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P62510

- ERR3_RAT

UniProt

P62510 - ERR3_RAT

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Protein

Estrogen-related receptor gamma

Gene

Esrrg

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 20076Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 14821NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18825NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. AF-2 domain binding Source: UniProtKB
  2. retinoic acid receptor activity Source: InterPro
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. steroid binding Source: InterPro
  6. steroid hormone receptor activity Source: InterPro
  7. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_242509. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene namesi
Name:Esrrg
Synonyms:Errg, Nr3b3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1303236. Esrrg.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Estrogen-related receptor gammaPRO_0000053668Add
BLAST

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP62510.

PTM databases

PhosphoSiteiP62510.

Expressioni

Gene expression databases

GenevestigatoriP62510.

Interactioni

Subunit structurei

Homodimer. Interacts with NRIP1, NCOA1 and NCOR2. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP62510.
SMRiP62510. Positions 120-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri128 – 14821NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18825NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282629.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiP62510.
KOiK08554.
OMAiHVEDPRR.
OrthoDBiEOG7288S1.
PhylomeDBiP62510.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P62510-1) [UniParc]FASTAAdd to Basket

Also known as: Errg-1, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF

LEMLEAKV
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62510-2) [UniParc]FASTAAdd to Basket

Also known as: Errg-2, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti276 – 2761L → W in AAQ90023. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 2. 1 PublicationVSP_010767Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126962 mRNA. Translation: BAD08616.1.
AB126963 mRNA. Translation: BAD08617.1.
AY341057 mRNA. Translation: AAQ90023.1.
RefSeqiNP_976081.1. NM_203336.2. [P62510-2]
XP_006250505.1. XM_006250443.2. [P62510-1]
UniGeneiRn.214491.

Genome annotation databases

EnsembliENSRNOT00000003489; ENSRNOP00000003489; ENSRNOG00000002593. [P62510-1]
GeneIDi360896.
KEGGirno:360896.
UCSCiRGD:1303236. rat. [P62510-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126962 mRNA. Translation: BAD08616.1 .
AB126963 mRNA. Translation: BAD08617.1 .
AY341057 mRNA. Translation: AAQ90023.1 .
RefSeqi NP_976081.1. NM_203336.2. [P62510-2 ]
XP_006250505.1. XM_006250443.2. [P62510-1 ]
UniGenei Rn.214491.

3D structure databases

ProteinModelPortali P62510.
SMRi P62510. Positions 120-458.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P62510.

PTM databases

PhosphoSitei P62510.

Proteomic databases

PRIDEi P62510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000003489 ; ENSRNOP00000003489 ; ENSRNOG00000002593 . [P62510-1 ]
GeneIDi 360896.
KEGGi rno:360896.
UCSCi RGD:1303236. rat. [P62510-1 ]

Organism-specific databases

CTDi 2104.
RGDi 1303236. Esrrg.

Phylogenomic databases

eggNOGi NOG282629.
GeneTreei ENSGT00760000118887.
HOGENOMi HOG000233467.
HOVERGENi HBG108344.
InParanoidi P62510.
KOi K08554.
OMAi HVEDPRR.
OrthoDBi EOG7288S1.
PhylomeDBi P62510.
TreeFami TF323751.

Enzyme and pathway databases

Reactomei REACT_242509. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi 674519.
PROi P62510.

Gene expression databases

Genevestigatori P62510.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSi PR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Specificity of binding sequence recognition of estrogen receptor-related receptor gamma."
    Razzaque M.A., Masuda N., Maeda Y., Endo Y., Tsukamoto T., Osumi T.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Molecular cloning and expression study of estrogen receptor-related receptor gamma in rat prostate."
    Lui K., Chen S., Chan F.L.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Noble.

Entry informationi

Entry nameiERR3_RAT
AccessioniPrimary (citable) accession number: P62510
Secondary accession number(s): Q5QJE4, Q75T51, Q75T52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3