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P62509

- ERR3_MOUSE

UniProt

P62509 - ERR3_MOUSE

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Protein

Estrogen-related receptor gamma

Gene

Esrrg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 20076Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri128 – 14821NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18825NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calmodulin binding Source: UniProtKB
  2. DNA binding Source: UniProtKB
  3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  4. retinoic acid receptor activity Source: InterPro
  5. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  6. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  7. steroid binding Source: InterPro
  8. steroid hormone receptor activity Source: InterPro
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  4. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_234105. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene namesi
Name:Esrrg
Synonyms:Err3, Kiaa0832, Nr3b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1347056. Esrrg.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi449 – 4491L → A: Loss of transcriptional activation; when associated with A-450. 1 Publication
Mutagenesisi450 – 4501F → A: Loss of transcriptional activation; when associated with A-449. 1 Publication
Mutagenesisi453 – 4531M → A: Loss of transcriptional activation; when associated with A-454. 1 Publication
Mutagenesisi454 – 4541L → A: Loss of transcriptional activation; when associated with A-453. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Estrogen-related receptor gammaPRO_0000053666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki40 – 40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei45 – 451PhosphoserineCurated

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).By similarity
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.By similarity
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP62509.
PRIDEiP62509.

PTM databases

PhosphoSiteiP62509.

Expressioni

Tissue specificityi

Highly expressed in the heart, brain and kidney and low expression in the liver.1 Publication

Gene expression databases

BgeeiP62509.
CleanExiMM_ESRRG.
ExpressionAtlasiP62509. baseline and differential.
GenevestigatoriP62509.

Interactioni

Subunit structurei

Homodimer. Interacts with NRIP1, NCOA1 and NCOR2 (By similarity). Binds TLE1, PNRC1 and PNRC2 (By similarity). Binds GRIP1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CREBZFQ9NS373EBI-5274019,EBI-632965From a different organism.
CrebzfQ91ZR33EBI-5274019,EBI-5274001

Protein-protein interaction databases

BioGridi204939. 4 interactions.
IntActiP62509. 2 interactions.

Structurei

Secondary structure

1
458
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi236 – 2438Combined sources
Helixi261 – 28323Combined sources
Turni287 – 2915Combined sources
Helixi294 – 31623Combined sources
Turni317 – 3193Combined sources
Beta strandi320 – 3223Combined sources
Beta strandi324 – 3274Combined sources
Beta strandi330 – 3323Combined sources
Helixi334 – 3385Combined sources
Turni339 – 3413Combined sources
Helixi343 – 35917Combined sources
Helixi363 – 37513Combined sources
Helixi385 – 40622Combined sources
Helixi413 – 4186Combined sources
Helixi421 – 44020Combined sources
Helixi448 – 4558Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S9PX-ray2.13A/B/C/D232-458[»]
1S9QX-ray2.20A/B229-456[»]
ProteinModelPortaliP62509.
SMRiP62509. Positions 120-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri128 – 14821NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18825NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282629.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiP62509.
KOiK08554.
OMAiHVEDPRR.
PhylomeDBiP62509.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P62509-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF

LEMLEAKV
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62509-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO

Sequence cautioni

The sequence BAC41450.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531K → N in BAC41450. (PubMed:12465718)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 2. 2 PublicationsVSP_010766Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117254 mRNA. Translation: AAD48369.1.
AB093266 mRNA. Translation: BAC41450.1. Different initiation.
AK052731 mRNA. Translation: BAC35120.1.
BC082324 mRNA. Translation: AAH82324.1.
CCDSiCCDS15606.1. [P62509-1]
CCDS56666.1. [P62509-2]
RefSeqiNP_001230721.1. NM_001243792.1. [P62509-2]
NP_036065.1. NM_011935.3. [P62509-1]
XP_006497227.1. XM_006497164.1. [P62509-2]
XP_006497228.1. XM_006497165.1. [P62509-2]
XP_006497229.1. XM_006497166.1. [P62509-2]
XP_006497230.1. XM_006497167.1. [P62509-2]
XP_006497231.1. XM_006497168.1. [P62509-2]
XP_006497232.1. XM_006497169.1. [P62509-2]
XP_006497233.1. XM_006497170.1. [P62509-2]
UniGeneiMm.388156.
Mm.421613.
Mm.89989.

