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P62482

- KCAB2_MOUSE

UniProt

P62482 - KCAB2_MOUSE

Protein

Voltage-gated potassium channel subunit beta-2

Gene

Kcnab2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631NADPBy similarity
    Binding sitei85 – 851NADPBy similarity
    Binding sitei90 – 901NADPBy similarity
    Binding sitei214 – 2141NADPBy similarity
    Binding sitei254 – 2541NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 572NADPBy similarity
    Nucleotide bindingi188 – 1892NADPBy similarity
    Nucleotide bindingi243 – 2486NADPBy similarity
    Nucleotide bindingi323 – 3297NADPBy similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. voltage-gated potassium channel activity Source: InterPro

    GO - Biological processi

    1. hematopoietic progenitor cell differentiation Source: MGI
    2. protein heterooligomerization Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    NADP, Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-gated potassium channel subunit beta-2
    Alternative name(s):
    K(+) channel subunit beta-2
    Kv-beta-2
    Neuroimmune protein F5
    Gene namesi
    Name:Kcnab2
    Synonyms:Ckbeta2, I2rf5, Kcnb3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:109239. Kcnab2.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: InterPro
    3. juxtaparanode region of axon Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367Voltage-gated potassium channel subunit beta-2PRO_0000148747Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91PhosphoserineBy similarity
    Modified residuei124 – 1241N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP62482.
    PaxDbiP62482.
    PRIDEiP62482.

    PTM databases

    PhosphoSiteiP62482.

    Expressioni

    Tissue specificityi

    Strongest expression in brain and eye. Highest levels in brain detected in brainstem and diencephalon. Strong expression also detected in lung and heart. Moderate expression in kidney, T-lymphocytes and skeletal muscle.2 Publications

    Developmental stagei

    Not detected prior to birth, low levels of expression detected from postnatal days 1 to 7. Expression reaches adult levels by postnatal day 21.1 Publication

    Gene expression databases

    ArrayExpressiP62482.
    BgeeiP62482.
    GenevestigatoriP62482.

    Interactioni

    Subunit structurei

    Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ By similarity.By similarity

    Protein-protein interaction databases

    BioGridi200884. 3 interactions.
    IntActiP62482. 6 interactions.
    MINTiMINT-138568.

    Structurei

    3D structure databases

    ProteinModelPortaliP62482.
    SMRiP62482. Positions 36-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0667.
    GeneTreeiENSGT00550000074567.
    HOGENOMiHOG000250283.
    HOVERGENiHBG052216.
    InParanoidiP62482.
    KOiK04883.
    OrthoDBiEOG71G9TR.
    PhylomeDBiP62482.
    TreeFamiTF324563.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PRINTSiPR01579. KCNAB2CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62482-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS    50
    CLGLGTWVTF GGQITDEMAE HLMTLAYDNG INLFDTAEVY AAGKAEVVLG 100
    NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE 150
    YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS 200
    VARQFNLIPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI 250
    VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG 300
    CTLPQLAIAW CLRNEGVSSV LLGASNAEQL MENIGAIQVL PKLSSSIVHE 350
    IDSILGNKPY SKKDYRS 367
    Length:367
    Mass (Da):41,021
    Last modified:July 5, 2004 - v1
    Checksum:i5303FD1411B324FC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641I → L in AAB37263. (PubMed:8824288)Curated
    Sequence conflicti99 – 1002LG → FR in AAA75174. (PubMed:1573677)Curated
    Sequence conflicti202 – 2021A → G in AAB37263. (PubMed:8824288)Curated
    Sequence conflicti266 – 2661S → L in AAA75174. (PubMed:1573677)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L48983 mRNA. Translation: AAB00829.1.
    U65592 mRNA. Translation: AAB37263.1.
    U31908 mRNA. Translation: AAA75174.1.
    BC039178 mRNA. Translation: AAH39178.1.
    CCDSiCCDS19000.1.
    RefSeqiNP_001239585.1. NM_001252656.1.
    NP_034728.2. NM_010598.3.
    UniGeneiMm.388924.

    Genome annotation databases

    EnsembliENSMUST00000105648; ENSMUSP00000101273; ENSMUSG00000028931.
    ENSMUST00000160884; ENSMUSP00000125058; ENSMUSG00000028931.
    GeneIDi16498.
    KEGGimmu:16498.
    UCSCiuc008wal.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L48983 mRNA. Translation: AAB00829.1 .
    U65592 mRNA. Translation: AAB37263.1 .
    U31908 mRNA. Translation: AAA75174.1 .
    BC039178 mRNA. Translation: AAH39178.1 .
    CCDSi CCDS19000.1.
    RefSeqi NP_001239585.1. NM_001252656.1.
    NP_034728.2. NM_010598.3.
    UniGenei Mm.388924.

    3D structure databases

    ProteinModelPortali P62482.
    SMRi P62482. Positions 36-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200884. 3 interactions.
    IntActi P62482. 6 interactions.
    MINTi MINT-138568.

    PTM databases

    PhosphoSitei P62482.

    Proteomic databases

    MaxQBi P62482.
    PaxDbi P62482.
    PRIDEi P62482.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105648 ; ENSMUSP00000101273 ; ENSMUSG00000028931 .
    ENSMUST00000160884 ; ENSMUSP00000125058 ; ENSMUSG00000028931 .
    GeneIDi 16498.
    KEGGi mmu:16498.
    UCSCi uc008wal.2. mouse.

    Organism-specific databases

    CTDi 8514.
    MGIi MGI:109239. Kcnab2.

    Phylogenomic databases

    eggNOGi COG0667.
    GeneTreei ENSGT00550000074567.
    HOGENOMi HOG000250283.
    HOVERGENi HBG052216.
    InParanoidi P62482.
    KOi K04883.
    OrthoDBi EOG71G9TR.
    PhylomeDBi P62482.
    TreeFami TF324563.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 289815.
    PROi P62482.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62482.
    Bgeei P62482.
    Genevestigatori P62482.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PRINTSi PR01579. KCNAB2CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits."
      Uebele V.N., England S.K., Chaudhary A., Tamkun M.M., Snyders D.J.
      J. Biol. Chem. 271:2406-2412(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Fibroblast.
    2. "A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression."
      Fink M., Duprat F., Lesage F., Heurteaux C., Romey G., Barhanin J., Lazdunski M.
      J. Biol. Chem. 271:26341-26348(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain cortex.
    3. "Characterization of a novel mRNA expressed by neurons in mature brain."
      Cohen J.A., Arai M., Prak E.L., Brooks S.A., Young L.H., Prystowsky M.B.
      J. Neurosci. Res. 31:273-284(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: C57BL/6N.
      Tissue: Brain and T-cell.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiKCAB2_MOUSE
    AccessioniPrimary (citable) accession number: P62482
    Secondary accession number(s): P97381, Q60942, Q64284
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3