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Protein

Estrogen-related receptor gamma

Gene

Esrrg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 200Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene namesi
Name:Esrrg
Synonyms:Err3, Kiaa0832, Nr3b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1347056. Esrrg.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi449L → A: Loss of transcriptional activation; when associated with A-450. 1 Publication1
Mutagenesisi450F → A: Loss of transcriptional activation; when associated with A-449. 1 Publication1
Mutagenesisi453M → A: Loss of transcriptional activation; when associated with A-454. 1 Publication1
Mutagenesisi454L → A: Loss of transcriptional activation; when associated with A-453. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL3585238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536661 – 458Estrogen-related receptor gammaAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei45PhosphoserineCurated1

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).By similarity
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.By similarity
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP62509.
PaxDbiP62509.
PeptideAtlasiP62509.
PRIDEiP62509.

PTM databases

iPTMnetiP62509.
PhosphoSitePlusiP62509.

Expressioni

Tissue specificityi

Highly expressed in the heart, brain and kidney and low expression in the liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000026610.
CleanExiMM_ESRRG.
ExpressionAtlasiP62509. baseline and differential.
GenevisibleiP62509. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with NRIP1, NCOA1 and NCOR2 (By similarity). Binds TLE1, PNRC1 and PNRC2 (By similarity). Binds GRIP1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CREBZFQ9NS373EBI-5274019,EBI-632965From a different organism.
CrebzfQ91ZR33EBI-5274019,EBI-5274001

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi204939. 4 interactors.
IntActiP62509. 2 interactors.
STRINGi10090.ENSMUSP00000027906.

Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi236 – 243Combined sources8
Helixi261 – 283Combined sources23
Turni287 – 291Combined sources5
Helixi294 – 316Combined sources23
Turni317 – 319Combined sources3
Beta strandi320 – 322Combined sources3
Beta strandi324 – 327Combined sources4
Beta strandi330 – 332Combined sources3
Helixi334 – 338Combined sources5
Turni339 – 341Combined sources3
Helixi343 – 359Combined sources17
Helixi363 – 375Combined sources13
Helixi385 – 406Combined sources22
Helixi413 – 418Combined sources6
Helixi421 – 440Combined sources20
Helixi448 – 455Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S9PX-ray2.13A/B/C/D232-458[»]
1S9QX-ray2.20A/B229-456[»]
ProteinModelPortaliP62509.
SMRiP62509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiP62509.
KOiK08554.
OMAiPRLLCRM.
OrthoDBiEOG091G0DYP.
PhylomeDBiP62509.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62509-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF

LEMLEAKV
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62509-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO

Sequence cautioni

The sequence BAC41450 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153K → N in BAC41450 (PubMed:12465718).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107661 – 23Missing in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117254 mRNA. Translation: AAD48369.1.
AB093266 mRNA. Translation: BAC41450.1. Different initiation.
AK052731 mRNA. Translation: BAC35120.1.
BC082324 mRNA. Translation: AAH82324.1.
CCDSiCCDS15606.1. [P62509-1]
CCDS56666.1. [P62509-2]
RefSeqiNP_001230721.1. NM_001243792.1. [P62509-2]
NP_036065.1. NM_011935.3. [P62509-1]
XP_006497227.1. XM_006497164.3. [P62509-2]
XP_006497228.1. XM_006497165.3. [P62509-2]
XP_006497230.1. XM_006497167.3. [P62509-2]
XP_006497233.1. XM_006497170.1. [P62509-2]
UniGeneiMm.388156.
Mm.421613.
Mm.89989.

Genome annotation databases

EnsembliENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610. [P62509-1]
ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610. [P62509-2]
ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610. [P62509-2]
GeneIDi26381.
KEGGimmu:26381.
UCSCiuc007eaa.2. mouse. [P62509-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117254 mRNA. Translation: AAD48369.1.
AB093266 mRNA. Translation: BAC41450.1. Different initiation.
AK052731 mRNA. Translation: BAC35120.1.
BC082324 mRNA. Translation: AAH82324.1.
CCDSiCCDS15606.1. [P62509-1]
CCDS56666.1. [P62509-2]
RefSeqiNP_001230721.1. NM_001243792.1. [P62509-2]
NP_036065.1. NM_011935.3. [P62509-1]
XP_006497227.1. XM_006497164.3. [P62509-2]
XP_006497228.1. XM_006497165.3. [P62509-2]
XP_006497230.1. XM_006497167.3. [P62509-2]
XP_006497233.1. XM_006497170.1. [P62509-2]
UniGeneiMm.388156.
Mm.421613.
Mm.89989.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S9PX-ray2.13A/B/C/D232-458[»]
1S9QX-ray2.20A/B229-456[»]
ProteinModelPortaliP62509.
SMRiP62509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204939. 4 interactors.
IntActiP62509. 2 interactors.
STRINGi10090.ENSMUSP00000027906.

Chemistry databases

ChEMBLiCHEMBL3585238.

PTM databases

iPTMnetiP62509.
PhosphoSitePlusiP62509.

Proteomic databases

MaxQBiP62509.
PaxDbiP62509.
PeptideAtlasiP62509.
PRIDEiP62509.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027906; ENSMUSP00000027906; ENSMUSG00000026610. [P62509-1]
ENSMUST00000110938; ENSMUSP00000106563; ENSMUSG00000026610. [P62509-2]
ENSMUST00000110939; ENSMUSP00000106564; ENSMUSG00000026610. [P62509-2]
GeneIDi26381.
KEGGimmu:26381.
UCSCiuc007eaa.2. mouse. [P62509-1]

Organism-specific databases

CTDi2104.
MGIiMGI:1347056. Esrrg.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiP62509.
KOiK08554.
OMAiPRLLCRM.
OrthoDBiEOG091G0DYP.
PhylomeDBiP62509.
TreeFamiTF323751.

Enzyme and pathway databases

ReactomeiR-MMU-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

PROiP62509.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026610.
CleanExiMM_ESRRG.
ExpressionAtlasiP62509. baseline and differential.
GenevisibleiP62509. MM.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERR3_MOUSE
AccessioniPrimary (citable) accession number: P62509
Secondary accession number(s): O75454
, O96021, Q8CHC9, Q9R1F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.