P62465 (UPPP_LEPIC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	LIC_11457

Organism

Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) [Complete proteome] [HAMAP]

Taxonomic identifier

267671 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Leptospiraceae › Leptospira › Leptospira interrogans › Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151160
Regions
	Transmembrane	19 – 39	21	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	122 – 142	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	257 – 277	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P62465 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 664C38B6E9EFEE10	FASTA	277	31,374
	10 20 30 40 50 60 MNPYLNAFLR SIIEAITEFL PVSSTGHLFL FSSFFPFYGE NVEFDDLFDI FIQSGAILSV 70 80 90 100 110 120 LFLYREKFKS QIVSSFRYIL KQNSDSEGFH FLIQICIGAF PILIAGFIAK KFLDTIKARP 130 140 150 160 170 180 DLLEILSGAW IFGGVLILVA EWYFHQRPEE KKSIGFKDSI LIGIFQCMAL IPGMSRSAAT 190 200 210 220 230 240 IITARFLGKD TKSSAEFSFF LAVPVLLAAG IYKLIKYRSI LNGNTIPVLM FGFLVSFLLC 250 260 270 TLVIRWFLRY IQKHSFSVFG VYRILLGVGV LVLTKLI

References

[1]

"Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis." Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B., Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V., Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L., Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S. , Ferro M.I.T., Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H., Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M., Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L., Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A., Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A., Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A. J. Bacteriol. 186:2164-2172(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fiocruz L1-130.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016823 Genomic DNA. Translation: AAS70055.1.
RefSeq	YP_001418.1. NC_005823.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	267671.LIC11457.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS70055; AAS70055; LIC_11457.
GeneID	2771065.
KEGG	lic:LIC11457.
PATRIC	22375237. VBILepInt6257_1785.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K06153.
OMA	TGHQLLI.
ProtClustDB	CLSK574452.
Enzyme and pathway databases
BioCyc	LINT267671:GHQI-1726-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_LEPIC

Accession

Primary (citable) accession number: P62465

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program