Reviewed, UniProtKB/Swiss-Prot P62511 (NRK1_ASHGO)

Names and origin

Protein names

Recommended name:
    Nicotinamide riboside kinase
      Short name=NmR-K
      Short name=NRK
    EC=2.7.1.22
Alternative name(s):
    Ribosylnicotinamide kinase
      Short name=RNK
    Nicotinic acid riboside kinase
    EC=2.7.1.n4
    Ribosylnicotinic acid kinase

Gene names

Name:	NRK1
Ordered Locus Names:	AGR342C

Organism

Ashbya gossypii (Yeast) (Eremothecium gossypii) [Complete proteome]

Taxonomic identifier

33169 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Eremothecium

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN) By similarity.
Catalytic activity	ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide. ATP + D-ribosylnicotinate = ADP + nicotinate D-ribonucleotide.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis.
Sequence similarities	Belongs to the uridine kinase family. NRK subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribosylnicotinamide kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Nicotinamide riboside kinase		PRO_0000215896
Regions
	Nucleotide binding	21 – 29	9	ATP By similarity
Sites
	Active site	47	1	Proton acceptor By similarity
	Metal binding	28	1	Magnesium By similarity
	Metal binding	47	1	Magnesium By similarity
	Binding site	68	1	Substrate By similarity
	Binding site	163	1	ATP By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	167	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62511-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 42D107778344E403	FASTA	241	27,239
	10 20 30 40 50 60 MTSQLAGFKG TRGTLLVGIG GCSSSGKSTI AKLAVQVLED AVLVHQDDFY RHDDEVPFDE 70 80 90 100 110 120 EYQIGNWDVP EALDMAQFER ELDHIRATGR PAAKLVHNGN IDDVGKFGIS EEYLEELRRR 130 140 150 160 170 180 YRGRISQPVV LVDGFMLYHD DKVAARFDCR LLVRAPYATM KARRASRGGY KTLDSFWQDP 190 200 210 220 230 240 PFYFDKFVYK SYAATHARLF RNCDVEDRLV APDVQEIYNG DEAQITCVLE QVLDAIAAAQ C

References

[1]

"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome." Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P. Science 304:304-307(2004) [PubMed: 15001715] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10895 / NRRL Y-1056 / CBS 109.51.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016820 Genomic DNA. Translation: AAS54832.1. Different initiation.
RefSeq	NP_987008.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P62511.
Genome annotation databases
GeneID	4623311.
GenomeReviews	Gene locus AGR342C in contig AE016820_GR.
KEGG	ago:AGOS_AGR342C.
NMPDR	fig|33169.1.peg.4653.
Organism-specific databases
AGD	AGR342C.
Phylogenomic databases
HOGENOM	P62511.
OMA	FKQWDVI.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

NRK1_ASHGO

Accession

Primary (citable) accession number: P62511
Secondary accession number(s): Q74Z64

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)