Reviewed, UniProtKB/Swiss-Prot P62463 (UPPP3_BACC1)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 3
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 3
    Bacitracin resistance protein 3

Gene names

Name:	uppP3
Synonyms:	bacA3, upk3
Ordered Locus Names:	BCE_2732

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Undecaprenyl-diphosphatase 3 HAMAP MF_01006		PRO_0000151090
Regions
	Transmembrane	1 – 21	21	Potential
	Transmembrane	39 – 59	21	Potential
	Transmembrane	71 – 91	21	Potential
	Transmembrane	99 – 119	21	Potential
	Transmembrane	133 – 153	21	Potential
	Transmembrane	174 – 194	21	Potential
	Transmembrane	208 – 228	21	Potential
	Transmembrane	236 – 256	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P62463-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 545969E859BB8A16	FASTA	259	29,212
	10 20 30 40 50 60 MNWLEAFILG IIQGLTEFLP ISSTGHLYLG RHLFQLDEAG LFLDTMLHIG TLLAVFIYYK 70 80 90 100 110 120 KEFIYLIKNP FSKLMLLLIV GTIPAVVIGL LFKDFFEDIS KTGITIGWEF LVTGFFLYMA 130 140 150 160 170 180 DKXKNGRKKM DDITYKDAFI IGSFXAVAIF PAISRSGMTI VAALWRKLDR ETAAYFSFLL 190 200 210 220 230 240 STPAIVGAII LQFVDVFQGK AESISSTSLI VGTLSAAFFG YIAVSWMIQY LKRHSLKVFA 250 YYVWGLGILI LTLQFTRVF

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017194 Genomic DNA. Translation: AAS41644.1.
RefSeq	NP_979036.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P62463.
Genome annotation databases
GeneID	2752540.
GenomeReviews	Gene locus BCE_2732 in contig AE017194_GR.
KEGG	bca:BCE_2732.
NMPDR	fig|222523.1.peg.2708.
TIGR	BCE_2732.
Phylogenomic databases
HOGENOM	P62463.
OMA	FGLLFKD.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP3_BACC1

Accession

Primary (citable) accession number: P62463

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)