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P62457

- HISX_DESVH

UniProt

P62457 - HISX_DESVH

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421SubstrateUniRule annotation
Metal bindingi264 – 2641ZincUniRule annotation
Binding sitei264 – 2641SubstrateUniRule annotation
Metal bindingi267 – 2671ZincUniRule annotation
Binding sitei267 – 2671SubstrateUniRule annotation
Active sitei332 – 3321Proton acceptorUniRule annotation
Active sitei333 – 3331Proton acceptorUniRule annotation
Binding sitei333 – 3331SubstrateUniRule annotation
Metal bindingi366 – 3661ZincUniRule annotation
Binding sitei366 – 3661SubstrateUniRule annotation
Binding sitei420 – 4201SubstrateUniRule annotation
Metal bindingi425 – 4251ZincUniRule annotation
Binding sitei425 – 4251SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciDVUL882:GJIL-820-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:DVU_0796
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Histidinol dehydrogenasePRO_0000135768Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi882.DVU0796.

Structurei

3D structure databases

ProteinModelPortaliP62457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.
PhylomeDBiP62457.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62457-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPCRILTLQS EAQWPLLGDM LAGRYDPDDA VEPVVRDILA AVRSKGDEAL
60 70 80 90 100
AEYTRRFDCP DFTPALLHVT SEEVAQAVAS VPADDIAIIR QAADNIRSFH
110 120 130 140 150
EAQKERSWFV THDDGTILGQ KVTPVDRAGL YVPGGKGGDT PLLSSLLMNA
160 170 180 190 200
IPAQVAGVTS ITVASPPRPD GTLNPHLLAA AHILGITDII RAGSAWAVAA
210 220 230 240 250
FAFGTQTIAP VDVIAGPGNI FVTTAKRMVQ GRVAIDMIAG PSEILILADA
260 270 280 290 300
TARPDWVAAD MLSQAEHDPL ASSILVTTEP ALAEAVTAEL ERQLATLPRA
310 320 330 340 350
DIARKALADW GAVVVVPDMD VAVAIANRVA PEHLEVLTAQ PWELAGSLRH
360 370 380 390 400
AGALFLGPYS PEPLGDYFAG PNHVLPTMGT ARFSSALSVQ TFCKRTSIIA
410 420 430
ASRAFAERNA DAVARLARLE GLEAHARSAA SRNSQQ
Length:436
Mass (Da):46,131
Last modified:July 5, 2004 - v1
Checksum:i070577443146D3A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS95276.1.
RefSeqiYP_010017.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS95276; AAS95276; DVU_0796.
GeneIDi2794518.
KEGGidvu:DVU0796.
PATRICi32061518. VBIDesVul119526_0747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS95276.1 .
RefSeqi YP_010017.1. NC_002937.3.

3D structure databases

ProteinModelPortali P62457.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU0796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS95276 ; AAS95276 ; DVU_0796 .
GeneIDi 2794518.
KEGGi dvu:DVU0796.
PATRICi 32061518. VBIDesVul119526_0747.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.
PhylomeDBi P62457.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci DVUL882:GJIL-820-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiHISX_DESVH
AccessioniPrimary (citable) accession number: P62457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3