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P62509

- ERR3_MOUSE

UniProt

P62509 - ERR3_MOUSE

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Protein
Estrogen-related receptor gamma
Gene
Esrrg, Err3, Kiaa0832, Nr3b3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 20076Nuclear receptor
Add
BLAST
Zinc fingeri128 – 14821NR C4-type
Add
BLAST
Zinc fingeri164 – 18825NR C4-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. calmodulin binding Source: UniProtKB
  3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. retinoic acid receptor activity Source: InterPro
  6. sequence-specific DNA binding Source: InterPro
  7. steroid binding Source: InterPro
  8. steroid hormone receptor activity Source: InterPro
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
  3. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene namesi
Name:Esrrg
Synonyms:Err3, Kiaa0832, Nr3b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1347056. Esrrg.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi449 – 4491L → A: Loss of transcriptional activation; when associated with A-450. 1 Publication
Mutagenesisi450 – 4501F → A: Loss of transcriptional activation; when associated with A-449. 1 Publication
Mutagenesisi453 – 4531M → A: Loss of transcriptional activation; when associated with A-454. 1 Publication
Mutagenesisi454 – 4541L → A: Loss of transcriptional activation; when associated with A-453. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Estrogen-related receptor gamma
PRO_0000053666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki40 – 40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei45 – 451Phosphoserine Inferred

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro) By similarity.
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity By similarity.
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity By similarity.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP62509.

PTM databases

PhosphoSiteiP62509.

Expressioni

Tissue specificityi

Highly expressed in the heart, brain and kidney and low expression in the liver.1 Publication

Gene expression databases

ArrayExpressiP62509.
BgeeiP62509.
CleanExiMM_ESRRG.
GenevestigatoriP62509.

Interactioni

Subunit structurei

Homodimer. Interacts with NRIP1, NCOA1 and NCOR2 By similarity. Binds TLE1, PNRC1 and PNRC2 By similarity. Binds GRIP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CREBZFQ9NS373EBI-5274019,EBI-632965From a different organism.
CrebzfQ91ZR33EBI-5274019,EBI-5274001

Protein-protein interaction databases

BioGridi204939. 4 interactions.
IntActiP62509. 2 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi236 – 2438
Helixi261 – 28323
Turni287 – 2915
Helixi294 – 31623
Turni317 – 3193
Beta strandi320 – 3223
Beta strandi324 – 3274
Beta strandi330 – 3323
Helixi334 – 3385
Turni339 – 3413
Helixi343 – 35917
Helixi363 – 37513
Helixi385 – 40622
Helixi413 – 4186
Helixi421 – 44020
Helixi448 – 4558

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S9PX-ray2.13A/B/C/D232-458[»]
1S9QX-ray2.20A/B229-456[»]
ProteinModelPortaliP62509.
SMRiP62509. Positions 120-458.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282629.
GeneTreeiENSGT00730000110346.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiP62509.
KOiK08554.
OMAiHVEDPRR.
PhylomeDBiP62509.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P62509-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT    50
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL 100
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA 150
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL 200
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY 250
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL 300
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL 350
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ 400
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF 450
LEMLEAKV 458
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62509-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO

Sequence cautioni

The sequence BAC41450.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 2.
VSP_010766Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531K → N in BAC41450. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117254 mRNA. Translation: AAD48369.1.
AB093266 mRNA. Translation: BAC41450.1. Different initiation.
AK052731 mRNA. Translation: BAC35120.1.
BC082324 mRNA. Translation: AAH82324.1.
CCDSiCCDS15606.1. [P62509-1]
CCDS56666.1. [P62509-2]
RefSeqiNP_001230721.1. NM_001243792.1. [P62509-2]
NP_036065.1. NM_011935.3. [P62509-1]
XP_006497227.1. XM_006497164.1. [P62509-2]
XP_006497228.1. XM_006497165.1. [P62509-2]
XP_006497229.1. XM_006497166.1. [P62509-2]
XP_006497230.1. XM_006497167.1. [P62509-2]
XP_006497231.1. XM_006497168.1. [P62509-2]
XP_006497232.1. XM_006497169.1. [P62509-2]
XP_006497233.1. XM_006497170.1. [P62509-2]
UniGeneiMm.388156.
Mm.421613.
Mm.89989.

