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Protein

Estrogen-related receptor gamma

Gene

ESRRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 200Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33433-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiP62508.
SIGNORiP62508.

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen-related receptor gamma
Alternative name(s):
ERR gamma-2
Estrogen receptor-related protein 3
Nuclear receptor subfamily 3 group B member 3
Gene namesi
Name:ESRRG
Synonyms:ERR3, ERRG2, KIAA0832, NR3B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3474. ESRRG.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38F → A or E: No effect on transcriptional activity. 1 Publication1
Mutagenesisi39I → A: 4-fold increase in transcriptional activity. 1 Publication1
Mutagenesisi40K → R: Abolishes sumoylation. 7-fold increase in transcriptional activity. 3 Publications1
Mutagenesisi41T → A: No effect on transcriptional activity. 1 Publication1
Mutagenesisi42E → A: 4-fold increase in transcriptional activity. 1 Publication1
Mutagenesisi44S → A or E: No effect on transcriptional activity. 1 Publication1
Mutagenesisi45S → A: Abolishes sumoylation. Increased transcriptional activity. 2 Publications1
Mutagenesisi45S → D: No change in sumoylation nor transcriptional activity. 2 Publications1

Organism-specific databases

DisGeNETi2104.
OpenTargetsiENSG00000196482.
PharmGKBiPA27891.

Chemistry databases

ChEMBLiCHEMBL4245.
DrugBankiDB02659. Cholic Acid.
DB00255. Diethylstilbestrol.
GuidetoPHARMACOLOGYi624.

Polymorphism and mutation databases

BioMutaiESRRG.
DMDMi50402102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536651 – 458Estrogen-related receptor gammaAdd BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei45Phosphoserine2 Publications1

Post-translational modificationi

Acetylated by PCAF/KAT2 (in vitro).1 Publication
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.3 Publications
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP62508.
PaxDbiP62508.
PeptideAtlasiP62508.
PRIDEiP62508.

PTM databases

iPTMnetiP62508.
PhosphoSitePlusiP62508.

Expressioni

Tissue specificityi

Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.2 Publications

Developmental stagei

Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.1 Publication

Gene expression databases

BgeeiENSG00000196482.
ExpressionAtlasiP62508. baseline and differential.
GenevisibleiP62508. HS.

Organism-specific databases

HPAiHPA044678.

Interactioni

Subunit structurei

Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-2834260,EBI-10175576
CCDC67Q05D603EBI-2834260,EBI-748597
KIFC3Q9BVG83EBI-2834260,EBI-2125614
MEOX2A4D1273EBI-2834260,EBI-10172134
NR0B1P518433EBI-2834260,EBI-946109
NUP160Q127693EBI-2834260,EBI-295715
PPARGC1AQ9UBK23EBI-2834260,EBI-765486
SHTN1A0MZ663EBI-2834260,EBI-308778

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108407. 28 interactors.
IntActiP62508. 23 interactors.
MINTiMINT-4824700.
STRINGi9606.ENSP00000386171.

Chemistry databases

BindingDBiP62508.

Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi236 – 243Combined sources8
Beta strandi255 – 257Combined sources3
Helixi261 – 283Combined sources23
Helixi289 – 291Combined sources3
Helixi294 – 316Combined sources23
Turni317 – 319Combined sources3
Beta strandi320 – 322Combined sources3
Beta strandi324 – 327Combined sources4
Beta strandi330 – 332Combined sources3
Helixi334 – 339Combined sources6
Helixi343 – 359Combined sources17
Helixi363 – 375Combined sources13
Helixi385 – 406Combined sources22
Helixi413 – 418Combined sources6
Helixi421 – 441Combined sources21
Helixi448 – 454Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KV6X-ray2.70A/B229-458[»]
1TFCX-ray2.40A/B229-458[»]
1VJBX-ray3.20A/B229-458[»]
2E2RX-ray1.60A222-458[»]
2EWPX-ray2.30A/B/C/D/E233-458[»]
2GP7X-ray2.45A/B/C/D229-458[»]
2GPOX-ray1.95A229-458[»]
2GPPX-ray2.60A/B229-458[»]
2GPUX-ray1.70A229-458[»]
2GPVX-ray2.85A/B/C/D/E/F229-458[»]
2P7AX-ray2.30A229-458[»]
2P7GX-ray2.10A229-458[»]
2P7ZX-ray2.50A229-458[»]
2ZASX-ray2.00A222-458[»]
2ZBSX-ray1.80A222-458[»]
2ZKCX-ray1.70A222-458[»]
ProteinModelPortaliP62508.
SMRiP62508.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62508.

