P62462 (UPPP2_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 2
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2

Gene names

Name:	uppP2
Synonyms:	bacA2, upk2
Ordered Locus Names:	BCE_1502

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151089
Regions
	Transmembrane	15 – 37	23	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	106 – 126	21	Helical; Potential
	Transmembrane	142 – 162	21	Helical; Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Transmembrane	216 – 236	21	Helical; Potential
	Transmembrane	242 – 262	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P62462 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 61C06BD6CF6C0F0E	FASTA	263	28,347
	10 20 30 40 50 60 MADWLIGIIM GAVEGLTEFL PVSSTGHMIL TGHLLGFDDE RAKVFEVVIQ LGSILAVVVI 70 80 90 100 110 120 FWKRLWSLVG IGKVTDGPSL NLLHIIIGMI PAGVLGVLFH SAIKEVLFGP GPVVISLVAG 130 140 150 160 170 180 GILMIVAEKF SKPSTARTLD EITYKQAFTI GMFQCLALWP GFSRSGSTIS GGLLARVSHT 190 200 210 220 230 240 AAAEYTFILA VPMMVAASGL DLIKSWDILS AADIPLFATG FITAFVVAML AIVSFLKLLS 250 260 RVKLTPFAYY RFILAAVFYF FIM

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS40431.1.
RefSeq	NP_977823.1. NC_003909.8.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P62462.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000027936; EBBACP00000027286; EBBACG00000027927.
GeneID	2750099.
GenomeReviews	Gene locus BCE_1502 in contig AE017194_GR.
KEGG	bca:BCE_1502.
NMPDR	fig|222523.1.peg.1495.
PATRIC	18851848. VBIBacCer118379_1428.
TIGR	BCE_1502.
Phylogenomic databases
eggNOG	COG1968.
GeneTree	EBGT00050000002490.
HOGENOM	HBG391969.
OMA	DWLIGLI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_1502-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. Undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_BACC1

Accession

Primary (citable) accession number: P62462

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program