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P62489

- RPB7_RAT

UniProt

P62489 - RPB7_RAT

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Protein

DNA-directed RNA polymerase II subunit RPB7

Gene

Polr2g

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA By similarity.By similarity

GO - Molecular functioni

  1. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. single-stranded DNA binding Source: RefGenome
  3. single-stranded RNA binding Source: RefGenome
  4. translation initiation factor binding Source: RefGenome

GO - Biological processi

  1. apoptotic process Source: RGD
  2. nuclear-transcribed mRNA catabolic process, exonucleolytic Source: RefGenome
  3. positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: RefGenome
  4. positive regulation of translational initiation Source: RefGenome
  5. transcription from RNA polymerase II promoter Source: UniProtKB
  6. transcription initiation from RNA polymerase II promoter Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_208719. mRNA Splicing - Major Pathway.
REACT_216099. Processing of Capped Intron-Containing Pre-mRNA.
REACT_216241. RNA Polymerase II Pre-transcription Events.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB7
Short name:
RNA polymerase II subunit B7
Alternative name(s):
DNA-directed RNA polymerase II subunit G
Gene namesi
Name:Polr2g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi621284. Polr2g.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasmic mRNA processing body Source: RefGenome
  2. DNA-directed RNA polymerase II, core complex Source: UniProtKB
  3. nucleolus Source: Ensembl
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172DNA-directed RNA polymerase II subunit RPB7PRO_0000073988Add
BLAST

Proteomic databases

PRIDEiP62489.

Expressioni

Gene expression databases

GenevestigatoriP62489.

Interactioni

Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.

Protein-protein interaction databases

BioGridi250618. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP62489.
SMRiP62489. Positions 1-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1095.
GeneTreeiENSGT00390000008975.
HOGENOMiHOG000158201.
HOVERGENiHBG055233.
InParanoidiP62489.
KOiK03015.
OMAiPPQFTNN.
OrthoDBiEOG76MK9S.
PhylomeDBiP62489.
TreeFamiTF103042.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.1490.120. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR005576. RNA_pol_Rpb7_N.
IPR022967. S1_dom.
[Graphical view]
PfamiPF00575. S1. 1 hit.
PF03876. SHS2_Rpb7-N. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF88798. SSF88798. 1 hit.

Sequencei

Sequence statusi: Complete.

P62489-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT
60 70 80 90 100
IDNIGAGVIQ PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE
110 120 130 140 150
IGPMSCFISR HSIPSEMEFD PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT
160 170
RVDKNDIFAI GSLMDDYLGL VS
Length:172
Mass (Da):19,294
Last modified:July 19, 2004 - v1
Checksum:iAF3CE655F658CD5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71925 mRNA. Translation: CAA96468.1.
BC060550 mRNA. Translation: AAH60550.1.
BC060595 mRNA. Translation: AAH60595.1.
RefSeqiNP_446400.1. NM_053948.4.
XP_006231035.1. XM_006230973.1.
UniGeneiRn.106248.

Genome annotation databases

EnsembliENSRNOT00000026313; ENSRNOP00000026313; ENSRNOG00000019439.
GeneIDi117017.
KEGGirno:117017.
UCSCiRGD:621284. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71925 mRNA. Translation: CAA96468.1 .
BC060550 mRNA. Translation: AAH60550.1 .
BC060595 mRNA. Translation: AAH60595.1 .
RefSeqi NP_446400.1. NM_053948.4.
XP_006231035.1. XM_006230973.1.
UniGenei Rn.106248.

3D structure databases

ProteinModelPortali P62489.
SMRi P62489. Positions 1-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250618. 1 interaction.

Proteomic databases

PRIDEi P62489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026313 ; ENSRNOP00000026313 ; ENSRNOG00000019439 .
GeneIDi 117017.
KEGGi rno:117017.
UCSCi RGD:621284. rat.

Organism-specific databases

CTDi 5436.
RGDi 621284. Polr2g.

Phylogenomic databases

eggNOGi COG1095.
GeneTreei ENSGT00390000008975.
HOGENOMi HOG000158201.
HOVERGENi HBG055233.
InParanoidi P62489.
KOi K03015.
OMAi PPQFTNN.
OrthoDBi EOG76MK9S.
PhylomeDBi P62489.
TreeFami TF103042.

Enzyme and pathway databases

Reactomei REACT_208719. mRNA Splicing - Major Pathway.
REACT_216099. Processing of Capped Intron-Containing Pre-mRNA.
REACT_216241. RNA Polymerase II Pre-transcription Events.

Miscellaneous databases

NextBioi 619759.
PROi P62489.

Gene expression databases

Genevestigatori P62489.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.1490.120. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR005576. RNA_pol_Rpb7_N.
IPR022967. S1_dom.
[Graphical view ]
Pfami PF00575. S1. 1 hit.
PF03876. SHS2_Rpb7-N. 1 hit.
[Graphical view ]
SMARTi SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF88798. SSF88798. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Gillen C., Gleichmann M., Mueller H.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Sciatic nerve.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiRPB7_RAT
AccessioniPrimary (citable) accession number: P62489
Secondary accession number(s): P52433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3