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P62483

- KCAB2_RAT

UniProt

P62483 - KCAB2_RAT

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Protein

Voltage-gated potassium channel subunit beta-2

Gene
Kcnab2, Ckbeta2, Kcnb3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631NADP
Binding sitei85 – 851NADP
Binding sitei90 – 901NADP
Binding sitei214 – 2141NADP
Binding sitei254 – 2541NADP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 572NADP
Nucleotide bindingi188 – 1892NADP
Nucleotide bindingi243 – 2486NADP
Nucleotide bindingi323 – 3297NADP

GO - Molecular functioni

  1. protein binding Source: RGD
  2. voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

  1. protein heterooligomerization Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

NADP, Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-2
Alternative name(s):
K(+) channel subunit beta-2
Kv-beta-2
Gene namesi
Name:Kcnab2
Synonyms:Ckbeta2, Kcnb3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi61828. Kcnab2.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: InterPro
  3. juxtaparanode region of axon Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Voltage-gated potassium channel subunit beta-2PRO_0000148748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine By similarity
Modified residuei124 – 1241N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62483.
PRIDEiP62483.

PTM databases

PhosphoSiteiP62483.

Expressioni

Gene expression databases

GenevestigatoriP62483.

Interactioni

Subunit structurei

Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ.1 Publication

Protein-protein interaction databases

BioGridi248350. 7 interactions.
IntActiP62483. 1 interaction.

Structurei

Secondary structure

1
367
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 425
Beta strandi48 – 558
Helixi59 – 635
Helixi66 – 7813
Beta strandi83 – 875
Helixi90 – 934
Helixi94 – 10613
Helixi110 – 1123
Beta strandi114 – 1218
Helixi126 – 1283
Beta strandi129 – 1324
Helixi133 – 14715
Beta strandi152 – 1598
Helixi166 – 17813
Beta strandi181 – 1899
Helixi192 – 20413
Beta strandi212 – 2165
Helixi223 – 23614
Beta strandi239 – 2435
Helixi247 – 2526
Turni253 – 2575
Helixi264 – 2663
Helixi271 – 2788
Helixi280 – 29920
Helixi303 – 31210
Beta strandi319 – 3224
Helixi327 – 3348
Helixi335 – 3428
Helixi345 – 35511

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EXBX-ray2.10A36-367[»]
1QRQX-ray2.80A/B/C/D36-360[»]
2A79X-ray2.90A36-367[»]
2R9RX-ray2.40A/G36-367[»]
3EAUX-ray1.82A36-361[»]
3EB3X-ray2.00A36-361[»]
3EB4X-ray2.00A36-361[»]
3LNMX-ray2.90A/C36-367[»]
3LUTX-ray2.90A1-367[»]
4JTAX-ray2.50A/P36-367[»]
4JTCX-ray2.56A/G36-367[»]
4JTDX-ray2.54A/G36-367[»]
ProteinModelPortaliP62483.
SMRiP62483. Positions 36-361.

Miscellaneous databases

EvolutionaryTraceiP62483.

Family & Domainsi

Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit Inferred.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0667.
GeneTreeiENSGT00550000074567.
HOGENOMiHOG000250283.
HOVERGENiHBG052216.
KOiK04883.
OMAiSNAEQLM.
OrthoDBiEOG71G9TR.
PhylomeDBiP62483.
TreeFamiTF324563.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR01579. KCNAB2CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMiSSF51430. SSF51430. 1 hit.
TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

P62483-1 [UniParc]FASTAAdd to Basket

« Hide

MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS    50
CLGLGTWVTF GGQITDEMAE HLMTLAYDNG INLFDTAEVY AAGKAEVVLG 100
NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE 150
YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS 200
VARQFNLIPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI 250
VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG 300
CTLPQLAIAW CLRNEGVSSV LLGASNAEQL MENIGAIQVL PKLSSSIVHE 350
IDSILGNKPY SKKDYRS 367
Length:367
Mass (Da):41,021
Last modified:July 5, 2004 - v1
Checksum:i5303FD1411B324FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76724 mRNA. Translation: CAA54142.1.
PIRiS45312.
RefSeqiNP_059000.1. NM_017304.2.
UniGeneiRn.10757.

Genome annotation databases

EnsembliENSRNOT00000015840; ENSRNOP00000015840; ENSRNOG00000011550.
GeneIDi29738.
KEGGirno:29738.
UCSCiRGD:61828. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76724 mRNA. Translation: CAA54142.1 .
PIRi S45312.
RefSeqi NP_059000.1. NM_017304.2.
UniGenei Rn.10757.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EXB X-ray 2.10 A 36-367 [» ]
1QRQ X-ray 2.80 A/B/C/D 36-360 [» ]
2A79 X-ray 2.90 A 36-367 [» ]
2R9R X-ray 2.40 A/G 36-367 [» ]
3EAU X-ray 1.82 A 36-361 [» ]
3EB3 X-ray 2.00 A 36-361 [» ]
3EB4 X-ray 2.00 A 36-361 [» ]
3LNM X-ray 2.90 A/C 36-367 [» ]
3LUT X-ray 2.90 A 1-367 [» ]
4JTA X-ray 2.50 A/P 36-367 [» ]
4JTC X-ray 2.56 A/G 36-367 [» ]
4JTD X-ray 2.54 A/G 36-367 [» ]
ProteinModelPortali P62483.
SMRi P62483. Positions 36-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248350. 7 interactions.
IntActi P62483. 1 interaction.

PTM databases

PhosphoSitei P62483.

Proteomic databases

PaxDbi P62483.
PRIDEi P62483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015840 ; ENSRNOP00000015840 ; ENSRNOG00000011550 .
GeneIDi 29738.
KEGGi rno:29738.
UCSCi RGD:61828. rat.

Organism-specific databases

CTDi 8514.
RGDi 61828. Kcnab2.

Phylogenomic databases

eggNOGi COG0667.
GeneTreei ENSGT00550000074567.
HOGENOMi HOG000250283.
HOVERGENi HBG052216.
KOi K04883.
OMAi SNAEQLM.
OrthoDBi EOG71G9TR.
PhylomeDBi P62483.
TreeFami TF324563.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

EvolutionaryTracei P62483.
NextBioi 289815.
PROi P62483.

Gene expression databases

Genevestigatori P62483.

Family and domain databases

Gene3Di 3.20.20.100. 1 hit.
InterProi IPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
IPR023210. NADP_OxRdtase_dom.
[Graphical view ]
PANTHERi PTHR11732. PTHR11732. 1 hit.
Pfami PF00248. Aldo_ket_red. 1 hit.
[Graphical view ]
PRINTSi PR01579. KCNAB2CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMi SSF51430. SSF51430. 1 hit.
TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit."
    Rettig J., Heinemann S.H., Wunder F., Lorra C., Parcej D.N., Dolly J.O., Pongs O.
    Nature 369:289-294(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.
  2. "Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2."
    Gong J., Xu J., Bezanilla M., van Huizen R., Derin R., Li M.
    Science 285:1565-1569(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SQSTM1 AND PRKCZ, PHOSPHORYLATION BY PRKCZ.
  3. "The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination."
    Wooten M.W., Geetha T., Seibenhener M.L., Babu J.R., Diaz-Meco M.T., Moscat J.
    J. Biol. Chem. 280:35625-35629(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SQSTM1; IKBKB AND TRAF6.
  4. "Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels."
    Gulbis J.M., Zhou M., Mann S., MacKinnon R.
    Science 289:123-127(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 36-367, INTERACTION WITH KCNA1, TETRAMERIZATION.
  5. "Crystal structure of a mammalian voltage-dependent Shaker family K+ channel."
    Long S.B., Campbell E.B., Mackinnon R.
    Science 309:897-903(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 36-367 IN COMPLEX WITH NADP AND KCNA2.

Entry informationi

Entry nameiKCAB2_RAT
AccessioniPrimary (citable) accession number: P62483
Secondary accession number(s): P97381, Q60942, Q64284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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