P62461 (UPPP1_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 1
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1

Gene names

Name:	uppP1
Synonyms:	bacA1, upk1
Ordered Locus Names:	BCE_0750

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus cereus

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006		PRO_0000151088
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Transmembrane	192 – 212	21	Helical; Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Transmembrane	250 – 270	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P62461 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A7A6AA4C7262FCDC	FASTA	270	29,976
	10 20 30 40 50 60 MEQFYYILKY LILGLFQGLT EPIPISSSGH LVLAQHLLGL KIEGFSFELL VNSASLLAVL 70 80 90 100 110 120 LIYRNDLIRL TKNGLSYIFT RAEDAKSDFF FIIYLVIATI PAGVIGVLFK DYIDQYLKGV 130 140 150 160 170 180 KMVGISLLIT AVGLWIIRNL RGRKNDGDLS MKDAIIVGLA QACALIPGIS RSGATIVAAM 190 200 210 220 230 240 LLGMKQETAL RFSFLLYIPV SLGGLLLSIT DIAKDPNLDT LFVPYIVAFI ATFIMTYISL 250 260 270 KWFMNIMAKG NLKYFSFYCI IVGVLTLIFL

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS39683.1.
RefSeq	NP_977075.1. NC_003909.8.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	222523.BCE_0750.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS39683; AAS39683; BCE_0750.
GeneID	2747079.
KEGG	bca:BCE_0750.
PATRIC	18850370. VBIBacCer118379_0713.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	HMMWALI.
ProtClustDB	PRK12554.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_BACC1

Accession

Primary (citable) accession number: P62461

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program