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P62459

- HISX_PHOPR

UniProt

P62459 - HISX_PHOPR

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Protein

Histidinol dehydrogenase

Gene
hisD, PBPRA1091
Organism
Photobacterium profundum (Photobacterium sp. (strain SS9))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei185 – 1851NAD By similarity
Binding sitei208 – 2081NAD By similarity
Binding sitei234 – 2341Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Active sitei323 – 3231Proton acceptor By similarity
Active sitei324 – 3241Proton acceptor By similarity
Binding sitei324 – 3241Substrate By similarity
Metal bindingi357 – 3571Zinc By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei411 – 4111Substrate By similarity
Metal bindingi416 – 4161Zinc By similarity
Binding sitei416 – 4161Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PBPRA1091
OrganismiPhotobacterium profundum (Photobacterium sp. (strain SS9))
Taxonomic identifieri74109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
ProteomesiUP000000593: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Histidinol dehydrogenaseUniRule annotationPRO_0000135812Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi298386.PBPRA1091.

Structurei

3D structure databases

ProteinModelPortaliP62459.
SMRiP62459. Positions 6-430.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62459-1 [UniParc]FASTAAdd to Basket

« Hide

MKTVVWQSLS ENQQESLLQR PAITEGANIT AIVADVVADV RQRGDEALLE    50
LTEKFDRVRP DSIRVSEQEV TAATSRLSDN MKQALQQAYQ NIATFHKAQK 100
TKPLRVETQP GVVCEQVTRP INSVGLYIPG GSAPLPSTVL MLGVPAQIAG 150
CRQVVLCSPP PIADEILYVA QLCGITEIYN IGGSQAIAAM AYGTKSVARV 200
DKIFGPGNAF VTEAKRQVSN DFRGAAIDMP AGPSEVLVIA DKTADPDFIA 250
ADLLSQAEHG PDSQVILLTP EPSIADRVAD AIQLQLKVLP RADIARQALG 300
SSILIVTETI SQCISISNHY GPEHLIVQTR EPRELVPLLD NAGSIFLGDW 350
SPESVGDYAS GTNHVLPTYG YTRTYSSLGL ADFSKRMTVQ ELTADGLKIL 400
APTVVTMAEA EGLDAHKRAV TIRIEKLQQQ EILKAQQVEE KEA 443
Length:443
Mass (Da):47,825
Last modified:July 5, 2004 - v1
Checksum:i581F0F745ACECB4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378666 Genomic DNA. Translation: CAG19502.1.
RefSeqiYP_129304.1. NC_006370.1.

Genome annotation databases

EnsemblBacteriaiCAG19502; CAG19502; PBPRA1091.
GeneIDi3123241.
KEGGippr:PBPRA1091.
PATRICi22932942. VBIPhoPro109272_1190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR378666 Genomic DNA. Translation: CAG19502.1 .
RefSeqi YP_129304.1. NC_006370.1.

3D structure databases

ProteinModelPortali P62459.
SMRi P62459. Positions 6-430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 298386.PBPRA1091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG19502 ; CAG19502 ; PBPRA1091 .
GeneIDi 3123241.
KEGGi ppr:PBPRA1091.
PATRICi 22932942. VBIPhoPro109272_1190.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SS9.

Entry informationi

Entry nameiHISX_PHOPR
AccessioniPrimary (citable) accession number: P62459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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