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Protein

Estrogen-related receptor gamma

Gene

Esrrg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 200Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene namesi
Name:Esrrg
Synonyms:Errg, Nr3b3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1303236 Esrrg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536681 – 458Estrogen-related receptor gammaAdd BLAST458

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP62510

PTM databases

PhosphoSitePlusiP62510

Expressioni

Gene expression databases

BgeeiENSRNOG00000002593
GenevisibleiP62510 RN

Interactioni

Subunit structurei

Homodimer. Interacts with NRIP1, NCOA1 and NCOR2. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003489

Structurei

3D structure databases

ProteinModelPortaliP62510
SMRiP62510
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 457NR LBDPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000233467
HOVERGENiHBG108344
InParanoidiP62510
KOiK08554
OMAiPRLLCRM
OrthoDBiEOG091G0DYP
PhylomeDBiP62510
TreeFamiTF323751

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR027289 Oest-rel_rcp
IPR024178 Oest_rcpt/oest-rel_rcp
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF002527 ER-like_NR, 1 hit
PIRSF500939 ERR1-2-3, 1 hit
PRINTSiPR01292 RETNOICACIDR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62510-1) [UniParc]FASTAAdd to basket
Also known as: Errg-1, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF

LEMLEAKV
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62510-2) [UniParc]FASTAAdd to basket
Also known as: Errg-2, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276L → W in AAQ90023 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107671 – 23Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126962 mRNA Translation: BAD08616.1
AB126963 mRNA Translation: BAD08617.1
AY341057 mRNA Translation: AAQ90023.1
RefSeqiNP_976081.1, NM_203336.2 [P62510-2]
XP_006250505.1, XM_006250443.3 [P62510-1]
XP_017454353.1, XM_017598864.1 [P62510-2]
XP_017454354.1, XM_017598865.1 [P62510-2]
XP_017454355.1, XM_017598866.1 [P62510-2]
XP_017454356.1, XM_017598867.1 [P62510-2]
XP_017454357.1, XM_017598868.1 [P62510-2]
XP_017454358.1, XM_017598869.1 [P62510-2]
XP_017454359.1, XM_017598870.1 [P62510-2]
UniGeneiRn.214491

Genome annotation databases

EnsembliENSRNOT00000003489; ENSRNOP00000003489; ENSRNOG00000002593 [P62510-1]
GeneIDi360896
KEGGirno:360896
UCSCiRGD:1303236 rat [P62510-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiERR3_RAT
AccessioniPrimary (citable) accession number: P62510
Secondary accession number(s): Q5QJE4, Q75T51, Q75T52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health