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P62482 (KCAB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-gated potassium channel subunit beta-2
Alternative name(s):
K(+) channel subunit beta-2
Kv-beta-2
Neuroimmune protein F5
Gene names
Name:Kcnab2
Synonyms:Ckbeta2, I2rf5, Kcnb3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Ref.1

Subunit structure

Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ By similarity.

Subcellular location

Cytoplasm Potential.

Tissue specificity

Strongest expression in brain and eye. Highest levels in brain detected in brainstem and diencephalon. Strong expression also detected in lung and heart. Moderate expression in kidney, T-lymphocytes and skeletal muscle. Ref.2 Ref.3

Developmental stage

Not detected prior to birth, low levels of expression detected from postnatal days 1 to 7. Expression reaches adult levels by postnatal day 21. Ref.3

Domain

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit Probable.

Post-translational modification

Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1 By similarity.

Sequence similarities

Belongs to the shaker potassium channel beta subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Voltage-gated potassium channel subunit beta-2
PRO_0000148747

Regions

Nucleotide binding56 – 572NADP By similarity
Nucleotide binding188 – 1892NADP By similarity
Nucleotide binding243 – 2486NADP By similarity
Nucleotide binding323 – 3297NADP By similarity

Sites

Binding site631NADP By similarity
Binding site851NADP By similarity
Binding site901NADP By similarity
Binding site2141NADP By similarity
Binding site2541NADP By similarity

Amino acid modifications

Modified residue91Phosphoserine By similarity
Modified residue1241N6-acetyllysine By similarity

Experimental info

Sequence conflict641I → L in AAB37263. Ref.2
Sequence conflict99 – 1002LG → FR in AAA75174. Ref.3
Sequence conflict2021A → G in AAB37263. Ref.2
Sequence conflict2661S → L in AAA75174. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P62482 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5303FD1411B324FC

FASTA36741,021
        10         20         30         40         50         60 
MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS CLGLGTWVTF 

        70         80         90        100        110        120 
GGQITDEMAE HLMTLAYDNG INLFDTAEVY AAGKAEVVLG NIIKKKGWRR SSLVITTKIF 

       130        140        150        160        170        180 
WGGKAETERG LSRKHIIEGL KASLERLQLE YVDVVFANRP DPNTPMEETV RAMTHVINQG 

       190        200        210        220        230        240 
MAMYWGTSRW SSMEIMEAYS VARQFNLIPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA 

       250        260        270        280        290        300 
MTWSPLACGI VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG 

       310        320        330        340        350        360 
CTLPQLAIAW CLRNEGVSSV LLGASNAEQL MENIGAIQVL PKLSSSIVHE IDSILGNKPY 


SKKDYRS 

« Hide

References

« Hide 'large scale' references
[1]"Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits."
Uebele V.N., England S.K., Chaudhary A., Tamkun M.M., Snyders D.J.
J. Biol. Chem. 271:2406-2412(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Tissue: Fibroblast.
[2]"A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression."
Fink M., Duprat F., Lesage F., Heurteaux C., Romey G., Barhanin J., Lazdunski M.
J. Biol. Chem. 271:26341-26348(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain cortex.
[3]"Characterization of a novel mRNA expressed by neurons in mature brain."
Cohen J.A., Arai M., Prak E.L., Brooks S.A., Young L.H., Prystowsky M.B.
J. Neurosci. Res. 31:273-284(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: C57BL/6N.
Tissue: Brain and T-cell.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L48983 mRNA. Translation: AAB00829.1.
U65592 mRNA. Translation: AAB37263.1.
U31908 mRNA. Translation: AAA75174.1.
BC039178 mRNA. Translation: AAH39178.1.
RefSeqNP_001239585.1. NM_001252656.1.
NP_034728.2. NM_010598.3.
UniGeneMm.388924.

3D structure databases

ProteinModelPortalP62482.
SMRP62482. Positions 36-361.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200884. 3 interactions.
IntActP62482. 6 interactions.
MINTMINT-138568.

PTM databases

PhosphoSiteP62482.

Proteomic databases

PaxDbP62482.
PRIDEP62482.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105648; ENSMUSP00000101273; ENSMUSG00000028931.
ENSMUST00000160884; ENSMUSP00000125058; ENSMUSG00000028931.
GeneID16498.
KEGGmmu:16498.
UCSCuc008wal.2. mouse.

Organism-specific databases

CTD8514.
MGIMGI:109239. Kcnab2.

Phylogenomic databases

eggNOGCOG0667.
GeneTreeENSGT00550000074567.
HOGENOMHOG000250283.
HOVERGENHBG052216.
InParanoidP62482.
KOK04883.
OrthoDBEOG71G9TR.
PhylomeDBP62482.
TreeFamTF324563.

Gene expression databases

ArrayExpressP62482.
BgeeP62482.
GenevestigatorP62482.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PTHR11732:SF14. PTHR11732:SF14. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSPR01579. KCNAB2CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMSSF51430. SSF51430. 1 hit.
TIGRFAMsTIGR01293. Kv_beta. 1 hit.
ProtoNetSearch...

Other

NextBio289815.
PROP62482.
SOURCESearch...

Entry information

Entry nameKCAB2_MOUSE
AccessionPrimary (citable) accession number: P62482
Secondary accession number(s): P97381, Q60942, Q64284
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot