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P62465 (UPPP_LEPIC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:LIC_11457
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130) [Complete proteome] [HAMAP]
Taxonomic identifier267671 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151160

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane44 – 6421Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P62465 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 664C38B6E9EFEE10

FASTA27731,374
        10         20         30         40         50         60 
MNPYLNAFLR SIIEAITEFL PVSSTGHLFL FSSFFPFYGE NVEFDDLFDI FIQSGAILSV 

        70         80         90        100        110        120 
LFLYREKFKS QIVSSFRYIL KQNSDSEGFH FLIQICIGAF PILIAGFIAK KFLDTIKARP 

       130        140        150        160        170        180 
DLLEILSGAW IFGGVLILVA EWYFHQRPEE KKSIGFKDSI LIGIFQCMAL IPGMSRSAAT 

       190        200        210        220        230        240 
IITARFLGKD TKSSAEFSFF LAVPVLLAAG IYKLIKYRSI LNGNTIPVLM FGFLVSFLLC 

       250        260        270 
TLVIRWFLRY IQKHSFSVFG VYRILLGVGV LVLTKLI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016823 Genomic DNA. Translation: AAS70055.1.
RefSeqYP_001418.1. NC_005823.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267671.LIC11457.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS70055; AAS70055; LIC_11457.
GeneID2771065.
KEGGlic:LIC11457.
PATRIC22375237. VBILepInt6257_1785.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK574452.

Enzyme and pathway databases

BioCycLINT267671:GHQI-1454-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_LEPIC
AccessionPrimary (citable) accession number: P62465
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families