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Protein

Protein S100-A10

Gene

S100A10

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
S100 calcium-binding protein A10
Gene namesi
Name:S100A10
Synonyms:CAL1L
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9796Protein S100-A10PRO_0000144003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysineBy similarity
Modified residuei28 – 281N6-acetyllysineBy similarity
Modified residuei37 – 371N6-acetyllysineBy similarity
Modified residuei54 – 541N6-acetyllysineBy similarity
Modified residuei57 – 571N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP62504.

Expressioni

Gene expression databases

ExpressionAtlasiP62504. baseline.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000039024.

Structurei

3D structure databases

ProteinModelPortaliP62504.
SMRiP62504. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 7112Ancestral calcium siteAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated

Phylogenomic databases

eggNOGiENOG410IXW9. Eukaryota.
ENOG410YSSI. LUCA.
GeneTreeiENSGT00760000119034.
HOVERGENiHBG001479.
InParanoidiP62504.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF74. PTHR11639:SF74. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK
Length:97
Mass (Da):11,203
Last modified:January 23, 2007 - v2
Checksum:i3E8E03A6E7DD7A8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179865 mRNA. Translation: AAO21200.1.
RefSeqiNP_001028124.1. NM_001032952.3.
NP_001265347.1. NM_001278418.1.
XP_015005957.1. XM_015150471.1.
XP_015005963.1. XM_015150477.1.
XP_015005974.1. XM_015150488.1.
UniGeneiMmu.2483.

Genome annotation databases

EnsembliENSMMUT00000016330; ENSMMUP00000015300; ENSMMUG00000011656.
ENSMMUT00000045985; ENSMMUP00000039024; ENSMMUG00000011656.
GeneIDi574374.
KEGGimcc:574374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179865 mRNA. Translation: AAO21200.1.
RefSeqiNP_001028124.1. NM_001032952.3.
NP_001265347.1. NM_001278418.1.
XP_015005957.1. XM_015150471.1.
XP_015005963.1. XM_015150477.1.
XP_015005974.1. XM_015150488.1.
UniGeneiMmu.2483.

3D structure databases

ProteinModelPortaliP62504.
SMRiP62504. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000039024.

Proteomic databases

PRIDEiP62504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000016330; ENSMMUP00000015300; ENSMMUG00000011656.
ENSMMUT00000045985; ENSMMUP00000039024; ENSMMUG00000011656.
GeneIDi574374.
KEGGimcc:574374.

Organism-specific databases

CTDi6281.

Phylogenomic databases

eggNOGiENOG410IXW9. Eukaryota.
ENOG410YSSI. LUCA.
GeneTreeiENSGT00760000119034.
HOVERGENiHBG001479.
InParanoidiP62504.
KOiK17274.
OMAiAMETLMF.
OrthoDBiEOG7R833W.
TreeFamiTF332727.

Miscellaneous databases

NextBioi19976586.

Gene expression databases

ExpressionAtlasiP62504. baseline.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR028476. S100-A10.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF74. PTHR11639:SF74. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of genes critical to embryo implantation from Rhesus monkey by suppression subtractive hybridization."
    Sun X.-Y., Tan Y.-F., Qin L., Bai S.-X., Li F.-X., Qiu W., Piao Y.-S., Wang Y.-L.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiS10AA_MACMU
AccessioniPrimary (citable) accession number: P62504
Secondary accession number(s): Q6PHU3, Q6Y5H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.