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Protein

Zinc finger protein-like 1

Gene

zfpl1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for cis-Golgi integrity and efficient ER to Golgi transport.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 4343B box-type; degenerateAdd
BLAST
Zinc fingeri53 – 10149RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein-like 1
Gene namesi
Name:zfpl1
ORF Names:zgc:63760
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1255. zfpl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 271271CytoplasmicSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Topological domaini293 – 31725LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Zinc finger protein-like 1PRO_0000056320Add
BLAST

Proteomic databases

PaxDbiP62447.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000037977.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi141 – 1444Poly-Glu

Sequence similaritiesi

Belongs to the ZFPL1 family.Curated
Contains 1 B box-type zinc finger.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 4343B box-type; degenerateAdd
BLAST
Zinc fingeri53 – 10149RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG3970. Eukaryota.
ENOG410ZR2P. LUCA.
HOGENOMiHOG000031475.
HOVERGENiHBG079377.
InParanoidiP62447.
PhylomeDBiP62447.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLCKCPKKK VTNLFCFKHR VNVCEHCLVS NHNKCIVQSY LQWLQDSDYN
60 70 80 90 100
PNCSLCIQPL DSQDTVRLVC YDLFHWSCLN ELASHQPLNT APDGYQCPTC
110 120 130 140 150
QGPVFPPRNL ASPVADMLRE QLSSVNWARA GLGLPLIEDP EEEETTTHSG
160 170 180 190 200
TSFSEWSTFE TTSVDVSMSN PTLTSLPPHQ DGEHIYNNRE QSAPNNTVFN
210 220 230 240 250
MVTTSATDTV TISTVTSPRK LYDTRDLGHS AVMQIDFDDD KYRRRPALNW
260 270 280 290 300
FAQVLKNCTS TKKKTLALKH RIFLLLLFGV IGFFTLIIIM AKFGRASAET
310
DPNLDPLLNP NIRIGNM
Length:317
Mass (Da):35,704
Last modified:July 5, 2004 - v1
Checksum:iB94A3849E2F7C869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058063 mRNA. Translation: AAH58063.1.
RefSeqiNP_956967.1. NM_200673.1.
UniGeneiDr.107192.

Genome annotation databases

GeneIDi393646.
KEGGidre:393646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058063 mRNA. Translation: AAH58063.1.
RefSeqiNP_956967.1. NM_200673.1.
UniGeneiDr.107192.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000037977.

Proteomic databases

PaxDbiP62447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393646.
KEGGidre:393646.

Organism-specific databases

CTDi7542.
ZFINiZDB-GENE-040426-1255. zfpl1.

Phylogenomic databases

eggNOGiKOG3970. Eukaryota.
ENOG410ZR2P. LUCA.
HOGENOMiHOG000031475.
HOVERGENiHBG079377.
InParanoidiP62447.
PhylomeDBiP62447.

Miscellaneous databases

NextBioi20814654.
PROiP62447.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiZFPL1_DANRE
AccessioniPrimary (citable) accession number: P62447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.