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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1852-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:TT_C1814
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 3123HelicalUniRule annotationAdd
BLAST
Transmembranei46 – 6621HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10021HelicalUniRule annotationAdd
BLAST
Transmembranei102 – 12221HelicalUniRule annotationAdd
BLAST
Transmembranei137 – 15721HelicalUniRule annotationAdd
BLAST
Transmembranei180 – 20021HelicalUniRule annotationAdd
BLAST
Transmembranei209 – 22921HelicalUniRule annotationAdd
BLAST
Transmembranei240 – 26021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Undecaprenyl-diphosphatasePRO_0000151228Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC1814.

Structurei

3D structure databases

ProteinModelPortaliP62467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVSAWEAL LLGVVEGLTE FLPVSSTGHL TLLFHLLGLP VEEDPFLKTF
60 70 80 90 100
LVAIQLGAIL AVLLLYGRRL AADRALWLRI AVAFVPTGVI GFFFYPLIKG
110 120 130 140 150
VILGNDAVVA FFLFFVGAVL LFADRLAERA QYQDVKALPL ARVAWIGVFQ
160 170 180 190 200
GLAALFPGTS RSGATILGGL LLGLNRQAAA EFSFLLALPT MFAAVGYDLW
210 220 230 240 250
KSAPEVPEGG WSLLLLGFLA ALATALVTVR WMLAFVARHG FRPFALYRMA
260
LAAVYAFFFL R
Length:261
Mass (Da):28,351
Last modified:July 5, 2004 - v1
Checksum:i80860C992084A9A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82156.1.
RefSeqiWP_011174169.1. NC_005835.1.
YP_005783.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS82156; AAS82156; TT_C1814.
KEGGitth:TTC1814.
PATRICi23954097. VBITheThe54392_1814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017221 Genomic DNA. Translation: AAS82156.1.
RefSeqiWP_011174169.1. NC_005835.1.
YP_005783.1. NC_005835.1.

3D structure databases

ProteinModelPortaliP62467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262724.TTC1814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS82156; AAS82156; TT_C1814.
KEGGitth:TTC1814.
PATRICi23954097. VBITheThe54392_1814.

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1852-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiUPPP_THET2
AccessioniPrimary (citable) accession number: P62467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.