Reviewed,
UniProtKB/Swiss-Prot P62514 (COX1_ASHGO)
Last modified
January 19, 2010.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome c oxidase subunit 1 EC=1.9.3.1 Alternative name(s): Cytochrome c oxidase polypeptide I | ||||||
| Gene names |
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| Encoded on | Mitochondrion | ||||||
| Organism | Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome] | ||||||
| Taxonomic identifier | 33169 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium |
Protein attributes
| Sequence length | 535 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. |
| Catalytic activity | 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the heme-copper respiratory oxidase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 535 | 535 | Cytochrome c oxidase subunit 1 | PRO_0000183289 | |||||||
Regions | |||||||||||
| Transmembrane | 15 – 37 | 23 | Potential | ||||||||
| Transmembrane | 58 – 80 | 23 | Potential | ||||||||
| Transmembrane | 147 – 169 | 23 | Potential | ||||||||
| Transmembrane | 190 – 212 | 23 | Potential | ||||||||
| Transmembrane | 238 – 260 | 23 | Potential | ||||||||
| Transmembrane | 267 – 289 | 23 | Potential | ||||||||
| Transmembrane | 304 – 326 | 23 | Potential | ||||||||
| Transmembrane | 339 – 361 | 23 | Potential | ||||||||
| Transmembrane | 376 – 398 | 23 | Potential | ||||||||
| Transmembrane | 415 – 437 | 23 | Potential | ||||||||
| Transmembrane | 452 – 474 | 23 | Potential | ||||||||
Sites | |||||||||||
| Metal binding | 63 | 1 | Iron (heme A axial ligand) By similarity | ||||||||
| Metal binding | 242 | 1 | Copper B By similarity | ||||||||
| Metal binding | 246 | 1 | Copper B By similarity | ||||||||
| Metal binding | 291 | 1 | Copper B By similarity | ||||||||
| Metal binding | 292 | 1 | Copper B By similarity | ||||||||
| Metal binding | 377 | 1 | Iron (heme A3 axial ligand) By similarity | ||||||||
| Metal binding | 379 | 1 | Iron (heme A axial ligand) By similarity | ||||||||
Amino acid modifications | |||||||||||
| Cross-link | 242 ↔ 246 | 1'-histidyl-3'-tyrosine (His-Tyr) By similarity | |||||||||
Sequences
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References
| [1] | "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016821 Genomic DNA. Translation: AAS50169.1. |
| RefSeq | NP_987079.1. |
3D structure databases | |
| SMR | P62514. Positions 1-532. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P62514. |
Genome annotation databases | |
| GeneID | 2760766. |
| GenomeReviews | Gene locus AMI002W in contig AE016821_GR. |
| KEGG | ago:AGOS_AMI002W. |
| NMPDR | fig|33169.1.peg.4720. |
Organism-specific databases | |
| AGD | AMI002W. |
Phylogenomic databases | |
| eggNOG | fuNOG07675. |
| HOGENOM | HBG603668. |
| OrthoDB | EOG9KPVV3. |
Enzyme and pathway databases | |
| BioCyc | AGOS-XXX-01:AGOS-XXX-01-004720-MONOMER. |
| BRENDA | 1.9.3.1. 279361. |
Family and domain databases | |
| InterPro | IPR000883. Cyt_c_oxidase_su1. [Graphical view] |
| Gene3D | G3DSA:1.20.210.10. COX1. 1 hit. |
| PANTHER | PTHR10422. COX1. 1 hit. |
| Pfam | PF00115. COX1. 1 hit. [Graphical view] |
| PRINTS | PR01165. CYCOXIDASEI. |
| PROSITE | PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | COX1_ASHGO | ||||||||
| Accession | Primary (citable) accession number: P62514 Secondary accession number(s): Q75G35 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