Genome annotation databases

EnsembliENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610. [P62509-1]
ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610. [P62509-2]
ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610. [P62509-2]
GeneIDi26381.
KEGGimmu:26381.
UCSCiuc007eaa.2. mouse. [P62509-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117254 mRNA. Translation: AAD48369.1 .
AB093266 mRNA. Translation: BAC41450.1 . Different initiation.
AK052731 mRNA. Translation: BAC35120.1 .
BC082324 mRNA. Translation: AAH82324.1 .
CCDSi CCDS15606.1. [P62509-1 ]
CCDS56666.1. [P62509-2 ]
RefSeqi NP_001230721.1. NM_001243792.1. [P62509-2 ]
NP_036065.1. NM_011935.3. [P62509-1 ]
XP_006497227.1. XM_006497164.1. [P62509-2 ]
XP_006497228.1. XM_006497165.1. [P62509-2 ]
XP_006497229.1. XM_006497166.1. [P62509-2 ]
XP_006497230.1. XM_006497167.1. [P62509-2 ]
XP_006497231.1. XM_006497168.1. [P62509-2 ]
XP_006497232.1. XM_006497169.1. [P62509-2 ]
XP_006497233.1. XM_006497170.1. [P62509-2 ]
UniGenei Mm.388156.
Mm.421613.
Mm.89989.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1S9P X-ray 2.13 A/B/C/D 232-458 [» ]
1S9Q X-ray 2.20 A/B 229-456 [» ]
ProteinModelPortali P62509.
SMRi P62509. Positions 120-458.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204939. 4 interactions.
IntActi P62509. 2 interactions.

Chemistry

BindingDBi P62509.

PTM databases

PhosphoSitei P62509.

Proteomic databases

MaxQBi P62509.
PRIDEi P62509.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027906 ; ENSMUSP00000027906 ; ENSMUSG00000026610 . [P62509-1 ]
ENSMUST00000110938 ; ENSMUSP00000106563 ; ENSMUSG00000026610 . [P62509-2 ]
ENSMUST00000110939 ; ENSMUSP00000106564 ; ENSMUSG00000026610 . [P62509-2 ]
GeneIDi 26381.
KEGGi mmu:26381.
UCSCi uc007eaa.2. mouse. [P62509-1 ]

Organism-specific databases

CTDi 2104.
MGIi MGI:1347056. Esrrg.
Rougei Search...

Phylogenomic databases

eggNOGi NOG282629.
GeneTreei ENSGT00760000118887.
HOGENOMi HOG000233467.
HOVERGENi HBG108344.
InParanoidi P62509.
KOi K08554.
OMAi HVEDPRR.
PhylomeDBi P62509.
TreeFami TF323751.

Enzyme and pathway databases

Reactomei REACT_234105. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi 304297.
PROi P62509.
SOURCEi Search...

Gene expression databases

Bgeei P62509.
CleanExi MM_ESRRG.
ExpressionAtlasi P62509. baseline and differential.
Genevestigatori P62509.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSi PR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3."
    Hong H., Yang L., Stallcup M.R.
    J. Biol. Chem. 274:22618-22626(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH GRIP1, MUTAGENESIS OF LEU-449; PHE-450; MET-453 AND LEU-454, FUNCTION, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity."
    Greschik H., Flaig R., Renaud J.-P., Moras D.
    J. Biol. Chem. 279:33639-33646(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 229-458 IN COMPLEXES WITH INVERSE AGONISTS, SUBUNIT.

Entry informationi

Entry nameiERR3_MOUSE
AccessioniPrimary (citable) accession number: P62509
Secondary accession number(s): O75454
, O96021, Q8CHC9, Q9R1F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3