 90 100
GQNQLFNVLV TGHTILMVFF LVMPMLIGGF GNYYLPLMIG ASDMSFARLN
110 120 130 140 150
NISFWTLPPT LICLLTSTMV ESGTGTGWTV YPPLSSIQSH SGASVDLAIF
160 170 180 190 200
SLHLTTISSL LGTINFIVTA LNMRTNGMTL HKMPLFTWSI LITAVMLLMS
210 220 230 240 250
LPVLSAGVTM LLMDRNFNTS FFEVQGGGDP ILYQHLFWFF GHPEVYIMIV
260 270 280 290 300
PTFGMMSHIV STYSKKPVFG EISMIYTMGS ISLLGFLVWS HHMYVVGLDT
310 320 330 340 350
DTRAYFTSAT MIITIPTSIK VFSWLTTIYG GSLRLTTPML YTLSFLFLFT
360 370 380 390 400
VGGLTGVVLA NTSLDVAFHD TYYVVTHFHY VLSLGAVFSM FAGYYYWSPT
410 420 430 440 450
VLGLNYNEKL SQIQFWLIFL GTNIIFFPMH FLGINGMPRR IPDYPDTFTG
460 470 480 490 500
WNLVSSFGSM MTIMSLMLFT YIIYDQLMNG LTNKVNNKSI NYMKTPDFIE
510 520 530
SNNIFLMNTT KSSSIEFMLN SPPTIHSFNT PTIQS
Length:535
Mass (Da):60,173
Last modified:July 19, 2004 - v1
Checksum:iBBEC610E44873A2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016821 Genomic DNA. Translation: AAS50169.1.
RefSeqiNP_987079.1. NC_005789.1.

Genome annotation databases

EnsemblFungiiAAS50169; AAS50169; AGOS_AMI002W.
GeneIDi2760766.
KEGGiago:AGOS_AMI002W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016821 Genomic DNA. Translation: AAS50169.1.
RefSeqiNP_987079.1. NC_005789.1.

3D structure databases

ProteinModelPortaliP62514.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAS50169; AAS50169; AGOS_AMI002W.
GeneIDi2760766.
KEGGiago:AGOS_AMI002W.

Phylogenomic databases

HOGENOMiHOG000085274.
InParanoidiP62514.
KOiK02256.
OMAiPYHTFEE.
OrthoDBiEOG092C2KU4.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_ASHGO
AccessioniPrimary (citable) accession number: P62514
Secondary accession number(s): Q75G35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.