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P62514

- COX1_ASHGO

UniProt

P62514 - COX1_ASHGO

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1, AMI002W, AgCOX1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Iron (heme A axial ligand) By similarity
Metal bindingi242 – 2421Copper B By similarity
Metal bindingi246 – 2461Copper B By similarity
Metal bindingi291 – 2911Copper B By similarity
Metal bindingi292 – 2921Copper B By similarity
Metal bindingi377 – 3771Iron (heme A3 axial ligand) By similarity
Metal bindingi379 – 3791Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. mitochondrial electron transport, cytochrome c to oxygen Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Ordered Locus Names:AMI002W
ORF Names:AgCOX1
Encoded oniMitochondrion
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3723Helical; Reviewed prediction
Add
BLAST
Transmembranei58 – 8023Helical; Reviewed prediction
Add
BLAST
Transmembranei147 – 16923Helical; Reviewed prediction
Add
BLAST
Transmembranei190 – 21223Helical; Reviewed prediction
Add
BLAST
Transmembranei238 – 26023Helical; Reviewed prediction
Add
BLAST
Transmembranei267 – 28923Helical; Reviewed prediction
Add
BLAST
Transmembranei304 – 32623Helical; Reviewed prediction
Add
BLAST
Transmembranei339 – 36123Helical; Reviewed prediction
Add
BLAST
Transmembranei376 – 39823Helical; Reviewed prediction
Add
BLAST
Transmembranei415 – 43723Helical; Reviewed prediction
Add
BLAST
Transmembranei452 – 47423Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Cytochrome c oxidase subunit 1
PRO_0000183289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki242 ↔ 2461'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

STRINGi33169.AGOS_AMI002W.

Structurei

3D structure databases

ProteinModelPortaliP62514.
SMRiP62514. Positions 1-532.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02256.
OrthoDBiEOG72C58S.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62514-1 [UniParc]FASTAAdd to Basket

« Hide

MYLQRWLFST NAKDIAILYF IFSTFCGLAG TAMSFIIRME LSAPGQQYLQ    50
GQNQLFNVLV TGHTILMVFF LVMPMLIGGF GNYYLPLMIG ASDMSFARLN 100
NISFWTLPPT LICLLTSTMV ESGTGTGWTV YPPLSSIQSH SGASVDLAIF 150
SLHLTTISSL LGTINFIVTA LNMRTNGMTL HKMPLFTWSI LITAVMLLMS 200
LPVLSAGVTM LLMDRNFNTS FFEVQGGGDP ILYQHLFWFF GHPEVYIMIV 250
PTFGMMSHIV STYSKKPVFG EISMIYTMGS ISLLGFLVWS HHMYVVGLDT 300
DTRAYFTSAT MIITIPTSIK VFSWLTTIYG GSLRLTTPML YTLSFLFLFT 350
VGGLTGVVLA NTSLDVAFHD TYYVVTHFHY VLSLGAVFSM FAGYYYWSPT 400
VLGLNYNEKL SQIQFWLIFL GTNIIFFPMH FLGINGMPRR IPDYPDTFTG 450
WNLVSSFGSM MTIMSLMLFT YIIYDQLMNG LTNKVNNKSI NYMKTPDFIE 500
SNNIFLMNTT KSSSIEFMLN SPPTIHSFNT PTIQS 535
Length:535
Mass (Da):60,173
Last modified:July 19, 2004 - v1
Checksum:iBBEC610E44873A2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016821 Genomic DNA. Translation: AAS50169.1.
RefSeqiNP_987079.1. NC_005789.1.

Genome annotation databases

EnsemblFungiiAAS50169; AAS50169; AGOS_AMI002W.
GeneIDi2760766.
KEGGiago:AGOS_AMI002W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016821 Genomic DNA. Translation: AAS50169.1 .
RefSeqi NP_987079.1. NC_005789.1.

3D structure databases

ProteinModelPortali P62514.
SMRi P62514. Positions 1-532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_AMI002W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS50169 ; AAS50169 ; AGOS_AMI002W .
GeneIDi 2760766.
KEGGi ago:AGOS_AMI002W.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02256.
OrthoDBi EOG72C58S.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiCOX1_ASHGO
AccessioniPrimary (citable) accession number: P62514
Secondary accession number(s): Q75G35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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