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri128 – 148NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri164 – 188NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiP62508.
KOiK08554.
OMAiPRLLCRM.
OrthoDBiEOG091G0DYP.
PhylomeDBiP62508.
TreeFamiTF323751.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62508-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT
60 70 80 90 100
DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL
110 120 130 140 150
YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA
160 170 180 190 200
FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL
210 220 230 240 250
DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY
260 270 280 290 300
AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL
310 320 330 340 350
LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL
360 370 380 390 400
QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ
410 420 430 440 450
DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF

LEMLEAKV
Length:458
Mass (Da):51,306
Last modified:July 19, 2004 - v1
Checksum:i63D36CFD37573152
GO
Isoform 2 (identifier: P62508-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:435
Mass (Da):48,581
Checksum:i63F81CDBE3A9C2D5
GO
Isoform 3 (identifier: P62508-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     234-234: Y → LLWSDPAD

Show »
Length:442
Mass (Da):49,316
Checksum:i09B8CD0EE90CAEF5
GO
Isoform 4 (identifier: P62508-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     158-196: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):44,073
Checksum:i614E044D8A31361C
GO
Isoform 5 (identifier: P62508-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MDSVELCLPESFSLHYEEE → MWRECDWGLGAVKSDLACVPSAKR
     234-234: Y → LLWSDPAD

Note: Gene prediction based on EST data.
Show »
Length:470
Mass (Da):52,462
Checksum:iC0C4BD53ABAF5CE4
GO

Sequence cautioni

The sequence AAH08218 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74855 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19E → K in AAQ93376 (PubMed:10707956).Curated1
Sequence conflicti151F → S in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti155T → K in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti158G → A in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti227V → A in BAG54746 (PubMed:14702039).Curated1
Sequence conflicti271L → C in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti313V → F in AAC39899 (PubMed:9676434).Curated1
Sequence conflicti449L → P in CAH18320 (PubMed:14702039).Curated1
Sequence conflicti458V → VC in AAC39899 (PubMed:9676434).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01922950T → M.1 PublicationCorresponds to variant rs11572693dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0037021 – 23Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST23
Alternative sequenceiVSP_0471561 – 19MDSVE…HYEEE → MWRECDWGLGAVKSDLACVP SAKR in isoform 5. CuratedAdd BLAST19
Alternative sequenceiVSP_045980158 – 196Missing in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_013301234Y → LLWSDPAD in isoform 3 and isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094518 mRNA. Translation: AAC99410.1.
AB020639 mRNA. Translation: BAA74855.2. Different initiation.
AF058291 mRNA. Translation: AAC39899.1.
AY388456 mRNA. Translation: AAQ93376.1.
AY388457 mRNA. Translation: AAQ93377.1.
AY388458 mRNA. Translation: AAQ93378.1.
AY388459 mRNA. Translation: AAQ93379.1.
AY388460 mRNA. Translation: AAQ93380.1.
AY388461 mRNA. Translation: AAQ93381.1.
AK131193 mRNA. Translation: BAG54746.1.
AK290945 mRNA. Translation: BAF83634.1.
AK291028 mRNA. Translation: BAF83717.1.
AK291647 mRNA. Translation: BAF84336.1.
CR749497 mRNA. Translation: CAH18320.1.
AY528719 Genomic DNA. Translation: AAS00098.1.
AL445650, AL512650, AC096635 Genomic DNA. Translation: CAH70618.1.
AL445650, AC096635, AL512650 Genomic DNA. Translation: CAH70619.1.
AL512650, AC096635, AL445650 Genomic DNA. Translation: CAH71594.1.
AL512650, AC096635, AL445650 Genomic DNA. Translation: CAH71595.1.
AC096634 Genomic DNA. No translation available.
AL391216 Genomic DNA. No translation available.
AL512626 Genomic DNA. No translation available.
AL513312 Genomic DNA. No translation available.
AL603752 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93335.1.
BC008218 mRNA. Translation: AAH08218.1. Sequence problems.
BC064700 mRNA. Translation: AAH64700.1.
AF117255 mRNA. Translation: AAD48370.1.
CCDSiCCDS1517.1. [P62508-2]
CCDS41468.1.
CCDS58060.1. [P62508-4]
CCDS58061.1. [P62508-5]
RefSeqiNP_001127757.1. NM_001134285.2. [P62508-2]
NP_001230434.1. NM_001243505.1.
NP_001230435.1. NM_001243506.1.
NP_001230436.1. NM_001243507.1. [P62508-4]
NP_001230438.1. NM_001243509.1. [P62508-2]
NP_001230439.1. NM_001243510.2. [P62508-2]
NP_001230440.1. NM_001243511.2. [P62508-2]
NP_001230441.1. NM_001243512.1. [P62508-2]
NP_001230442.1. NM_001243513.1. [P62508-2]
NP_001230443.1. NM_001243514.1. [P62508-2]
NP_001230444.1. NM_001243515.1. [P62508-2]
NP_001230447.1. NM_001243518.1. [P62508-5]
NP_001230448.1. NM_001243519.1. [P62508-2]
NP_001429.2. NM_001438.3. [P62508-1]
NP_996317.1. NM_206594.2. [P62508-2]
NP_996318.1. NM_206595.2. [P62508-2]
XP_011507569.1. XM_011509267.1. [P62508-5]
XP_011507570.1. XM_011509268.2. [P62508-5]
XP_011507571.1. XM_011509269.2. [P62508-5]
XP_011507576.1. XM_011509274.1. [P62508-3]
XP_011507577.1. XM_011509275.1. [P62508-3]
XP_011507578.1. XM_011509276.1. [P62508-3]
XP_011507579.1. XM_011509277.1. [P62508-3]
XP_011507580.1. XM_011509278.1. [P62508-3]
XP_011507581.1. XM_011509279.1. [P62508-3]
XP_011507582.1. XM_011509280.2. [P62508-3]
XP_016856120.1. XM_017000631.1. [P62508-3]
XP_016856121.1. XM_017000632.1. [P62508-3]
XP_016856122.1. XM_017000633.1. [P62508-3]
XP_016856123.1. XM_017000634.1. [P62508-3]
XP_016856124.1. XM_017000635.1. [P62508-3]
XP_016856125.1. XM_017000636.1. [P62508-3]
XP_016856126.1. XM_017000637.1. [P62508-3]
XP_016856127.1. XM_017000638.1. [P62508-2]
XP_016856128.1. XM_017000639.1. [P62508-2]
XP_016856129.1. XM_017000640.1. [P62508-2]
XP_016856130.1. XM_017000641.1. [P62508-2]
XP_016856131.1. XM_017000642.1. [P62508-2]
XP_016856132.1. XM_017000643.1. [P62508-2]
XP_016856133.1. XM_017000644.1. [P62508-2]
XP_016856134.1. XM_017000645.1. [P62508-2]
XP_016856135.1. XM_017000646.1. [P62508-2]
XP_016856136.1. XM_017000647.1. [P62508-2]
XP_016856137.1. XM_017000648.1. [P62508-2]
XP_016856138.1. XM_017000649.1. [P62508-2]
UniGeneiHs.444225.
Hs.738938.

Genome annotation databases

EnsembliENST00000359162; ENSP00000352077; ENSG00000196482. [P62508-2]
ENST00000360012; ENSP00000353108; ENSG00000196482. [P62508-2]
ENST00000361395; ENSP00000354584; ENSG00000196482. [P62508-2]
ENST00000361525; ENSP00000355225; ENSG00000196482. [P62508-2]
ENST00000366937; ENSP00000355904; ENSG00000196482. [P62508-5]
ENST00000366938; ENSP00000355905; ENSG00000196482. [P62508-2]
ENST00000366940; ENSP00000355907; ENSG00000196482. [P62508-2]
ENST00000391890; ENSP00000375761; ENSG00000196482. [P62508-2]
ENST00000408911; ENSP00000386171; ENSG00000196482. [P62508-1]
ENST00000463665; ENSP00000418629; ENSG00000196482. [P62508-4]
ENST00000487276; ENSP00000419155; ENSG00000196482. [P62508-2]
ENST00000493603; ENSP00000419594; ENSG00000196482. [P62508-2]
ENST00000493748; ENSP00000417374; ENSG00000196482. [P62508-2]
ENST00000616180; ENSP00000481528; ENSG00000196482. [P62508-2]
GeneIDi2104.
KEGGihsa:2104.
UCSCiuc001hkw.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094518 mRNA. Translation: AAC99410.1.
AB020639 mRNA. Translation: BAA74855.2. Different initiation.
AF058291 mRNA. Translation: AAC39899.1.
AY388456 mRNA. Translation: AAQ93376.1.
AY388457 mRNA. Translation: AAQ93377.1.
AY388458 mRNA. Translation: AAQ93378.1.
AY388459 mRNA. Translation: AAQ93379.1.
AY388460 mRNA. Translation: AAQ93380.1.
AY388461 mRNA. Translation: AAQ93381.1.
AK131193 mRNA. Translation: BAG54746.1.
AK290945 mRNA. Translation: BAF83634.1.
AK291028 mRNA. Translation: BAF83717.1.
AK291647 mRNA. Translation: BAF84336.1.
CR749497 mRNA. Translation: CAH18320.1.
AY528719 Genomic DNA. Translation: AAS00098.1.
AL445650, AL512650, AC096635 Genomic DNA. Translation: CAH70618.1.
AL445650, AC096635, AL512650 Genomic DNA. Translation: CAH70619.1.
AL512650, AC096635, AL445650 Genomic DNA. Translation: CAH71594.1.
AL512650, AC096635, AL445650 Genomic DNA. Translation: CAH71595.1.
AC096634 Genomic DNA. No translation available.
AL391216 Genomic DNA. No translation available.
AL512626 Genomic DNA. No translation available.
AL513312 Genomic DNA. No translation available.
AL603752 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93335.1.
BC008218 mRNA. Translation: AAH08218.1. Sequence problems.
BC064700 mRNA. Translation: AAH64700.1.
AF117255 mRNA. Translation: AAD48370.1.
CCDSiCCDS1517.1. [P62508-2]
CCDS41468.1.
CCDS58060.1. [P62508-4]
CCDS58061.1. [P62508-5]
RefSeqiNP_001127757.1. NM_001134285.2. [P62508-2]
NP_001230434.1. NM_001243505.1.
NP_001230435.1. NM_001243506.1.
NP_001230436.1. NM_001243507.1. [P62508-4]
NP_001230438.1. NM_001243509.1. [P62508-2]
NP_001230439.1. NM_001243510.2. [P62508-2]
NP_001230440.1. NM_001243511.2. [P62508-2]
NP_001230441.1. NM_001243512.1. [P62508-2]
NP_001230442.1. NM_001243513.1. [P62508-2]
NP_001230443.1. NM_001243514.1. [P62508-2]
NP_001230444.1. NM_001243515.1. [P62508-2]
NP_001230447.1. NM_001243518.1. [P62508-5]
NP_001230448.1. NM_001243519.1. [P62508-2]
NP_001429.2. NM_001438.3. [P62508-1]
NP_996317.1. NM_206594.2. [P62508-2]
NP_996318.1. NM_206595.2. [P62508-2]
XP_011507569.1. XM_011509267.1. [P62508-5]
XP_011507570.1. XM_011509268.2. [P62508-5]
XP_011507571.1. XM_011509269.2. [P62508-5]
XP_011507576.1. XM_011509274.1. [P62508-3]
XP_011507577.1. XM_011509275.1. [P62508-3]
XP_011507578.1. XM_011509276.1. [P62508-3]
XP_011507579.1. XM_011509277.1. [P62508-3]
XP_011507580.1. XM_011509278.1. [P62508-3]
XP_011507581.1. XM_011509279.1. [P62508-3]
XP_011507582.1. XM_011509280.2. [P62508-3]
XP_016856120.1. XM_017000631.1. [P62508-3]
XP_016856121.1. XM_017000632.1. [P62508-3]
XP_016856122.1. XM_017000633.1. [P62508-3]
XP_016856123.1. XM_017000634.1. [P62508-3]
XP_016856124.1. XM_017000635.1. [P62508-3]
XP_016856125.1. XM_017000636.1. [P62508-3]
XP_016856126.1. XM_017000637.1. [P62508-3]
XP_016856127.1. XM_017000638.1. [P62508-2]
XP_016856128.1. XM_017000639.1. [P62508-2]
XP_016856129.1. XM_017000640.1. [P62508-2]
XP_016856130.1. XM_017000641.1. [P62508-2]
XP_016856131.1. XM_017000642.1. [P62508-2]
XP_016856132.1. XM_017000643.1. [P62508-2]
XP_016856133.1. XM_017000644.1. [P62508-2]
XP_016856134.1. XM_017000645.1. [P62508-2]
XP_016856135.1. XM_017000646.1. [P62508-2]
XP_016856136.1. XM_017000647.1. [P62508-2]
XP_016856137.1. XM_017000648.1. [P62508-2]
XP_016856138.1. XM_017000649.1. [P62508-2]
UniGeneiHs.444225.
Hs.738938.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KV6X-ray2.70A/B229-458[»]
1TFCX-ray2.40A/B229-458[»]
1VJBX-ray3.20A/B229-458[»]
2E2RX-ray1.60A222-458[»]
2EWPX-ray2.30A/B/C/D/E233-458[»]
2GP7X-ray2.45A/B/C/D229-458[»]
2GPOX-ray1.95A229-458[»]
2GPPX-ray2.60A/B229-458[»]
2GPUX-ray1.70A229-458[»]
2GPVX-ray2.85A/B/C/D/E/F229-458[»]
2P7AX-ray2.30A229-458[»]
2P7GX-ray2.10A229-458[»]
2P7ZX-ray2.50A229-458[»]
2ZASX-ray2.00A222-458[»]
2ZBSX-ray1.80A222-458[»]
2ZKCX-ray1.70A222-458[»]
ProteinModelPortaliP62508.
SMRiP62508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108407. 28 interactors.
IntActiP62508. 23 interactors.
MINTiMINT-4824700.
STRINGi9606.ENSP00000386171.

Chemistry databases

BindingDBiP62508.
ChEMBLiCHEMBL4245.
DrugBankiDB02659. Cholic Acid.
DB00255. Diethylstilbestrol.
GuidetoPHARMACOLOGYi624.

PTM databases

iPTMnetiP62508.
PhosphoSitePlusiP62508.

Polymorphism and mutation databases

BioMutaiESRRG.
DMDMi50402102.

Proteomic databases

MaxQBiP62508.
PaxDbiP62508.
PeptideAtlasiP62508.
PRIDEiP62508.

Protocols and materials databases

DNASUi2104.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359162; ENSP00000352077; ENSG00000196482. [P62508-2]
ENST00000360012; ENSP00000353108; ENSG00000196482. [P62508-2]
ENST00000361395; ENSP00000354584; ENSG00000196482. [P62508-2]
ENST00000361525; ENSP00000355225; ENSG00000196482. [P62508-2]
ENST00000366937; ENSP00000355904; ENSG00000196482. [P62508-5]
ENST00000366938; ENSP00000355905; ENSG00000196482. [P62508-2]
ENST00000366940; ENSP00000355907; ENSG00000196482. [P62508-2]
ENST00000391890; ENSP00000375761; ENSG00000196482. [P62508-2]
ENST00000408911; ENSP00000386171; ENSG00000196482. [P62508-1]
ENST00000463665; ENSP00000418629; ENSG00000196482. [P62508-4]
ENST00000487276; ENSP00000419155; ENSG00000196482. [P62508-2]
ENST00000493603; ENSP00000419594; ENSG00000196482. [P62508-2]
ENST00000493748; ENSP00000417374; ENSG00000196482. [P62508-2]
ENST00000616180; ENSP00000481528; ENSG00000196482. [P62508-2]
GeneIDi2104.
KEGGihsa:2104.
UCSCiuc001hkw.3. human.

Organism-specific databases

CTDi2104.
DisGeNETi2104.
GeneCardsiESRRG.
HGNCiHGNC:3474. ESRRG.
HPAiHPA044678.
MIMi602969. gene.
neXtProtiNX_P62508.
OpenTargetsiENSG00000196482.
PharmGKBiPA27891.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118887.
HOGENOMiHOG000233467.
HOVERGENiHBG108344.
InParanoidiP62508.
KOiK08554.
OMAiPRLLCRM.
OrthoDBiEOG091G0DYP.
PhylomeDBiP62508.
TreeFamiTF323751.

Enzyme and pathway databases

BioCyciZFISH:G66-33433-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiP62508.
SIGNORiP62508.

Miscellaneous databases

ChiTaRSiESRRG. human.
EvolutionaryTraceiP62508.
GeneWikiiEstrogen-related_receptor_gamma.
GenomeRNAii2104.
PROiP62508.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196482.
ExpressionAtlasiP62508. baseline and differential.
GenevisibleiP62508. HS.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR003078. Retinoic_acid_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERR3_HUMAN
AccessioniPrimary (citable) accession number: P62508
Secondary accession number(s): A8K4I0
, A8K6I2, B3KY84, E9PGB7, F8W8J3, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.