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P62494 (RB11A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-11A

Short name=Rab-11
Alternative name(s):
24KG
Gene names
Name:Rab11a
Synonyms:Rab11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. Ref.3

Subunit structure

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39. Interacts with EXOC6 in a GTP-dependent manner By similarity. Interacts with RIP11. Interacts with STXBP6. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce By similarity. May interact with TBC1D14 By similarity. Ref.3 Ref.4 Ref.5

Subcellular location

Cell membrane; Peripheral membrane protein By similarity. Recycling endosome membrane; Peripheral membrane protein By similarity. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis By similarity. Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.

Tissue specificity

Detected in various tissues, such as brain, testis, spleen, and heart. Ref.1

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
   Biological processCell cycle
Protein transport
Transport
   Cellular componentCell membrane
Cytoplasmic vesicle
Endosome
Membrane
   LigandGTP-binding
Nucleotide-binding
   PTMAcetylation
Lipoprotein
Methylation
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGTP catabolic process

Inferred from direct assay PubMed 16473307. Source: RGD

cytokinesis

Inferred from electronic annotation. Source: Ensembl

melanosome transport

Inferred from sequence or structural similarity. Source: UniProtKB

neuron projection development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of axon extension

Inferred from electronic annotation. Source: Ensembl

protein localization to plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of long-term neuronal synaptic plasticity

Inferred from mutant phenotype PubMed 18045925. Source: RGD

regulation of protein transport

Inferred from mutant phenotype PubMed 18045925. Source: RGD

small GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

vesicle-mediated transport

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon

Inferred from electronic annotation. Source: Ensembl

cleavage furrow

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrion

Inferred from electronic annotation. Source: Ensembl

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

phagocytic vesicle

Inferred from sequence or structural similarity. Source: UniProtKB

phagocytic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

protein complex

Inferred from electronic annotation. Source: Ensembl

recycling endosome

Inferred from direct assay PubMed 10468577PubMed 18353411. Source: RGD

recycling endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

trans-Golgi network

Inferred from electronic annotation. Source: Ensembl

transport vesicle

Inferred from direct assay PubMed 14578858. Source: RGD

   Molecular_functionGTP binding

Inferred from direct assay PubMed 17158030. Source: RGD

GTPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 213212Ras-related protein Rab-11A
PRO_0000121156
Propeptide214 – 2163Removed in mature form Potential
PRO_0000370812

Regions

Nucleotide binding18 – 269GTP By similarity
Nucleotide binding66 – 705GTP By similarity
Nucleotide binding124 – 1274GTP By similarity
Nucleotide binding154 – 1563GTP By similarity
Motif40 – 489Effector region By similarity

Amino acid modifications

Modified residue21N-acetylglycine By similarity
Modified residue2131Cysteine methyl ester Potential
Lipidation2121S-geranylgeranyl cysteine By similarity
Lipidation2131S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62494 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 76FC1E113A29B269

FASTA21624,394
        10         20         30         40         50         60 
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI 

        70         80         90        100        110        120 
KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM 

       130        140        150        160        170        180 
LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF IETSALDSTN VEAAFQTILT EIYRIVSQKQ 

       190        200        210 
MSDRRENDMS PSNNVVPIHV PPTTENKPKV QCCQNI 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver."
Sakurada K., Uchida K., Yamaguchi K., Aisaka K., Ito S., Ohmori T., Takeyama Y., Ueda T., Hori Y., Ohyanagi H., Saitoh Y., Kaibuchi K., Takai Y.
Biochem. Biophys. Res. Commun. 177:1224-1232(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes."
Prekeris R., Klumperman J., Scheller R.H.
Mol. Cell 6:1437-1448(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH RIP11.
[4]"Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly."
Scales S.J., Hesser B.A., Masuda E.S., Scheller R.H.
J. Biol. Chem. 277:28271-28279(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH STXBP6.
[5]"Protrudin induces neurite formation by directional membrane trafficking."
Shirane M., Nakayama K.I.
Science 314:818-821(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ZFYVE27.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M75153 mRNA. Translation: AAA42012.1.
BC085727 mRNA. Translation: AAH85727.1.
PIRJN0056.
RefSeqNP_112414.1. NM_031152.2.
UniGeneRn.1016.

3D structure databases

ProteinModelPortalP62494.
SMRP62494. Positions 6-173.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249688. 1 interaction.
DIPDIP-46857N.
IntActP62494. 4 interactions.
MINTMINT-4131864.
STRING10116.ENSRNOP00000015598.

Proteomic databases

PaxDbP62494.
PRIDEP62494.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015598; ENSRNOP00000015598; ENSRNOG00000011302.
GeneID81830.
KEGGrno:81830.
UCSCRGD:619762. rat.

Organism-specific databases

CTD8766.
RGD619762. Rab11a.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00710000106372.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidP62494.
KOK07904.
OMAAMGTRDD.
OrthoDBEOG7SFHZ2.
PhylomeDBP62494.
TreeFamTF300099.

Gene expression databases

GenevestigatorP62494.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615779.
PROP62494.

Entry information

Entry nameRB11A_RAT
AccessionPrimary (citable) accession number: P62494
Secondary accession number(s): P24410, Q9JLX1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families