Genome annotation databases

EnsembliENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610. [P62509-1]
ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610. [P62509-2]
ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610. [P62509-2]
GeneIDi26381.
KEGGimmu:26381.
UCSCiuc007eaa.2. mouse. [P62509-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117254 mRNA. Translation: AAD48369.1 .
AB093266 mRNA. Translation: BAC41450.1 . Different initiation.
AK052731 mRNA. Translation: BAC35120.1 .
BC082324 mRNA. Translation: AAH82324.1 .
CCDSi CCDS15606.1. [P62509-1 ]
CCDS56666.1. [P62509-2 ]
RefSeqi NP_001230721.1. NM_001243792.1. [P62509-2 ]
NP_036065.1. NM_011935.3. [P62509-1 ]
XP_006497227.1. XM_006497164.1. [P62509-2 ]
XP_006497228.1. XM_006497165.1. [P62509-2 ]
XP_006497229.1. XM_006497166.1. [P62509-2 ]
XP_006497230.1. XM_006497167.1. [P62509-2 ]
XP_006497231.1. XM_006497168.1. [P62509-2 ]
XP_006497232.1. XM_006497169.1. [P62509-2 ]
XP_006497233.1. XM_006497170.1. [P62509-2 ]
UniGenei Mm.388156.
Mm.421613.
Mm.89989.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1S9P X-ray 2.13 A/B/C/D 232-458 [» ]
1S9Q X-ray 2.20 A/B 229-456 [» ]
ProteinModelPortali P62509.
SMRi P62509. Positions 120-458.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204939. 4 interactions.
IntActi P62509. 2 interactions.

Chemistry

BindingDBi P62509.

PTM databases

PhosphoSitei P62509.

Proteomic databases

PRIDEi P62509.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027906 ; ENSMUSP00000027906 ; ENSMUSG00000026610 . [P62509-1 ]
ENSMUST00000110938 ; ENSMUSP00000106563 ; ENSMUSG00000026610 . [P62509-2 ]
ENSMUST00000110939 ; ENSMUSP00000106564 ; ENSMUSG00000026610 . [P62509-2 ]
GeneIDi 26381.
KEGGi mmu:26381.
UCSCi uc007eaa.2. mouse. [P62509-1 ]

Organism-specific databases

CTDi 2104.
MGIi MGI:1347056. Esrrg.
Rougei Search...

Phylogenomic databases

eggNOGi NOG282629.
GeneTreei ENSGT00730000110346.
HOGENOMi HOG000233467.
HOVERGENi HBG108344.
InParanoidi P62509.
KOi K08554.
OMAi HVEDPRR.
PhylomeDBi P62509.
TreeFami TF323751.

Miscellaneous databases

NextBioi 304297.
PROi P62509.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62509.
Bgeei P62509.
CleanExi MM_ESRRG.
Genevestigatori P62509.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PIRSFi PIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSi PR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3."
    Hong H., Yang L., Stallcup M.R.
    J. Biol. Chem. 274:22618-22626(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH GRIP1, MUTAGENESIS OF LEU-449; PHE-450; MET-453 AND LEU-454, FUNCTION, TISSUE SPECIFICITY.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity."
    Greschik H., Flaig R., Renaud J.-P., Moras D.
    J. Biol. Chem. 279:33639-33646(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 229-458 IN COMPLEXES WITH INVERSE AGONISTS, SUBUNIT.

Entry informationi

Entry nameiERR3_MOUSE
AccessioniPrimary (citable) accession number: P62509
Secondary accession number(s): O75454
, O96021, Q8CHC9, Q9R1F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG By similarity.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi