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Protein

TSC22 domain family protein 1

Gene

Tsc22d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 1
Alternative name(s):
Regulatory protein TSC-22
TGFB-stimulated clone 22 homolog
Transforming growth factor beta-1-induced transcript 4 protein
Gene namesi
Name:Tsc22d1
Synonyms:Tgfb1i4, Tsc22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi3850. Tsc22d1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143TSC22 domain family protein 1PRO_0000219367Add
BLAST

Proteomic databases

PaxDbiP62501.
PRIDEiP62501.

Expressioni

Tissue specificityi

Fairly ubiquitous, slightly higher in bone.

Inductioni

By transforming growth factor beta-1 and other growth factors.

Gene expression databases

BgeeiENSRNOG00000001030.
ExpressionAtlasiP62501. baseline and differential.
GenevisibleiP62501. RN.

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi269855. 1 interaction.
STRINGi10116.ENSRNOP00000055007.

Structurei

3D structure databases

ProteinModelPortaliP62501.
SMRiP62501. Positions 58-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 9722Leucine-zipperAdd
BLAST

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797. Eukaryota.
ENOG411251N. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000015349.
HOVERGENiHBG075918.
InParanoidiP62501.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSQWCRPVA MDLGVYQLRH FSISFLSSLL GTENASVRLD NSSGASVVAI
60 70 80 90 100
DNKIEQAMDL VKSHLMYAVR EEVEVLKEQI KELIEKNSQL EQENNLLKTL
110 120 130 140
ASPEQLAQFQ AQLQTGSPPA TTQPQGTTQP PAQPASQGSG STA
Length:143
Mass (Da):15,583
Last modified:July 19, 2004 - v1
Checksum:i729D4688572496F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25785 mRNA. Translation: AAA20685.1.
BC059146 mRNA. Translation: AAH59146.1.
BC127547 mRNA. Translation: AAI27548.1.
RefSeqiNP_037175.1. NM_013043.2.
UniGeneiRn.3545.

Genome annotation databases

EnsembliENSRNOT00000001360; ENSRNOP00000001360; ENSRNOG00000001030.
GeneIDi498545.
KEGGirno:498545.
UCSCiRGD:3850. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25785 mRNA. Translation: AAA20685.1.
BC059146 mRNA. Translation: AAH59146.1.
BC127547 mRNA. Translation: AAI27548.1.
RefSeqiNP_037175.1. NM_013043.2.
UniGeneiRn.3545.

3D structure databases

ProteinModelPortaliP62501.
SMRiP62501. Positions 58-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi269855. 1 interaction.
STRINGi10116.ENSRNOP00000055007.

Proteomic databases

PaxDbiP62501.
PRIDEiP62501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001360; ENSRNOP00000001360; ENSRNOG00000001030.
GeneIDi498545.
KEGGirno:498545.
UCSCiRGD:3850. rat.

Organism-specific databases

CTDi8848.
RGDi3850. Tsc22d1.

Phylogenomic databases

eggNOGiKOG4797. Eukaryota.
ENOG411251N. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000015349.
HOVERGENiHBG075918.
InParanoidiP62501.

Miscellaneous databases

PROiP62501.

Gene expression databases

BgeeiENSRNOG00000001030.
ExpressionAtlasiP62501. baseline and differential.
GenevisibleiP62501. RN.

Family and domain databases

InterProiIPR000580. TSC-22_Dip_Bun.
[Graphical view]
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiPF01166. TSC22. 1 hit.
[Graphical view]
ProDomiPD007152. TSC-22_Dip_Bun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01289. TSC22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT22D1_RAT
AccessioniPrimary (citable) accession number: P62501
Secondary accession number(s): A0JPR0, Q00992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.