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P62467

- UPPP_THET2

UniProt

P62467 - UPPP_THET2

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, bacA, upk, TT_C1814
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1852-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:TT_C1814
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 3123Helical; Reviewed prediction
Add
BLAST
Transmembranei46 – 6621Helical; Reviewed prediction
Add
BLAST
Transmembranei80 – 10021Helical; Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Reviewed prediction
Add
BLAST
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Transmembranei180 – 20021Helical; Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Reviewed prediction
Add
BLAST
Transmembranei240 – 26021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Undecaprenyl-diphosphataseUniRule annotation
PRO_0000151228Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1814.

Structurei

3D structure databases

ProteinModelPortaliP62467.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiLHIILAC.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62467-1 [UniParc]FASTAAdd to Basket

« Hide

MGRVSAWEAL LLGVVEGLTE FLPVSSTGHL TLLFHLLGLP VEEDPFLKTF    50
LVAIQLGAIL AVLLLYGRRL AADRALWLRI AVAFVPTGVI GFFFYPLIKG 100
VILGNDAVVA FFLFFVGAVL LFADRLAERA QYQDVKALPL ARVAWIGVFQ 150
GLAALFPGTS RSGATILGGL LLGLNRQAAA EFSFLLALPT MFAAVGYDLW 200
KSAPEVPEGG WSLLLLGFLA ALATALVTVR WMLAFVARHG FRPFALYRMA 250
LAAVYAFFFL R 261
Length:261
Mass (Da):28,351
Last modified:July 5, 2004 - v1
Checksum:i80860C992084A9A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82156.1.
RefSeqiYP_005783.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82156; AAS82156; TT_C1814.
GeneIDi2774703.
KEGGitth:TTC1814.
PATRICi23954097. VBITheThe54392_1814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS82156.1 .
RefSeqi YP_005783.1. NC_005835.1.

3D structure databases

ProteinModelPortali P62467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC1814.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS82156 ; AAS82156 ; TT_C1814 .
GeneIDi 2774703.
KEGGi tth:TTC1814.
PATRICi 23954097. VBITheThe54392_1814.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi LHIILAC.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1852-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiUPPP_THET2
AccessioniPrimary (citable) accession number: P62467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi