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P62494

- RB11A_RAT

UniProt

P62494 - RB11A_RAT

Protein

Ras-related protein Rab-11A

Gene

Rab11a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269GTPBy similarity
    Nucleotide bindingi66 – 705GTPBy similarity
    Nucleotide bindingi124 – 1274GTPBy similarity
    Nucleotide bindingi154 – 1563GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. GTP binding Source: RGD

    GO - Biological processi

    1. cytokinesis Source: Ensembl
    2. GTP catabolic process Source: RGD
    3. melanosome transport Source: UniProtKB
    4. neuron projection development Source: UniProtKB
    5. positive regulation of axon extension Source: Ensembl
    6. protein localization to plasma membrane Source: UniProtKB
    7. protein transport Source: UniProtKB-KW
    8. regulation of long-term neuronal synaptic plasticity Source: RGD
    9. regulation of protein transport Source: RGD
    10. small GTPase mediated signal transduction Source: InterPro
    11. vesicle-mediated transport Source: Ensembl

    Keywords - Biological processi

    Cell cycle, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-11A
    Short name:
    Rab-11
    Alternative name(s):
    24KG
    Gene namesi
    Name:Rab11a
    Synonyms:Rab11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi619762. Rab11a.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity. Recycling endosome membrane By similarity; Peripheral membrane protein By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis By similarity. Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cleavage furrow Source: UniProtKB
    3. mitochondrion Source: Ensembl
    4. perinuclear region of cytoplasm Source: Ensembl
    5. phagocytic vesicle Source: UniProtKB
    6. phagocytic vesicle membrane Source: UniProtKB-SubCell
    7. plasma membrane Source: UniProtKB-SubCell
    8. protein complex Source: Ensembl
    9. recycling endosome Source: RGD
    10. recycling endosome membrane Source: UniProtKB-SubCell
    11. trans-Golgi network Source: Ensembl
    12. transport vesicle Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 213212Ras-related protein Rab-11APRO_0000121156Add
    BLAST
    Propeptidei214 – 2163Removed in mature formSequence AnalysisPRO_0000370812

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity
    Modified residuei213 – 2131Cysteine methyl esterSequence Analysis
    Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP62494.
    PRIDEiP62494.

    Expressioni

    Tissue specificityi

    Detected in various tissues, such as brain, testis, spleen, and heart.1 Publication

    Gene expression databases

    GenevestigatoriP62494.

    Interactioni

    Subunit structurei

    Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39. Interacts with EXOC6 in a GTP-dependent manner By similarity. Interacts with RIP11. Interacts with STXBP6. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce By similarity. May interact with TBC1D14 By similarity. Interacts with UNC119; in a cell cycle-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249688. 1 interaction.
    DIPiDIP-46857N.
    IntActiP62494. 4 interactions.
    MINTiMINT-4131864.
    STRINGi10116.ENSRNOP00000015598.

    Structurei

    3D structure databases

    ProteinModelPortaliP62494.
    SMRiP62494. Positions 6-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 489Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00710000106372.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP62494.
    KOiK07904.
    OMAiAMGTRDD.
    OrthoDBiEOG7SFHZ2.
    PhylomeDBiP62494.
    TreeFamiTF300099.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62494-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT    50
    RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 100
    NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF 150
    IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV 200
    PPTTENKPKV QCCQNI 216
    Length:216
    Mass (Da):24,394
    Last modified:January 23, 2007 - v3
    Checksum:i76FC1E113A29B269
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75153 mRNA. Translation: AAA42012.1.
    BC085727 mRNA. Translation: AAH85727.1.
    PIRiJN0056.
    RefSeqiNP_112414.1. NM_031152.2.
    UniGeneiRn.1016.

    Genome annotation databases

    EnsembliENSRNOT00000015598; ENSRNOP00000015598; ENSRNOG00000011302.
    GeneIDi81830.
    KEGGirno:81830.
    UCSCiRGD:619762. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75153 mRNA. Translation: AAA42012.1 .
    BC085727 mRNA. Translation: AAH85727.1 .
    PIRi JN0056.
    RefSeqi NP_112414.1. NM_031152.2.
    UniGenei Rn.1016.

    3D structure databases

    ProteinModelPortali P62494.
    SMRi P62494. Positions 6-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249688. 1 interaction.
    DIPi DIP-46857N.
    IntActi P62494. 4 interactions.
    MINTi MINT-4131864.
    STRINGi 10116.ENSRNOP00000015598.

    Proteomic databases

    PaxDbi P62494.
    PRIDEi P62494.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015598 ; ENSRNOP00000015598 ; ENSRNOG00000011302 .
    GeneIDi 81830.
    KEGGi rno:81830.
    UCSCi RGD:619762. rat.

    Organism-specific databases

    CTDi 8766.
    RGDi 619762. Rab11a.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00710000106372.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P62494.
    KOi K07904.
    OMAi AMGTRDD.
    OrthoDBi EOG7SFHZ2.
    PhylomeDBi P62494.
    TreeFami TF300099.

    Miscellaneous databases

    NextBioi 615779.
    PROi P62494.

    Gene expression databases

    Genevestigatori P62494.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver."
      Sakurada K., Uchida K., Yamaguchi K., Aisaka K., Ito S., Ohmori T., Takeyama Y., Ueda T., Hori Y., Ohyanagi H., Saitoh Y., Kaibuchi K., Takai Y.
      Biochem. Biophys. Res. Commun. 177:1224-1232(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes."
      Prekeris R., Klumperman J., Scheller R.H.
      Mol. Cell 6:1437-1448(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RIP11.
    4. "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly."
      Scales S.J., Hesser B.A., Masuda E.S., Scheller R.H.
      J. Biol. Chem. 277:28271-28279(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STXBP6.
    5. "Protrudin induces neurite formation by directional membrane trafficking."
      Shirane M., Nakayama K.I.
      Science 314:818-821(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZFYVE27.

    Entry informationi

    Entry nameiRB11A_RAT
    AccessioniPrimary (citable) accession number: P62494
    Secondary accession number(s): P24410, Q9JLX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3