Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P62514

- COX1_ASHGO

UniProt

P62514 - COX1_ASHGO

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi63 – 631Iron (heme A axial ligand)By similarity
    Metal bindingi242 – 2421Copper BBy similarity
    Metal bindingi246 – 2461Copper BBy similarity
    Metal bindingi291 – 2911Copper BBy similarity
    Metal bindingi292 – 2921Copper BBy similarity
    Metal bindingi377 – 3771Iron (heme A3 axial ligand)By similarity
    Metal bindingi379 – 3791Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. mitochondrial electron transport, cytochrome c to oxygen Source: EnsemblFungi

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Ordered Locus Names:AMI002W
    ORF Names:AgCOX1
    Encoded oniMitochondrion
    OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
    Taxonomic identifieri284811 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
    ProteomesiUP000000591: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: EnsemblFungi

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 535535Cytochrome c oxidase subunit 1PRO_0000183289Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki242 ↔ 2461'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi33169.AGOS_AMI002W.

    Structurei

    3D structure databases

    ProteinModelPortaliP62514.
    SMRiP62514. Positions 1-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 8023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 26023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei339 – 36123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei415 – 43723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei452 – 47423HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02256.
    OrthoDBiEOG72C58S.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62514-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLQRWLFST NAKDIAILYF IFSTFCGLAG TAMSFIIRME LSAPGQQYLQ    50
    GQNQLFNVLV TGHTILMVFF LVMPMLIGGF GNYYLPLMIG ASDMSFARLN 100
    NISFWTLPPT LICLLTSTMV ESGTGTGWTV YPPLSSIQSH SGASVDLAIF 150
    SLHLTTISSL LGTINFIVTA LNMRTNGMTL HKMPLFTWSI LITAVMLLMS 200
    LPVLSAGVTM LLMDRNFNTS FFEVQGGGDP ILYQHLFWFF GHPEVYIMIV 250
    PTFGMMSHIV STYSKKPVFG EISMIYTMGS ISLLGFLVWS HHMYVVGLDT 300
    DTRAYFTSAT MIITIPTSIK VFSWLTTIYG GSLRLTTPML YTLSFLFLFT 350
    VGGLTGVVLA NTSLDVAFHD TYYVVTHFHY VLSLGAVFSM FAGYYYWSPT 400
    VLGLNYNEKL SQIQFWLIFL GTNIIFFPMH FLGINGMPRR IPDYPDTFTG 450
    WNLVSSFGSM MTIMSLMLFT YIIYDQLMNG LTNKVNNKSI NYMKTPDFIE 500
    SNNIFLMNTT KSSSIEFMLN SPPTIHSFNT PTIQS 535
    Length:535
    Mass (Da):60,173
    Last modified:July 19, 2004 - v1
    Checksum:iBBEC610E44873A2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016821 Genomic DNA. Translation: AAS50169.1.
    RefSeqiNP_987079.1. NC_005789.1.

    Genome annotation databases

    EnsemblFungiiAAS50169; AAS50169; AGOS_AMI002W.
    GeneIDi2760766.
    KEGGiago:AGOS_AMI002W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016821 Genomic DNA. Translation: AAS50169.1 .
    RefSeqi NP_987079.1. NC_005789.1.

    3D structure databases

    ProteinModelPortali P62514.
    SMRi P62514. Positions 1-532.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33169.AGOS_AMI002W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAS50169 ; AAS50169 ; AGOS_AMI002W .
    GeneIDi 2760766.
    KEGGi ago:AGOS_AMI002W.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02256.
    OrthoDBi EOG72C58S.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
      Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
      Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
    2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
      Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
      G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

    Entry informationi

    Entry nameiCOX1_ASHGO
    AccessioniPrimary (citable) accession number: P62514
    Secondary accession number(s): Q75G35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3