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P62484

- ABI2_MOUSE

UniProt

P62484 - ABI2_MOUSE

Protein

Abl interactor 2

Gene

Abi2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.1 Publication

    GO - Biological processi

    1. actin polymerization or depolymerization Source: InterPro
    2. camera-type eye development Source: MGI
    3. cell migration Source: MGI
    4. dendrite development Source: MGI
    5. learning or memory Source: MGI
    6. peptidyl-tyrosine phosphorylation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abl interactor 2
    Alternative name(s):
    Abelson interactor 2
    Short name:
    Abi-2
    Gene namesi
    Name:Abi2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:106913. Abi2.

    Subcellular locationi

    Cytoplasm. Cell projectionlamellipodium. Cell projectionfilopodium. Cytoplasmcytoskeleton
    Note: Localized to protruding lamellipodia and filopodia tips.

    GO - Cellular componenti

    1. cell-cell adherens junction Source: MGI
    2. cytoskeleton Source: UniProtKB-SubCell
    3. cytosol Source: MGI
    4. dendrite Source: MGI
    5. filopodium Source: UniProtKB-SubCell
    6. lamellipodium Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Abl interactor 2PRO_0000191791Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei221 – 2211PhosphoserineBy similarity
    Modified residuei301 – 3011PhosphoserineBy similarity

    Post-translational modificationi

    Is a substrate for ABL1.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP62484.
    PaxDbiP62484.
    PRIDEiP62484.

    PTM databases

    PhosphoSiteiP62484.

    Expressioni

    Tissue specificityi

    Expresses in embryonic and adult brain. In adult brain prominently expressed in the neocortex, hippocampus and dentate gyrus.1 Publication

    Developmental stagei

    Detected at E10 in developing brain, and expression is more prominent in the neuroepithelium compared to the surrounding tissue. At E12 expression is enhanced throughout the CNS and is detected along the full length of the spinal chord. At E16 expression remains enhanced in the CNS, and is particularly prominent in the olfactory bulb. Also highly expressed in dorsal root ganglia.1 Publication

    Gene expression databases

    BgeeiP62484.
    CleanExiMM_ABI2.
    GenevestigatoriP62484.

    Interactioni

    Subunit structurei

    Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 By similarity. Interacts with ABL1 and ABL2.By similarity

    Protein-protein interaction databases

    DIPiDIP-48418N.

    Structurei

    3D structure databases

    ProteinModelPortaliP62484.
    SMRiP62484. Positions 1-155, 377-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 10763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST
    Domaini384 – 44360SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi166 – 356191Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABI family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG262939.
    GeneTreeiENSGT00390000003756.
    HOGENOMiHOG000293213.
    HOVERGENiHBG050446.
    KOiK05751.
    OMAiVNGGPFY.
    OrthoDBiEOG7J17ZT.
    PhylomeDBiP62484.
    TreeFamiTF314303.

    Family and domain databases

    InterProiIPR028457. ABI.
    IPR028454. Abi2.
    IPR012849. Abl-interactor_HHR_dom.
    IPR001452. SH3_domain.
    IPR000727. T_SNARE_dom.
    [Graphical view]
    PANTHERiPTHR10460. PTHR10460. 1 hit.
    PTHR10460:SF3. PTHR10460:SF3. 1 hit.
    PfamiPF07815. Abi_HHR. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62484-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELQMLLEE EIPGGRRALF DSYTNLERVA DYCENNYIQS PDKQRALEET    50
    KAYTTQSLAS VAYLINTLAN NVLQMLDIQA SQLRRMESSI NHISQTVDIH 100
    KEKVARREIG ILTTNKNTSR THKIIAPANL ERPVRYIRKP IDYTILDDIG 150
    HGVKVSTQNM KMGGLPRTTP PTQKPPSPPM SGKGTLGRHS PYRTLEPVRP 200
    PVVPNDYVPS PTRNMAPSQQ SPVRTASVNQ RNRTYSSSGS SGGSHPSSRS 250
    SSRENSGSGS VGVPIAVPTP SPPSVFPGHP VQFYSMNRPA SRHTPPTIGG 300
    SLPYRRPPSI TSQTSLQNQM NGGPFYNQNP VSDTPPPPPP VEEPVFDESP 350
    PPPPPPEDYE EEEAAVVEYS DPYAEEDPPW APRAYLEKVV AIYDYTKDKE 400
    DELSFQEGAI IYVIKKNDDG WYEGVMNGVT GLFPGNYVES IMHYSE 446
    Length:446
    Mass (Da):49,387
    Last modified:July 19, 2004 - v1
    Checksum:i8EC1FB543D93BEAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC056345 mRNA. Translation: AAH56345.1.
    CCDSiCCDS14991.1.
    RefSeqiNP_001185499.1. NM_001198570.1.
    NP_001185500.1. NM_001198571.1.
    NP_937760.1. NM_198127.2.
    UniGeneiMm.212066.
    Mm.465571.

    Genome annotation databases

    EnsembliENSMUST00000052332; ENSMUSP00000058754; ENSMUSG00000026782.
    GeneIDi329165.
    KEGGimmu:329165.
    UCSCiuc007beq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC056345 mRNA. Translation: AAH56345.1 .
    CCDSi CCDS14991.1.
    RefSeqi NP_001185499.1. NM_001198570.1.
    NP_001185500.1. NM_001198571.1.
    NP_937760.1. NM_198127.2.
    UniGenei Mm.212066.
    Mm.465571.

    3D structure databases

    ProteinModelPortali P62484.
    SMRi P62484. Positions 1-155, 377-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48418N.

    PTM databases

    PhosphoSitei P62484.

    Proteomic databases

    MaxQBi P62484.
    PaxDbi P62484.
    PRIDEi P62484.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052332 ; ENSMUSP00000058754 ; ENSMUSG00000026782 .
    GeneIDi 329165.
    KEGGi mmu:329165.
    UCSCi uc007beq.2. mouse.

    Organism-specific databases

    CTDi 10152.
    MGIi MGI:106913. Abi2.

    Phylogenomic databases

    eggNOGi NOG262939.
    GeneTreei ENSGT00390000003756.
    HOGENOMi HOG000293213.
    HOVERGENi HBG050446.
    KOi K05751.
    OMAi VNGGPFY.
    OrthoDBi EOG7J17ZT.
    PhylomeDBi P62484.
    TreeFami TF314303.

    Miscellaneous databases

    NextBioi 398613.
    PROi P62484.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62484.
    CleanExi MM_ABI2.
    Genevestigatori P62484.

    Family and domain databases

    InterProi IPR028457. ABI.
    IPR028454. Abi2.
    IPR012849. Abl-interactor_HHR_dom.
    IPR001452. SH3_domain.
    IPR000727. T_SNARE_dom.
    [Graphical view ]
    PANTHERi PTHR10460. PTHR10460. 1 hit.
    PTHR10460:SF3. PTHR10460:SF3. 1 hit.
    Pfami PF07815. Abi_HHR. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia."
      Stradal T.E.B., Courtney K.D., Rottner K., Hahne P., Small J.V., Pendergast A.M.
      Curr. Biol. 11:891-895(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    3. "Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels."
      Echarri A., Lai M.J., Robinson M.R., Pendergast A.M.
      Mol. Cell. Biol. 24:4979-4993(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system."
      Courtney K.D., Grove M., Vandongen H., Vandongen A., LaMantia A.-S., Pendergast A.M.
      Mol. Cell. Neurosci. 16:244-257(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiABI2_MOUSE
    AccessioniPrimary (citable) accession number: P62484
    Secondary accession number(s): Q6PHU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3