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P62484 (ABI2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abl interactor 2
Alternative name(s):
Abelson interactor 2
Short name=Abi-2
Gene names
Name:Abi2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. Ref.3

Subunit structure

Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 By similarity. Interacts with ABL1 and ABL2.

Subcellular location

Cytoplasm. Cell projectionlamellipodium. Cell projectionfilopodium. Cytoplasmcytoskeleton. Note: Localized to protruding lamellipodia and filopodia tips. Ref.2 Ref.3

Tissue specificity

Expresses in embryonic and adult brain. In adult brain prominently expressed in the neocortex, hippocampus and dentate gyrus. Ref.4

Developmental stage

Detected at E10 in developing brain, and expression is more prominent in the neuroepithelium compared to the surrounding tissue. At E12 expression is enhanced throughout the CNS and is detected along the full length of the spinal chord. At E16 expression remains enhanced in the CNS, and is particularly prominent in the olfactory bulb. Also highly expressed in dorsal root ganglia. Ref.4

Post-translational modification

Is a substrate for ABL1 By similarity.

Sequence similarities

Belongs to the ABI family.

Contains 1 SH3 domain.

Contains 1 t-SNARE coiled-coil homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Abl interactor 2
PRO_0000191791

Regions

Domain45 – 10763t-SNARE coiled-coil homology
Domain384 – 44360SH3
Compositional bias166 – 356191Pro-rich

Amino acid modifications

Modified residue2211Phosphoserine By similarity
Modified residue3011Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62484 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 8EC1FB543D93BEAA

FASTA44649,387
        10         20         30         40         50         60 
MAELQMLLEE EIPGGRRALF DSYTNLERVA DYCENNYIQS PDKQRALEET KAYTTQSLAS 

        70         80         90        100        110        120 
VAYLINTLAN NVLQMLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR 

       130        140        150        160        170        180 
THKIIAPANL ERPVRYIRKP IDYTILDDIG HGVKVSTQNM KMGGLPRTTP PTQKPPSPPM 

       190        200        210        220        230        240 
SGKGTLGRHS PYRTLEPVRP PVVPNDYVPS PTRNMAPSQQ SPVRTASVNQ RNRTYSSSGS 

       250        260        270        280        290        300 
SGGSHPSSRS SSRENSGSGS VGVPIAVPTP SPPSVFPGHP VQFYSMNRPA SRHTPPTIGG 

       310        320        330        340        350        360 
SLPYRRPPSI TSQTSLQNQM NGGPFYNQNP VSDTPPPPPP VEEPVFDESP PPPPPPEDYE 

       370        380        390        400        410        420 
EEEAAVVEYS DPYAEEDPPW APRAYLEKVV AIYDYTKDKE DELSFQEGAI IYVIKKNDDG 

       430        440 
WYEGVMNGVT GLFPGNYVES IMHYSE 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia."
Stradal T.E.B., Courtney K.D., Rottner K., Hahne P., Small J.V., Pendergast A.M.
Curr. Biol. 11:891-895(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[3]"Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels."
Echarri A., Lai M.J., Robinson M.R., Pendergast A.M.
Mol. Cell. Biol. 24:4979-4993(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system."
Courtney K.D., Grove M., Vandongen H., Vandongen A., LaMantia A.-S., Pendergast A.M.
Mol. Cell. Neurosci. 16:244-257(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC056345 mRNA. Translation: AAH56345.1.
CCDSCCDS14991.1.
RefSeqNP_001185499.1. NM_001198570.1.
NP_001185500.1. NM_001198571.1.
NP_937760.1. NM_198127.2.
UniGeneMm.212066.
Mm.465571.

3D structure databases

ProteinModelPortalP62484.
SMRP62484. Positions 1-155, 377-441.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-48418N.

PTM databases

PhosphoSiteP62484.

Proteomic databases

MaxQBP62484.
PaxDbP62484.
PRIDEP62484.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052332; ENSMUSP00000058754; ENSMUSG00000026782.
GeneID329165.
KEGGmmu:329165.
UCSCuc007beq.2. mouse.

Organism-specific databases

CTD10152.
MGIMGI:106913. Abi2.

Phylogenomic databases

eggNOGNOG262939.
GeneTreeENSGT00390000003756.
HOGENOMHOG000293213.
HOVERGENHBG050446.
KOK05751.
OMAVNGGPFY.
OrthoDBEOG7J17ZT.
PhylomeDBP62484.
TreeFamTF314303.

Gene expression databases

BgeeP62484.
CleanExMM_ABI2.
GenevestigatorP62484.

Family and domain databases

InterProIPR028457. ABI.
IPR028454. Abi2.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF3. PTHR10460:SF3. 1 hit.
PfamPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50002. SH3. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio398613.
PROP62484.
SOURCESearch...

Entry information

Entry nameABI2_MOUSE
AccessionPrimary (citable) accession number: P62484
Secondary accession number(s): Q6PHU3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot