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P62483

- KCAB2_RAT

UniProt

P62483 - KCAB2_RAT

Protein

Voltage-gated potassium channel subunit beta-2

Gene

Kcnab2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631NADP1 Publication
    Binding sitei85 – 851NADP1 Publication
    Binding sitei90 – 901NADP1 Publication
    Binding sitei214 – 2141NADP1 Publication
    Binding sitei254 – 2541NADP1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 572NADP1 Publication
    Nucleotide bindingi188 – 1892NADP1 Publication
    Nucleotide bindingi243 – 2486NADP1 Publication
    Nucleotide bindingi323 – 3297NADP1 Publication

    GO - Molecular functioni

    1. protein binding Source: RGD
    2. voltage-gated potassium channel activity Source: InterPro

    GO - Biological processi

    1. protein heterooligomerization Source: RGD

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    NADP, Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199159. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-gated potassium channel subunit beta-2
    Alternative name(s):
    K(+) channel subunit beta-2
    Kv-beta-2
    Gene namesi
    Name:Kcnab2
    Synonyms:Ckbeta2, Kcnb3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi61828. Kcnab2.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: InterPro
    3. juxtaparanode region of axon Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367Voltage-gated potassium channel subunit beta-2PRO_0000148748Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91PhosphoserineBy similarity
    Modified residuei124 – 1241N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP62483.
    PRIDEiP62483.

    PTM databases

    PhosphoSiteiP62483.

    Expressioni

    Gene expression databases

    GenevestigatoriP62483.

    Interactioni

    Subunit structurei

    Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ.1 Publication

    Protein-protein interaction databases

    BioGridi248350. 7 interactions.
    IntActiP62483. 1 interaction.

    Structurei

    Secondary structure

    1
    367
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi38 – 425
    Beta strandi48 – 558
    Helixi59 – 635
    Helixi66 – 7813
    Beta strandi83 – 875
    Helixi90 – 934
    Helixi94 – 10613
    Helixi110 – 1123
    Beta strandi114 – 1218
    Helixi126 – 1283
    Beta strandi129 – 1324
    Helixi133 – 14715
    Beta strandi152 – 1598
    Helixi166 – 17813
    Beta strandi181 – 1899
    Helixi192 – 20413
    Beta strandi212 – 2165
    Helixi223 – 23614
    Beta strandi239 – 2435
    Helixi247 – 2526
    Turni253 – 2575
    Helixi264 – 2663
    Helixi271 – 2788
    Helixi280 – 29920
    Helixi303 – 31210
    Beta strandi319 – 3224
    Helixi327 – 3348
    Helixi335 – 3428
    Helixi345 – 35511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EXBX-ray2.10A36-367[»]
    1QRQX-ray2.80A/B/C/D36-360[»]
    2A79X-ray2.90A36-367[»]
    2R9RX-ray2.40A/G36-367[»]
    3EAUX-ray1.82A36-361[»]
    3EB3X-ray2.00A36-361[»]
    3EB4X-ray2.00A36-361[»]
    3LNMX-ray2.90A/C36-367[»]
    3LUTX-ray2.90A1-367[»]
    4JTAX-ray2.50A/P36-367[»]
    4JTCX-ray2.56A/G36-367[»]
    4JTDX-ray2.54A/G36-367[»]
    ProteinModelPortaliP62483.
    SMRiP62483. Positions 36-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP62483.

    Family & Domainsi

    Domaini

    Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0667.
    GeneTreeiENSGT00550000074567.
    HOGENOMiHOG000250283.
    HOVERGENiHBG052216.
    KOiK04883.
    OMAiSNAEQLM.
    OrthoDBiEOG71G9TR.
    PhylomeDBiP62483.
    TreeFamiTF324563.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PRINTSiPR01579. KCNAB2CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62483-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS    50
    CLGLGTWVTF GGQITDEMAE HLMTLAYDNG INLFDTAEVY AAGKAEVVLG 100
    NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE 150
    YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS 200
    VARQFNLIPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI 250
    VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG 300
    CTLPQLAIAW CLRNEGVSSV LLGASNAEQL MENIGAIQVL PKLSSSIVHE 350
    IDSILGNKPY SKKDYRS 367
    Length:367
    Mass (Da):41,021
    Last modified:July 5, 2004 - v1
    Checksum:i5303FD1411B324FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76724 mRNA. Translation: CAA54142.1.
    PIRiS45312.
    RefSeqiNP_059000.1. NM_017304.2.
    UniGeneiRn.10757.

    Genome annotation databases

    EnsembliENSRNOT00000015840; ENSRNOP00000015840; ENSRNOG00000011550.
    GeneIDi29738.
    KEGGirno:29738.
    UCSCiRGD:61828. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76724 mRNA. Translation: CAA54142.1 .
    PIRi S45312.
    RefSeqi NP_059000.1. NM_017304.2.
    UniGenei Rn.10757.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EXB X-ray 2.10 A 36-367 [» ]
    1QRQ X-ray 2.80 A/B/C/D 36-360 [» ]
    2A79 X-ray 2.90 A 36-367 [» ]
    2R9R X-ray 2.40 A/G 36-367 [» ]
    3EAU X-ray 1.82 A 36-361 [» ]
    3EB3 X-ray 2.00 A 36-361 [» ]
    3EB4 X-ray 2.00 A 36-361 [» ]
    3LNM X-ray 2.90 A/C 36-367 [» ]
    3LUT X-ray 2.90 A 1-367 [» ]
    4JTA X-ray 2.50 A/P 36-367 [» ]
    4JTC X-ray 2.56 A/G 36-367 [» ]
    4JTD X-ray 2.54 A/G 36-367 [» ]
    ProteinModelPortali P62483.
    SMRi P62483. Positions 36-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248350. 7 interactions.
    IntActi P62483. 1 interaction.

    PTM databases

    PhosphoSitei P62483.

    Proteomic databases

    PaxDbi P62483.
    PRIDEi P62483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015840 ; ENSRNOP00000015840 ; ENSRNOG00000011550 .
    GeneIDi 29738.
    KEGGi rno:29738.
    UCSCi RGD:61828. rat.

    Organism-specific databases

    CTDi 8514.
    RGDi 61828. Kcnab2.

    Phylogenomic databases

    eggNOGi COG0667.
    GeneTreei ENSGT00550000074567.
    HOGENOMi HOG000250283.
    HOVERGENi HBG052216.
    KOi K04883.
    OMAi SNAEQLM.
    OrthoDBi EOG71G9TR.
    PhylomeDBi P62483.
    TreeFami TF324563.

    Enzyme and pathway databases

    Reactomei REACT_199159. Voltage gated Potassium channels.

    Miscellaneous databases

    EvolutionaryTracei P62483.
    NextBioi 289815.
    PROi P62483.

    Gene expression databases

    Genevestigatori P62483.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PRINTSi PR01579. KCNAB2CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit."
      Rettig J., Heinemann S.H., Wunder F., Lorra C., Parcej D.N., Dolly J.O., Pongs O.
      Nature 369:289-294(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain cortex.
    2. "Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2."
      Gong J., Xu J., Bezanilla M., van Huizen R., Derin R., Li M.
      Science 285:1565-1569(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SQSTM1 AND PRKCZ, PHOSPHORYLATION BY PRKCZ.
    3. "The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination."
      Wooten M.W., Geetha T., Seibenhener M.L., Babu J.R., Diaz-Meco M.T., Moscat J.
      J. Biol. Chem. 280:35625-35629(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SQSTM1; IKBKB AND TRAF6.
    4. "Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels."
      Gulbis J.M., Zhou M., Mann S., MacKinnon R.
      Science 289:123-127(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 36-367, INTERACTION WITH KCNA1, TETRAMERIZATION.
    5. "Crystal structure of a mammalian voltage-dependent Shaker family K+ channel."
      Long S.B., Campbell E.B., Mackinnon R.
      Science 309:897-903(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 36-367 IN COMPLEX WITH NADP AND KCNA2.

    Entry informationi

    Entry nameiKCAB2_RAT
    AccessioniPrimary (citable) accession number: P62483
    Secondary accession number(s): P97381, Q60942, Q64284
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3