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P62460

- HISX_THET2

UniProt

P62460 - HISX_THET2

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation
Binding sitei199 – 1991NADUniRule annotation
Binding sitei222 – 2221SubstrateUniRule annotation
Metal bindingi244 – 2441ZincUniRule annotation
Binding sitei244 – 2441SubstrateUniRule annotation
Metal bindingi247 – 2471ZincUniRule annotation
Binding sitei247 – 2471SubstrateUniRule annotation
Active sitei311 – 3111Proton acceptorUniRule annotation
Active sitei312 – 3121Proton acceptorUniRule annotation
Binding sitei312 – 3121SubstrateUniRule annotation
Metal bindingi345 – 3451ZincUniRule annotation
Binding sitei345 – 3451SubstrateUniRule annotation
Binding sitei399 – 3991SubstrateUniRule annotation
Metal bindingi404 – 4041ZincUniRule annotation
Binding sitei404 – 4041SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-379-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:TT_C0370
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Histidinol dehydrogenasePRO_0000135870Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC0370.

Structurei

3D structure databases

ProteinModelPortaliP62460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiAHERIRR.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62460-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIYAAEEVRA RFARRGLSFD PTVEEIVRGI LEAVREEGDE ALDRFSRDLD
60 70 80 90 100
GYPVEEVPKR AWREAYEDLD EDLRDALETA RERIEAFYRE EARGGFLRAE
110 120 130 140 150
GGGVLAQLVR PLERVGVYVP GGSAPLLSTL LMTVVPAKVA GVREVIVASP
160 170 180 190 200
PKVHPGVLAA AWVAGADRLF AMGGAQAIAA LAYGTGRVPR VDKIVGPGNR
210 220 230 240 250
YVVAAKRLVY GTVGIDGLAG PTETMIIADG SASPRLLAAD LLAQAEHGPD
260 270 280 290 300
SEPWLLSPDR ALLERVEAEL SRQLQDLPRA EVARQALEKG GLVLTKDLEE
310 320 330 340 350
AFALANLYAP EHLSLALSDP LPWLEKVQNA GGVFLGEGSP EALGDYIAGP
360 370 380 390 400
SHVMPTSGTA RFQGGLAVRD FLKVIPVVGL SEGAARELAK KGALLARAEG
410
LEGHARSLDL RR
Length:412
Mass (Da):44,093
Last modified:July 5, 2004 - v1
Checksum:i4A4BBB724BE5CE6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS80718.1.
RefSeqiWP_011172819.1. NC_005835.1.
YP_004345.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS80718; AAS80718; TT_C0370.
GeneIDi2775807.
KEGGitth:TTC0370.
PATRICi23951135. VBITheThe54392_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS80718.1 .
RefSeqi WP_011172819.1. NC_005835.1.
YP_004345.1. NC_005835.1.

3D structure databases

ProteinModelPortali P62460.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC0370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS80718 ; AAS80718 ; TT_C0370 .
GeneIDi 2775807.
KEGGi tth:TTC0370.
PATRICi 23951135. VBITheThe54392_0367.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi AHERIRR.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci TTHE262724:GCAT-379-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiHISX_THET2
AccessioniPrimary (citable) accession number: P62460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3