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P62482

- KCAB2_MOUSE

UniProt

P62482 - KCAB2_MOUSE

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Protein

Voltage-gated potassium channel subunit beta-2

Gene

Kcnab2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631NADPBy similarity
Binding sitei85 – 851NADPBy similarity
Binding sitei90 – 901NADPBy similarity
Binding sitei214 – 2141NADPBy similarity
Binding sitei254 – 2541NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 572NADPBy similarity
Nucleotide bindingi188 – 1892NADPBy similarity
Nucleotide bindingi243 – 2486NADPBy similarity
Nucleotide bindingi323 – 3297NADPBy similarity

GO - Molecular functioni

  1. voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

  1. hematopoietic progenitor cell differentiation Source: MGI
  2. protein heterooligomerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

NADP, Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-2
Alternative name(s):
K(+) channel subunit beta-2
Kv-beta-2
Neuroimmune protein F5
Gene namesi
Name:Kcnab2
Synonyms:Ckbeta2, I2rf5, Kcnb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:109239. Kcnab2.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: InterPro
  3. juxtaparanode region of axon Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Voltage-gated potassium channel subunit beta-2PRO_0000148747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei124 – 1241N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP62482.
PaxDbiP62482.
PRIDEiP62482.

PTM databases

PhosphoSiteiP62482.

Expressioni

Tissue specificityi

Strongest expression in brain and eye. Highest levels in brain detected in brainstem and diencephalon. Strong expression also detected in lung and heart. Moderate expression in kidney, T-lymphocytes and skeletal muscle.2 Publications

Developmental stagei

Not detected prior to birth, low levels of expression detected from postnatal days 1 to 7. Expression reaches adult levels by postnatal day 21.1 Publication

Gene expression databases

BgeeiP62482.
ExpressionAtlasiP62482. baseline and differential.
GenevestigatoriP62482.

Interactioni

Subunit structurei

Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).By similarity

Protein-protein interaction databases

BioGridi200884. 3 interactions.
IntActiP62482. 6 interactions.
MINTiMINT-138568.

Structurei

3D structure databases

ProteinModelPortaliP62482.
SMRiP62482. Positions 36-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0667.
GeneTreeiENSGT00550000074567.
HOGENOMiHOG000250283.
HOVERGENiHBG052216.
InParanoidiP62482.
KOiK04883.
OrthoDBiEOG71G9TR.
PhylomeDBiP62482.
TreeFamiTF324563.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR01579. KCNAB2CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMiSSF51430. SSF51430. 1 hit.
TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

P62482 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS
60 70 80 90 100
CLGLGTWVTF GGQITDEMAE HLMTLAYDNG INLFDTAEVY AAGKAEVVLG
110 120 130 140 150
NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE
160 170 180 190 200
YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS
210 220 230 240 250
VARQFNLIPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI
260 270 280 290 300
VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG
310 320 330 340 350
CTLPQLAIAW CLRNEGVSSV LLGASNAEQL MENIGAIQVL PKLSSSIVHE
360
IDSILGNKPY SKKDYRS
Length:367
Mass (Da):41,021
Last modified:July 5, 2004 - v1
Checksum:i5303FD1411B324FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641I → L in AAB37263. (PubMed:8824288)Curated
Sequence conflicti99 – 1002LG → FR in AAA75174. (PubMed:1573677)Curated
Sequence conflicti202 – 2021A → G in AAB37263. (PubMed:8824288)Curated
Sequence conflicti266 – 2661S → L in AAA75174. (PubMed:1573677)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L48983 mRNA. Translation: AAB00829.1.
U65592 mRNA. Translation: AAB37263.1.
U31908 mRNA. Translation: AAA75174.1.
BC039178 mRNA. Translation: AAH39178.1.
CCDSiCCDS19000.1.
RefSeqiNP_001239585.1. NM_001252656.1.
NP_034728.2. NM_010598.3.
UniGeneiMm.388924.

Genome annotation databases

EnsembliENSMUST00000105648; ENSMUSP00000101273; ENSMUSG00000028931.
ENSMUST00000160884; ENSMUSP00000125058; ENSMUSG00000028931.
GeneIDi16498.
KEGGimmu:16498.
UCSCiuc008wal.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L48983 mRNA. Translation: AAB00829.1 .
U65592 mRNA. Translation: AAB37263.1 .
U31908 mRNA. Translation: AAA75174.1 .
BC039178 mRNA. Translation: AAH39178.1 .
CCDSi CCDS19000.1.
RefSeqi NP_001239585.1. NM_001252656.1.
NP_034728.2. NM_010598.3.
UniGenei Mm.388924.

3D structure databases

ProteinModelPortali P62482.
SMRi P62482. Positions 36-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200884. 3 interactions.
IntActi P62482. 6 interactions.
MINTi MINT-138568.

PTM databases

PhosphoSitei P62482.

Proteomic databases

MaxQBi P62482.
PaxDbi P62482.
PRIDEi P62482.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105648 ; ENSMUSP00000101273 ; ENSMUSG00000028931 .
ENSMUST00000160884 ; ENSMUSP00000125058 ; ENSMUSG00000028931 .
GeneIDi 16498.
KEGGi mmu:16498.
UCSCi uc008wal.2. mouse.

Organism-specific databases

CTDi 8514.
MGIi MGI:109239. Kcnab2.

Phylogenomic databases

eggNOGi COG0667.
GeneTreei ENSGT00550000074567.
HOGENOMi HOG000250283.
HOVERGENi HBG052216.
InParanoidi P62482.
KOi K04883.
OrthoDBi EOG71G9TR.
PhylomeDBi P62482.
TreeFami TF324563.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289815.
PROi P62482.
SOURCEi Search...

Gene expression databases

Bgeei P62482.
ExpressionAtlasi P62482. baseline and differential.
Genevestigatori P62482.

Family and domain databases

Gene3Di 3.20.20.100. 1 hit.
InterProi IPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005401. K_chnl_volt-dep_bsu_KCNAB2.
IPR023210. NADP_OxRdtase_dom.
[Graphical view ]
PANTHERi PTHR11732. PTHR11732. 1 hit.
Pfami PF00248. Aldo_ket_red. 1 hit.
[Graphical view ]
PRINTSi PR01579. KCNAB2CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMi SSF51430. SSF51430. 1 hit.
TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits."
    Uebele V.N., England S.K., Chaudhary A., Tamkun M.M., Snyders D.J.
    J. Biol. Chem. 271:2406-2412(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Fibroblast.
  2. "A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression."
    Fink M., Duprat F., Lesage F., Heurteaux C., Romey G., Barhanin J., Lazdunski M.
    J. Biol. Chem. 271:26341-26348(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain cortex.
  3. "Characterization of a novel mRNA expressed by neurons in mature brain."
    Cohen J.A., Arai M., Prak E.L., Brooks S.A., Young L.H., Prystowsky M.B.
    J. Neurosci. Res. 31:273-284(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6N.
    Tissue: Brain and T-cell.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKCAB2_MOUSE
AccessioniPrimary (citable) accession number: P62482
Secondary accession number(s): P97381, Q60942, Q64284
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3