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P62462 (UPPP2_BACC1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Synonyms:bacA2, upk2
Ordered Locus Names:BCE_1502
OrganismBacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]
Taxonomic identifier222523 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000151089

Regions

Transmembrane15 – 3723Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane106 – 12621Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane242 – 26221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P62462 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 61C06BD6CF6C0F0E

FASTA26328,347
        10         20         30         40         50         60 
MADWLIGIIM GAVEGLTEFL PVSSTGHMIL TGHLLGFDDE RAKVFEVVIQ LGSILAVVVI 

        70         80         90        100        110        120 
FWKRLWSLVG IGKVTDGPSL NLLHIIIGMI PAGVLGVLFH SAIKEVLFGP GPVVISLVAG 

       130        140        150        160        170        180 
GILMIVAEKF SKPSTARTLD EITYKQAFTI GMFQCLALWP GFSRSGSTIS GGLLARVSHT 

       190        200        210        220        230        240 
AAAEYTFILA VPMMVAASGL DLIKSWDILS AADIPLFATG FITAFVVAML AIVSFLKLLS 

       250        260 
RVKLTPFAYY RFILAAVFYF FIM 

« Hide

References

[1]"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1."
Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.
Nucleic Acids Res. 32:977-988(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017194 Genomic DNA. Translation: AAS40431.1.
RefSeqNP_977823.1. NC_003909.8.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING222523.BCE_1502.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS40431; AAS40431; BCE_1502.
GeneID2750099.
KEGGbca:BCE_1502.
PATRIC18851848. VBIBacCer118379_1428.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAWRKISSS.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP2_BACC1
AccessionPrimary (citable) accession number: P62462
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families