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P62484

- ABI2_MOUSE

UniProt

P62484 - ABI2_MOUSE

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Protein
Abl interactor 2
Gene
Abi2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.1 Publication

GO - Biological processi

  1. actin polymerization or depolymerization Source: InterPro
  2. camera-type eye development Source: MGI
  3. cell migration Source: MGI
  4. dendrite development Source: MGI
  5. learning or memory Source: MGI
  6. peptidyl-tyrosine phosphorylation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Abl interactor 2
Alternative name(s):
Abelson interactor 2
Short name:
Abi-2
Gene namesi
Name:Abi2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:106913. Abi2.

Subcellular locationi

Cytoplasm. Cell projectionlamellipodium. Cell projectionfilopodium. Cytoplasmcytoskeleton
Note: Localized to protruding lamellipodia and filopodia tips.2 Publications

GO - Cellular componenti

  1. cell-cell adherens junction Source: MGI
  2. cytoskeleton Source: UniProtKB-SubCell
  3. cytosol Source: MGI
  4. dendrite Source: MGI
  5. filopodium Source: UniProtKB-SubCell
  6. lamellipodium Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Abl interactor 2
PRO_0000191791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei221 – 2211Phosphoserine By similarity
Modified residuei301 – 3011Phosphoserine By similarity

Post-translational modificationi

Is a substrate for ABL1 By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP62484.
PaxDbiP62484.
PRIDEiP62484.

PTM databases

PhosphoSiteiP62484.

Expressioni

Tissue specificityi

Expresses in embryonic and adult brain. In adult brain prominently expressed in the neocortex, hippocampus and dentate gyrus.1 Publication

Developmental stagei

Detected at E10 in developing brain, and expression is more prominent in the neuroepithelium compared to the surrounding tissue. At E12 expression is enhanced throughout the CNS and is detected along the full length of the spinal chord. At E16 expression remains enhanced in the CNS, and is particularly prominent in the olfactory bulb. Also highly expressed in dorsal root ganglia.1 Publication

Gene expression databases

BgeeiP62484.
CleanExiMM_ABI2.
GenevestigatoriP62484.

Interactioni

Subunit structurei

Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 By similarity. Interacts with ABL1 and ABL2.

Protein-protein interaction databases

DIPiDIP-48418N.

Structurei

3D structure databases

ProteinModelPortaliP62484.
SMRiP62484. Positions 1-155, 377-441.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 10763t-SNARE coiled-coil homology
Add
BLAST
Domaini384 – 44360SH3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi166 – 356191Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the ABI family.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG262939.
GeneTreeiENSGT00390000003756.
HOGENOMiHOG000293213.
HOVERGENiHBG050446.
KOiK05751.
OMAiVNGGPFY.
OrthoDBiEOG7J17ZT.
PhylomeDBiP62484.
TreeFamiTF314303.

Family and domain databases

InterProiIPR028457. ABI.
IPR028454. Abi2.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF3. PTHR10460:SF3. 1 hit.
PfamiPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62484-1 [UniParc]FASTAAdd to Basket

« Hide

MAELQMLLEE EIPGGRRALF DSYTNLERVA DYCENNYIQS PDKQRALEET    50
KAYTTQSLAS VAYLINTLAN NVLQMLDIQA SQLRRMESSI NHISQTVDIH 100
KEKVARREIG ILTTNKNTSR THKIIAPANL ERPVRYIRKP IDYTILDDIG 150
HGVKVSTQNM KMGGLPRTTP PTQKPPSPPM SGKGTLGRHS PYRTLEPVRP 200
PVVPNDYVPS PTRNMAPSQQ SPVRTASVNQ RNRTYSSSGS SGGSHPSSRS 250
SSRENSGSGS VGVPIAVPTP SPPSVFPGHP VQFYSMNRPA SRHTPPTIGG 300
SLPYRRPPSI TSQTSLQNQM NGGPFYNQNP VSDTPPPPPP VEEPVFDESP 350
PPPPPPEDYE EEEAAVVEYS DPYAEEDPPW APRAYLEKVV AIYDYTKDKE 400
DELSFQEGAI IYVIKKNDDG WYEGVMNGVT GLFPGNYVES IMHYSE 446
Length:446
Mass (Da):49,387
Last modified:July 19, 2004 - v1
Checksum:i8EC1FB543D93BEAA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC056345 mRNA. Translation: AAH56345.1.
CCDSiCCDS14991.1.
RefSeqiNP_001185499.1. NM_001198570.1.
NP_001185500.1. NM_001198571.1.
NP_937760.1. NM_198127.2.
UniGeneiMm.212066.
Mm.465571.

Genome annotation databases

EnsembliENSMUST00000052332; ENSMUSP00000058754; ENSMUSG00000026782.
GeneIDi329165.
KEGGimmu:329165.
UCSCiuc007beq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC056345 mRNA. Translation: AAH56345.1 .
CCDSi CCDS14991.1.
RefSeqi NP_001185499.1. NM_001198570.1.
NP_001185500.1. NM_001198571.1.
NP_937760.1. NM_198127.2.
UniGenei Mm.212066.
Mm.465571.

3D structure databases

ProteinModelPortali P62484.
SMRi P62484. Positions 1-155, 377-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48418N.

PTM databases

PhosphoSitei P62484.

Proteomic databases

MaxQBi P62484.
PaxDbi P62484.
PRIDEi P62484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052332 ; ENSMUSP00000058754 ; ENSMUSG00000026782 .
GeneIDi 329165.
KEGGi mmu:329165.
UCSCi uc007beq.2. mouse.

Organism-specific databases

CTDi 10152.
MGIi MGI:106913. Abi2.

Phylogenomic databases

eggNOGi NOG262939.
GeneTreei ENSGT00390000003756.
HOGENOMi HOG000293213.
HOVERGENi HBG050446.
KOi K05751.
OMAi VNGGPFY.
OrthoDBi EOG7J17ZT.
PhylomeDBi P62484.
TreeFami TF314303.

Miscellaneous databases

NextBioi 398613.
PROi P62484.
SOURCEi Search...

Gene expression databases

Bgeei P62484.
CleanExi MM_ABI2.
Genevestigatori P62484.

Family and domain databases

InterProi IPR028457. ABI.
IPR028454. Abi2.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR10460. PTHR10460. 1 hit.
PTHR10460:SF3. PTHR10460:SF3. 1 hit.
Pfami PF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia."
    Stradal T.E.B., Courtney K.D., Rottner K., Hahne P., Small J.V., Pendergast A.M.
    Curr. Biol. 11:891-895(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels."
    Echarri A., Lai M.J., Robinson M.R., Pendergast A.M.
    Mol. Cell. Biol. 24:4979-4993(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system."
    Courtney K.D., Grove M., Vandongen H., Vandongen A., LaMantia A.-S., Pendergast A.M.
    Mol. Cell. Neurosci. 16:244-257(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiABI2_MOUSE
AccessioniPrimary (citable) accession number: P62484
Secondary accession number(s): Q6PHU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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