Voltage-gated potassium channel subunit beta-2

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P62482 (KCAB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Voltage-gated potassium channel subunit beta-2

Alternative name(s):
K(+) channel subunit beta-2
Kv-beta-2
Neuroimmune protein F5

Gene names

Name:	Kcnab2
Synonyms:	Ckbeta2, I2rf5, Kcnb3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Ref.1
Subunit structure	Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ By similarity.
Subcellular location	Cytoplasm Potential.
Tissue specificity	Strongest expression in brain and eye. Highest levels in brain detected in brainstem and diencephalon. Strong expression also detected in lung and heart. Moderate expression in kidney, T-lymphocytes and skeletal muscle. Ref.2 Ref.3
Developmental stage	Not detected prior to birth, low levels of expression detected from postnatal days 1 to 7. Expression reaches adult levels by postnatal day 21. Ref.3
Domain	Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit Probable.
Post-translational modification	Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1 By similarity.
Sequence similarities	Belongs to the shaker potassium channel beta subunit family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cytoplasm
Ligand	NADP Potassium
Molecular function	Ion channel Voltage-gated channel
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein heterooligomerization Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro juxtaparanode region of axon Inferred from direct assay PubMed 12963709. Source: BHF-UCL
Molecular_function	voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 367

367

Voltage-gated potassium channel subunit beta-2

PRO_0000148747

Regions

Nucleotide binding

56 – 57

NADP By similarity

Nucleotide binding

188 – 189

NADP By similarity

Nucleotide binding

243 – 248

NADP By similarity

Nucleotide binding

323 – 329

NADP By similarity

Sites

Binding site

NADP By similarity

Binding site

NADP By similarity

Binding site

NADP By similarity

Binding site

214

NADP By similarity

Binding site

254

NADP By similarity

Amino acid modifications

Modified residue

Phosphoserine Ref.6

Modified residue

Phosphoserine Ref.5

Modified residue

Phosphotyrosine Ref.5

Modified residue

124

N6-acetyllysine By similarity

Modified residue

360

Phosphotyrosine Ref.5

Experimental info

Sequence conflict

I → L in AAB37263. Ref.2

Sequence conflict

99 – 100

LG → FR in AAA75174. Ref.3

Sequence conflict

202

A → G in AAB37263. Ref.2

Sequence conflict

266

S → L in AAA75174. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P62482 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5303FD1411B324FC
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FASTA

367

41,021

        10         20         30         40         50         60 
MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS CLGLGTWVTF 

        70         80         90        100        110        120 
GGQITDEMAE HLMTLAYDNG INLFDTAEVY AAGKAEVVLG NIIKKKGWRR SSLVITTKIF 

       130        140        150        160        170        180 
WGGKAETERG LSRKHIIEGL KASLERLQLE YVDVVFANRP DPNTPMEETV RAMTHVINQG 

       190        200        210        220        230        240 
MAMYWGTSRW SSMEIMEAYS VARQFNLIPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA 

       250        260        270        280        290        300 
MTWSPLACGI VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG 

       310        320        330        340        350        360 
CTLPQLAIAW CLRNEGVSSV LLGASNAEQL MENIGAIQVL PKLSSSIVHE IDSILGNKPY 


SKKDYRS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits." Uebele V.N., England S.K., Chaudhary A., Tamkun M.M., Snyders D.J. J. Biol. Chem. 271:2406-2412(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Fibroblast.
[2]	"A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression." Fink M., Duprat F., Lesage F., Heurteaux C., Romey G., Barhanin J., Lazdunski M. J. Biol. Chem. 271:26341-26348(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain cortex.
[3]	"Characterization of a novel mRNA expressed by neurons in mature brain." Cohen J.A., Arai M., Prak E.L., Brooks S.A., Young L.H., Prystowsky M.B. J. Neurosci. Res. 31:273-284(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: C57BL/6N. Tissue: Brain and T-cell.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[5]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; TYR-25 AND TYR-360, MASS SPECTROMETRY. Tissue: Brain.
[6]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L48983 mRNA. Translation: AAB00829.1. U65592 mRNA. Translation: AAB37263.1. U31908 mRNA. Translation: AAA75174.1. BC039178 mRNA. Translation: AAH39178.1.
IPI	IPI00315359.
RefSeq	NP_001239585.1. NM_001252656.1. NP_034728.2. NM_010598.3.
UniGene	Mm.388924.
3D structure databases
ProteinModelPortal	P62482.
SMR	P62482. Positions 36-361.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62482. 5 interactions.
MINT	MINT-138568.
PTM databases
PhosphoSite	P62482.
Proteomic databases
PaxDb	P62482.
PRIDE	P62482.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000105648; ENSMUSP00000101273; ENSMUSG00000028931. ENSMUST00000160884; ENSMUSP00000125058; ENSMUSG00000028931.
GeneID	16498.
KEGG	mmu:16498.
UCSC	uc008wal.1. mouse.
Organism-specific databases
CTD	8514.
MGI	MGI:109239. Kcnab2.
Phylogenomic databases
eggNOG	COG0667.
GeneTree	ENSGT00550000074567.
HOGENOM	HOG000250283.
HOVERGEN	HBG052216.
InParanoid	P62482.
KO	K04883.
OrthoDB	EOG476K0F.
Gene expression databases
ArrayExpress	P62482.
Bgee	P62482.
Genevestigator	P62482.
GermOnline	ENSMUSG00000028931. Mus musculus.
Family and domain databases
Gene3D	3.20.20.100. 1 hit.
InterPro	IPR001395. Aldo/ket_red. IPR005983. K_chnl_volt-dep_bsu_KCNAB. IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel. IPR005401. K_chnl_volt-dep_bsu_KCNAB2. IPR023210. NADP_OxRdtase_dom. [Graphical view]
PANTHER	PTHR11732. PTHR11732. 1 hit. PTHR11732:SF14. PTHR11732:SF14. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PRINTS	PR01579. KCNAB2CHANEL. PR01577. KCNABCHANNEL.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
TIGRFAMs	TIGR01293. Kv_beta. 1 hit.
ProtoNet	Search...
Other
NextBio	289815.
SOURCE	Search...

Entry information

Entry name

KCAB2_MOUSE

Accession

Primary (citable) accession number: P62482
Secondary accession number(s): P97381, Q60942, Q64284

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents