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P62460

- HISX_THET2

UniProt

P62460 - HISX_THET2

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Protein
Histidinol dehydrogenase
Gene
hisD, TT_C0370
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181NAD By similarity
Binding sitei176 – 1761NAD By similarity
Binding sitei199 – 1991NAD By similarity
Binding sitei222 – 2221Substrate By similarity
Metal bindingi244 – 2441Zinc By similarity
Binding sitei244 – 2441Substrate By similarity
Metal bindingi247 – 2471Zinc By similarity
Binding sitei247 – 2471Substrate By similarity
Active sitei311 – 3111Proton acceptor By similarity
Active sitei312 – 3121Proton acceptor By similarity
Binding sitei312 – 3121Substrate By similarity
Metal bindingi345 – 3451Zinc By similarity
Binding sitei345 – 3451Substrate By similarity
Binding sitei399 – 3991Substrate By similarity
Metal bindingi404 – 4041Zinc By similarity
Binding sitei404 – 4041Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-379-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:TT_C0370
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Histidinol dehydrogenaseUniRule annotation
PRO_0000135870Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262724.TTC0370.

Structurei

3D structure databases

ProteinModelPortaliP62460.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiAHERIRR.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62460-1 [UniParc]FASTAAdd to Basket

« Hide

MIYAAEEVRA RFARRGLSFD PTVEEIVRGI LEAVREEGDE ALDRFSRDLD    50
GYPVEEVPKR AWREAYEDLD EDLRDALETA RERIEAFYRE EARGGFLRAE 100
GGGVLAQLVR PLERVGVYVP GGSAPLLSTL LMTVVPAKVA GVREVIVASP 150
PKVHPGVLAA AWVAGADRLF AMGGAQAIAA LAYGTGRVPR VDKIVGPGNR 200
YVVAAKRLVY GTVGIDGLAG PTETMIIADG SASPRLLAAD LLAQAEHGPD 250
SEPWLLSPDR ALLERVEAEL SRQLQDLPRA EVARQALEKG GLVLTKDLEE 300
AFALANLYAP EHLSLALSDP LPWLEKVQNA GGVFLGEGSP EALGDYIAGP 350
SHVMPTSGTA RFQGGLAVRD FLKVIPVVGL SEGAARELAK KGALLARAEG 400
LEGHARSLDL RR 412
Length:412
Mass (Da):44,093
Last modified:July 5, 2004 - v1
Checksum:i4A4BBB724BE5CE6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS80718.1.
RefSeqiYP_004345.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS80718; AAS80718; TT_C0370.
GeneIDi2775807.
KEGGitth:TTC0370.
PATRICi23951135. VBITheThe54392_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS80718.1 .
RefSeqi YP_004345.1. NC_005835.1.

3D structure databases

ProteinModelPortali P62460.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC0370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS80718 ; AAS80718 ; TT_C0370 .
GeneIDi 2775807.
KEGGi tth:TTC0370.
PATRICi 23951135. VBITheThe54392_0367.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi AHERIRR.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci TTHE262724:GCAT-379-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiHISX_THET2
AccessioniPrimary (citable) accession number: P62460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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