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P62494

- RB11A_RAT

UniProt

P62494 - RB11A_RAT

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Protein

Ras-related protein Rab-11A

Gene

Rab11a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB
  2. GTP binding Source: RGD

GO - Biological processi

  1. cytokinesis Source: Ensembl
  2. GTP catabolic process Source: RGD
  3. melanosome transport Source: UniProtKB
  4. neuron projection development Source: UniProtKB
  5. positive regulation of axon extension Source: Ensembl
  6. protein localization to plasma membrane Source: UniProtKB
  7. protein transport Source: UniProtKB-KW
  8. regulation of long-term neuronal synaptic plasticity Source: RGD
  9. regulation of protein transport Source: RGD
  10. small GTPase mediated signal transduction Source: InterPro
  11. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_259181. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11A
Short name:
Rab-11
Alternative name(s):
24KG
Gene namesi
Name:Rab11a
Synonyms:Rab11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi619762. Rab11a.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity. Recycling endosome membrane By similarity; Peripheral membrane protein By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (By similarity). Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity).By similarity

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cleavage furrow Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. mitochondrion Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
  6. phagocytic vesicle Source: UniProtKB
  7. plasma membrane Source: UniProtKB-KW
  8. protein complex Source: Ensembl
  9. recycling endosome Source: RGD
  10. trans-Golgi network Source: Ensembl
  11. transport vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 213212Ras-related protein Rab-11APRO_0000121156Add
BLAST
Propeptidei214 – 2163Removed in mature formSequence AnalysisPRO_0000370812

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity
Modified residuei213 – 2131Cysteine methyl esterSequence Analysis
Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP62494.
PRIDEiP62494.

Expressioni

Tissue specificityi

Detected in various tissues, such as brain, testis, spleen, and heart.1 Publication

Gene expression databases

GenevestigatoriP62494.

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39. Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RIP11. Interacts with STXBP6. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce (By similarity). May interact with TBC1D14 (By similarity). Interacts with UNC119; in a cell cycle-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi249688. 1 interaction.
DIPiDIP-46857N.
IntActiP62494. 4 interactions.
MINTiMINT-4131864.
STRINGi10116.ENSRNOP00000015598.

Structurei

3D structure databases

ProteinModelPortaliP62494.
SMRiP62494. Positions 6-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62494.
KOiK07904.
OMAiAMGTRDD.
OrthoDBiEOG7SFHZ2.
PhylomeDBiP62494.
TreeFamiTF300099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62494-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF
160 170 180 190 200
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV
210
PPTTENKPKV QCCQNI
Length:216
Mass (Da):24,394
Last modified:January 23, 2007 - v3
Checksum:i76FC1E113A29B269
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75153 mRNA. Translation: AAA42012.1.
BC085727 mRNA. Translation: AAH85727.1.
PIRiJN0056.
RefSeqiNP_112414.1. NM_031152.2.
UniGeneiRn.1016.

Genome annotation databases

EnsembliENSRNOT00000015598; ENSRNOP00000015598; ENSRNOG00000011302.
GeneIDi81830.
KEGGirno:81830.
UCSCiRGD:619762. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75153 mRNA. Translation: AAA42012.1 .
BC085727 mRNA. Translation: AAH85727.1 .
PIRi JN0056.
RefSeqi NP_112414.1. NM_031152.2.
UniGenei Rn.1016.

3D structure databases

ProteinModelPortali P62494.
SMRi P62494. Positions 6-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249688. 1 interaction.
DIPi DIP-46857N.
IntActi P62494. 4 interactions.
MINTi MINT-4131864.
STRINGi 10116.ENSRNOP00000015598.

Proteomic databases

PaxDbi P62494.
PRIDEi P62494.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015598 ; ENSRNOP00000015598 ; ENSRNOG00000011302 .
GeneIDi 81830.
KEGGi rno:81830.
UCSCi RGD:619762. rat.

Organism-specific databases

CTDi 8766.
RGDi 619762. Rab11a.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118841.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P62494.
KOi K07904.
OMAi AMGTRDD.
OrthoDBi EOG7SFHZ2.
PhylomeDBi P62494.
TreeFami TF300099.

Enzyme and pathway databases

Reactomei REACT_259181. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

NextBioi 615779.
PROi P62494.

Gene expression databases

Genevestigatori P62494.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver."
    Sakurada K., Uchida K., Yamaguchi K., Aisaka K., Ito S., Ohmori T., Takeyama Y., Ueda T., Hori Y., Ohyanagi H., Saitoh Y., Kaibuchi K., Takai Y.
    Biochem. Biophys. Res. Commun. 177:1224-1232(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes."
    Prekeris R., Klumperman J., Scheller R.H.
    Mol. Cell 6:1437-1448(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RIP11.
  4. "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly."
    Scales S.J., Hesser B.A., Masuda E.S., Scheller R.H.
    J. Biol. Chem. 277:28271-28279(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STXBP6.
  5. "Protrudin induces neurite formation by directional membrane trafficking."
    Shirane M., Nakayama K.I.
    Science 314:818-821(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFYVE27.

Entry informationi

Entry nameiRB11A_RAT
AccessioniPrimary (citable) accession number: P62494
Secondary accession number(s): P24410, Q9JLX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3