SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P62492

- RB11A_MOUSE

UniProt

P62492 - RB11A_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ras-related protein Rab-11A
Gene
Rab11a, Rab11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes By similarity. May also play a role in melanosome transport and release from melanocytes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269GTP By similarity
Nucleotide bindingi66 – 705GTP By similarity
Nucleotide bindingi124 – 1274GTP By similarity
Nucleotide bindingi154 – 1563GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. cytokinesis Source: Ensembl
  2. melanosome transport Source: UniProtKB
  3. neuron projection development Source: UniProtKB
  4. positive regulation of axon extension Source: MGI
  5. protein localization to plasma membrane Source: UniProtKB
  6. protein transport Source: UniProtKB-KW
  7. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  8. regulation of protein transport Source: Ensembl
  9. small GTPase mediated signal transduction Source: InterPro
  10. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_213947. Regulation of water balance by renal Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11A
Short name:
Rab-11
Gene namesi
Name:Rab11a
Synonyms:Rab11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1858202. Rab11a.

Subcellular locationi

Cell membrane; Peripheral membrane protein By similarity. Recycling endosome membrane; Peripheral membrane protein By similarity. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity
Note: Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis By similarity. Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.

GO - Cellular componenti

  1. axon Source: MGI
  2. cleavage furrow Source: UniProtKB
  3. cytoplasm Source: MGI
  4. mitochondrion Source: MGI
  5. perinuclear region of cytoplasm Source: MGI
  6. phagocytic vesicle Source: UniProtKB
  7. phagocytic vesicle membrane Source: UniProtKB-SubCell
  8. plasma membrane Source: UniProtKB-SubCell
  9. protein complex Source: Ensembl
  10. recycling endosome Source: UniProtKB
  11. recycling endosome membrane Source: UniProtKB-SubCell
  12. trans-Golgi network Source: MGI
  13. transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 213212Ras-related protein Rab-11A
PRO_0000121152Add
BLAST
Propeptidei214 – 2163Removed in mature form Reviewed prediction
PRO_0000370808

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity
Lipidationi212 – 2121S-geranylgeranyl cysteine By similarity
Modified residuei213 – 2131Cysteine methyl ester Reviewed prediction
Lipidationi213 – 2131S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP62492.
PRIDEiP62492.

PTM databases

PhosphoSiteiP62492.

Expressioni

Gene expression databases

ArrayExpressiP62492.
BgeeiP62492.
CleanExiMM_RAB11A.
GenevestigatoriP62492.

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with RIP11 and STXBP6. Interacts (GDP-bound form) with ZFYVE27 By similarity. Interacts with SGSM1, SGSM2, SGSM3 and VIPAS39. Interacts with EXOC6 in a GTP-dependent manner. Interacts with BIRC6/bruce By similarity. May interact with TBC1D14 By similarity.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Rab3ipQ627394EBI-770256,EBI-2028671From a different organism.
Vps33bP590163EBI-770256,EBI-2656383

Protein-protein interaction databases

IntActiP62492. 15 interactions.
MINTiMINT-4131841.

Structurei

3D structure databases

ProteinModelPortaliP62492.
SMRiP62492. Positions 6-173.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP62492.
KOiK07904.
OMAiAMGTRDD.
OrthoDBiEOG7SFHZ2.
PhylomeDBiP62492.
TreeFamiTF300099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62492-1 [UniParc]FASTAAdd to Basket

« Hide

MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT    50
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 100
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF 150
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV 200
PPTTENKPKV QCCQNI 216
Length:216
Mass (Da):24,394
Last modified:January 23, 2007 - v3
Checksum:i76FC1E113A29B269
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801Q → H in AAF36458. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF127669 Genomic DNA. Translation: AAF36458.1.
AK014268 mRNA. Translation: BAB29233.1.
AK132072 mRNA. Translation: BAE20971.1.
AK132159 mRNA. Translation: BAE21003.1.
AK147122 mRNA. Translation: BAE27693.1.
BC010722 mRNA. Translation: AAH10722.1.
CCDSiCCDS23282.1.
RefSeqiNP_059078.2. NM_017382.5.
UniGeneiMm.1387.

Genome annotation databases

EnsembliENSMUST00000172298; ENSMUSP00000129163; ENSMUSG00000004771.
GeneIDi53869.
KEGGimmu:53869.
UCSCiuc009qce.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF127669 Genomic DNA. Translation: AAF36458.1 .
AK014268 mRNA. Translation: BAB29233.1 .
AK132072 mRNA. Translation: BAE20971.1 .
AK132159 mRNA. Translation: BAE21003.1 .
AK147122 mRNA. Translation: BAE27693.1 .
BC010722 mRNA. Translation: AAH10722.1 .
CCDSi CCDS23282.1.
RefSeqi NP_059078.2. NM_017382.5.
UniGenei Mm.1387.

3D structure databases

ProteinModelPortali P62492.
SMRi P62492. Positions 6-173.
ModBasei Search...

Protein-protein interaction databases

IntActi P62492. 15 interactions.
MINTi MINT-4131841.

PTM databases

PhosphoSitei P62492.

Proteomic databases

PaxDbi P62492.
PRIDEi P62492.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000172298 ; ENSMUSP00000129163 ; ENSMUSG00000004771 .
GeneIDi 53869.
KEGGi mmu:53869.
UCSCi uc009qce.1. mouse.

Organism-specific databases

CTDi 8766.
MGIi MGI:1858202. Rab11a.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P62492.
KOi K07904.
OMAi AMGTRDD.
OrthoDBi EOG7SFHZ2.
PhylomeDBi P62492.
TreeFami TF300099.

Enzyme and pathway databases

Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_213947. Regulation of water balance by renal Aquaporins.

Miscellaneous databases

NextBioi 310717.
PROi P62492.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62492.
Bgeei P62492.
CleanExi MM_RAB11A.
Genevestigatori P62492.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion and Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 14-24; 42-51 AND 83-95, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  5. "Sec15 is an effector for the Rab11 GTPase in mammalian cells."
    Zhang X.-M., Ellis S., Sriratana A., Mitchell C.A., Rowe T.
    J. Biol. Chem. 279:43027-43034(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EXOC6.
  6. "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway."
    Yang H., Sasaki T., Minoshima S., Shimizu N.
    Genomics 90:249-260(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SGSM1; SGSM2 AND SGSM3.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: INTERACTION WITH VIPAS39.
  9. "The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking."
    Beaumont K.A., Hamilton N.A., Moores M.T., Brown D.L., Ohbayashi N., Cairncross O., Cook A.L., Smith A.G., Misaki R., Fukuda M., Taguchi T., Sturm R.A., Stow J.L.
    Traffic 12:627-643(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MELANOSOME TRANSPORT.

Entry informationi

Entry nameiRB11A_MOUSE
AccessioniPrimary (citable) accession number: P62492
Secondary accession number(s): P24410, Q3V1Z6, Q9JLX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi