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P62510 (ERR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Estrogen-related receptor gamma
Alternative name(s):
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene names
Name:Esrrg
Synonyms:Errg, Nr3b3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle By similarity.

Subunit structure

Homodimer. Interacts with NRIP1, NCOA1 and NCOR2. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 By similarity.

Subcellular location

Nucleus Probable.

Post-translational modification

Acetylated by PCAF/KAT2 (in vitro) By similarity.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P62510-1)

Also known as: Errg-1; Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P62510-2)

Also known as: Errg-2; Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Estrogen-related receptor gamma
PRO_0000053668

Regions

DNA binding125 – 20076Nuclear receptor
Zinc finger128 – 14821NR C4-type
Zinc finger164 – 18825NR C4-type

Natural variations

Alternative sequence1 – 2323Missing in isoform 2.
VSP_010767

Experimental info

Sequence conflict2761L → W in AAQ90023. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Errg-1) (Long) [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 63D36CFD37573152

FASTA45851,306
        10         20         30         40         50         60 
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT DSVNHHSPGG 

        70         80         90        100        110        120 
SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL YDDCSSTIVE DPQTKCEYML 

       130        140        150        160        170        180 
NSMPKRLCLV CGDIASGYHY GVASCEACKA FFKRTIQGNI EYSCPATNEC EITKRRRKSC 

       190        200        210        220        230        240 
QACRFMKCLK VGMLKEGVRL DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH 

       250        260        270        280        290        300 
LLVAEPEKIY AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL 

       310        320        330        340        350        360 
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL QLVKKYKSMK 

       370        380        390        400        410        420 
LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ DYEAGQHMED PRRAGKMLMT 

       430        440        450 
LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF LEMLEAKV 

« Hide

Isoform 2 (Errg-2) (Short) [UniParc].

Checksum: 63F81CDBE3A9C2D5
Show »

FASTA43548,581

References

[1]"Specificity of binding sequence recognition of estrogen receptor-related receptor gamma."
Razzaque M.A., Masuda N., Maeda Y., Endo Y., Tsukamoto T., Osumi T.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Molecular cloning and expression study of estrogen receptor-related receptor gamma in rat prostate."
Lui K., Chen S., Chan F.L.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: Noble.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB126962 mRNA. Translation: BAD08616.1.
AB126963 mRNA. Translation: BAD08617.1.
AY341057 mRNA. Translation: AAQ90023.1.
RefSeqNP_976081.1. NM_203336.2.
XP_006250505.1. XM_006250443.1.
XP_006250506.1. XM_006250444.1.
XP_006250507.1. XM_006250445.1.
XP_006250508.1. XM_006250446.1.
XP_006250509.1. XM_006250447.1.
UniGeneRn.214491.

3D structure databases

ProteinModelPortalP62510.
SMRP62510. Positions 122-458.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP62510.
DrugBankDB00255. Diethylstilbestrol.

PTM databases

PhosphoSiteP62510.

Proteomic databases

PRIDEP62510.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003489; ENSRNOP00000003489; ENSRNOG00000002593. [P62510-1]
GeneID360896.
KEGGrno:360896.
UCSCRGD:1303236. rat. [P62510-1]

Organism-specific databases

CTD2104.
RGD1303236. Esrrg.

Phylogenomic databases

eggNOGNOG282629.
GeneTreeENSGT00730000110346.
HOGENOMHOG000233467.
HOVERGENHBG108344.
InParanoidP62510.
KOK08554.
OMAHVEDPRR.
OrthoDBEOG7288S1.
PhylomeDBP62510.
TreeFamTF323751.

Gene expression databases

GenevestigatorP62510.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio674519.
PROP62510.

Entry information

Entry nameERR3_RAT
AccessionPrimary (citable) accession number: P62510
Secondary accession number(s): Q5QJE4, Q75T51, Q75T52
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families