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Protein

TSC22 domain family protein 1

Gene

Tsc22d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 1
Alternative name(s):
Regulatory protein TSC-22
TGFB-stimulated clone 22 homolog
Transforming growth factor beta-1-induced transcript 4 protein
Gene namesi
Name:Tsc22d1
Synonyms:Tgfb1i4, Tsc22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi3850. Tsc22d1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193671 – 143TSC22 domain family protein 1Add BLAST143

Proteomic databases

PaxDbiP62501.
PRIDEiP62501.

Expressioni

Tissue specificityi

Fairly ubiquitous, slightly higher in bone.

Inductioni

By transforming growth factor beta-1 and other growth factors.

Gene expression databases

BgeeiENSRNOG00000001030.
ExpressionAtlasiP62501. baseline and differential.
GenevisibleiP62501. RN.

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi269855. 1 interactor.
STRINGi10116.ENSRNOP00000055007.

Structurei

3D structure databases

ProteinModelPortaliP62501.
SMRiP62501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 97Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797. Eukaryota.
ENOG411251N. LUCA.
GeneTreeiENSGT00530000063062.
HOGENOMiHOG000015349.
HOVERGENiHBG075918.
InParanoidiP62501.

Family and domain databases

InterProiView protein in InterPro
IPR000580. TSC-22_Dip_Bun.
PANTHERiPTHR12348. PTHR12348. 1 hit.
PfamiView protein in Pfam
PF01166. TSC22. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152. TSC-22_Dip_Bun. 1 hit.
PROSITEiView protein in PROSITE
PS01289. TSC22. 1 hit.

Sequencei

Sequence statusi: Complete.

P62501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSQWCRPVA MDLGVYQLRH FSISFLSSLL GTENASVRLD NSSGASVVAI
60 70 80 90 100
DNKIEQAMDL VKSHLMYAVR EEVEVLKEQI KELIEKNSQL EQENNLLKTL
110 120 130 140
ASPEQLAQFQ AQLQTGSPPA TTQPQGTTQP PAQPASQGSG STA
Length:143
Mass (Da):15,583
Last modified:July 19, 2004 - v1
Checksum:i729D4688572496F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25785 mRNA. Translation: AAA20685.1.
BC059146 mRNA. Translation: AAH59146.1.
BC127547 mRNA. Translation: AAI27548.1.
RefSeqiNP_037175.1. NM_013043.2.
UniGeneiRn.3545.

Genome annotation databases

EnsembliENSRNOT00000001360; ENSRNOP00000001360; ENSRNOG00000001030.
GeneIDi498545.
KEGGirno:498545.
UCSCiRGD:3850. rat.

Similar proteinsi

Entry informationi

Entry nameiT22D1_RAT
AccessioniPrimary (citable) accession number: P62501
Secondary accession number(s): A0JPR0, Q00992
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families