P62511 (NRK1_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinamide riboside kinase
Short name=NRK
Short name=NmR-K
EC=2.7.1.22

Alternative name(s):
Nicotinic acid riboside kinase
EC=2.7.1.n4
Ribosylnicotinamide kinase
Short name=RNK
Ribosylnicotinic acid kinase

Gene names

Name:	NRK1
Ordered Locus Names:	AGR342C

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

284811 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN) By similarity.
Catalytic activity	ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide. ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis.
Sequence similarities	Belongs to the uridine kinase family. NRK subfamily.
Sequence caution	The sequence AAS54832.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribosylnicotinamide kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Nicotinamide riboside kinase		PRO_0000215896
Regions
	Nucleotide binding	21 – 29	9	ATP By similarity
Sites
	Active site	47	1	Proton acceptor By similarity
	Metal binding	28	1	Magnesium By similarity
	Metal binding	47	1	Magnesium By similarity
	Binding site	68	1	Substrate By similarity
	Binding site	163	1	ATP By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	167	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62511 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 42D107778344E403	FASTA	241	27,239
	10 20 30 40 50 60 MTSQLAGFKG TRGTLLVGIG GCSSSGKSTI AKLAVQVLED AVLVHQDDFY RHDDEVPFDE 70 80 90 100 110 120 EYQIGNWDVP EALDMAQFER ELDHIRATGR PAAKLVHNGN IDDVGKFGIS EEYLEELRRR 130 140 150 160 170 180 YRGRISQPVV LVDGFMLYHD DKVAARFDCR LLVRAPYATM KARRASRGGY KTLDSFWQDP 190 200 210 220 230 240 PFYFDKFVYK SYAATHARLF RNCDVEDRLV APDVQEIYNG DEAQITCVLE QVLDAIAAAQ C

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016820 Genomic DNA. Translation: AAS54832.1. Different initiation.
RefSeq	NP_987008.2. NM_212070.2.
3D structure databases
ProteinModelPortal	P62511.
ModBase	Search...
Protein-protein interaction databases
STRING	P62511.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4623311.
GenomeReviews	Gene locus AGR342C in contig AE016820_GR.
KEGG	ago:AGOS_AGR342C.
NMPDR	fig|33169.1.peg.4653.
Organism-specific databases
AGD	AGR342C.
Phylogenomic databases
eggNOG	fuNOG09257.
HOGENOM	HBG397986.
OMA	DWDCPEA.
OrthoDB	EOG4BGD5P.
PhylomeDB	P62511.
Family and domain databases
KO	K10524.
ProtoNet	Search...

Entry information

Entry name

NRK1_ASHGO

Accession

Primary (citable) accession number: P62511
Secondary accession number(s): Q74Z64

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program