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P62489

- RPB7_RAT

UniProt

P62489 - RPB7_RAT

Protein

DNA-directed RNA polymerase II subunit RPB7

Gene

Polr2g

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA By similarity.By similarity

    GO - Molecular functioni

    1. DNA-directed RNA polymerase activity Source: UniProtKB-KW
    2. single-stranded DNA binding Source: RefGenome
    3. single-stranded RNA binding Source: RefGenome
    4. translation initiation factor binding Source: RefGenome

    GO - Biological processi

    1. apoptotic process Source: RGD
    2. nuclear-transcribed mRNA catabolic process, exonucleolytic Source: RefGenome
    3. positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: RefGenome
    4. positive regulation of translational initiation Source: RefGenome
    5. transcription from RNA polymerase II promoter Source: UniProtKB
    6. transcription initiation from RNA polymerase II promoter Source: RefGenome

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_208719. mRNA Splicing - Major Pathway.
    REACT_216099. Processing of Capped Intron-Containing Pre-mRNA.
    REACT_216241. RNA Polymerase II Pre-transcription Events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase II subunit RPB7
    Short name:
    RNA polymerase II subunit B7
    Alternative name(s):
    DNA-directed RNA polymerase II subunit G
    Gene namesi
    Name:Polr2g
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi621284. Polr2g.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: RefGenome
    2. DNA-directed RNA polymerase II, core complex Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 172172DNA-directed RNA polymerase II subunit RPB7PRO_0000073988Add
    BLAST

    Proteomic databases

    PRIDEiP62489.

    Expressioni

    Gene expression databases

    GenevestigatoriP62489.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.

    Protein-protein interaction databases

    BioGridi250618. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP62489.
    SMRiP62489. Positions 1-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1095.
    GeneTreeiENSGT00390000008975.
    HOGENOMiHOG000158201.
    HOVERGENiHBG055233.
    InParanoidiP62489.
    KOiK03015.
    OMAiPPQFTNN.
    OrthoDBiEOG76MK9S.
    PhylomeDBiP62489.
    TreeFamiTF103042.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.30.1490.120. 1 hit.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR005576. RNA_pol_Rpb7_N.
    [Graphical view]
    PfamiPF00575. S1. 1 hit.
    PF03876. SHS2_Rpb7-N. 1 hit.
    [Graphical view]
    SMARTiSM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF88798. SSF88798. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62489-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT    50
    IDNIGAGVIQ PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE 100
    IGPMSCFISR HSIPSEMEFD PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT 150
    RVDKNDIFAI GSLMDDYLGL VS 172
    Length:172
    Mass (Da):19,294
    Last modified:July 19, 2004 - v1
    Checksum:iAF3CE655F658CD5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71925 mRNA. Translation: CAA96468.1.
    BC060550 mRNA. Translation: AAH60550.1.
    BC060595 mRNA. Translation: AAH60595.1.
    RefSeqiNP_446400.1. NM_053948.4.
    XP_006231035.1. XM_006230973.1.
    UniGeneiRn.106248.

    Genome annotation databases

    EnsembliENSRNOT00000026313; ENSRNOP00000026313; ENSRNOG00000019439.
    GeneIDi117017.
    KEGGirno:117017.
    UCSCiRGD:621284. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71925 mRNA. Translation: CAA96468.1 .
    BC060550 mRNA. Translation: AAH60550.1 .
    BC060595 mRNA. Translation: AAH60595.1 .
    RefSeqi NP_446400.1. NM_053948.4.
    XP_006231035.1. XM_006230973.1.
    UniGenei Rn.106248.

    3D structure databases

    ProteinModelPortali P62489.
    SMRi P62489. Positions 1-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250618. 1 interaction.

    Proteomic databases

    PRIDEi P62489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026313 ; ENSRNOP00000026313 ; ENSRNOG00000019439 .
    GeneIDi 117017.
    KEGGi rno:117017.
    UCSCi RGD:621284. rat.

    Organism-specific databases

    CTDi 5436.
    RGDi 621284. Polr2g.

    Phylogenomic databases

    eggNOGi COG1095.
    GeneTreei ENSGT00390000008975.
    HOGENOMi HOG000158201.
    HOVERGENi HBG055233.
    InParanoidi P62489.
    KOi K03015.
    OMAi PPQFTNN.
    OrthoDBi EOG76MK9S.
    PhylomeDBi P62489.
    TreeFami TF103042.

    Enzyme and pathway databases

    Reactomei REACT_208719. mRNA Splicing - Major Pathway.
    REACT_216099. Processing of Capped Intron-Containing Pre-mRNA.
    REACT_216241. RNA Polymerase II Pre-transcription Events.

    Miscellaneous databases

    NextBioi 619759.
    PROi P62489.

    Gene expression databases

    Genevestigatori P62489.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.30.1490.120. 1 hit.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR022967. RNA-binding_domain_S1.
    IPR005576. RNA_pol_Rpb7_N.
    [Graphical view ]
    Pfami PF00575. S1. 1 hit.
    PF03876. SHS2_Rpb7-N. 1 hit.
    [Graphical view ]
    SMARTi SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF88798. SSF88798. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Gillen C., Gleichmann M., Mueller H.
      Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Sciatic nerve.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiRPB7_RAT
    AccessioniPrimary (citable) accession number: P62489
    Secondary accession number(s): P52433
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3