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P62467

- UPPP_THET2

UniProt

P62467 - UPPP_THET2

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1852-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:TT_C1814
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Undecaprenyl-diphosphatasePRO_0000151228Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262724.TTC1814.

    Structurei

    3D structure databases

    ProteinModelPortaliP62467.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 3123HelicalUniRule annotationAdd
    BLAST
    Transmembranei46 – 6621HelicalUniRule annotationAdd
    BLAST
    Transmembranei80 – 10021HelicalUniRule annotationAdd
    BLAST
    Transmembranei102 – 12221HelicalUniRule annotationAdd
    BLAST
    Transmembranei137 – 15721HelicalUniRule annotationAdd
    BLAST
    Transmembranei180 – 20021HelicalUniRule annotationAdd
    BLAST
    Transmembranei209 – 22921HelicalUniRule annotationAdd
    BLAST
    Transmembranei240 – 26021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    KOiK06153.
    OMAiLHIILAC.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62467-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRVSAWEAL LLGVVEGLTE FLPVSSTGHL TLLFHLLGLP VEEDPFLKTF    50
    LVAIQLGAIL AVLLLYGRRL AADRALWLRI AVAFVPTGVI GFFFYPLIKG 100
    VILGNDAVVA FFLFFVGAVL LFADRLAERA QYQDVKALPL ARVAWIGVFQ 150
    GLAALFPGTS RSGATILGGL LLGLNRQAAA EFSFLLALPT MFAAVGYDLW 200
    KSAPEVPEGG WSLLLLGFLA ALATALVTVR WMLAFVARHG FRPFALYRMA 250
    LAAVYAFFFL R 261
    Length:261
    Mass (Da):28,351
    Last modified:July 5, 2004 - v1
    Checksum:i80860C992084A9A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS82156.1.
    RefSeqiYP_005783.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS82156; AAS82156; TT_C1814.
    GeneIDi2774703.
    KEGGitth:TTC1814.
    PATRICi23954097. VBITheThe54392_1814.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS82156.1 .
    RefSeqi YP_005783.1. NC_005835.1.

    3D structure databases

    ProteinModelPortali P62467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262724.TTC1814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS82156 ; AAS82156 ; TT_C1814 .
    GeneIDi 2774703.
    KEGGi tth:TTC1814.
    PATRICi 23954097. VBITheThe54392_1814.

    Phylogenomic databases

    eggNOGi COG1968.
    KOi K06153.
    OMAi LHIILAC.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci TTHE262724:GCAT-1852-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.

    Entry informationi

    Entry nameiUPPP_THET2
    AccessioniPrimary (citable) accession number: P62467
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3